 Allosteric Regulation
"Allosteric Regulation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The modification of the reactivity of ENZYMES by the binding of effectors to sites (ALLOSTERIC SITES) on the enzymes other than the substrate BINDING SITES.
| Descriptor ID |
D000494
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| MeSH Number(s) |
G02.111.044
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| Concept/Terms |
Allosteric Regulation- Allosteric Regulation
- Regulation, Allosteric
- Allosteric Regulations
- Regulations, Allosteric
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Below are MeSH descriptors whose meaning is more general than "Allosteric Regulation".
Below are MeSH descriptors whose meaning is more specific than "Allosteric Regulation".
This graph shows the total number of publications written about "Allosteric Regulation" by people in this website by year, and whether "Allosteric Regulation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 3 | 4 | | 2007 | 0 | 4 | 4 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 3 | 3 | | 2012 | 0 | 2 | 2 | | 2013 | 0 | 5 | 5 | | 2014 | 0 | 5 | 5 | | 2015 | 0 | 3 | 3 | | 2016 | 0 | 9 | 9 | | 2017 | 1 | 3 | 4 | | 2018 | 0 | 3 | 3 | | 2019 | 0 | 4 | 4 | | 2020 | 1 | 2 | 3 |
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Below are the most recent publications written about "Allosteric Regulation" by people in Profiles.
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Shenasa H, Movassat M, Forouzmand E, Hertel KJ. Allosteric regulation of U1 snRNP by splicing regulatory proteins controls spliceosomal assembly. RNA. 2020 10; 26(10):1389-1399.
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Hongdusit A, Zwart PH, Sankaran B, Fox JM. Minimally disruptive optical control of protein tyrosine phosphatase 1B. Nat Commun. 2020 02 07; 11(1):788.
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Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):723-733.e6.
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Born A, Henen MA, Vögeli B. Activity and Affinity of Pin1 Variants. Molecules. 2019 Dec 20; 25(1).
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Pegram LM, Liddle JC, Xiao Y, Hoh M, Rudolph J, Iverson DB, Vigers GP, Smith D, Zhang H, Wang W, Moffat JG, Ahn NG. Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2. Proc Natl Acad Sci U S A. 2019 07 30; 116(31):15463-15468.
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Anantharajan J, Zhou H, Zhang L, Hotz T, Vincent MY, Blevins MA, Jansson AE, Kuan JWL, Ng EY, Yeo YK, Baburajendran N, Lin G, Hung AW, Joy J, Patnaik S, Marugan J, Rudra P, Ghosh D, Hill J, Keller TH, Zhao R, Ford HL, Kang C. Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells. . 2019 09; 18(9):1484-1496.
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Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife. 2019 05 23; 8.
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Born A, Nichols PJ, Henen MA, Chi CN, Strotz D, Bayer P, Tate SI, Peng JW, Vögeli B. Backbone and side-chain chemical shift assignments of full-length, apo, human Pin1, a phosphoprotein regulator with interdomain allostery. Biomol NMR Assign. 2019 04; 13(1):85-89.
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Gates C, Backos DS, Reigan P, Kang HJ, Koerner C, Mirzaei J, Natale NR. Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4. Bioorg Med Chem. 2018 09 15; 26(17):4797-4803.
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Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F. 3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound. Elife. 2018 02 20; 7.
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