 Allosteric Regulation
"Allosteric Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.
| Descriptor ID |
D000494
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| MeSH Number(s) |
G02.111.044
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| Concept/Terms |
Allosteric Regulation- Allosteric Regulation
- Regulation, Allosteric
- Allosteric Regulations
- Regulations, Allosteric
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Below are MeSH descriptors whose meaning is more general than "Allosteric Regulation".
Below are MeSH descriptors whose meaning is more specific than "Allosteric Regulation".
This graph shows the total number of publications written about "Allosteric Regulation" by people in this website by year, and whether "Allosteric Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 3 | 4 | | 2007 | 0 | 2 | 2 | | 2010 | 0 | 2 | 2 | | 2011 | 0 | 3 | 3 | | 2012 | 0 | 2 | 2 | | 2013 | 0 | 5 | 5 | | 2014 | 0 | 5 | 5 | | 2015 | 0 | 2 | 2 | | 2016 | 0 | 9 | 9 | | 2017 | 1 | 3 | 4 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Allosteric Regulation" by people in Profiles.
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Gates C, Backos DS, Reigan P, Kang HJ, Koerner C, Mirzaei J, Natale NR. Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4. Bioorg Med Chem. 2018 09 15; 26(17):4797-4803.
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Zukowski A, Al-Afaleq NO, Duncan ED, Yao T, Johnson AM. Recruitment and allosteric stimulation of a histone-deubiquitinating enzyme during heterochromatin assembly. J Biol Chem. 2018 02 16; 293(7):2498-2509.
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Block A, Ahmed MM, Rueda N, Hernandez MC, Martinez-Cué C, Gardiner KJ. The GABAAa5-selective Modulator, RO4938581, Rescues Protein Anomalies in the Ts65Dn Mouse Model of Down Syndrome. Neuroscience. 2018 02 21; 372:192-212.
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Gee KW, Olincy A, Kanner R, Johnson L, Hogenkamp D, Harris J, Tran M, Edmonds SA, Sauer W, Yoshimura R, Johnstone T, Freedman R. First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. J Psychopharmacol. 2017 04; 31(4):434-441.
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Holliday MJ, Camilloni C, Armstrong GS, Vendruscolo M, Eisenmesser EZ. Networks of Dynamic Allostery Regulate Enzyme Function. Structure. 2017 02 07; 25(2):276-286.
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Pey AL, Martínez-Cruz LA, Kraus JP, Majtan T. Oligomeric status of human cystathionine beta-synthase modulates AdoMet binding. FEBS Lett. 2016 Dec; 590(24):4461-4471.
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Jeremy Johnson R, Applegarth J, Bennett S, Caskey S, Coatney C, Corsbie K, Cotter A, Cotter D, Coulis A, Hansen H, Hart W, Koehler C, Koelper A, Kuhlman S, Mitchell C, Moskal B, Murfield O, Paton A, Schemenauer D, Stankavich B, Taylor C, Waibel B, Williams LD. Proteopedia entry: G-protein coupled receptors. Biochem Mol Biol Educ. 2017 05; 45(3):277-278.
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Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. J Biol Chem. 2016 Nov 04; 291(45):23569-23577.
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Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies. Protein Sci. 2016 11; 25(11):1911-1917.
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Agharbaoui FE, Hoyte AC, Ferro S, Gitto R, Buemi MR, Fuchs JR, Kvaratskhelia M, De Luca L. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10; 123:673-683.
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