 RNA, Small Interfering
"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
| Descriptor ID |
D034741
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| MeSH Number(s) |
D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
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| Concept/Terms |
RNA, Small Interfering- RNA, Small Interfering
- Interfering RNA, Small
- Short Interfering RNA
- Interfering RNA, Short
- RNA, Short Interfering
- Small Interfering RNA
- siRNA
Piwi-Interacting RNA- Piwi-Interacting RNA
- Piwi Interacting RNA
- RNA, Piwi-Interacting
- RNA, Piwi Interacting
- piRNA
Short Hairpin RNA- Short Hairpin RNA
- Hairpin RNA, Short
- RNA, Short Hairpin
- Small Hairpin RNA
- Hairpin RNA, Small
- RNA, Small Hairpin
- shRNA
Repeat-Associated siRNA- Repeat-Associated siRNA
- Repeat Associated siRNA
- siRNA, Repeat-Associated
- siRNA, Repeat Associated
Scan RNA- Scan RNA
- scnRNA
- Small Scan RNA
- RNA, Small Scan
- Scan RNA, Small
- RNA, Scan
Trans-Acting siRNA- Trans-Acting siRNA
- Trans Acting siRNA
- tasiRNA
- siRNA, Trans-Acting
- siRNA, Trans Acting
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Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".
Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".
This graph shows the total number of publications written about "RNA, Small Interfering" by people in this website by year, and whether "RNA, Small Interfering" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 4 | 4 | | 2003 | 3 | 3 | 6 | | 2004 | 1 | 14 | 15 | | 2005 | 0 | 9 | 9 | | 2006 | 1 | 13 | 14 | | 2007 | 2 | 15 | 17 | | 2008 | 3 | 29 | 32 | | 2009 | 4 | 28 | 32 | | 2010 | 2 | 15 | 17 | | 2011 | 6 | 33 | 39 | | 2012 | 4 | 36 | 40 | | 2013 | 4 | 40 | 44 | | 2014 | 4 | 17 | 21 | | 2015 | 3 | 22 | 25 | | 2016 | 1 | 16 | 17 | | 2017 | 3 | 14 | 17 | | 2018 | 0 | 15 | 15 | | 2019 | 1 | 10 | 11 | | 2020 | 1 | 14 | 15 | | 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "RNA, Small Interfering" by people in Profiles.
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Tanner AR, Lynch CS, Kennedy VC, Ali A, Winger QA, Rozance PJ, Anthony RV. CSH RNA Interference Reduces Global Nutrient Uptake and Umbilical Blood Flow Resulting in Intrauterine Growth Restriction. Int J Mol Sci. 2021 Jul 29; 22(15).
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Wu H, Voeltz GK. Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites. Dev Cell. 2021 01 11; 56(1):52-66.e7.
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Zou M, Zhang X, Jiang D, Zhao Y, Wu T, Gong Q, Su H, Wu D, Moreland L, Li G. Transcriptional Regulation of CD40 Expression by 4 Ribosomal Proteins via a Functional SNP on a Disease-Associated CD40 Locus. Genes (Basel). 2020 12 21; 11(12).
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Wu SK, Roberts JT, Balas MM, Johnson AM. RNA matchmaking in chromatin regulation. Biochem Soc Trans. 2020 12 18; 48(6):2467-2481.
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Zhang X, Xu Q, Zi Z, Liu Z, Wan C, Crisman L, Shen J, Liu X. Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications. Dev Cell. 2020 12 21; 55(6):784-801.e9.
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Guo H, Zhang Q, Dai R, Yu B, Hoekzema K, Tan J, Tan S, Jia X, Chung WK, Hernan R, Alkuraya FS, Alsulaiman A, Al-Muhaizea MA, Lesca G, Pons L, Labalme A, Laux L, Bryant E, Brown NJ, Savva E, Ayres S, Eratne D, Peeters H, Bilan F, Letienne-Cejudo L, Gilbert-Dussardier B, Ruiz-Arana IL, Merlini JM, Boizot A, Bartoloni L, Santoni F, Karlowicz D, McDonald M, Wu H, Hu Z, Chen G, Ou J, Brasch-Andersen C, Fagerberg CR, Dreyer I, Chun-Hui Tsai A, Slegesky V, McGee RB, Daniels B, Sellars EA, Carpenter LA, Schaefer B, Sacoto MJG, Begtrup A, Schnur RE, Punj S, Wentzensen IM, Rhodes L, Pan Q, Bernier RA, Chen C, Eichler EE, Xia K. NCKAP1 Disruptive Variants Lead to a Neurodevelopmental Disorder with Core Features of Autism. Am J Hum Genet. 2020 11 05; 107(5):963-976.
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Morgan CP, Shetty AC, Chan JC, Berger DS, Ament SA, Epperson CN, Bale TL. Repeated sampling facilitates within- and between-subject modeling of the human sperm transcriptome to identify dynamic and stress-responsive sncRNAs. Sci Rep. 2020 10 15; 10(1):17498.
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Lin CY, Huang YN, Fu RH, Liao YH, Kuo TY, Tsai CW. Promotion of mitochondrial biogenesis via the regulation of PARIS and PGC-1a by parkin as a mechanism of neuroprotection by carnosic acid. Phytomedicine. 2021 Jan; 80:153369.
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Morrison JH, Miller C, Bankers L, Crameri G, Wang LF, Poeschla EM. A Potent Postentry Restriction to Primate Lentiviruses in a Yinpterochiropteran Bat. mBio. 2020 09 15; 11(5).
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Barbier-Torres L, Fortner KA, Iruzubieta P, Delgado TC, Giddings E, Chen Y, Champagne D, Fernández-Ramos D, Mestre D, Gomez-Santos B, Varela-Rey M, de Juan VG, Fernández-Tussy P, Zubiete-Franco I, García-Monzón C, González-Rodríguez Á, Oza D, Valença-Pereira F, Fang Q, Crespo J, Aspichueta P, Tremblay F, Christensen BC, Anguita J, Martínez-Chantar ML, Rincón M. Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation. Nat Commun. 2020 07 03; 11(1):3360.
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