 Cellular Senescence
"Cellular Senescence" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
| Descriptor ID |
D016922
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| MeSH Number(s) |
G04.043
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| Concept/Terms |
Cell Aging- Cell Aging
- Cellular Ageing
- Ageing, Cellular
- Aging, Cell
- Senescence, Replicative
- Cellular Aging
- Aging, Cellular
- Replicative Senescence
- Cell Ageing
- Ageing, Cell
Senescence-Associated Secretory Phenotype- Senescence-Associated Secretory Phenotype
- Phenotype, Senescence-Associated Secretory
- Secretory Phenotype, Senescence-Associated
- Senescence Associated Secretory Phenotype
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Below are MeSH descriptors whose meaning is more general than "Cellular Senescence".
Below are MeSH descriptors whose meaning is more specific than "Cellular Senescence".
This graph shows the total number of publications written about "Cellular Senescence" by people in this website by year, and whether "Cellular Senescence" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 | | 1994 | 0 | 3 | 3 | | 1995 | 0 | 4 | 4 | | 1997 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 1 | 3 | 4 | | 2003 | 2 | 1 | 3 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2007 | 2 | 2 | 4 | | 2008 | 1 | 2 | 3 | | 2009 | 2 | 3 | 5 | | 2010 | 3 | 4 | 7 | | 2011 | 3 | 3 | 6 | | 2012 | 3 | 2 | 5 | | 2013 | 3 | 3 | 6 | | 2014 | 2 | 2 | 4 | | 2015 | 2 | 3 | 5 | | 2016 | 6 | 2 | 8 | | 2017 | 2 | 1 | 3 | | 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "Cellular Senescence" by people in Profiles.
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Tricola GM, Simons MJP, Atema E, Boughton RK, Brown JL, Dearborn DC, Divoky G, Eimes JA, Huntington CE, Kitaysky AS, Juola FA, Lank DB, Litwa HP, Mulder EGA, Nisbet ICT, Okanoya K, Safran RJ, Schoech SJ, Schreiber EA, Thompson PM, Verhulst S, Wheelwright NT, Winkler DW, Young R, Vleck CM, Haussmann MF. The rate of telomere loss is related to maximum lifespan in birds. Philos Trans R Soc Lond B Biol Sci. 2018 03 05; 373(1741).
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Hijmans JG, Stockleman K, Reiakvam W, Levy MV, Brewster LM, Bammert TD, Greiner JJ, Connick E, DeSouza CA. Effects of HIV-1 gp120 and tat on endothelial cell sensescence and senescence-associated microRNAs. Physiol Rep. 2018 03; 6(6):e13647.
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Rossman MJ, Kaplon RE, Hill SD, McNamara MN, Santos-Parker JR, Pierce GL, Seals DR, Donato AJ. Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function. Am J Physiol Heart Circ Physiol. 2017 Nov 01; 313(5):H890-H895.
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Blaber EA, Pecaut MJ, Jonscher KR. Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver. Int J Mol Sci. 2017 Sep 27; 18(10).
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Gidfar S, Milani FY, Milani BY, Shen X, Eslani M, Putra I, Huvard MJ, Sagha H, Djalilian AR. Rapamycin Prolongs the Survival of Corneal Epithelial Cells in Culture. Sci Rep. 2017 01 05; 7:40308.
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Joselow A, Lynn D, Terzian T, Box NF. Senescence-Like Phenotypes in Human Nevi. Methods Mol Biol. 2017; 1534:175-184.
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Marino Gammazza A, Campanella C, Barone R, Caruso Bavisotto C, Gorska M, Wozniak M, Carini F, Cappello F, D'Anneo A, Lauricella M, Zummo G, Conway de Macario E, Macario AJ, Di Felice V. Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence. Cancer Lett. 2017 01 28; 385:75-86.
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Aird KM, Iwasaki O, Kossenkov AV, Tanizawa H, Fatkhutdinov N, Bitler BG, Le L, Alicea G, Yang TL, Johnson FB, Noma KI, Zhang R. HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci. J Cell Biol. 2016 Nov 07; 215(3):325-334.
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Sufit A, Lee-Sherick AB, DeRyckere D, Rupji M, Dwivedi B, Varella-Garcia M, Pierce AM, Kowalski J, Wang X, Frye SV, Earp HS, Keating AK, Graham DK. MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme. PLoS One. 2016; 11(10):e0165107.
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Lesniewski LA, Seals DR, Walker AE, Henson GD, Blimline MW, Trott DW, Bosshardt GC, LaRocca TJ, Lawson BR, Zigler MC, Donato AJ. Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways. Aging Cell. 2017 Feb; 16(1):17-26.
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