 Betaine-Homocysteine S-Methyltransferase
"Betaine-Homocysteine S-Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ZINC metalloenzyme that catalyzes the transfer of a methyl group from BETAINE to HOMOCYSTEINE to produce dimethylglycine and METHIONINE, respectively. This enzyme is a member of a family of ZINC-dependent METHYLTRANSFERASES that use THIOLS or selenols as methyl acceptors.
| Descriptor ID |
D050940
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| MeSH Number(s) |
D08.811.913.555.500.175
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| Concept/Terms |
Betaine-Homocysteine S-Methyltransferase- Betaine-Homocysteine S-Methyltransferase
- Betaine Homocysteine S Methyltransferase
- S-Methyltransferase, Betaine-Homocysteine
- Betaine Homocysteine Methyltransferase
- Homocysteine Methyltransferase, Betaine
- Methyltransferase, Betaine Homocysteine
- Betaine-Homocysteine Methyltransferase
- Methyltransferase, Betaine-Homocysteine
- Bet-HCys MTase
- Bet HCys MTase
- MTase, Bet-HCys
Betaine-Homocysteine Methyltransferase 2- Betaine-Homocysteine Methyltransferase 2
- Betaine Homocysteine Methyltransferase 2
- Methyltransferase 2, Betaine-Homocysteine
- Betaine-Homocysteine Methyltransferase-2
- Methyltransferase-2, Betaine-Homocysteine
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Below are MeSH descriptors whose meaning is more general than "Betaine-Homocysteine S-Methyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Betaine-Homocysteine S-Methyltransferase".
This graph shows the total number of publications written about "Betaine-Homocysteine S-Methyltransferase" by people in this website by year, and whether "Betaine-Homocysteine S-Methyltransferase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Betaine-Homocysteine S-Methyltransferase" by people in Profiles.
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Maclean KN, Jiang H, Phinney WN, Keating AK, Hurt KJ, Stabler SP. Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine ?-synthase-deficient homocystinuria. FASEB J. 2019 05; 33(5):6339-6353.
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Neuman JC, Albright KA, Schalinske KL. Exercise prevents hyperhomocysteinemia in a dietary folate-restricted mouse model. Nutr Res. 2013 Jun; 33(6):487-93.
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Maclean KN, Jiang H, Greiner LS, Allen RH, Stabler SP. Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk. Mol Genet Metab. 2012 Mar; 105(3):395-403.
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Chadwick LH, McCandless SE, Silverman GL, Schwartz S, Westaway D, Nadeau JH. Betaine-homocysteine methyltransferase-2: cDNA cloning, gene sequence, physical mapping, and expression of the human and mouse genes. Genomics. 2000 Nov 15; 70(1):66-73.
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Allen RH, Stabler SP, Lindenbaum J. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism. 1993 Nov; 42(11):1448-60.
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