 DNA Damage
"DNA Damage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
| Descriptor ID |
D004249
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| MeSH Number(s) |
G05.200
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| Concept/Terms |
DNA Damage- DNA Damage
- DNA Damages
- Damage, DNA
- Damages, DNA
- DNA Injury
- DNA Injuries
- Injuries, DNA
- Injury, DNA
Genotoxic Stress- Genotoxic Stress
- Genotoxic Stresses
- Stresses, Genotoxic
- Stress, Genotoxic
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Below are MeSH descriptors whose meaning is more general than "DNA Damage".
Below are MeSH descriptors whose meaning is more specific than "DNA Damage".
This graph shows the total number of publications written about "DNA Damage" by people in this website by year, and whether "DNA Damage" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 1996 | 0 | 2 | 2 | | 1998 | 2 | 0 | 2 | | 1999 | 1 | 1 | 2 | | 2000 | 1 | 1 | 2 | | 2001 | 1 | 2 | 3 | | 2002 | 1 | 1 | 2 | | 2003 | 1 | 3 | 4 | | 2004 | 4 | 5 | 9 | | 2005 | 3 | 10 | 13 | | 2006 | 8 | 11 | 19 | | 2007 | 2 | 4 | 6 | | 2008 | 2 | 7 | 9 | | 2009 | 2 | 11 | 13 | | 2010 | 4 | 3 | 7 | | 2011 | 8 | 9 | 17 | | 2012 | 1 | 7 | 8 | | 2013 | 2 | 8 | 10 | | 2014 | 4 | 11 | 15 | | 2015 | 5 | 11 | 16 | | 2016 | 5 | 6 | 11 | | 2017 | 7 | 8 | 15 | | 2018 | 4 | 6 | 10 | | 2019 | 9 | 8 | 17 | | 2020 | 2 | 8 | 10 | | 2021 | 8 | 4 | 12 | | 2022 | 1 | 6 | 7 | | 2023 | 2 | 2 | 4 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Damage" by people in Profiles.
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Yadav M, Kandhari K, Mathan SV, Ali M, Singh RP. Fisetin induces G2/M phase arrest and caspase-mediated cleavage of p21Cip1 and p27Kip1 leading to apoptosis and tumor growth inhibition in HNSCC. Mol Carcinog. 2024 Sep; 63(9):1697-1711.
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Stojanovic P, Luger K, Rudolph J. Slow Dissociation from the PARP1-HPF1 Complex Drives Inhibitor Potency. Biochemistry. 2023 08 15; 62(16):2382-2390.
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Rosas R, Aguilar RR, Arslanovic N, Seck A, Smith DJ, Tyler JK, Churchill MEA. A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function. Elife. 2023 07 11; 12.
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Pearson ADJ, Federico S, Gatz SA, Ortiz M, Lesa G, Scobie N, Gounaris I, Weiner SL, Weigel B, Unger TJ, Stewart E, Smith M, Slotkin EK, Reaman G, Pappo A, Nysom K, Norga K, McDonough J, Marshall LV, Ludwinski D, Ligas F, Karres D, Kool M, Horner TJ, Henssen A, Heenen D, Hawkins DS, Gore L, Bender JG, Galluzzo S, Fox E, de Rojas T, Davies BR, Chakrabarti J, Carmichael J, Bradford D, Blanc P, Bernardi R, Benchetrit S, Akindele K, Vassal G. Paediatric Strategy Forum for medicinal product development of DNA damage response pathway inhibitors in children and adolescents with cancer: ACCELERATE in collaboration with the European Medicines Agency with participation of the Food and Drug Administration. Eur J Cancer. 2023 09; 190:112950.
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Rudolph J, Luger K. PARP1 and HPF1 team up to flag down DNA-repair machinery. Nat Struct Mol Biol. 2023 05; 30(5):568-569.
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Wang Y, Chen Y, Garcia-Milian R, Golla JP, Charkoftaki G, Lam TT, Thompson DC, Vasiliou V. Proteomic profiling reveals an association between ALDH and oxidative phosphorylation and DNA damage repair pathways in human colon adenocarcinoma stem cells. Chem Biol Interact. 2022 Dec 01; 368:110175.
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McClure AW, Canal B, Diffley JFX. A DNA replication fork-centric view of the budding yeast DNA damage response. DNA Repair (Amst). 2022 11; 119:103393.
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Mendez-Bermudez A, Lototska L, Pousse M, Tessier F, Croce O, Latrick CM, Cherdyntseva V, Nassour J, Xiaohua J, Lu Y, Abbadie C, Gagos S, Ye J, Gilson E. Selective pericentromeric heterochromatin dismantling caused by TP53 activation during senescence. Nucleic Acids Res. 2022 07 22; 50(13):7493-7510.
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Sturmlechner I, Sine CC, Jeganathan KB, Zhang C, Fierro Velasco RO, Baker DJ, Li H, van Deursen JM. Senescent cells limit p53 activity via multiple mechanisms to remain viable. Nat Commun. 2022 06 28; 13(1):3722.
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Lin X, Jiang W, Rudolph J, Lee BJ, Luger K, Zha S. PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites. Nucleic Acids Res. 2022 04 22; 50(7):3958-3973.
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