 Mice, Inbred MRL lpr
"Mice, Inbred MRL lpr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
| Descriptor ID |
D019463
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| MeSH Number(s) |
B01.050.050.199.520.520.555 B01.050.150.900.649.313.992.635.505.500.400.555
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| Concept/Terms |
Mice, Inbred MRL lpr- Mice, Inbred MRL lpr
- Mouse, MRL lpr
- MRL lpr Mouse
- Mice, MRL lpr
- MRL lpr Mice
- Mouse, Inbred MRL lpr
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Below are MeSH descriptors whose meaning is more general than "Mice, Inbred MRL lpr".
Below are MeSH descriptors whose meaning is more specific than "Mice, Inbred MRL lpr".
This graph shows the total number of publications written about "Mice, Inbred MRL lpr" by people in this website by year, and whether "Mice, Inbred MRL lpr" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1997 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 4 | 4 | | 2004 | 0 | 3 | 3 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 3 | 3 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 2 | 2 | | 2014 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mice, Inbred MRL lpr" by people in Profiles.
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Kulik L, Laskowski J, Renner B, Woolaver R, Zhang L, Lyubchenko T, You Z, Thurman JM, Holers VM. Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus. J Immunol. 2019 12 15; 203(12):3136-3147.
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Sang A, Danhorn T, Peterson JN, Rankin AL, O'Connor BP, Leach SM, Torres RM, Pelanda R. Innate and adaptive signals enhance differentiation and expansion of dual-antibody autoreactive B cells in lupus. Nat Commun. 2018 09 28; 9(1):3973.
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Mehta G, Ferreira VP, Skerka C, Zipfel PF, Banda NK. New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases. Mol Immunol. 2014 Nov; 62(1):235-48.
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Fournier EM, Velez MG, Leahy K, Swanson CL, Rubtsov AV, Torres RM, Pelanda R. Dual-reactive B cells are autoreactive and highly enriched in the plasmablast and memory B cell subsets of autoimmune mice. J Exp Med. 2012 Sep 24; 209(10):1797-812.
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Larson JD, Thurman JM, Rubtsov AV, Claypool D, Marrack P, van Dyk LF, Torres RM, Pelanda R. Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):E1092-100.
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Sargsyan SA, Serkova NJ, Renner B, Hasebroock KM, Larsen B, Stoldt C, McFann K, Pickering MC, Thurman JM. Detection of glomerular complement C3 fragments by magnetic resonance imaging in murine lupus nephritis. Kidney Int. 2012 Jan; 81(2):152-9.
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Favilli F, Anzilotti C, Martinelli L, Quattroni P, De Martino S, Pratesi F, Neumann D, Beermann S, Novick D, Dinarello CA, Boraschi D, Migliorini P. IL-18 activity in systemic lupus erythematosus. Ann N Y Acad Sci. 2009 Sep; 1173:301-9.
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Lenert P, Yasuda K, Busconi L, Nelson P, Fleenor C, Ratnabalasuriar RS, Nagy PL, Ashman RF, Rifkin IR, Marshak-Rothstein A. DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitro and autoantibody production in lupus-prone MRL-Fas(lpr/lpr) mice in vivo. Arthritis Res Ther. 2009; 11(3):R79.
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Li Y, Chen F, Putt M, Koo YK, Madaio M, Cambier JC, Cohen PL, Eisenberg RA. B cell depletion with anti-CD79 mAbs ameliorates autoimmune disease in MRL/lpr mice. J Immunol. 2008 Sep 01; 181(5):2961-72.
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Baudino L, Yoshinobu K, Morito N, Kikuchi S, Fossati-Jimack L, Morley BJ, Vyse TJ, Hirose S, Jørgensen TN, Tucker RM, Roark CL, Kotzin BL, Evans LH, Izui S. Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis. J Immunol. 2008 Aug 15; 181(4):2846-54.
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