 Microglia
"Microglia" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
| Descriptor ID |
D017628
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| MeSH Number(s) |
A08.637.400 A11.650.400
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Microglia".
Below are MeSH descriptors whose meaning is more specific than "Microglia".
This graph shows the total number of publications written about "Microglia" by people in this website by year, and whether "Microglia" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2005 | 2 | 3 | 5 | | 2006 | 4 | 0 | 4 | | 2007 | 1 | 1 | 2 | | 2008 | 2 | 2 | 4 | | 2009 | 0 | 2 | 2 | | 2010 | 1 | 4 | 5 | | 2011 | 2 | 1 | 3 | | 2012 | 2 | 2 | 4 | | 2013 | 8 | 1 | 9 | | 2014 | 7 | 3 | 10 | | 2015 | 3 | 5 | 8 | | 2016 | 4 | 5 | 9 | | 2017 | 6 | 6 | 12 | | 2018 | 3 | 9 | 12 | | 2019 | 5 | 5 | 10 | | 2020 | 4 | 7 | 11 | | 2021 | 5 | 6 | 11 | | 2022 | 3 | 10 | 13 | | 2023 | 4 | 4 | 8 | | 2024 | 11 | 3 | 14 | | 2025 | 8 | 2 | 10 |
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Below are the most recent publications written about "Microglia" by people in Profiles.
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de Castro LL, Gomes da Rosa B, Peixoto-Rodrigues MC, Revoredo Vicentino AR, Fraga-Junior VdS, Cascabulho CM, Diniz LP, Benjamim CF, Bracko O, Scharfstein J, Adesse D. Toxoplasma gondii impairs CX3CL1/fractalkine shedding from mouse cortical neurons, leading to microglia activation. Microbiol Spectr. 2025 Oct 07; 13(10):e0107425.
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Sprenger KG, Lietzke EE, Melchior JT, Bruce KD. Lipid and lipoprotein metabolism in microglia: Alzheimer's disease mechanisms and interventions. J Lipid Res. 2025 Oct; 66(10):100872.
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Basak JM, Falk M, Dingman AL, Moore A, Tiemeier E, Aimale G, Quillinan N. Microglia interact with dendritic spines and regulate spine numbers after brain injury following resuscitation from a cardiac arrest. Exp Neurol. 2025 Oct; 392:115364.
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Mills WA, Savory NA, Lopez-Ortiz AO, Lentferink DH, González Ibáñez F, Agochi P, Rastegar E, Gupta A, Gupta D, Suram A, Isakson BE, Tremblay MÈ, Eyo UB. Microglial cyclooxygenase-1 modulates cerebral capillary basal tone in vivo in mice. Nat Commun. 2025 Jul 01; 16(1):5704.
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Liu S, Li L, Zhang F, Garcia-Corral M, Meyer K, Fortuna PRJ, van Sambeek B, Appleton E, Ng AHM, Khoshakhlagh P, Lu YR, Cameron J, Ramirez RN, Chen Y, Wu CT, Huang JY, Tan Y, Chao G, Aach J, Lim ET, Tam JM, Raychaudhuri S, Church GM. Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC. Nat Commun. 2025 Jun 10; 16(1):5136.
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Useinovic N, Newson A, Near M, Maksimovic S, Volvovitz B, Quillinan N, Jevtovic-Todorovic V. Anesthesia-induced developmental neurotoxicity in the setting of systemic inflammation: the role of microglia. Exp Biol Med (Maywood). 2025; 250:10549.
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Mondal K, Gary AA, Dash A, Del Mar NA, Stephenson DJ, Chalfant CE, Reiner A, Sears B, Mandal N. Oral Supplementation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Can Prevent TBI-Induced Visual, Motor, and Emotional Deficits in Mice. Mol Neurobiol. 2025 Sep; 62(9):11972-11985.
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Anton PE, Twardy S, Nagpal P, Moreno JA, Burchill MA, Chatterjee A, Busquet N, Mesches M, Kovacs EJ, McCullough RL. Suppression of NF-?B/NLRP3 by nanoligomer therapy mitigates ethanol and advanced age-related neuroinflammation. J Leukoc Biol. 2025 Apr 23; 117(4).
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Sturno AM, Hassell JE, Lanaspa MA, Bruce KD. Do microglia metabolize fructose in Alzheimer's disease? J Neuroinflammation. 2025 Mar 15; 22(1):85.
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Gross PS, Durán-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK. Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. Nat Commun. 2025 Mar 07; 16(1):2283.
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