 Glutamate Decarboxylase
"Glutamate Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.
| Descriptor ID |
D005968
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| MeSH Number(s) |
D08.811.520.224.125.250
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| Concept/Terms |
Glutamate Decarboxylase- Glutamate Decarboxylase
- Decarboxylase, Glutamate
- Glutamic Acid Decarboxylase
- Acid Decarboxylase, Glutamic
- Decarboxylase, Glutamic Acid
- Glutamate Carboxy-Lyase
- Carboxy-Lyase, Glutamate
- Glutamate Carboxy Lyase
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Below are MeSH descriptors whose meaning is more general than "Glutamate Decarboxylase".
Below are MeSH descriptors whose meaning is more specific than "Glutamate Decarboxylase".
This graph shows the total number of publications written about "Glutamate Decarboxylase" by people in this website by year, and whether "Glutamate Decarboxylase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1993 | 0 | 1 | 1 | | 1995 | 1 | 1 | 2 | | 1996 | 0 | 3 | 3 | | 1998 | 0 | 1 | 1 | | 1999 | 1 | 3 | 4 | | 2000 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 0 | 2 | 2 | | 2004 | 1 | 2 | 3 | | 2006 | 1 | 4 | 5 | | 2007 | 1 | 1 | 2 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 1 | 1 | | 2010 | 1 | 3 | 4 | | 2011 | 1 | 8 | 9 | | 2012 | 0 | 1 | 1 | | 2013 | 2 | 4 | 6 | | 2014 | 2 | 1 | 3 | | 2015 | 1 | 2 | 3 | | 2016 | 1 | 6 | 7 | | 2017 | 1 | 8 | 9 | | 2018 | 1 | 4 | 5 | | 2019 | 0 | 1 | 1 | | 2020 | 0 | 2 | 2 | | 2021 | 0 | 3 | 3 | | 2022 | 0 | 6 | 6 |
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Below are the most recent publications written about "Glutamate Decarboxylase" by people in Profiles.
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Kwon BC, Achenbach P, Anand V, Frohnert BI, Hagopian W, Hu J, Koski E, Lernmark ?, Lou O, Martin F, Ng K, Toppari J, Veijola R. Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals With Presymptomatic Type 1 Diabetes. Diabetes. 2022 Dec 01; 71(12):2632-2641.
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Salami F, Tamura R, You L, Lernmark ?, Larsson HE, Lundgren M, Krischer J, Ziegler AG, Toppari J, Veijola R, Rewers M, Haller MJ, Hagopian W, Akolkar B, T?rn C. HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children. Pediatr Diabetes. 2022 12; 23(8):1586-1593.
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Ghalwash M, Dunne JL, Lundgren M, Rewers M, Ziegler AG, Anand V, Toppari J, Veijola R, Hagopian W. Two-age islet-autoantibody screening for childhood type 1 diabetes: a prospective cohort study. Lancet Diabetes Endocrinol. 2022 08; 10(8):589-596.
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Jia X, He L, Miao D, Zhang C, Rewers M, Yu L. A High-throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19. J Vis Exp. 2022 07 05; (185).
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Triolo TM, Pyle L, Broncucia H, Armstrong T, Yu L, Gottlieb PA, Steck AK. Association of High-Affinity Autoantibodies With Type 1 Diabetes High-Risk HLA Haplotypes. J Clin Endocrinol Metab. 2022 03 24; 107(4):e1510-e1517.
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Ng K, Stavropoulos H, Anand V, Veijola R, Toppari J, Maziarz M, Lundgren M, Waugh K, Frohnert BI, Martin F, Hagopian W, Achenbach P. Islet Autoantibody Type-Specific Titer Thresholds Improve Stratification of Risk of Progression to Type 1 Diabetes in Children. Diabetes Care. 2022 01 01; 45(1):160-168.
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Leslie RD, Evans-Molina C, Freund-Brown J, Buzzetti R, Dabelea D, Gillespie KM, Goland R, Jones AG, Kacher M, Phillips LS, Rolandsson O, Wardian JL, Dunne JL. Adult-Onset Type 1 Diabetes: Current Understanding and Challenges. Diabetes Care. 2021 11; 44(11):2449-2456.
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Gu Y, Jia X, Vartak T, Miao D, Dong F, Jerram ST, Rewers M, Ferrara A, Lawrence JM, Yu L, Leslie RD. Improving clinical utility of GAD65 autoantibodies by electrochemiluminescence assay and clinical phenotype when identifying autoimmune adult-onset diabetes. Diabetologia. 2021 09; 64(9):2052-2060.
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Buckner T, Vanderlinden LA, DeFelice BC, Carry PM, Kechris K, Dong F, Fiehn O, Frohnert BI, Clare-Salzler M, Rewers M, Norris JM. The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY). Diabetologia. 2021 08; 64(8):1785-1794.
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Vehik K, Bonifacio E, Lernmark ?, Yu L, Williams A, Schatz D, Rewers M, She JX, Toppari J, Hagopian W, Akolkar B, Ziegler AG, Krischer JP. Hierarchical Order of Distinct Autoantibody Spreading and Progression to Type 1 Diabetes in the TEDDY Study. Diabetes Care. 2020 09; 43(9):2066-2073.
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