 Cellular Senescence
"Cellular Senescence" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
| Descriptor ID |
D016922
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| MeSH Number(s) |
G04.043
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| Concept/Terms |
Cell Aging- Cell Aging
- Cellular Ageing
- Ageing, Cellular
- Aging, Cell
- Senescence, Replicative
- Cellular Aging
- Aging, Cellular
- Replicative Senescence
- Cell Ageing
- Ageing, Cell
Senescence-Associated Secretory Phenotype- Senescence-Associated Secretory Phenotype
- Phenotype, Senescence-Associated Secretory
- Secretory Phenotype, Senescence-Associated
- Senescence Associated Secretory Phenotype
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Below are MeSH descriptors whose meaning is more general than "Cellular Senescence".
Below are MeSH descriptors whose meaning is more specific than "Cellular Senescence".
This graph shows the total number of publications written about "Cellular Senescence" by people in this website by year, and whether "Cellular Senescence" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 1 | 2 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 1 | 1 | 2 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 2 | 3 | 5 | | 2008 | 1 | 3 | 4 | | 2009 | 3 | 1 | 4 | | 2010 | 3 | 2 | 5 | | 2011 | 3 | 3 | 6 | | 2012 | 3 | 3 | 6 | | 2013 | 5 | 4 | 9 | | 2014 | 2 | 2 | 4 | | 2015 | 2 | 4 | 6 | | 2016 | 6 | 3 | 9 | | 2017 | 2 | 0 | 2 | | 2018 | 3 | 5 | 8 | | 2019 | 7 | 3 | 10 | | 2020 | 3 | 1 | 4 | | 2021 | 3 | 3 | 6 | | 2022 | 1 | 2 | 3 | | 2023 | 2 | 6 | 8 | | 2024 | 4 | 2 | 6 | | 2025 | 13 | 1 | 14 |
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Below are the most recent publications written about "Cellular Senescence" by people in Profiles.
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Singer J, Chow L, Ammons D, Sabino I, Impastato R, Dow S, Pezzanite LM. Senescence-associated gene pathways are differentially expressed in equine aging-related osteoarthritis. Am J Vet Res. 2026 Apr 01; 87(4).
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Fernandez B, Passanisi VJ, Ashraf HM, Spencer SL. Single-cell RNA sequencing reveals a quiescence-senescence continuum and distinct senotypes following chemotherapy. Nat Commun. 2025 Dec 23; 17(1):169.
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Tufa DM, Hoffmeyer E, Schaller KL, Kooiman B, Woods E, Wang D, Jones D, Hall S, Cruz JC, Verneris MR. Innate lymphoid cells prevent graft-versus-host disease via IL-9-driven T-cell senescence. Blood. 2025 Nov 27; 146(22):2656-2669.
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Walrath TM, Evans MR, Meza Monge K, Najarro KM, Orlicky DJ, Idrovo JP, McMahan RH, Kovacs EJ. Impaired intestinal cell proliferation parallels increased senescence after burn injury in aged mice. Am J Physiol Gastrointest Liver Physiol. 2026 Jan 01; 330(1):G1-G9.
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Singh P, Venkatasubramanian R, Mahoney SA, Darrah MA, Ludwig KR, Zhang A, Kaneshiro K, Najera LE, Wimer L, Shanmugam MM, Morazan E, Galligan JJ, Trujillo MN, Sarpong R, Seals DR, Kapahi P, Clayton ZS. Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence. Aging (Albany NY). 2025 Nov 14; 17(11):2717-2743.
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Venkatasubramanian R, Mahoney SA, Hutton DA, VanDongen NS, Brunt VE, Greenberg NT, Longtine AG, Brandt L, Beyer AM, Melov S, Rossman MJ, Seals DR, Clayton ZS. Cellular senescence mediates doxorubicin chemotherapy-induced vascular endothelial dysfunction: translational evidence of prevention with senolytic treatment. Am J Physiol Heart Circ Physiol. 2025 Dec 01; 329(6):H1672-H1683.
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Schneider SE, Scott AK, Gallagher KM, Miller EY, Ghosh S, Neu CP. Mechanical Stress Triggers Premature Senescence in Cardiac Fibroblasts. Adv Sci (Weinh). 2025 Dec; 12(47):e13314.
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Bousamaki J, Rørbeck EA, Petersen AG, Korntner SH, Pors SE, Redente EF, Oró D, Salinas CG, Olsen RW, Simonsen U, Feigh M, Hansen HH. Distinct lung functional, histological and cell senescence signatures in the single and repetitive bleomycin mouse models of idiopathic pulmonary fibrosis. Physiol Rep. 2025 Sep; 13(18):e70560.
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Venkatasubramanian R, Darrah MA, Mahoney SA, Hutton DA, Maurer GS, Ludwig KR, Van Dongen NS, Greenberg NT, Longtine AG, Brunt VE, Singh P, Galligan JJ, Trujillo MN, Kapahi P, Melov S, Rossman MJ, Seals DR, Clayton ZS. Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress. Hypertension. 2025 Oct; 82(10):1767-1777.
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Murray KO, Mahoney SA, Ludwig KR, Miyamoto-Ditmon JH, VanDongen NS, Banskota N, Herman AB, Seals DR, Mankowski RT, Rossman MJ, Clayton ZS. Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches. Aging Cell. 2025 Aug; 24(8):e70114.
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