 Cellular Senescence
"Cellular Senescence" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
| Descriptor ID |
D016922
|
| MeSH Number(s) |
G04.043
|
| Concept/Terms |
Cell Aging- Cell Aging
- Cellular Ageing
- Ageing, Cellular
- Aging, Cell
- Senescence, Replicative
- Cellular Aging
- Aging, Cellular
- Replicative Senescence
- Cell Ageing
- Ageing, Cell
Senescence-Associated Secretory Phenotype- Senescence-Associated Secretory Phenotype
- Phenotype, Senescence-Associated Secretory
- Secretory Phenotype, Senescence-Associated
- Senescence Associated Secretory Phenotype
|
Below are MeSH descriptors whose meaning is more general than "Cellular Senescence".
Below are MeSH descriptors whose meaning is more specific than "Cellular Senescence".
This graph shows the total number of publications written about "Cellular Senescence" by people in this website by year, and whether "Cellular Senescence" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 2 | 2 | | 1999 | 1 | 1 | 2 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 1 | 1 | 2 | | 2005 | 0 | 1 | 1 | | 2007 | 2 | 2 | 4 | | 2008 | 1 | 3 | 4 | | 2009 | 3 | 1 | 4 | | 2010 | 4 | 2 | 6 | | 2011 | 3 | 3 | 6 | | 2012 | 3 | 3 | 6 | | 2013 | 5 | 4 | 9 | | 2014 | 2 | 2 | 4 | | 2015 | 2 | 5 | 7 | | 2016 | 6 | 3 | 9 | | 2017 | 2 | 0 | 2 | | 2018 | 3 | 4 | 7 | | 2019 | 7 | 3 | 10 | | 2020 | 2 | 1 | 3 | | 2021 | 3 | 3 | 6 | | 2022 | 1 | 2 | 3 | | 2023 | 2 | 6 | 8 | | 2024 | 4 | 2 | 6 | | 2025 | 6 | 1 | 7 |
To return to the timeline, click here.
Below are the most recent publications written about "Cellular Senescence" by people in Profiles.
-
Bousamaki J, Rørbeck EA, Petersen AG, Korntner SH, Pors SE, Redente EF, Oró D, Salinas CG, Olsen RW, Simonsen U, Feigh M, Hansen HH. Distinct lung functional, histological and cell senescence signatures in the single and repetitive bleomycin mouse models of idiopathic pulmonary fibrosis. Physiol Rep. 2025 Sep; 13(18):e70560.
-
Venkatasubramanian R, Darrah MA, Mahoney SA, Hutton DA, Maurer GS, Ludwig KR, Van Dongen NS, Greenberg NT, Longtine AG, Brunt VE, Singh P, Galligan JJ, Trujillo MN, Kapahi P, Melov S, Rossman MJ, Seals DR, Clayton ZS. Cellular Senescence Mediates Doxorubicin Chemotherapy-Induced Aortic Stiffening: Role of Glycation Stress. Hypertension. 2025 Oct; 82(10):1767-1777.
-
Murray KO, Mahoney SA, Ludwig KR, Miyamoto-Ditmon JH, VanDongen NS, Banskota N, Herman AB, Seals DR, Mankowski RT, Rossman MJ, Clayton ZS. Intermittent Supplementation With Fisetin Improves Physical Function and Decreases Cellular Senescence in Skeletal Muscle With Aging: A Comparison to Genetic Clearance of Senescent Cells and Synthetic Senolytic Approaches. Aging Cell. 2025 Aug; 24(8):e70114.
-
Molteni R, Fiumara M, Campochiaro C, Alfieri R, Pacini G, Licari E, Tomelleri A, Diral E, Varesi A, Weber A, Quaranta P, Albano L, Gaddoni C, Basso-Ricci L, Stefanoni D, Alessandrini L, Degl'Innocenti S, Sanvito F, Bergonzi GM, Annoni A, Panigada M, Cantoni E, Canarutto D, Xie SZ, D'Alessandro A, Di Micco R, Aiuti A, Ciceri F, De Luca G, Dagna L, Matucci-Cerinic M, Merelli I, Cenci S, Scala S, Cavalli G, Naldini L, Ferrari S. Mechanisms of hematopoietic clonal dominance in VEXAS syndrome. Nat Med. 2025 Jun; 31(6):1911-1924.
-
Peltier S, Marin M, Dzieciatkowska M, Dussiot M, Roy MK, Bruce J, Leblanc L, Hadjou Y, Georgeault S, Fricot A, Roussel C, Stephenson D, Casimir M, Sissoko A, Paye F, Dokmak S, Ndour PA, Roingeard P, Gautier EF, Spitalnik SL, Hermine O, Buffet PA, D'Alessandro A, Amireault P. Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance. J Clin Invest. 2025 May 01; 135(9).
-
Gross PS, Durán-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK. Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. Nat Commun. 2025 Mar 07; 16(1):2283.
-
Shen Z, Wang Y, Gao J, Gu W, Ren Z, Xu L, Qian R, Miao Q, Hu X, Wu Y, Liu W, Cai Y, Wan CC, Zhu Y, Sun L, Yan T. The EZH2/MCM Complex/hTERT axis facilitates hepatocellular carcinoma progression by inhibiting cellular senescence. Mech Ageing Dev. 2025 Apr; 224:112040.
-
Srour E, Martin N, Drullion C, De Schutter C, Giroud J, Pioger A, Deslé J, Saas L, Nassour J, Théry J, Decanter G, Penel N, Vercamer C, Salazar-Cardozo C, Abbadie C, Pluquet O. Prostaglandin E2 regulates senescence and post-senescence neoplastic escape in primary human keratinocytes. Aging (Albany NY). 2024 Nov 18; 16(21):13201-13224.
-
Ionescu RB, Nicaise AM, Reisz JA, Williams EC, Prasad P, Willis CM, Simões-Abade MBC, Sbarro L, Dzieciatkowska M, Stephenson D, Suarez Cubero M, Rizzi S, Pirvan L, Peruzzotti-Jametti L, Fossati V, Edenhofer F, Leonardi T, Frezza C, Mohorianu I, D'Alessandro A, Pluchino S. Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis. Cell Stem Cell. 2024 Nov 07; 31(11):1574-1590.e11.
-
Kumar S, Vassallo JD, Nattamai KJ, Hassan A, Vollmer A, Karns R, Sacma M, Nemkov T, D'Alessandro A, Geiger H. Rejuvenation of the reconstitution potential and reversal of myeloid bias of aged HSCs upon pH treatment. Aging Cell. 2024 Oct; 23(10):e14324.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|