 Microglia
"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
| Descriptor ID |
D017628
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| MeSH Number(s) |
A08.637.400 A11.650.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microglia".
Below are MeSH descriptors whose meaning is more specific than "Microglia".
This graph shows the total number of publications written about "Microglia" by people in this website by year, and whether "Microglia" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1999 | 1 | 0 | 1 | | 2003 | 1 | 1 | 2 | | 2004 | 0 | 2 | 2 | | 2005 | 2 | 3 | 5 | | 2006 | 2 | 0 | 2 | | 2007 | 1 | 3 | 4 | | 2008 | 3 | 3 | 6 | | 2009 | 1 | 2 | 3 | | 2010 | 1 | 4 | 5 | | 2011 | 3 | 1 | 4 | | 2012 | 4 | 5 | 9 | | 2013 | 8 | 1 | 9 | | 2014 | 5 | 5 | 10 | | 2015 | 3 | 6 | 9 | | 2016 | 6 | 4 | 10 | | 2017 | 6 | 5 | 11 | | 2018 | 3 | 5 | 8 | | 2019 | 1 | 1 | 2 |
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Below are the most recent publications written about "Microglia" by people in Profiles.
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Chang KC, Shieh B, Petrash JM. Role of aldose reductase in diabetes-induced retinal microglia activation. Chem Biol Interact. 2019 Apr 01; 302:46-52.
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Hutter G, Theruvath J, Graef CM, Zhang M, Schoen MK, Manz EM, Bennett ML, Olson A, Azad TD, Sinha R, Chan C, Assad Kahn S, Gholamin S, Wilson C, Grant G, He J, Weissman IL, Mitra SS, Cheshier SH. Microglia are effector cells of CD47-SIRPa antiphagocytic axis disruption against glioblastoma. Proc Natl Acad Sci U S A. 2019 01 15; 116(3):997-1006.
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Liang LP, Pearson-Smith JN, Huang J, Day BJ, Patel M. Neuroprotective effects of a catalytic antioxidant in a rat nerve agent model. Redox Biol. 2019 01; 20:275-284.
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Seitz S, Clarke P, Tyler KL. Pharmacologic Depletion of Microglia Increases Viral Load in the Brain and Enhances Mortality in Murine Models of Flavivirus-Induced Encephalitis. J Virol. 2018 08 15; 92(16).
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Pryce G, Baker D. Oligoclonal bands in multiple sclerosis; Functional significance and therapeutic implications. Does the specificity matter? Mult Scler Relat Disord. 2018 Oct; 25:131-137.
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Anttila JE, Albert K, Wires ES, Mätlik K, Loram LC, Watkins LR, Rice KC, Wang Y, Harvey BK, Airavaara M. Post-stroke Intranasal (+)-Naloxone Delivery Reduces Microglial Activation and Improves Behavioral Recovery from Ischemic Injury. eNeuro. 2018 Mar-Apr; 5(2).
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Schindler SM, Frank MG, Annis JL, Maier SF, Klegeris A. Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM). Mol Cell Neurosci. 2018 06; 89:71-79.
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Grace PM, Wang X, Strand KA, Baratta MV, Zhang Y, Galer EL, Yin H, Maier SF, Watkins LR. DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats. Exp Neurol. 2018 06; 304:125-131.
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Fonken LK, Frank MG, Gaudet AD, D'Angelo HM, Daut RA, Hampson EC, Ayala MT, Watkins LR, Maier SF. Neuroinflammatory priming to stress is differentially regulated in male and female rats. Brain Behav Immun. 2018 05; 70:257-267.
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Clevenger AC, Kim H, Salcedo E, Yonchek JC, Rodgers KM, Orfila JE, Dietz RM, Quillinan N, Traystman RJ, Herson PS. Endogenous Sex Steroids Dampen Neuroinflammation and Improve Outcome of Traumatic Brain Injury in Mice. J Mol Neurosci. 2018 Mar; 64(3):410-420.
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