 Mitogen-Activated Protein Kinases
"Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
| Descriptor ID |
D020928
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| MeSH Number(s) |
D08.811.913.696.620.682.700.567 D12.644.360.450 D12.776.476.450
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| Concept/Terms |
Mitogen-Activated Protein Kinases- Mitogen-Activated Protein Kinases
- Kinases, Mitogen-Activated Protein
- Mitogen Activated Protein Kinases
- Protein Kinases, Mitogen-Activated
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Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinases".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinases".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinases" by people in this website by year, and whether "Mitogen-Activated Protein Kinases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 2 | 0 | 2 | | 1995 | 1 | 0 | 1 | | 1996 | 4 | 0 | 4 | | 1997 | 4 | 0 | 4 | | 1998 | 8 | 0 | 8 | | 1999 | 6 | 3 | 9 | | 2000 | 10 | 5 | 15 | | 2001 | 10 | 4 | 14 | | 2002 | 10 | 11 | 21 | | 2003 | 10 | 22 | 32 | | 2004 | 10 | 13 | 23 | | 2005 | 2 | 1 | 3 | | 2006 | 2 | 3 | 5 | | 2007 | 1 | 3 | 4 | | 2008 | 0 | 5 | 5 | | 2009 | 1 | 1 | 2 | | 2010 | 2 | 1 | 3 | | 2011 | 1 | 2 | 3 | | 2012 | 1 | 1 | 2 | | 2013 | 0 | 3 | 3 | | 2014 | 3 | 0 | 3 | | 2015 | 3 | 0 | 3 | | 2016 | 3 | 0 | 3 | | 2017 | 2 | 1 | 3 | | 2019 | 1 | 0 | 1 | | 2020 | 4 | 0 | 4 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinases" by people in Profiles.
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Liao P, Song K, Zhu Z, Liu Z, Zhang W, Li W, Hu J, Hu Q, Chen C, Chen B, McLeod HL, Pei H, Chen L, He Y. Propranolol Suppresses the Growth of Colorectal Cancer Through Simultaneously Activating Autologous CD8+ T Cells and Inhibiting Tumor AKT/MAPK Pathway. Clin Pharmacol Ther. 2020 09; 108(3):606-615.
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Brózman O, Novák J, Bauer AK, Babica P. Airborne PAHs inhibit gap junctional intercellular communication and activate MAPKs in human bronchial epithelial cell line. Environ Toxicol Pharmacol. 2020 Oct; 79:103422.
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Weaver BP, Weaver YM, Omi S, Yuan W, Ewbank JJ, Han M. Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development. Dev Cell. 2020 05 04; 53(3):358-369.e6.
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Anwar A, Anwar H, Yamauchi T, Tseng R, Agarwal R, Horwitz LD, Zhai Z, Fujita M. Bucillamine Inhibits UVB-Induced MAPK Activation and Apoptosis in Human HaCaT Keratinocytes and SKH-1 Hairless Mouse Skin. Photochem Photobiol. 2020 07; 96(4):870-876.
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Mikheil DM, Prabhakar K, Arshad A, Rodriguez CI, Newton MA, Setaluri V. Notch signaling activation induces cell death in MAPKi-resistant melanoma cells. Pigment Cell Melanoma Res. 2019 07; 32(4):528-539.
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Basken J, Stuart SA, Kavran AJ, Lee T, Ebmeier CC, Old WM, Ahn NG. Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells. Mol Cell Proteomics. 2018 04; 17(4):550-564.
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Osgood RS, Upham BL, Bushel PR, Velmurugan K, Xiong KN, Bauer AK. Secondhand Smoke-Prevalent Polycyclic Aromatic Hydrocarbon Binary Mixture-Induced Specific Mitogenic and Pro-inflammatory Cell Signaling Events in Lung Epithelial Cells. Toxicol Sci. 2017 05 01; 157(1):156-171.
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Dheeraj A, Rigby CM, O'Bryant CL, Agarwal C, Singh RP, Deep G, Agarwal R. Silibinin Treatment Inhibits the Growth of Hedgehog Inhibitor-Resistant Basal Cell Carcinoma Cells via Targeting EGFR-MAPK-Akt and Hedgehog Signaling. Photochem Photobiol. 2017 07; 93(4):999-1007.
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Lim YH, Bacchiocchi A, Qiu J, Straub R, Bruckner A, Bercovitch L, Narayan D, McNiff J, Ko C, Robinson-Bostom L, Antaya R, Halaban R, Choate KA. GNA14 Somatic Mutation Causes Congenital and Sporadic Vascular Tumors by MAPK Activation. Am J Hum Genet. 2016 Aug 04; 99(2):443-50.
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Munkácsy E, Khan MH, Lane RK, Borror MB, Park JH, Bokov AF, Fisher AL, Link CD, Rea SL. DLK-1, SEK-3 and PMK-3 Are Required for the Life Extension Induced by Mitochondrial Bioenergetic Disruption in C. elegans. PLoS Genet. 2016 07; 12(7):e1006133.
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