 Sterol Regulatory Element Binding Protein 1
"Sterol Regulatory Element Binding Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
| Descriptor ID |
D051780
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| MeSH Number(s) |
D12.776.260.103.500.750.500 D12.776.260.108.092.750.500 D12.776.930.125.500.750.500 D12.776.930.127.092.750.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sterol Regulatory Element Binding Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Sterol Regulatory Element Binding Protein 1".
This graph shows the total number of publications written about "Sterol Regulatory Element Binding Protein 1" by people in this website by year, and whether "Sterol Regulatory Element Binding Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2002 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 4 | 4 | | 2005 | 1 | 5 | 6 | | 2006 | 2 | 3 | 5 | | 2007 | 0 | 2 | 2 | | 2008 | 0 | 2 | 2 | | 2010 | 2 | 1 | 3 | | 2011 | 0 | 1 | 1 | | 2013 | 0 | 2 | 2 | | 2014 | 1 | 1 | 2 | | 2016 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2021 | 1 | 1 | 2 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sterol Regulatory Element Binding Protein 1" by people in Profiles.
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Yousof TR, Bouchard CC, Alb M, Lynn EG, Lhot?k S, Jiang H, MacDonald M, Li H, Byun JH, Makda Y, Athanasopoulos M, Maclean KN, Cherrington NJ, Naqvi A, Igdoura SA, Krepinsky JC, Steinberg GR, Austin RC. Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice. J Biol Chem. 2024 02; 300(2):105655.
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Sinnott-Armstrong N, Sousa IS, Laber S, Rendina-Ruedy E, Nitter Dankel SE, Ferreira T, Mellgren G, Karasik D, Rivas M, Pritchard J, Guntur AR, Cox RD, Lindgren CM, Hauner H, Sallari R, Rosen CJ, Hsu YH, Lander ES, Kiel DP, Claussnitzer M. A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. Cell Metab. 2021 03 02; 33(3):615-628.e13.
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Shochat C, Wang Z, Mo C, Nelson S, Donaka R, Huang J, Karasik D, Brotto M. Deletion of SREBF1, a Functional Bone-Muscle Pleiotropic Gene, Alters Bone Density and Lipid Signaling in Zebrafish. Endocrinology. 2021 01 01; 162(1).
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Grinman DY, Careaga VP, Wellberg EA, Dansey MV, Kordon EC, Anderson SM, Maier MS, Burton G, MacLean PS, Rudolph MC, Pecci A. Liver X receptor-a activation enhances cholesterol secretion in lactating mammary epithelium. Am J Physiol Endocrinol Metab. 2019 06 01; 316(6):E1136-E1145.
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Du T, Sikora MJ, Levine KM, Tasdemir N, Riggins RB, Wendell SG, Van Houten B, Oesterreich S. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. Breast Cancer Res. 2018 09 04; 20(1):106.
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Medina-Gomez C, Kemp JP, Dimou NL, Kreiner E, Chesi A, Zemel BS, B?nnelykke K, Boer CG, Ahluwalia TS, Bisgaard H, Evangelou E, Heppe DHM, Bonewald LF, Gorski JP, Ghanbari M, Demissie S, Duque G, Maurano MT, Kiel DP, Hsu YH, C J van der Eerden B, Ackert-Bicknell C, Reppe S, Gautvik KM, Raastad T, Karasik D, van de Peppel J, Jaddoe VWV, Uitterlinden AG, Tobias JH, Grant SFA, Bagos PG, Evans DM, Rivadeneira F. Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus. Nat Commun. 2017 07 25; 8(1):121.
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Irimia JM, Meyer CM, Segvich DM, Surendran S, DePaoli-Roach AA, Morral N, Roach PJ. Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. J Biol Chem. 2017 06 23; 292(25):10455-10464.
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Libby AE, Bales E, Orlicky DJ, McManaman JL. Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome. J Biol Chem. 2016 Nov 11; 291(46):24231-24246.
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Bruce KD, Szczepankiewicz D, Sihota KK, Ravindraanandan M, Thomas H, Lillycrop KA, Burdge GC, Hanson MA, Byrne CD, Cagampang FR. Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH. Biochim Biophys Acta. 2016 Jul; 1861(7):584-93.
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Nambiar DK, Deep G, Singh RP, Agarwal C, Agarwal R. Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1. Oncotarget. 2014 Oct 30; 5(20):10017-33.
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