 Osteopontin
"Osteopontin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A negatively-charged extracellular matrix protein that plays a role in the regulation of BONE metabolism and a variety of other biological functions. Cell signaling by osteopontin may occur through a cell adhesion sequence that recognizes INTEGRIN ALPHA-V BETA-3.
| Descriptor ID |
D053495
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| MeSH Number(s) |
D12.644.276.374.625 D12.776.395.700.837 D12.776.467.374.625 D12.776.860.300.762 D23.529.374.625
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| Concept/Terms |
Osteopontin- Osteopontin
- Sialoprotein 1
- Secreted Phosphoprotein 1
- Bone Sialoprotein 1
- Sialoprotein 1, Bone
- Bone Sialoprotein I
- Sialoprotein I, Bone
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Below are MeSH descriptors whose meaning is more general than "Osteopontin".
Below are MeSH descriptors whose meaning is more specific than "Osteopontin".
This graph shows the total number of publications written about "Osteopontin" by people in this website by year, and whether "Osteopontin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2005 | 0 | 1 | 1 | | 2006 | 0 | 2 | 2 | | 2009 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2017 | 1 | 0 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 1 | 1 | 2 |
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Below are the most recent publications written about "Osteopontin" by people in Profiles.
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Jia X, Toda K, He L, Miao D, Yamada S, Yu L, Kodama K. Expression-based Genome-wide Association Study Links OPN and IL1-RA With Newly Diagnosed Type 1 Diabetes in Children. J Clin Endocrinol Metab. 2022 06 16; 107(7):1825-1832.
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Wu G, Li X, Seo H, McLendon BA, Kramer AC, Bazer FW, Johnson GA. Osteopontin (OPN)/Secreted Phosphoprotein 1 (SPP1) Binds Integrins to Activate Transport of Ions Across the Porcine Placenta. Front Biosci (Landmark Ed). 2022 04 01; 27(4):117.
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Kramer AC, Erikson DW, McLendon BA, Seo H, Hayashi K, Spencer TE, Bazer FW, Burghardt RC, Johnson GA. SPP1 expression in the mouse uterus and placenta: implications for implantation†. Biol Reprod. 2021 10 11; 105(4):892-904.
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Kriss M, Golden-Mason L, Kaplan J, Mirshahi F, Setiawan VW, Sanyal AJ, Rosen HR. Increased hepatic and circulating chemokine and osteopontin expression occurs early in human NAFLD development. PLoS One. 2020; 15(7):e0236353.
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Posavi M, Diaz-Ortiz M, Liu B, Swanson CR, Skrinak RT, Hernandez-Con P, Amado DA, Fullard M, Rick J, Siderowf A, Weintraub D, McCluskey L, Trojanowski JQ, Dewey RB, Huang X, Chen-Plotkin AS. Characterization of Parkinson's disease using blood-based biomarkers: A multicohort proteomic analysis. PLoS Med. 2019 10; 16(10):e1002931.
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Wang M, Han J, Marcar L, Black J, Liu Q, Li X, Nagulapalli K, Sequist LV, Mak RH, Benes CH, Hong TS, Gurtner K, Krause M, Baumann M, Kang JX, Whetstine JR, Willers H. Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway. Cancer Res. 2017 04 15; 77(8):2018-2028.
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Moran CS, Rush CM, Dougan T, Jose RJ, Biros E, Norman PE, Gera L, Golledge J. Modulation of Kinin B2 Receptor Signaling Controls Aortic Dilatation and Rupture in the Angiotensin II-Infused Apolipoprotein E-Deficient Mouse. Arterioscler Thromb Vasc Biol. 2016 05; 36(5):898-907.
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Kurzbach D, Platzer G, Schwarz TC, Henen MA, Konrat R, Hinderberger D. Cooperative unfolding of compact conformations of the intrinsically disordered protein osteopontin. Biochemistry. 2013 Aug 06; 52(31):5167-75.
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Yang X, Meng X, Su X, Mauchley DC, Ao L, Cleveland JC, Fullerton DA. Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2. J Thorac Cardiovasc Surg. 2009 Oct; 138(4):1008-15.
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Gallant-Behm CL, Reno C, Tsao H, Hart DA. Genetic involvement in skin wound healing and scarring in domestic pigs: assessment of molecular expression patterns in (Yorkshire x Red Duroc) x Yorkshire backcross animals. J Invest Dermatol. 2007 Jan; 127(1):233-44.
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