 Polyadenylation
"Polyadenylation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The addition of a tail of polyadenylic acid (POLY A) to the 3' end of mRNA (RNA, MESSENGER). Polyadenylation involves recognizing the processing site signal, (AAUAAA), and cleaving of the mRNA to create a 3' OH terminal end to which poly A polymerase (POLYNUCLEOTIDE ADENYLYLTRANSFERASE) adds 60-200 adenylate residues. The 3' end processing of some messenger RNAs, such as histone mRNA, is carried out by a different process that does not include the addition of poly A as described here.
| Descriptor ID |
D026723
|
| MeSH Number(s) |
G02.111.760.225.710 G03.839.225.710 G05.308.700.225.710
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Polyadenylation".
Below are MeSH descriptors whose meaning is more specific than "Polyadenylation".
This graph shows the total number of publications written about "Polyadenylation" by people in this website by year, and whether "Polyadenylation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2013 | 1 | 2 | 3 | | 2015 | 3 | 1 | 4 | | 2017 | 2 | 2 | 4 | | 2020 | 0 | 2 | 2 | | 2021 | 4 | 1 | 5 | | 2022 | 2 | 2 | 4 |
To return to the timeline, click here.
Below are the most recent publications written about "Polyadenylation" by people in Profiles.
-
Geisberg JV, Moqtaderi Z, Fong N, Erickson B, Bentley DL, Struhl K. Nucleotide-level linkage of transcriptional elongation and polyadenylation. Elife. 2022 11 24; 11.
-
Witkowski MT, Lee S, Wang E, Lee AK, Talbot A, Ma C, Tsopoulidis N, Brumbaugh J, Zhao Y, Roberts KG, Hogg SJ, Nomikou S, Ghebrechristos YE, Thandapani P, Mullighan CG, Hochedlinger K, Chen W, Abdel-Wahab O, Eyquem J, Aifantis I. NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia. Nat Immunol. 2022 10; 23(10):1424-1432.
-
Lee S, Chen YC, Gillen AE, Taliaferro JM, Deplancke B, Li H, Lai EC. Diverse cell-specific patterns of alternative polyadenylation in Drosophila. Nat Commun. 2022 09 13; 13(1):5372.
-
Bilodeau DY, Sheridan RM, Balan B, Jex AR, Rissland OS. Precise gene models using long-read sequencing reveal a unique poly(A) signal in Giardia lamblia. RNA. 2022 05; 28(5):668-682.
-
Xu Z, Platig J, Lee S, Boueiz A, Chase R, Jain D, Gregory A, Suryadevara R, Berman S, Bowler R, Hersh CP, Laederach A, Castaldi PJ. Cigarette smoking-associated isoform switching and 3' UTR lengthening via alternative polyadenylation. Genomics. 2021 11; 113(6):4184-4195.
-
Goering R, Engel KL, Gillen AE, Fong N, Bentley DL, Taliaferro JM. LABRAT reveals association of alternative polyadenylation with transcript localization, RNA binding protein expression, transcription speed, and cancer survival. BMC Genomics. 2021 Jun 26; 22(1):476.
-
Amine H, Ripin N, Sharma S, Stoecklin G, Allain FH, S?raphin B, Mauxion F. A conserved motif in human BTG1 and BTG2 proteins mediates interaction with the poly(A) binding protein PABPC1 to stimulate mRNA deadenylation. RNA Biol. 2021 12; 18(12):2450-2465.
-
Gillen AE, Goering R, Taliaferro JM. Quantifying alternative polyadenylation in RNAseq data with LABRAT. Methods Enzymol. 2021; 655:245-263.
-
Lee S, Wei L, Zhang B, Goering R, Majumdar S, Wen J, Taliaferro JM, Lai EC. ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing. PLoS Genet. 2021 04; 17(4):e1009439.
-
Lusk R, Stene E, Banaei-Kashani F, Tabakoff B, Kechris K, Saba LM. Aptardi predicts polyadenylation sites in sample-specific transcriptomes using high-throughput RNA sequencing and DNA sequence. Nat Commun. 2021 03 12; 12(1):1652.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|