 Telomerase
"Telomerase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.
| Descriptor ID |
D019098
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| MeSH Number(s) |
D08.811.913.696.445.308.300.750.750 D12.776.157.687.613 D12.776.157.725.500.921 D12.776.660.720.613 D12.776.664.962.500.921
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| Concept/Terms |
Telomerase- Telomerase
- Telomerase Reverse Transcriptase
- Reverse Transcriptase, Telomerase
- Transcriptase, Telomerase Reverse
Telomerase Catalytic Subunit- Telomerase Catalytic Subunit
- Catalytic Subunit, Telomerase
- Subunit, Telomerase Catalytic
- Telomerase Reverse Transcriptase Catalytic Subunit
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Below are MeSH descriptors whose meaning is more general than "Telomerase".
Below are MeSH descriptors whose meaning is more specific than "Telomerase".
This graph shows the total number of publications written about "Telomerase" by people in this website by year, and whether "Telomerase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1996 | 2 | 0 | 2 | | 1997 | 11 | 0 | 11 | | 1998 | 6 | 1 | 7 | | 1999 | 6 | 0 | 6 | | 2000 | 8 | 1 | 9 | | 2001 | 2 | 0 | 2 | | 2002 | 5 | 2 | 7 | | 2003 | 9 | 1 | 10 | | 2004 | 3 | 10 | 13 | | 2005 | 5 | 0 | 5 | | 2006 | 4 | 0 | 4 | | 2007 | 2 | 1 | 3 | | 2008 | 7 | 5 | 12 | | 2009 | 1 | 3 | 4 | | 2010 | 7 | 3 | 10 | | 2011 | 3 | 2 | 5 | | 2012 | 4 | 0 | 4 | | 2013 | 8 | 2 | 10 | | 2014 | 6 | 4 | 10 | | 2015 | 7 | 1 | 8 | | 2016 | 2 | 0 | 2 | | 2017 | 2 | 1 | 3 | | 2018 | 1 | 0 | 1 | | 2019 | 4 | 2 | 6 | | 2020 | 5 | 0 | 5 | | 2021 | 2 | 2 | 4 |
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Below are the most recent publications written about "Telomerase" by people in Profiles.
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Dumbovic G, Braunschweig U, Langner HK, Smallegan M, Biayna J, Hass EP, Jastrzebska K, Blencowe B, Cech TR, Caruthers MH, Rinn JL. Nuclear compartmentalization of TERT mRNA and TUG1 lncRNA is driven by intron retention. Nat Commun. 2021 06 03; 12(1):3308.
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Choi JY, Abdulkina LR, Yin J, Chastukhina IB, Lovell JT, Agabekian IA, Young PG, Razzaque S, Shippen DE, Juenger TE, Shakirov EV, Purugganan MD. Natural variation in plant telomere length is associated with flowering time. Plant Cell. 2021 05 31; 33(4):1118-1134.
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Koubová J, Pangrácová M, Jankásek M, Lukšan O, Jehlík T, Brabcová J, Jedlicka P, Krivánek J, Capková Frydrychová R, Hanus R. Long-lived termite kings and queens activate telomerase in somatic organs. Proc Biol Sci. 2021 04 28; 288(1949):20210511.
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Lim CJ, Cech TR. Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021 04; 22(4):283-298.
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Mefford MA, Hass EP, Zappulla DC. A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit. Mol Cell Biol. 2020 11 20; 40(24).
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Rowland TJ, Bonham AJ, Cech TR. Allele-specific proximal promoter hypomethylation of the telomerase reverse transcriptase gene (TERT) associates with TERT expression in multiple cancers. Mol Oncol. 2020 10; 14(10):2358-2374.
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Kolb JM, Conzen K, Wachs M, Crossno J, McMahon B, Abidi MZ, Pomfret EA, Kriss M. Liver Transplantation for Decompensated Cirrhosis Secondary to Telomerase Reverse Transcriptase Mutation. Hepatology. 2020 07; 72(1):356-358.
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Shukla S, Jeong HC, Sturgeon CM, Parker R, Batista LFZ. Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita. Blood Adv. 2020 06 23; 4(12):2717-2722.
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Rinn JL, Chang HY. Long Noncoding RNAs: Molecular Modalities to Organismal Functions. Annu Rev Biochem. 2020 06 20; 89:283-308.
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Stern JL, Hibshman G, Hu K, Ferrara SE, Costello JC, Kim W, Tamayo P, Cech TR, Huang FW. Mesenchymal and MAPK Expression Signatures Associate with Telomerase Promoter Mutations in Multiple Cancers. Mol Cancer Res. 2020 07; 18(7):1050-1062.
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