 Sirolimus
"Sirolimus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
| Descriptor ID |
D020123
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| MeSH Number(s) |
D02.540.505.760
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sirolimus".
Below are MeSH descriptors whose meaning is more specific than "Sirolimus".
This graph shows the total number of publications written about "Sirolimus" by people in this website by year, and whether "Sirolimus" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1999 | 1 | 1 | 2 | | 2000 | 4 | 1 | 5 | | 2001 | 2 | 2 | 4 | | 2003 | 3 | 2 | 5 | | 2004 | 3 | 5 | 8 | | 2005 | 2 | 4 | 6 | | 2006 | 5 | 2 | 7 | | 2007 | 2 | 3 | 5 | | 2008 | 3 | 3 | 6 | | 2009 | 3 | 3 | 6 | | 2010 | 9 | 2 | 11 | | 2011 | 5 | 7 | 12 | | 2012 | 5 | 1 | 6 | | 2013 | 9 | 7 | 16 | | 2014 | 8 | 7 | 15 | | 2015 | 1 | 2 | 3 | | 2016 | 6 | 4 | 10 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 2 | 3 | | 2019 | 3 | 1 | 4 | | 2020 | 1 | 4 | 5 | | 2021 | 0 | 4 | 4 | | 2022 | 0 | 3 | 3 |
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Below are the most recent publications written about "Sirolimus" by people in Profiles.
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Elgendy TY, Waldner M, Zhang W, Kim DY, Minervini MI, Komatsu C, Kulahci Y, Washington KM, Gorantla VS, Ezzelarab MB, Solari MG, Thomson AW. Tacrolimus before CTLA4Ig and rapamycin promotes vascularized composite allograft survival in MGH miniature swine. Transpl Immunol. 2022 12; 75:101696.
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Freeman CL, Pararajalingam P, Jin L, Balasubramanian S, Jiang A, Xu W, Grau M, Zapukhlyak M, Boyle M, Hodkinson B, Schaffer M, Enny C, Deshpande S, Sun S, Vermeulen J, Morin RD, Scott DW, Lenz G. Molecular determinants of outcomes in relapsed or refractory mantle cell lymphoma treated with ibrutinib or temsirolimus in the MCL3001 (RAY) trial. Leukemia. 2022 10; 36(10):2479-2487.
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Major A, Kline J, Karrison TG, Fishkin PAS, Kimball AS, Petrich AM, Nattam S, Rao K, Sleckman BG, Cohen K, Besien KV, Rapoport AP, Smith SM. Phase I/II clinical trial of temsirolimus and lenalidomide in patients with relapsed and refractory lymphomas. Haematologica. 2022 07 01; 107(7):1608-1618.
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Petrache I, de Boer E. Rapalogs Target the Endothelium to Set the Stage for Acute Lung Injury. Am J Respir Cell Mol Biol. 2021 12; 65(6):576-577.
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Wahl D, Cavalier AN, Smith M, Seals DR, LaRocca TJ. Healthy Aging Interventions Reduce Repetitive Element Transcripts. J Gerontol A Biol Sci Med Sci. 2021 04 30; 76(5):805-810.
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Greer HR, Orbach DB, Yock TI, Rodriguez-Galindo C, Green AL. Intra-arterial chemotherapy for rhabdomyosarcoma. Pediatr Hematol Oncol. 2021 05; 38(4):391-396.
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Hardesty A, Pandita A, Vieira K, Rogers R, Merhi B, Osband AJ, Aridi J, Shi Y, Bayliss G, Cosgrove C, Gohh R, Morrissey P, Beckwith CG, Farmakiotis D. Coronavirus Disease 2019 in Kidney Transplant Recipients: Single-Center Experience and Case-Control Study. Transplant Proc. 2021 May; 53(4):1187-1193.
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Moya NA, Tanner MK, Smith AM, Balolia A, Davis JKP, Bonar K, Jaime J, Hubert T, Silva J, Whitworth W, Loetz EC, Bland ST, Greenwood BN. Acute exercise enhances fear extinction through a mechanism involving central mTOR signaling. Neurobiol Learn Mem. 2020 12; 176:107328.
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Pohl K, Grimm XA, Caceres SM, Poch KR, Rysavy N, Saavedra M, Nick JA, Malcolm KC. Mycobacterium abscessus Clearance by Neutrophils Is Independent of Autophagy. Infect Immun. 2020 07 21; 88(8).
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Kern JA, Kim J, Foster DG, Mishra R, Gardner EE, Poirier JT, Rivard C, Yu H, Finigan JH, Dowlati A, Rudin CM, Tan AC. Role of mTOR As an Essential Kinase in SCLC. J Thorac Oncol. 2020 09; 15(9):1522-1534.
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