Teniposide
"Teniposide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells from entering into the mitotic phase of the cell cycle, and lead to cell death. Teniposide acts primarily in the G2 and S phases of the cycle.
Descriptor ID |
D013713
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MeSH Number(s) |
D09.408.348.800
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Concept/Terms |
Teniposide- Teniposide
- Demethyl Epipodophyllotoxin Thenylidine Glucoside
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Below are MeSH descriptors whose meaning is more general than "Teniposide".
Below are MeSH descriptors whose meaning is more specific than "Teniposide".
This graph shows the total number of publications written about "Teniposide" by people in this website by year, and whether "Teniposide" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Teniposide" by people in Profiles.
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Simon GR, Bunn PA. Taxanes in the treatment of advanced (stage III and IV) non-small cell lung cancer (NSCLC): recent developments. Cancer Invest. 2003; 21(1):87-104.
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Relling MV, Mulhern RK, Fairclough D, Baker D, Pui CH. Chlorpromazine with and without lorazepam as antiemetic therapy in children receiving uniform chemotherapy. J Pediatr. 1993 Nov; 123(5):811-6.
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Tyc VL, Mulhern RK, Fairclough D, Ward PM, Relling MV, Longmire W. Chemotherapy induced nausea and emesis in pediatric cancer patients: external validity of child and parent emesis ratings. J Dev Behav Pediatr. 1993 Aug; 14(4):236-41.
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Kellie SJ, Crist WM, Pui CH, Crone ME, Fairclough DL, Rodman JH, Rivera GK. Hypersensitivity reactions to epipodophyllotoxins in children with acute lymphoblastic leukemia. Cancer. 1991 Feb 15; 67(4):1070-5.
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Schaack J, Schedl P, Shenk T. Topoisomerase I and II cleavage of adenovirus DNA in vivo: both topoisomerase activities appear to be required for adenovirus DNA replication. J Virol. 1990 Jan; 64(1):78-85.
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Abromowitch M, Ochs J, Pui CH, Kalwinsky D, Rivera GK, Fairclough D, Look AT, Hustu HO, Murphy SB, Evans WE, et al. High-dose methotrexate improves clinical outcome in children with acute lymphoblastic leukemia: St. Jude Total Therapy Study X. Med Pediatr Oncol. 1988; 16(5):297-303.
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Thomas MR, Robinson WA, Dantas M, Koeppler H, Drebing C, Glode LM. Autologous marrow transplantation for patients with chronic myelogenous leukemia (CML) in blast crisis. Am J Hematol. 1984 Feb; 16(2):105-12.
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Radice PA, Bunn PA, Ihde DC. Therapeutic trials with VP-16-213 and VM-26: active agents in small cell lung cancer, non-Hodgkin's lymphomas, and other malignancies. Cancer Treat Rep. 1979 Aug; 63(8):1231-9.
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