 Nitric Oxide
"Nitric Oxide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
| Descriptor ID |
D009569
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| MeSH Number(s) |
D01.339.387 D01.625.550.500 D01.625.700.500 D01.650.550.587.600
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| Concept/Terms |
Nitric Oxide- Nitric Oxide
- Oxide, Nitric
- Nitrogen Monoxide
- Monoxide, Nitrogen
- Nitric Oxide, Endothelium-Derived
- Endothelium-Derived Nitric Oxide
- Nitric Oxide, Endothelium Derived
- Endogenous Nitrate Vasodilator
- Nitrate Vasodilator, Endogenous
- Vasodilator, Endogenous Nitrate
- Mononitrogen Monoxide
- Monoxide, Mononitrogen
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Below are MeSH descriptors whose meaning is more general than "Nitric Oxide".
Below are MeSH descriptors whose meaning is more specific than "Nitric Oxide".
This graph shows the total number of publications written about "Nitric Oxide" by people in this website by year, and whether "Nitric Oxide" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1993 | 6 | 1 | 7 | | 1994 | 7 | 2 | 9 | | 1995 | 12 | 5 | 17 | | 1996 | 13 | 1 | 14 | | 1997 | 20 | 7 | 27 | | 1998 | 13 | 3 | 16 | | 1999 | 16 | 8 | 24 | | 2000 | 5 | 2 | 7 | | 2001 | 2 | 3 | 5 | | 2002 | 3 | 8 | 11 | | 2003 | 10 | 6 | 16 | | 2004 | 10 | 10 | 20 | | 2005 | 14 | 16 | 30 | | 2006 | 7 | 6 | 13 | | 2007 | 7 | 12 | 19 | | 2008 | 14 | 13 | 27 | | 2009 | 6 | 14 | 20 | | 2010 | 8 | 12 | 20 | | 2011 | 11 | 12 | 23 | | 2012 | 6 | 11 | 17 | | 2013 | 10 | 8 | 18 | | 2014 | 11 | 12 | 23 | | 2015 | 10 | 10 | 20 | | 2016 | 10 | 11 | 21 | | 2017 | 5 | 5 | 10 | | 2018 | 2 | 6 | 8 | | 2019 | 7 | 11 | 18 | | 2020 | 7 | 10 | 17 | | 2021 | 9 | 6 | 15 | | 2022 | 1 | 10 | 11 | | 2023 | 1 | 3 | 4 |
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Below are the most recent publications written about "Nitric Oxide" by people in Profiles.
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Cardenas HL, Evanoff NG, Fandl HK, Berry AR, Wegerson KN, Ostrander EI, Greiner JJ, Dufresne SR, Kotlyar M, Dengel DR, DeSouza CA, Garcia VP. Endothelial-derived extracellular vesicles associated with electronic cigarette use impair cerebral microvascular cell function. J Appl Physiol (1985). 2023 Aug 01; 135(2):271-278.
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Murray KO, Ludwig KR, Darvish S, Coppock ME, Seals DR, Rossman MJ. Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress. Am J Physiol Heart Circ Physiol. 2023 07 01; 325(1):H187-H194.
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Nie W, Yan C, Yang L, Roldin P, Liu Y, Vogel AL, Molteni U, Stolzenburg D, Finkenzeller H, Amorim A, Bianchi F, Curtius J, Dada L, Draper DC, Duplissy J, Hansel A, He XC, Hofbauer V, Jokinen T, Kim C, Lehtipalo K, Nichman L, Mauldin RL, Makhmutov V, Mentler B, Mizelli-Ojdanic A, Pet?j? T, Qu?l?ver LLJ, Schallhart S, Simon M, Tauber C, Tom? A, Volkamer R, Wagner AC, Wagner R, Wang M, Ye P, Li H, Huang W, Qi X, Lou S, Liu T, Chi X, Dommen J, Baltensperger U, El Haddad I, Kirkby J, Worsnop D, Kulmala M, Donahue NM, Ehn M, Ding A. NO at low concentration can enhance the formation of highly oxygenated biogenic molecules in the atmosphere. Nat Commun. 2023 Jun 08; 14(1):3347.
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Fandl HK, Garcia VP, Treuth JW, Brewster LM, Greiner JJ, Davy KP, Stauffer BL, Desouza CA. Endothelial-derived extracellular vesicles from obese/hypertensive adults increase factors associated with hypertrophy and fibrosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2023 05 01; 324(5):H675-H685.
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Schaid TR, Cohen MJ, D'Alessandro A, Silliman CC, Moore EE, Sauaia A, Dzieciatkowska M, Hallas W, Thielen O, DeBot M, Cralley A, LaCroix I, Erickson C, Mitra S, Banerjee A, Jones K, Hansen KC. TRAUMA INDUCES INTRAVASCULAR HEMOLYSIS, EXACERBATED BY RED BLOOD CELL TRANSFUSION AND ASSOCIATED WITH DISRUPTED ARGININE-NITRIC OXIDE METABOLISM. Shock. 2023 01 01; 59(1):12-19.
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Casso AG, VanDongen NS, Gioscia-Ryan RA, Clayton ZS, Greenberg NT, Ziemba BP, Hutton DA, Neilson AP, Davy KP, Seals DR, Brunt VE. Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice. J Physiol. 2022 11; 600(21):4633-4651.
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DuBose LE, Ozemek C, Wick T, Richardson V, Hildreth KL, Moreau KL. Role of BH4 deficiency as a mediator of oxidative stress-related endothelial dysfunction in menopausal women. Am J Physiol Heart Circ Physiol. 2022 11 01; 323(5):H975-H982.
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Keller AC, Chun JH, Knaub LA, Henckel MM, Hull SE, Scalzo RL, Pott GB, Walker LA, Reusch JEB. Thermoneutrality induces vascular dysfunction and impaired metabolic function in male Wistar rats: a new model of vascular disease. J Hypertens. 2022 11 01; 40(11):2133-2146.
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Ruhl AP, Jeffries N, Yang Y, Gutierrez OM, Muntner P, Naik RP, Pecker LH, Mott BT, Zakai NA, Safford MM, Lange LA, Winkler CA, Irvin MR, Cushman M, Ackerman HC. Alpha globin gene copy number and hypertension risk among Black Americans. PLoS One. 2022; 17(7):e0271031.
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Shannon OM, Clifford T, Seals DR, Craighead DH, Rossman MJ. Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes. Nitric Oxide. 2022 08 01; 125-126:31-39.
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