Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Bioenergetic and Metabolic Consequences of the Loss of Gonadal Function


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Collapse Overview 
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The?Colorado?Specialized?Center?of?Research?Excellence?on?Sex?Differences?(CO-?SCORE)?is?thematically? focused?on?Bioenergetic?and?Metabolic?Consequences?of?the?Loss?of?Gonadal?Function.?The?overarching? scientific?objective?of?the?CO-?SCORE?is?to?advance?knowledge?of?the?impact?of?gonadal?aging?on?the? regulation?of?bioenergetics,?abdominal?adiposity,?and?metabolism?by?conducting?mechanistically-?driven? research?across?the?basic-?to-?clinical?translational?spectrum.?The?scientific?premise?is?that?gonadal?failure? mediates?biological?changes?that?increase?risk?for?chronic?disease.?The?most?well-?studied?example?of?this?is?the? accelerated?decline?in?bone?mineral?density?at?menopause?and?the?associated?osteoporosis?risk.?However,?the? extent?to?which?gonadal?failure?increases?risk?for?chronic?diseases?other?than?osteoporosis?is?poorly? understood.?This?is?a?particularly?important?knowledge?gap?in?women?s?health,?because?gonadal?failure?is? inevitable?in?women?in?mid-?life,?but?rare?in?men?until?much?later?in?life.?The?overarching?educational?objective? is?to?engage?new?investigators?in?research?aligned?with?the?thematic?focus?of?the?CO-?SCORE.?The?CO-?SCORE? will?promote?mentored?career?development?and?provide?training?on?how?to?conduct?research?that?appropriately? addresses?sex?as?a?biological?variable?(SABV).?These?central?objectives?will?be?accomplished?through?the? following?Aims:?1)?The?three?CO-?SCORE?Research?Projects?(basic,?preclinical,?and?clinical)?will?advance? cutting-?edge,?paradigm-?challenging?translational?research?on?novel?mechanisms?postulated?to?contribute?to?the? increased?abdominal?adiposity?and?associated?metabolic?dysfunction?that?occur?in?the?estrogen-?deficient?state;?? 2)?The?Career?Enhancement?Core?(CEC)?will?provide?a?rich?training?environment?to?attract?and?support? outstanding?junior?investigators?with?research?interests?related?to?the?thematic?focus?of?the?CO-?SCORE.? SCORE?Scholars?and?Pilot?Awardees?will?be?selected?through?a?competitive?process?and?participate?in?a? comprehensive?career?development?program;??3)?The?Leadership?Administrative?Core?(LAC)?will?provide? infrastructural?support?for?the?Research?Projects,?CO-?SCORE?Pilot?Projects,?and?the?CEC,?including? biostatistics,?data?management,?financial?oversight,?and?administrative?support.?An?evaluation?specialist?will? use?innovative?strategies?for?assessing?whether?the?research,?trainees,?mentors,?and?the?CO-?SCORE?as?a? whole?are?achieving?a?high?level?of?impact?and?reach;??and?4)?The?CO-?SCORE?will?partner?with?other?Centers? and?Programs?at?CU-?AMC?to?elevate?the?visibility?and?multi-?disciplinary?reach?of?women?s?health?research?and? the?importance?of?investigating?SABV.?Activities?will?target?both?scientific?and?lay?communities?at?local,?regional,? and?national?levels.?Achieving?these?Aims?will?position?the?CO-?SCORE?as?a?national?leader?in?our?targeted? areas?of?women?s?health?research,?and?the?CEC?as?a?model?program?for?training?junior?investigators?to? appropriately?integrate?SABV?into?their?research,?thereby?addressing?the?ultimate?goal?of?the?SCORE?program? of?improving?the?health?of?women.?
Collapse sponsor award id
U54AG062319

Collapse Time 
Collapse start date
2012-09-20
Collapse end date
2023-05-31

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