 Telomerase
"Telomerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.
| Descriptor ID |
D019098
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| MeSH Number(s) |
D08.811.913.696.445.308.300.750.750 D12.776.157.687.613 D12.776.157.725.500.921 D12.776.660.720.613 D12.776.664.962.500.921
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| Concept/Terms |
Telomerase- Telomerase
- Telomerase Reverse Transcriptase
- Reverse Transcriptase, Telomerase
- Transcriptase, Telomerase Reverse
Telomerase Catalytic Subunit- Telomerase Catalytic Subunit
- Catalytic Subunit, Telomerase
- Subunit, Telomerase Catalytic
- Telomerase Reverse Transcriptase Catalytic Subunit
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Below are MeSH descriptors whose meaning is more general than "Telomerase".
Below are MeSH descriptors whose meaning is more specific than "Telomerase".
This graph shows the total number of publications written about "Telomerase" by people in this website by year, and whether "Telomerase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1996 | 1 | 0 | 1 | | 1997 | 9 | 0 | 9 | | 1998 | 3 | 1 | 4 | | 1999 | 6 | 0 | 6 | | 2000 | 5 | 0 | 5 | | 2001 | 2 | 0 | 2 | | 2002 | 3 | 2 | 5 | | 2003 | 4 | 1 | 5 | | 2004 | 2 | 8 | 10 | | 2005 | 4 | 0 | 4 | | 2006 | 1 | 0 | 1 | | 2007 | 2 | 1 | 3 | | 2008 | 3 | 2 | 5 | | 2009 | 0 | 2 | 2 | | 2010 | 4 | 2 | 6 | | 2011 | 3 | 2 | 5 | | 2012 | 3 | 0 | 3 | | 2013 | 8 | 2 | 10 | | 2014 | 4 | 1 | 5 | | 2015 | 3 | 0 | 3 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 1 | 2 | | 2018 | 1 | 0 | 1 | | 2019 | 2 | 1 | 3 | | 2020 | 3 | 0 | 3 | | 2021 | 4 | 2 | 6 |
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Below are the most recent publications written about "Telomerase" by people in Profiles.
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Zaug AJ, Lim CJ, Olson CL, Carilli MT, Goodrich KJ, Wuttke DS, Cech TR. CST does not evict elongating telomerase but prevents initiation by ssDNA binding. Nucleic Acids Res. 2021 11 18; 49(20):11653-11665.
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Agarwal N, Rinaldetti S, Cheikh BB, Zhou Q, Hass EP, Jones RT, Joshi M, LaBarbera DV, Knott SRV, Cech TR, Theodorescu D. TRIM28 is a transcriptional activator of the mutant TERT promoter in human bladder cancer. Proc Natl Acad Sci U S A. 2021 09 21; 118(38).
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Miglani M, Pasha Q, Gupta A, Priyadarshini A, Pati Pandey R, Vibhuti A. Seeding drug discovery: Telomeric tankyrase as a pharmacological target for the pathophysiology of high-altitude hypoxia. Drug Discov Today. 2021 11; 26(11):2774-2781.
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Dumbovic G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nat Commun. 2021 06 03; 12(1):3308.
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Choi JY, Abdulkina LR, Yin J, Chastukhina IB, Lovell JT, Agabekian IA, Young PG, Razzaque S, Shippen DE, Juenger TE, Shakirov EV, Purugganan MD. Natural variation in plant telomere length is associated with flowering time. Plant Cell. 2021 05 31; 33(4):1118-1134.
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Koubová J, Pangrácová M, Jankásek M, Lukšan O, Jehlík T, Brabcová J, Jedlicka P, Krivánek J, Capková Frydrychová R, Hanus R. Long-lived termite kings and queens activate telomerase in somatic organs. Proc Biol Sci. 2021 04 28; 288(1949):20210511.
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Lim CJ, Cech TR. Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021 04; 22(4):283-298.
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Miglani M, Rain M, Pasha Q, Raj VS, Thinlas T, Mohammad G, Gupta A, Pandey RP, Vibhuti A. Shorter telomere length, higher telomerase activity in association with tankyrase gene polymorphism contribute to high-altitude pulmonary edema. Hum Mol Genet. 2020 11 04; 29(18):3094-3106.
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Rowland TJ, Bonham AJ, Cech TR. Allele-specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers. Mol Oncol. 2020 10; 14(10):2358-2374.
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Shukla S, Jeong HC, Sturgeon CM, Parker R, Batista LFZ. Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita. Blood Adv. 2020 06 23; 4(12):2717-2722.
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