 Cyclin-Dependent Kinases
"Cyclin-Dependent Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.
| Descriptor ID |
D018844
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| MeSH Number(s) |
D08.811.913.696.620.682.700.646.500 D12.644.360.250 D12.776.167.200 D12.776.476.250
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| Concept/Terms |
Cyclin-Dependent Kinases- Cyclin-Dependent Kinases
- Cyclin Dependent Kinases
- Cyclin-Dependent Protein Kinases
- Cyclin Dependent Protein Kinases
- cdk Proteins
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Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinases".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinases".
This graph shows the total number of publications written about "Cyclin-Dependent Kinases" by people in this website by year, and whether "Cyclin-Dependent Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 2 | 0 | 2 | | 1997 | 2 | 2 | 4 | | 1998 | 1 | 2 | 3 | | 1999 | 2 | 0 | 2 | | 2000 | 1 | 0 | 1 | | 2001 | 0 | 4 | 4 | | 2002 | 1 | 6 | 7 | | 2003 | 2 | 2 | 4 | | 2004 | 1 | 6 | 7 | | 2005 | 1 | 2 | 3 | | 2006 | 2 | 2 | 4 | | 2007 | 2 | 3 | 5 | | 2008 | 2 | 2 | 4 | | 2009 | 3 | 0 | 3 | | 2010 | 1 | 3 | 4 | | 2011 | 1 | 2 | 3 | | 2012 | 2 | 1 | 3 | | 2013 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 1 | 1 | 2 | | 2017 | 2 | 2 | 4 | | 2018 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinases" by people in Profiles.
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Espinosa JM. Transcriptional CDKs in the spotlight. Transcription. 2019 04; 10(2):45-46.
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Fant CB, Taatjes DJ. Regulatory functions of the Mediator kinases CDK8 and CDK19. Transcription. 2019 04; 10(2):76-90.
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Galbraith MD, Bender H, Espinosa JM. Therapeutic targeting of transcriptional cyclin-dependent kinases. Transcription. 2019 04; 10(2):118-136.
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Galbraith MD, Andrysik Z, Pandey A, Hoh M, Bonner EA, Hill AA, Sullivan KD, Espinosa JM. CDK8 Kinase Activity Promotes Glycolysis. Cell Rep. 2017 Nov 07; 21(6):1495-1506.
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Blakely CM, Watkins TBK, Wu W, Gini B, Chabon JJ, McCoach CE, McGranahan N, Wilson GA, Birkbak NJ, Olivas VR, Rotow J, Maynard A, Wang V, Gubens MA, Banks KC, Lanman RB, Caulin AF, St John J, Cordero AR, Giannikopoulos P, Simmons AD, Mack PC, Gandara DR, Husain H, Doebele RC, Riess JW, Diehn M, Swanton C, Bivona TG. Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers. Nat Genet. 2017 Dec; 49(12):1693-1704.
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Ebmeier CC, Erickson B, Allen BL, Allen MA, Kim H, Fong N, Jacobsen JR, Liang K, Shilatifard A, Dowell RD, Old WM, Bentley DL, Taatjes DJ. Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications. Cell Rep. 2017 08 01; 20(5):1173-1186.
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Audetat KA, Galbraith MD, Odell AT, Lee T, Pandey A, Espinosa JM, Dowell RD, Taatjes DJ. A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response. Mol Cell Biol. 2017 07 01; 37(13).
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DiPippo AJ, Patel NK, Barnett CM. Cyclin-Dependent Kinase Inhibitors for the Treatment of Breast Cancer: Past, Present, and Future. Pharmacotherapy. 2016 06; 36(6):652-67.
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Poss ZC, Ebmeier CC, Odell AT, Tangpeerachaikul A, Lee T, Pelish HE, Shair MD, Dowell RD, Old WM, Taatjes DJ. Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics. Cell Rep. 2016 Apr 12; 15(2):436-50.
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Pelish HE, Liau BB, Nitulescu II, Tangpeerachaikul A, Poss ZC, Da Silva DH, Caruso BT, Arefolov A, Fadeyi O, Christie AL, Du K, Banka D, Schneider EV, Jestel A, Zou G, Si C, Ebmeier CC, Bronson RT, Krivtsov AV, Myers AG, Kohl NE, Kung AL, Armstrong SA, Lemieux ME, Taatjes DJ, Shair MD. Mediator kinase inhibition further activates super-enhancer-associated genes in AML. Nature. 2015 Oct 08; 526(7572):273-276.
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