Insulin Receptor Substrate Proteins
"Insulin Receptor Substrate Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.
Descriptor ID |
D055504
|
MeSH Number(s) |
D12.644.360.024.301 D12.776.157.057.045 D12.776.476.024.382
|
Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Insulin Receptor Substrate Proteins".
Below are MeSH descriptors whose meaning is more specific than "Insulin Receptor Substrate Proteins".
This graph shows the total number of publications written about "Insulin Receptor Substrate Proteins" by people in this website by year, and whether "Insulin Receptor Substrate Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
Year | Major Topic | Minor Topic | Total |
---|
1994 | 0 | 1 | 1 | 1996 | 0 | 1 | 1 | 1997 | 0 | 1 | 1 | 2000 | 0 | 1 | 1 | 2001 | 0 | 1 | 1 | 2002 | 0 | 2 | 2 | 2003 | 0 | 2 | 2 | 2004 | 0 | 2 | 2 | 2005 | 0 | 2 | 2 | 2006 | 0 | 3 | 3 | 2007 | 0 | 1 | 1 | 2008 | 1 | 1 | 2 | 2009 | 0 | 2 | 2 | 2010 | 0 | 1 | 1 | 2011 | 1 | 0 | 1 | 2012 | 0 | 3 | 3 | 2013 | 0 | 2 | 2 | 2014 | 0 | 1 | 1 | 2015 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Insulin Receptor Substrate Proteins" by people in Profiles.
-
Irimia JM, Meyer CM, Segvich DM, Surendran S, DePaoli-Roach AA, Morral N, Roach PJ. Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. J Biol Chem. 2017 06 23; 292(25):10455-10464.
-
Pugazhenthi S, Qin L, Bouchard R. Dipeptidyl peptidase-4 inhibition in diabetic rats leads to activation of the transcription factor CREB in ß-cells. Eur J Pharmacol. 2015 May 15; 755:42-9.
-
Lager S, Aye IL, Gaccioli F, Ramirez VI, Jansson T, Powell TL. Labor inhibits placental mechanistic target of rapamycin complex 1 signaling. Placenta. 2014 Dec; 35(12):1007-12.
-
Aye IL, Jansson T, Powell TL. Interleukin-1ß inhibits insulin signaling and prevents insulin-stimulated system A amino acid transport in primary human trophoblasts. Mol Cell Endocrinol. 2013 Dec 05; 381(1-2):46-55.
-
Low Wang CC, Lu L, Leitner JW, Sarraf M, Gianani R, Draznin B, Greyson CR, Reusch JE, Schwartz GG. Arterial insulin resistance in Yucatan micropigs with diet-induced obesity and metabolic syndrome. J Diabetes Complications. 2013 Jul-Aug; 27(4):307-15.
-
Wang CC, Adochio RL, Leitner JW, Abeyta IM, Draznin B, Cornier MA. Acute effects of different diet compositions on skeletal muscle insulin signalling in obese individuals during caloric restriction. Metabolism. 2013 Apr; 62(4):595-603.
-
Bergman BC, Perreault L, Hunerdosse D, Kerege A, Playdon M, Samek AM, Eckel RH. Novel and reversible mechanisms of smoking-induced insulin resistance in humans. Diabetes. 2012 Dec; 61(12):3156-66.
-
Velmurugan K, Balamurugan AN, Loganathan G, Ahmad A, Hering BJ, Pugazhenthi S. Antiapoptotic actions of exendin-4 against hypoxia and cytokines are augmented by CREB. Endocrinology. 2012 Mar; 153(3):1116-28.
-
Barbour LA, McCurdy CE, Hernandez TL, Friedman JE. Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum. J Clin Endocrinol Metab. 2011 May; 96(5):1431-41.
-
Jones HN, Jansson T, Powell TL. Full-length adiponectin attenuates insulin signaling and inhibits insulin-stimulated amino Acid transport in human primary trophoblast cells. Diabetes. 2010 May; 59(5):1161-70.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|