 Apolipoproteins E
"Apolipoproteins E" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D001057
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| MeSH Number(s) |
D10.532.091.500 D12.776.070.400.500 D12.776.521.120.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Apolipoproteins E".
Below are MeSH descriptors whose meaning is more specific than "Apolipoproteins E".
This graph shows the total number of publications written about "Apolipoproteins E" by people in this website by year, and whether "Apolipoproteins E" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 2 | 0 | 2 | | 1992 | 1 | 0 | 1 | | 1993 | 1 | 0 | 1 | | 1994 | 2 | 1 | 3 | | 1995 | 1 | 1 | 2 | | 1996 | 3 | 0 | 3 | | 1997 | 1 | 0 | 1 | | 1998 | 2 | 0 | 2 | | 1999 | 1 | 1 | 2 | | 2001 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 4 | 2 | 6 | | 2005 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2007 | 1 | 2 | 3 | | 2008 | 1 | 2 | 3 | | 2009 | 3 | 3 | 6 | | 2010 | 2 | 1 | 3 | | 2011 | 1 | 4 | 5 | | 2012 | 5 | 0 | 5 | | 2013 | 3 | 4 | 7 | | 2014 | 2 | 3 | 5 | | 2015 | 1 | 6 | 7 | | 2016 | 0 | 4 | 4 | | 2017 | 0 | 4 | 4 | | 2018 | 0 | 1 | 1 | | 2019 | 3 | 1 | 4 |
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Below are the most recent publications written about "Apolipoproteins E" by people in Profiles.
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Dumolt JH, Ma M, Mathew J, Patel MS, Rideout TC. Gestational hypercholesterolemia alters fetal hepatic lipid metabolism and microRNA expression in Apo-E-deficient mice. Am J Physiol Endocrinol Metab. 2019 11 01; 317(5):E831-E838.
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Potter H, Chial HJ. Targeting the Interaction Between Apolipoprotein E and Amyloid Precursor Protein: A Novel Alzheimer's Disease Therapy. Biol Psychiatry. 2019 08 01; 86(3):169-170.
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Reynolds CA, Smolen A, Corley RP, Munoz E, Friedman NP, Rhee SH, Stallings MC, DeFries JC, Wadsworth SJ. APOE effects on cognition from childhood to adolescence. Neurobiol Aging. 2019 12; 84:239.e1-239.e8.
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Pirim D, Radwan ZH, Wang X, Niemsiri V, Hokanson JE, Hamman RF, Feingold E, Bunker CH, Demirci FY, Kamboh MI. Apolipoprotein E-C1-C4-C2 gene cluster region and inter-individual variation in plasma lipoprotein levels: a comprehensive genetic association study in two ethnic groups. PLoS One. 2019; 14(3):e0214060.
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Derk J, Bermudez Hernandez K, Rodriguez M, He M, Koh H, Abedini A, Li H, Fenyö D, Schmidt AM. Diaphanous 1 (DIAPH1) is Highly Expressed in the Aged Human Medial Temporal Cortex and Upregulated in Myeloid Cells During Alzheimer's Disease. J Alzheimers Dis. 2018; 64(3):995-1007.
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Chao LL, Raymond MR, Leo CK, Abadjian LR. Evidence of Hippocampal Structural Alterations in Gulf War Veterans With Predicted Exposure to the Khamisiyah Plume. J Occup Environ Med. 2017 10; 59(10):923-929.
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Dumolt JH, Radhakrishnan SK, Moghadasian MH, Le K, Patel MS, Browne RW, Rideout TC. Maternal hypercholesterolemia enhances oxysterol concentration in mothers and newly weaned offspring but is attenuated by maternal phytosterol supplementation. J Nutr Biochem. 2018 02; 52:10-17.
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Casaletto KB, Elahi FM, Bettcher BM, Neuhaus J, Bendlin BB, Asthana S, Johnson SC, Yaffe K, Carlsson C, Blennow K, Zetterberg H, Kramer JH. Neurogranin, a synaptic protein, is associated with memory independent of Alzheimer biomarkers. Neurology. 2017 Oct 24; 89(17):1782-1788.
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Yue JK, Robinson CK, Burke JF, Winkler EA, Deng H, Cnossen MC, Lingsma HF, Ferguson AR, McAllister TW, Rosand J, Burchard EG, Sorani MD, Sharma S, Nielson JL, Satris GG, Talbott JF, Tarapore PE, Korley FK, Wang KKW, Yuh EL, Mukherjee P, Diaz-Arrastia R, Valadka AB, Okonkwo DO, Manley GT. Apolipoprotein E epsilon 4 (APOE-e4) genotype is associated with decreased 6-month verbal memory performance after mild traumatic brain injury. Brain Behav. 2017 09; 7(9):e00791.
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Bettcher BM, Ard MC, Reed BR, Benitez A, Simmons A, Larson EB, Sonnen JA, Montine TJ, Li G, Keene CD, Crane PK, Mungas D. Association between Cholesterol Exposure and Neuropathological Findings: The ACT Study. J Alzheimers Dis. 2017; 59(4):1307-1315.
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