 Antifibrinolytic Agents
"Antifibrinolytic Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. Several endogenous antiplasmins are known. The drugs are used to control massive hemorrhage and in other coagulation disorders.
| Descriptor ID |
D000933
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| MeSH Number(s) |
D27.505.519.421.500 D27.505.954.502.270.463.091
|
| Concept/Terms |
Plasmin Inhibitors- Plasmin Inhibitors
- Inhibitors, Plasmin
- Antiplasmins
- Plasmin Inhibitor
- Inhibitor, Plasmin
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Below are MeSH descriptors whose meaning is more general than "Antifibrinolytic Agents".
Below are MeSH descriptors whose meaning is more specific than "Antifibrinolytic Agents".
This graph shows the total number of publications written about "Antifibrinolytic Agents" by people in this website by year, and whether "Antifibrinolytic Agents" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 | | 2001 | 2 | 0 | 2 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2013 | 2 | 0 | 2 | | 2014 | 1 | 1 | 2 | | 2015 | 2 | 0 | 2 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 2 | 5 | 7 | | 2020 | 2 | 2 | 4 | | 2022 | 3 | 0 | 3 |
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Below are the most recent publications written about "Antifibrinolytic Agents" by people in Profiles.
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Spinella PC, Bochicchio K, Thomas KA, Staudt A, Shea SM, Pusateri AE, Schuerer D, Levy JH, Cap AP, Bochicchio G. The risk of thromboembolic events with early intravenous 2- and 4-g bolus dosing of tranexamic acid compared to placebo in patients with severe traumatic bleeding: A secondary analysis of a randomized, double-blind, placebo-controlled, single-center trial. Transfusion. 2022 08; 62 Suppl 1:S139-S150.
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Moore EE, Moore HB, Sauaia A. Reply to 'The role of tranexamic acid in trauma - a life-saving drug with proven benefit'. Nat Rev Dis Primers. 2022 05 26; 8(1):35.
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Kleiboer B, Layer MA, Cafuir LA, Cuker A, Escobar M, Eyster ME, Kraut E, Leavitt AD, Lentz SR, Quon D, Ragni MV, Thornhill D, Wang M, Key NS, Buckner TW. Postoperative bleeding complications in patients with hemophilia undergoing major orthopedic surgery: A prospective multicenter observational study. J Thromb Haemost. 2022 04; 20(4):857-865.
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Barrett CD, Vigneshwar N, Moore HB, Ghasabyan A, Chandler J, Moore EE, Yaffe MB. Tranexamic acid is associated with reduced complement activation in trauma patients with hemorrhagic shock and hyperfibrinolysis on thromboelastography. Blood Coagul Fibrinolysis. 2020 Dec; 31(8):578-582.
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Barrett CD, Moore HB, Vigneshwar N, Dhara S, Chandler J, Chapman MP, Sauaia A, Moore EE, Yaffe MB. Plasmin thrombelastography rapidly identifies trauma patients at risk for massive transfusion, mortality, and hyperfibrinolysis: A diagnostic tool to resolve an international debate on tranexamic acid? J Trauma Acute Care Surg. 2020 12; 89(6):991-998.
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Wu TB, Orfeo T, Moore HB, Sumislawski JJ, Cohen MJ, Petzold LR. Computational model of tranexamic acid on urokinase mediated fibrinolysis. PLoS One. 2020; 15(5):e0233640.
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Coleman JR, Moore EE, Moore HB, Chapman MP, Cohen MJ, Silliman CC, Sauaia A. Tranexamic acid disturbs the dynamics of postinjury fibrinolysis. ANZ J Surg. 2020 04; 90(4):420-422.
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Walsh SLF, Lederer DJ, Ryerson CJ, Kolb M, Maher TM, Nusser R, Poletti V, Richeldi L, Vancheri C, Wilsher ML, Antoniou KM, Behr J, Bendstrup E, Brown KK, Corte TJ, Cottin V, Crestani B, Flaherty KR, Glaspole IN, Grutters J, Inoue Y, Kondoh Y, Kreuter M, Johannson KA, Ley B, Martinez FJ, Molina-Molina M, Morais A, Nunes H, Raghu G, Selman M, Spagnolo P, Taniguchi H, Tomassetti S, Valeyre D, Wijsenbeek M, Wuyts WA, Wells AU. Diagnostic Likelihood Thresholds That Define a Working Diagnosis of Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 11 01; 200(9):1146-1153.
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Fisher AD, Carius BM, April MD, Naylor JF, Maddry JK, Schauer SG. An Analysis of Adherence to Tactical Combat Casualty Care Guidelines for the Administration of Tranexamic Acid. J Emerg Med. 2019 Nov; 57(5):646-652.
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Bruns LA, Isbey S, Tanverdi M, Kane I. Late-Onset Vitamin K Deficiency Presenting as Scrotal Bruising and Mediastinal Mass. Pediatr Emerg Care. 2019 Oct; 35(10):e192-e193.
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