 Drug Tolerance
"Drug Tolerance" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
| Descriptor ID |
D004361
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| MeSH Number(s) |
G07.690.773.992
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| Concept/Terms |
Drug Tolerance- Drug Tolerance
- Drug Tolerances
- Tolerance, Drug
- Tolerances, Drug
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Below are MeSH descriptors whose meaning is more general than "Drug Tolerance".
Below are MeSH descriptors whose meaning is more specific than "Drug Tolerance".
This graph shows the total number of publications written about "Drug Tolerance" by people in this website by year, and whether "Drug Tolerance" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 3 | 3 | | 1995 | 0 | 6 | 6 | | 1996 | 0 | 1 | 1 | | 1997 | 0 | 3 | 3 | | 1999 | 0 | 1 | 1 | | 2000 | 0 | 2 | 2 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 1 | 2 | | 2005 | 0 | 2 | 2 | | 2006 | 1 | 2 | 3 | | 2007 | 4 | 0 | 4 | | 2008 | 1 | 1 | 2 | | 2009 | 2 | 2 | 4 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2013 | 1 | 1 | 2 | | 2015 | 4 | 2 | 6 | | 2017 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 2 | 1 | 3 | | 2021 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Drug Tolerance" by people in Profiles.
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Schamiloglu S, Lewis E, Keeshen CM, Hergarden AC, Bender KJ, Whistler JL. Arrestin-3 Agonism at Dopamine D3 Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance. Biol Psychiatry. 2023 10 01; 94(7):531-542.
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Ballantyne CM, Bays H, Catapano AL, Goldberg A, Ray KK, Saseen JJ. Role of Bempedoic Acid in Clinical Practice. Cardiovasc Drugs Ther. 2021 08; 35(4):853-864.
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Gomez DM, Everett TJ, Hamilton LR, Ranganath A, Cheer JF, Oleson EB. Chronic cannabinoid exposure produces tolerance to the dopamine releasing effects of WIN 55,212-2 and heroin in adult male rats. Neuropharmacology. 2021 01; 182:108374.
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Radcliffe RA, Dowell R, Odell AT, Richmond PA, Bennett B, Larson C, Kechris K, Saba LM, Rudra P, Wen S. Systems genetics analysis of the LXS recombinant inbred mouse strains:Genetic and molecular insights into acute ethanol tolerance. PLoS One. 2020; 15(10):e0240253.
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Kanni T, Argyropoulou M, Dinarello CA, Simard J, Giamarellos-Bourboulis EJ. MABp1 targeting interleukin-1a in hidradenitis suppurativa ineligible for adalimumab treatment: results of the open-label extension period. Clin Exp Dermatol. 2021 Jan; 46(1):162-163.
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Smallegan MJ, Rinn JL. Linking long noncoding RNA to drug resistance. Proc Natl Acad Sci U S A. 2019 10 29; 116(44):21963-21965.
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Yi H, Kim HS. Antibiotic Scars Left on the Gut Microbiota from the Stringent Response. Trends Microbiol. 2018 09; 26(9):735-737.
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Yi H, Lee H, Cho KH, Kim HS. Mutations in MetG (methionyl-tRNA synthetase) and TrmD [tRNA (guanine-N1)-methyltransferase] conferring meropenem tolerance in Burkholderia thailandensis. J Antimicrob Chemother. 2018 02 01; 73(2):332-338.
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Gaudet AD, Ayala MT, Schleicher WE, Smith EJ, Bateman EM, Maier SF, Watkins LR. Exploring acute-to-chronic neuropathic pain in rats after contusion spinal cord injury. Exp Neurol. 2017 09; 295:46-54.
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Brown KK. COUNTERPOINT: Should All Patients With Idiopathic Pulmonary Fibrosis, Even Those With More Than Moderate Impairment, Be Treated With Nintedanib or Pirfenidone? No. Chest. 2016 08; 150(2):276-8.
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