 NF-kappa B
"NF-kappa B" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.
| Descriptor ID |
D016328
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| MeSH Number(s) |
D12.776.260.600 D12.776.660.600 D12.776.930.600
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| Concept/Terms |
NF-kappa B- NF-kappa B
- kappa B Enhancer Binding Protein
- NF-kappaB
- NF kappaB
- Transcription Factor NF-kB
- Factor NF-kB, Transcription
- NF-kB, Transcription Factor
- Transcription Factor NF kB
- NF-kB
- NF kB
- Immunoglobulin Enhancer-Binding Protein
- Enhancer-Binding Protein, Immunoglobulin
- Immunoglobulin Enhancer Binding Protein
- Nuclear Factor kappa B
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Below are MeSH descriptors whose meaning is more general than "NF-kappa B".
Below are MeSH descriptors whose meaning is more specific than "NF-kappa B".
This graph shows the total number of publications written about "NF-kappa B" by people in this website by year, and whether "NF-kappa B" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 1 | 0 | 1 | | 1993 | 2 | 0 | 2 | | 1994 | 0 | 1 | 1 | | 1995 | 4 | 1 | 5 | | 1996 | 4 | 2 | 6 | | 1997 | 4 | 2 | 6 | | 1998 | 3 | 1 | 4 | | 1999 | 5 | 5 | 10 | | 2000 | 9 | 4 | 13 | | 2001 | 6 | 9 | 15 | | 2002 | 8 | 16 | 24 | | 2003 | 16 | 16 | 32 | | 2004 | 13 | 7 | 20 | | 2005 | 9 | 15 | 24 | | 2006 | 7 | 9 | 16 | | 2007 | 6 | 20 | 26 | | 2008 | 6 | 22 | 28 | | 2009 | 12 | 12 | 24 | | 2010 | 4 | 15 | 19 | | 2011 | 5 | 18 | 23 | | 2012 | 7 | 17 | 24 | | 2013 | 7 | 16 | 23 | | 2014 | 11 | 15 | 26 | | 2015 | 6 | 9 | 15 | | 2016 | 1 | 11 | 12 | | 2017 | 3 | 10 | 13 | | 2018 | 7 | 3 | 10 | | 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "NF-kappa B" by people in Profiles.
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Mendez JM, Kolora LD, Lemon JS, Dupree SL, Keestra-Gounder AM. Activation of the Endoplasmic Reticulum Stress Response Impacts the NOD1 Signaling Pathway. Infect Immun. 2019 08; 87(8).
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Kirkley KS, Popichak KA, Hammond SL, Davies C, Hunt L, Tjalkens RB. Genetic suppression of IKK2/NF-?B in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease. Neurobiol Dis. 2019 07; 127:193-209.
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Woolaver RA, Wang X, Dollin Y, Xie P, Wang JH, Chen Z. TRAF2 Deficiency in B Cells Impairs CD40-Induced Isotype Switching That Can Be Rescued by Restoring NF-?B1 Activation. J Immunol. 2018 12 01; 201(11):3421-3430.
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Sanctuary MR, Huang RH, Jones AA, Luck ME, Aherne CM, Jedlicka P, de Zoeten EF, Collins CB. miR-106a deficiency attenuates inflammation in murine IBD models. Mucosal Immunol. 2019 01; 12(1):200-211.
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Singh AK, Fechtner S, Chourasia M, Sicalo J, Ahmed S. Critical role of IL-1a in IL-1ß-induced inflammatory responses: cooperation with NF-?Bp65 in transcriptional regulation. FASEB J. 2019 02; 33(2):2526-2536.
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Popichak KA, Hammond SL, Moreno JA, Afzali MF, Backos DS, Slayden RD, Safe S, Tjalkens RB. Compensatory Expression of Nur77 and Nurr1 Regulates NF-?B-Dependent Inflammatory Signaling in Astrocytes. Mol Pharmacol. 2018 10; 94(4):1174-1186.
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Janganati V, Ponder J, Balasubramaniam M, Bhat-Nakshatri P, Bar EE, Nakshatri H, Jordan CT, Crooks PA. MMB triazole analogs are potent NF-?B inhibitors and anti-cancer agents against both hematological and solid tumor cells. Eur J Med Chem. 2018 Sep 05; 157:562-581.
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Zhang L, Shi L, Soars SM, Kamps J, Yin H. Discovery of Novel Small-Molecule Inhibitors of NF-?B Signaling with Antiinflammatory and Anticancer Properties. J Med Chem. 2018 Jul 26; 61(14):5881-5899.
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Neog MK, Sultana F, Rasool M. Targeting RAW 264.7 macrophages (M1 type) with Withaferin-A decorated mannosylated liposomes induces repolarization via downregulation of NF-?B and controlled elevation of STAT-3. Int Immunopharmacol. 2018 Aug; 61:64-73.
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El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D'Alessandro A, Reisz JA, Nozik-Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1ß/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018 04 11; 9(1):1393.
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