 Drug Discovery
"Drug Discovery" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process of finding chemicals for potential therapeutic use.
| Descriptor ID |
D055808
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| MeSH Number(s) |
E05.295 H01.158.703.007.675 H01.181.466.675
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Drug Discovery".
Below are MeSH descriptors whose meaning is more specific than "Drug Discovery".
This graph shows the total number of publications written about "Drug Discovery" by people in this website by year, and whether "Drug Discovery" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 2 | 2 | | 2009 | 1 | 4 | 5 | | 2010 | 1 | 0 | 1 | | 2011 | 8 | 3 | 11 | | 2012 | 7 | 6 | 13 | | 2013 | 5 | 8 | 13 | | 2014 | 0 | 5 | 5 | | 2015 | 5 | 5 | 10 | | 2016 | 5 | 7 | 12 | | 2017 | 1 | 4 | 5 | | 2018 | 6 | 5 | 11 | | 2019 | 5 | 4 | 9 | | 2020 | 2 | 4 | 6 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Drug Discovery" by people in Profiles.
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Rogawski DS, Deng J, Li H, Miao H, Borkin D, Purohit T, Song J, Chase J, Li S, Ndoj J, Klossowski S, Kim E, Mao F, Zhou B, Ropa J, Krotoska MZ, Jin Z, Ernst P, Feng X, Huang G, Nishioka K, Kelly S, He M, Wen B, Sun D, Muntean A, Dou Y, Maillard I, Cierpicki T, Grembecka J. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun. 2021 05 14; 12(1):2792.
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Chitnis CE, Schellenberg D, Vekemans J, Asturias EJ, Bejon P, Collins KA, Crabb BS, Herrera S, Laufer M, Rabinovich NR, Roestenberg M, Shearley A, Tinto H, Wentworth M, O'Brien K, Alonso P. Building momentum for malaria vaccine research and development: key considerations. Malar J. 2020 Nov 23; 19(1):421.
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Zivanovic S, Bayarri G, Colizzi F, Moreno D, Gelpí JL, Soliva R, Hospital A, Orozco M. Bioactive Conformational Ensemble Server and Database. A Public Framework to Speed Up In Silico Drug Discovery. J Chem Theory Comput. 2020 Oct 13; 16(10):6586-6597.
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Esquer H, Zhou Q, Abraham AD, LaBarbera DV. Advanced High-Content-Screening Applications of Clonogenicity in Cancer. SLAS Discov. 2020 08; 25(7):734-743.
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Ball KA, Webb KJ, Coleman SJ, Cozzolino KA, Jacobsen J, Jones KR, Stowell MHB, Old WM. An isothermal shift assay for proteome scale drug-target identification. Commun Biol. 2020 02 14; 3(1):75.
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Detweiler CS. Infection-based chemical screens uncover host-pathogen interactions. Curr Opin Microbiol. 2020 04; 54:43-50.
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Liu X, Lu S, Song K, Shen Q, Ni D, Li Q, He X, Zhang H, Wang Q, Chen Y, Li X, Wu J, Sheng C, Chen G, Liu Y, Lu X, Zhang J. Unraveling allosteric landscapes of allosterome with ASD. Nucleic Acids Res. 2020 01 08; 48(D1):D394-D401.
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Esposito F, Sechi M, Pala N, Sanna A, Koneru PC, Kvaratskhelia M, Naesens L, Corona A, Grandi N, di Santo R, D'Amore VM, Di Leva FS, Novellino E, Cosconati S, Tramontano E. Discovery of dihydroxyindole-2-carboxylic acid derivatives as dual allosteric HIV-1 Integrase and Reverse Transcriptase associated Ribonuclease H inhibitors. Antiviral Res. 2020 02; 174:104671.
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Horswill AR, Gordon CP. Structure-Activity Relationship Studies of Small Molecule Modulators of the Staphylococcal Accessory Gene Regulator. J Med Chem. 2020 03 26; 63(6):2705-2730.
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Kim J, Hu C, Moufawad El Achkar C, Black LE, Douville J, Larson A, Pendergast MK, Goldkind SF, Lee EA, Kuniholm A, Soucy A, Vaze J, Belur NR, Fredriksen K, Stojkovska I, Tsytsykova A, Armant M, DiDonato RL, Choi J, Cornelissen L, Pereira LM, Augustine EF, Genetti CA, Dies K, Barton B, Williams L, Goodlett BD, Riley BL, Pasternak A, Berry ER, Pflock KA, Chu S, Reed C, Tyndall K, Agrawal PB, Beggs AH, Grant PE, Urion DK, Snyder RO, Waisbren SE, Poduri A, Park PJ, Patterson A, Biffi A, Mazzulli JR, Bodamer O, Berde CB, Yu TW. Patient-Customized Oligonucleotide Therapy for a Rare Genetic Disease. N Engl J Med. 2019 10 24; 381(17):1644-1652.
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