 Pro-Opiomelanocortin
"Pro-Opiomelanocortin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).
| Descriptor ID |
D011333
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| MeSH Number(s) |
D06.472.699.327.935 D06.472.699.631.525.600 D12.644.400.400.935 D12.644.548.365.935 D12.644.548.691.525.690 D12.776.631.650.405.935 D12.776.811.800
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| Concept/Terms |
Pro-Opiomelanocortin- Pro-Opiomelanocortin
- Pro Opiomelanocortin
- ACTH-Endorphin Precursor
- ACTH Endorphin Precursor
- Endorphin-ACTH Precursor
- Endorphin ACTH Precursor
- Corticotropin-beta-Lipotropin Precursor
- Corticotropin beta Lipotropin Precursor
- POMC
- Proopiomelanocortin
- Pro-Opiocortin
- Pro Opiocortin
- Pro-Opio-Melanocortin
- Pro Opio Melanocortin
- Proopiocortin
- ACTH-beta-Lipotropin Precursor
- ACTH beta Lipotropin Precursor
- Pro-ACTH-Endorphin
- Pro ACTH Endorphin
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Below are MeSH descriptors whose meaning is more general than "Pro-Opiomelanocortin".
Below are MeSH descriptors whose meaning is more specific than "Pro-Opiomelanocortin".
This graph shows the total number of publications written about "Pro-Opiomelanocortin" by people in this website by year, and whether "Pro-Opiomelanocortin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 1 | 2 | | 1999 | 3 | 0 | 3 | | 2000 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pro-Opiomelanocortin" by people in Profiles.
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Burmeister MA, Ayala JE, Smouse H, Landivar-Rocha A, Brown JD, Drucker DJ, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE. The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice. Diabetes. 2017 02; 66(2):372-384.
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Wang L, Meece K, Williams DJ, Lo KA, Zimmer M, Heinrich G, Martin Carli J, Leduc CA, Sun L, Zeltser LM, Freeby M, Goland R, Tsang SH, Wardlaw SL, Egli D, Leibel RL. Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest. 2015 Feb; 125(2):796-808.
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Osterlund C, Spencer RL. Corticosterone pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis activity via multiple actions that vary with time, site of action, and de novo protein synthesis. J Endocrinol. 2011 Mar; 208(3):311-22.
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Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA. MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression. J Biol Chem. 2010 Nov 05; 285(45):34718-28.
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Girotti M, Weinberg MS, Spencer RL. Differential responses of hypothalamus-pituitary-adrenal axis immediate early genes to corticosterone and circadian drive. Endocrinology. 2007 May; 148(5):2542-52.
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Ginsberg AB, Frank MG, Francis AB, Rubin BA, O'Connor KA, Spencer RL. Specific and time-dependent effects of glucocorticoid receptor agonist RU28362 on stress-induced pro-opiomelanocortin hnRNA, c-fos mRNA and zif268 mRNA in the pituitary. J Neuroendocrinol. 2006 Feb; 18(2):129-38.
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O'Connor KA, Ginsberg AB, Maksimova E, Wieseler Frank JL, Johnson JD, Spencer RL, Campeau S, Watkins LR, Maier SF. Stress-induced sensitization of the hypothalamic-pituitary adrenal axis is associated with alterations of hypothalamic and pituitary gene expression. Neuroendocrinology. 2004; 80(4):252-63.
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Scholzen TE, Kalden DH, Brzoska T, Fisbeck T, Fastrich M, Schiller M, Böhm M, Schwarz T, Armstrong CA, Ansel JC, Luger TA. Expression of proopiomelanocortin peptides in human dermal microvascular endothelial cells: evidence for a regulation by ultraviolet light and interleukin-1. J Invest Dermatol. 2000 Dec; 115(6):1021-8.
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Scholzen TE, Brzoska T, Kalden DH, Hartmeyer M, Fastrich M, Luger TA, Armstrong CA, Ansel JC. Expression of functional melanocortin receptors and proopiomelanocortin peptides by human dermal microvascular endothelial cells. Ann N Y Acad Sci. 1999 Oct 20; 885:239-53.
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Scholzen TE, Brzoska T, Kalden DH, Hartmeyer M, Luger TA, Armstrong CA, Ansel JC. Expression of proopiomelanocortin peptides and prohormone convertases by human dermal microvascular endothelial cells. Ann N Y Acad Sci. 1999 Oct 20; 885:444-7.
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