 Immunoglobulin Heavy Chains
"Immunoglobulin Heavy Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.
| Descriptor ID |
D007143
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| MeSH Number(s) |
D12.776.124.486.485.705.500 D12.776.124.790.651.705.500 D12.776.377.715.548.705.500
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| Concept/Terms |
Immunoglobulin Heavy Chains- Immunoglobulin Heavy Chains
- Heavy Chains, Immunoglobulin
- Ig Heavy Chains
- Heavy Chains, Ig
- Immunoglobulins, Heavy-Chain
- Immunoglobulins, Heavy Chain
- Heavy-Chain Immunoglobulins
- Heavy Chain Immunoglobulins
- Immunoglobulin Heavy Chain
- Heavy Chain, Immunoglobulin
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Heavy Chains".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Heavy Chains".
This graph shows the total number of publications written about "Immunoglobulin Heavy Chains" by people in this website by year, and whether "Immunoglobulin Heavy Chains" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 | | 1999 | 1 | 1 | 2 | | 2000 | 1 | 0 | 1 | | 2001 | 2 | 0 | 2 | | 2002 | 1 | 2 | 3 | | 2003 | 0 | 3 | 3 | | 2004 | 1 | 3 | 4 | | 2005 | 2 | 0 | 2 | | 2007 | 2 | 0 | 2 | | 2008 | 1 | 1 | 2 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 2 | 2 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 1 | 2 | | 2015 | 1 | 1 | 2 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 2 | 1 | 3 | | 2022 | 0 | 2 | 2 | | 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Immunoglobulin Heavy Chains" by people in Profiles.
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Rhodes ER, Faris JG, Petersen BM, Sprenger KG. Common framework mutations impact antibody interfacial dynamics and flexibility. Front Immunol. 2023; 14:1120582.
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Banach M, Harley ITW, Getahun A, Cambier JC. Comparative analysis of the repertoire of insulin-reactive B cells in type 1 diabetes-prone and resistant mice. Front Immunol. 2022; 13:961209.
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Poppova L, Pavlova S, Gonzalez B, Kotaskova J, Plevova K, Dumbovic G, Janovska P, Bystry V, Panovska A, Bezdekova L, Maslejova S, Brychtova Y, Doubek M, Krzyzankova M, Borsky M, Mayer J, Bryja V, Alonso S, Pospisilova S. Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene. Epigenetics. 2022 12; 17(12):1628-1635.
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Craddock AP, Kane WJ, Raghavan SS, Williams ES, Gru AA, Gradecki SE. Use of Ultrasensitive RNA In Situ Hybridization for Determining Clonality in Cutaneous B-Cell Lymphomas and Lymphoid Hyperplasia Decreases Subsequent Use of Molecular Testing and Is Cost-effective. Am J Surg Pathol. 2022 07 01; 46(7):956-962.
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Banach BB, Cerutti G, Fahad AS, Shen CH, Oliveira De Souza M, Katsamba PS, Tsybovsky Y, Wang P, Nair MS, Huang Y, Francino-Urd?niz IM, Steiner PJ, Guti?rrez-Gonz?lez M, Liu L, L?pez Acevedo SN, Nazzari AF, Wolfe JR, Luo Y, Olia AS, Teng IT, Yu J, Zhou T, Reddem ER, Bimela J, Pan X, Madan B, Laflin AD, Nimrania R, Yuen KY, Whitehead TA, Ho DD, Kwong PD, Shapiro L, DeKosky BJ. Paired heavy- and light-chain signatures contribute to potent SARS-CoV-2 neutralization in public antibody responses. Cell Rep. 2021 10 05; 37(1):109771.
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Petersen BM, Ulmer SA, Rhodes ER, Gutierrez-Gonzalez MF, Dekosky BJ, Sprenger KG, Whitehead TA. Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires. Front Immunol. 2021; 12:728694.
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Isola I, Moreno DF, Moga E, Mena MP, Tovar N, Rodr?guez-Lobato LG, Oliver-Cald?s A, Salgado MC, Bras?-Maristany F, Yag?e J, Cibeira MT, Prat A, Rosi?ol L, Blad? J, Fern?ndez de Larrea C. Immunoparesis defined by heavy/light chain pair suppression in smoldering multiple myeloma shows initial isotype specificity and involves other isotypes in advanced disease. Ann Hematol. 2021 Dec; 100(12):2997-3005.
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Palladini G, Kastritis E, Maurer MS, Zonder J, Minnema MC, Wechalekar AD, Jaccard A, Lee HC, Bumma N, Kaufman JL, Medvedova E, Kovacsovics T, Rosenzweig M, Sanchorawala V, Qin X, Vasey SY, Weiss BM, Vermeulen J, Merlini G, Comenzo RL. Daratumumab plus CyBorD for patients with newly diagnosed AL amyloidosis: safety run-in results of ANDROMEDA. Blood. 2020 07 02; 136(1):71-80.
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Chen Z, Wang JH. Signaling control of antibody isotype switching. Adv Immunol. 2019; 141:105-164.
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Guthmiller JJ, Dugan HL, Neu KE, Lan LY, Wilson PC. An Efficient Method to Generate Monoclonal Antibodies from Human B Cells. Methods Mol Biol. 2019; 1904:109-145.
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