 Drug Discovery
"Drug Discovery" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process of finding chemicals for potential therapeutic use.
| Descriptor ID |
D055808
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| MeSH Number(s) |
E05.295 H01.158.703.007.675 H01.181.466.675
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Drug Discovery".
Below are MeSH descriptors whose meaning is more specific than "Drug Discovery".
This graph shows the total number of publications written about "Drug Discovery" by people in this website by year, and whether "Drug Discovery" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 2 | 2 | | 2009 | 0 | 2 | 2 | | 2010 | 1 | 0 | 1 | | 2011 | 7 | 1 | 8 | | 2012 | 5 | 5 | 10 | | 2013 | 3 | 6 | 9 | | 2014 | 0 | 3 | 3 | | 2015 | 4 | 2 | 6 | | 2016 | 5 | 5 | 10 | | 2017 | 1 | 4 | 5 | | 2018 | 3 | 4 | 7 | | 2019 | 4 | 3 | 7 | | 2020 | 2 | 3 | 5 | | 2021 | 3 | 5 | 8 |
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Below are the most recent publications written about "Drug Discovery" by people in Profiles.
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Buchman TG, Draghia-Akli R, Adam SJ, Aggarwal NR, Fessel JP, Higgs ES, Menetski JP, Read SW, Hughes EA. Accelerating Coronavirus Disease 2019 Therapeutic Interventions and Vaccines-Selecting Compounds for Clinical Evaluation in Coronavirus Disease 2019 Clinical Trials. Crit Care Med. 2021 11 01; 49(11):1963-1973.
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Wooten DJ, Meyer CT, Lubbock ALR, Quaranta V, Lopez CF. MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery. Nat Commun. 2021 07 29; 12(1):4607.
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Miglani M, Pasha Q, Gupta A, Priyadarshini A, Pati Pandey R, Vibhuti A. Seeding drug discovery: Telomeric tankyrase as a pharmacological target for the pathophysiology of high-altitude hypoxia. Drug Discov Today. 2021 11; 26(11):2774-2781.
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Ma XR, Xu L, Xu S, Klein BJ, Wang H, Das S, Li K, Yang KS, Sohail S, Chapman A, Kutateladze TG, Shi X, Liu WR, Wen H. Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain. J Med Chem. 2021 08 12; 64(15):10997-11013.
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Robertson CC, Inshaw JRJ, Onengut-Gumuscu S, Chen WM, Santa Cruz DF, Yang H, Cutler AJ, Crouch DJM, Farber E, Bridges SL, Edberg JC, Kimberly RP, Buckner JH, Deloukas P, Divers J, Dabelea D, Lawrence JM, Marcovina S, Shah AS, Greenbaum CJ, Atkinson MA, Gregersen PK, Oksenberg JR, Pociot F, Rewers MJ, Steck AK, Dunger DB, Wicker LS, Concannon P, Todd JA, Rich SS. Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes. Nat Genet. 2021 07; 53(7):962-971.
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Rogawski DS, Deng J, Li H, Miao H, Borkin D, Purohit T, Song J, Chase J, Li S, Ndoj J, Klossowski S, Kim E, Mao F, Zhou B, Ropa J, Krotoska MZ, Jin Z, Ernst P, Feng X, Huang G, Nishioka K, Kelly S, He M, Wen B, Sun D, Muntean A, Dou Y, Maillard I, Cierpicki T, Grembecka J. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun. 2021 05 14; 12(1):2792.
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Iglesias-Carres L, Hughes MD, Steele CN, Ponder MA, Davy KP, Neilson AP. Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation. J Nutr Biochem. 2021 05; 91:108600.
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Xia L, Shen D, Zhang Y, Lu J, Wang M, Wang H, Chen Y, Xue D, Xie D, Li G. Targeting the TR4 nuclear receptor with antagonist bexarotene can suppress the proopiomelanocortin signalling in AtT-20 cells. J Cell Mol Med. 2021 03; 25(5):2404-2417.
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Kalita B, Saviola AJ, Mukherjee AK. From venom to drugs: a review and critical analysis of Indian snake venom toxins envisaged as anticancer drug prototypes. Drug Discov Today. 2021 04; 26(4):993-1005.
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Chitnis CE, Schellenberg D, Vekemans J, Asturias EJ, Bejon P, Collins KA, Crabb BS, Herrera S, Laufer M, Rabinovich NR, Roestenberg M, Shearley A, Tinto H, Wentworth M, O'Brien K, Alonso P. Building momentum for malaria vaccine research and development: key considerations. Malar J. 2020 Nov 23; 19(1):421.
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