 Cyclins
"Cyclins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large family of regulatory proteins that function as accessory subunits to a variety of CYCLIN-DEPENDENT KINASES. They generally function as ENZYME ACTIVATORS that drive the CELL CYCLE through transitions between phases. A subset of cyclins may also function as transcriptional regulators.
| Descriptor ID |
D016213
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| MeSH Number(s) |
D12.644.360.262 D12.776.167.218 D12.776.476.262
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cyclins".
Below are MeSH descriptors whose meaning is more specific than "Cyclins".
This graph shows the total number of publications written about "Cyclins" by people in this website by year, and whether "Cyclins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 3 | 4 | | 1995 | 2 | 0 | 2 | | 1996 | 2 | 2 | 4 | | 1997 | 2 | 0 | 2 | | 1998 | 1 | 1 | 2 | | 1999 | 1 | 2 | 3 | | 2000 | 3 | 1 | 4 | | 2002 | 2 | 0 | 2 | | 2003 | 3 | 6 | 9 | | 2004 | 2 | 1 | 3 | | 2005 | 1 | 3 | 4 | | 2006 | 0 | 1 | 1 | | 2007 | 0 | 2 | 2 | | 2008 | 2 | 3 | 5 | | 2009 | 0 | 2 | 2 | | 2010 | 1 | 0 | 1 | | 2012 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 2 | 2 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 1 | 2 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclins" by people in Profiles.
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Donovan MG, Galbraith MD, Espinosa JM. Multi-omics investigation reveals functional specialization of transcriptional cyclin dependent kinases in cancer biology. Sci Rep. 2022 12 28; 12(1):22505.
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Niemeyer BF, Sanford B, Gibson JE, Berger JN, Oko LM, Medina E, Clambey ET, van Dyk LF. The gammaherpesvirus 68 viral cyclin facilitates expression of LANA. PLoS Pathog. 2021 11; 17(11):e1010019.
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Yahya G, P?rez AP, Mendoza MB, Parisi E, Moreno DF, Art?s MH, Gallego C, Aldea M. Stress granules display bistable dynamics modulated by Cdk. J Cell Biol. 2021 03 01; 220(3).
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Benke TA, Kind PC. Proof-of-concept for a gene replacement approach to CDKL5 deficiency disorder. Brain. 2020 03 01; 143(3):716-718.
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Moreno DF, Jenkins K, Morlot S, Charvin G, Csikasz-Nagy A, Aldea M. Proteostasis collapse, a hallmark of aging, hinders the chaperone-Start network and arrests cells in G1. Elife. 2019 09 13; 8.
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Moreno DF, Parisi E, Yahya G, Vaggi F, Csik?sz-Nagy A, Aldea M. Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress. Life Sci Alliance. 2019 04; 2(2).
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Mart?nez-L?inez JM, Moreno DF, Parisi E, Clotet J, Aldea M. Centromeric signaling proteins boost G1 cyclin degradation and modulate cell size in budding yeast. PLoS Biol. 2018 08; 16(8):e2005388.
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Choudhury R, Bonacci T, Arceci A, Lahiri D, Mills CA, Kernan JL, Branigan TB, DeCaprio JA, Burke DJ, Emanuele MJ. APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry. Cell Rep. 2016 09 20; 16(12):3359-3372.
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Williams LM, Niemeyer BF, Franklin DS, Clambey ET, van Dyk LF. A Conserved Gammaherpesvirus Cyclin Specifically Bypasses Host p18(INK4c) To Promote Reactivation from Latency. J Virol. 2015 Nov; 89(21):10821-31.
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Lee KS, Suarez AL, Claypool DJ, Armstrong TK, Buckingham EM, van Dyk LF. Viral cyclins mediate separate phases of infection by integrating functions of distinct mammalian cyclins. PLoS Pathog. 2012 Feb; 8(2):e1002496.
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