 Apolipoproteins E
"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D001057
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| MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 | | 1994 | 2 | 0 | 2 | | 1995 | 0 | 1 | 1 | | 1996 | 3 | 0 | 3 | | 1998 | 2 | 0 | 2 | | 1999 | 2 | 1 | 3 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2004 | 4 | 3 | 7 | | 2005 | 1 | 0 | 1 | | 2007 | 1 | 2 | 3 | | 2008 | 1 | 2 | 3 | | 2009 | 2 | 2 | 4 | | 2010 | 2 | 1 | 3 | | 2011 | 0 | 4 | 4 | | 2012 | 1 | 0 | 1 | | 2013 | 3 | 4 | 7 | | 2014 | 1 | 2 | 3 | | 2015 | 0 | 5 | 5 | | 2016 | 0 | 4 | 4 | | 2017 | 0 | 4 | 4 | | 2018 | 1 | 1 | 2 | | 2019 | 3 | 1 | 4 | | 2021 | 0 | 2 | 2 | | 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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de la Fuente J, Grotzinger AD, Marioni RE, Nivard MG, Tucker-Drob EM. Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region. PLoS Genet. 2022 06; 18(6):e1010208.
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Dumolt JH, Patel MS, Rideout TC. Gestational hypercholesterolemia programs hepatic steatosis in a sex-specific manner in ApoE-deficient mice. J Nutr Biochem. 2022 03; 101:108945.
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Hsieh TJ, Lee WJ, Liao YC, Hsu CC, Fang YH, Chen TY, Lin YS, Chang IS, Wang SJ, Hsiung CA, Fuh JL. Association between Alzheimer's disease genes and trajectories of cognitive function decline in Han Chinese in Taiwan. Aging (Albany NY). 2021 07 02; 13(13):17237-17252.
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Memel M, Staffaroni AM, Cobigo Y, Casaletto KB, Fonseca C, Bettcher BM, Yassa MA, Elahi FM, Wolf A, Rosen HJ, Kramer JH. APOE moderates the effect of hippocampal blood flow on memory pattern separation in clinically normal older adults. Hippocampus. 2021 08; 31(8):845-857.
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Dumolt JH, Ma M, Mathew J, Patel MS, Rideout TC. Gestational hypercholesterolemia alters fetal hepatic lipid metabolism and microRNA expression in Apo-E-deficient mice. Am J Physiol Endocrinol Metab. 2019 11 01; 317(5):E831-E838.
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Potter H, Chial HJ. Targeting the Interaction Between Apolipoprotein E and Amyloid Precursor Protein: A Novel Alzheimer's Disease Therapy. Biol Psychiatry. 2019 08 01; 86(3):169-170.
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Reynolds CA, Smolen A, Corley RP, Munoz E, Friedman NP, Rhee SH, Stallings MC, DeFries JC, Wadsworth SJ. APOE effects on cognition from childhood to adolescence. Neurobiol Aging. 2019 12; 84:239.e1-239.e8.
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Pirim D, Radwan ZH, Wang X, Niemsiri V, Hokanson JE, Hamman RF, Feingold E, Bunker CH, Demirci FY, Kamboh MI. Apolipoprotein E-C1-C4-C2 gene cluster region and inter-individual variation in plasma lipoprotein levels: a comprehensive genetic association study in two ethnic groups. PLoS One. 2019; 14(3):e0214060.
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Tavazoie MF, Pollack I, Tanqueco R, Ostendorf BN, Reis BS, Gonsalves FC, Kurth I, Andreu-Agullo C, Derbyshire ML, Posada J, Takeda S, Tafreshian KN, Rowinsky E, Szarek M, Waltzman RJ, Mcmillan EA, Zhao C, Mita M, Mita A, Chmielowski B, Postow MA, Ribas A, Mucida D, Tavazoie SF. LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer. Cell. 2018 02 08; 172(4):825-840.e18.
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Derk J, Bermudez Hernandez K, Rodriguez M, He M, Koh H, Abedini A, Li H, Fenyö D, Schmidt AM. Diaphanous 1 (DIAPH1) is Highly Expressed in the Aged Human Medial Temporal Cortex and Upregulated in Myeloid Cells During Alzheimer's Disease. J Alzheimers Dis. 2018; 64(3):995-1007.
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