 Mitogen-Activated Protein Kinases
"Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
| Descriptor ID |
D020928
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| MeSH Number(s) |
D08.811.913.696.620.682.700.567 D12.644.360.450 D12.776.476.450
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| Concept/Terms |
Mitogen-Activated Protein Kinases- Mitogen-Activated Protein Kinases
- Kinases, Mitogen-Activated Protein
- Mitogen Activated Protein Kinases
- Protein Kinases, Mitogen-Activated
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Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinases".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinases".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinases" by people in this website by year, and whether "Mitogen-Activated Protein Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1991 | 1 | 0 | 1 | | 1992 | 2 | 0 | 2 | | 1995 | 1 | 0 | 1 | | 1996 | 4 | 0 | 4 | | 1997 | 6 | 0 | 6 | | 1998 | 10 | 0 | 10 | | 1999 | 9 | 5 | 14 | | 2000 | 15 | 11 | 26 | | 2001 | 21 | 6 | 27 | | 2002 | 16 | 21 | 37 | | 2003 | 19 | 25 | 44 | | 2004 | 14 | 16 | 30 | | 2005 | 3 | 2 | 5 | | 2006 | 3 | 4 | 7 | | 2007 | 2 | 5 | 7 | | 2008 | 1 | 4 | 5 | | 2009 | 1 | 4 | 5 | | 2010 | 2 | 4 | 6 | | 2011 | 0 | 3 | 3 | | 2012 | 1 | 3 | 4 | | 2013 | 2 | 3 | 5 | | 2014 | 3 | 1 | 4 | | 2015 | 3 | 0 | 3 | | 2016 | 4 | 0 | 4 | | 2017 | 3 | 2 | 5 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinases" by people in Profiles.
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Basken J, Stuart SA, Kavran AJ, Lee T, Ebmeier CC, Old WM, Ahn NG. Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. Mol Cell Proteomics. 2018 04; 17(4):550-564.
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Chen DB, Feng L, Hodges JK, Lechuga TJ, Zhang H. Human trophoblast-derived hydrogen sulfide stimulates placental artery endothelial cell angiogenesis. Biol Reprod. 2017 Sep 01; 97(3):478-489.
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Osgood RS, Upham BL, Bushel PR, Velmurugan K, Xiong KN, Bauer AK. Secondhand Smoke-Prevalent Polycyclic Aromatic Hydrocarbon Binary Mixture-Induced Specific Mitogenic and Pro-inflammatory Cell Signaling Events in Lung Epithelial Cells. Toxicol Sci. 2017 05 01; 157(1):156-171.
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Dheeraj A, Rigby CM, O'Bryant CL, Agarwal C, Singh RP, Deep G, Agarwal R. Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling. Photochem Photobiol. 2017 07; 93(4):999-1007.
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Khorasanizadeh M, Eskian M, Gelfand EW, Rezaei N. Mitogen-activated protein kinases as therapeutic targets for asthma. Pharmacol Ther. 2017 Jun; 174:112-126.
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Lim YH, Bacchiocchi A, Qiu J, Straub R, Bruckner A, Bercovitch L, Narayan D, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate KA. GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation. Am J Hum Genet. 2016 Aug 04; 99(2):443-50.
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Munkácsy E, Khan MH, Lane RK, Borror MB, Park JH, Bokov AF, Fisher AL, Link CD, Rea SL. DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genet. 2016 07; 12(7):e1006133.
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Goshen-Lago T, Goldberg-Carp A, Melamed D, Darlyuk-Saadon I, Bai C, Ahn NG, Admon A, Engelberg D. Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation. Mol Biol Cell. 2016 09 01; 27(17):2771-83.
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Stevenson DA, Schill L, Schoyer L, Andresen BS, Bakker A, Bayrak-Toydemir P, Burkitt-Wright E, Chatfield K, Elefteriou F, Elgersma Y, Fisher MJ, Franz D, Gelb BD, Goriely A, Gripp KW, Hardan AY, Keppler-Noreuil KM, Kerr B, Korf B, Leoni C, McCormick F, Plotkin SR, Rauen KA, Reilly K, Roberts A, Sandler A, Siegel D, Walsh K, Widemann BC. The Fourth International Symposium on Genetic Disorders of the Ras/MAPK pathway. Am J Med Genet A. 2016 08; 170(8):1959-66.
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Hrustanovic G, Olivas V, Pazarentzos E, Tulpule A, Asthana S, Blakely CM, Okimoto RA, Lin L, Neel DS, Sabnis A, Flanagan J, Chan E, Varella-Garcia M, Aisner DL, Vaishnavi A, Ou SH, Collisson EA, Ichihara E, Mack PC, Lovly CM, Karachaliou N, Rosell R, Riess JW, Doebele RC, Bivona TG. RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer. Nat Med. 2015 Sep; 21(9):1038-47.
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