RNA, Small Interfering
"RNA, Small Interfering" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Descriptor ID |
D034741
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MeSH Number(s) |
D13.150.650.700 D13.444.735.150.700 D13.444.735.790.552.875
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Concept/Terms |
RNA, Small Interfering- RNA, Small Interfering
- Interfering RNA, Small
- Short Interfering RNA
- Interfering RNA, Short
- RNA, Short Interfering
- Small Interfering RNA
- siRNA
Piwi-Interacting RNA- Piwi-Interacting RNA
- Piwi Interacting RNA
- RNA, Piwi-Interacting
- RNA, Piwi Interacting
- piRNA
Short Hairpin RNA- Short Hairpin RNA
- Hairpin RNA, Short
- RNA, Short Hairpin
- Small Hairpin RNA
- Hairpin RNA, Small
- RNA, Small Hairpin
- shRNA
Repeat-Associated siRNA- Repeat-Associated siRNA
- Repeat Associated siRNA
- siRNA, Repeat-Associated
- siRNA, Repeat Associated
Scan RNA- Scan RNA
- scnRNA
- Small Scan RNA
- RNA, Small Scan
- Scan RNA, Small
- RNA, Scan
Trans-Acting siRNA- Trans-Acting siRNA
- Trans Acting siRNA
- tasiRNA
- siRNA, Trans-Acting
- siRNA, Trans Acting
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Below are MeSH descriptors whose meaning is more general than "RNA, Small Interfering".
Below are MeSH descriptors whose meaning is more specific than "RNA, Small Interfering".
This graph shows the total number of publications written about "RNA, Small Interfering" by people in this website by year, and whether "RNA, Small Interfering" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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2002 | 0 | 2 | 2 | 2003 | 2 | 3 | 5 | 2004 | 1 | 12 | 13 | 2005 | 0 | 8 | 8 | 2006 | 1 | 11 | 12 | 2007 | 2 | 11 | 13 | 2008 | 4 | 24 | 28 | 2009 | 4 | 22 | 26 | 2010 | 3 | 15 | 18 | 2011 | 5 | 33 | 38 | 2012 | 5 | 33 | 38 | 2013 | 4 | 34 | 38 | 2014 | 5 | 21 | 26 | 2015 | 3 | 22 | 25 | 2016 | 3 | 16 | 19 | 2017 | 3 | 14 | 17 | 2018 | 1 | 13 | 14 | 2019 | 1 | 10 | 11 | 2020 | 1 | 10 | 11 | 2021 | 1 | 7 | 8 | 2022 | 1 | 2 | 3 | 2023 | 0 | 4 | 4 |
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Below are the most recent publications written about "RNA, Small Interfering" by people in Profiles.
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Smith S, Seth J, Midkiff A, Stahl R, Syu YC, Shkriabai N, Kvaratskhelia M, Musier-Forsyth K, Jain P, Green PL, Panfil AR. The Pleiotropic Effects of YBX1 on HTLV-1 Transcription. Int J Mol Sci. 2023 Aug 23; 24(17).
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Cheng HS, P?rez-Cremades D, Zhuang R, Jamaiyar A, Wu W, Chen J, Tzani A, Stone L, Plutzky J, Ryan TE, Goodney PP, Creager MA, Sabatine MS, Bonaca MP, Feinberg MW. Impaired angiogenesis in diabetic critical limb ischemia is mediated by a miR-130b/INHBA signaling axis. JCI Insight. 2023 05 22; 8(10).
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Ghosh S, Devereaux MW, Anderson AL, El Kasmi KC, Sokol RJ. Stat3 role in the protective effect of FXR Agonist in parenteral nutrition-associated cholestasis. Hepatol Commun. 2023 03 01; 7(3):e0056.
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Ray KK, Raal FJ, Kallend DG, Jaros MJ, Koenig W, Leiter LA, Landmesser U, Schwartz GG, Lawrence D, Friedman A, Garcia Conde L, Wright RS. Inclisiran and cardiovascular events: a patient-level analysis of phase III trials. Eur Heart J. 2023 01 07; 44(2):129-138.
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Tang W, Panja S, Jogdeo CM, Tang S, Ding L, Yu A, Foster KW, Dsouza DL, Chhonker YS, Jensen-Smith H, Jang HS, Boesen EI, Murry DJ, Padanilam B, Oupick? D. Modified chitosan for effective renal delivery of siRNA to treat acute kidney injury. Biomaterials. 2022 06; 285:121562.
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Ng CJ, Liu A, Venkataraman S, Ashworth KJ, Baker CD, O'Rourke R, Vibhakar R, Jones KL, Di Paola J. Single-cell transcriptional analysis of human endothelial colony-forming cells from patients with low VWF levels. Blood. 2022 04 07; 139(14):2240-2251.
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Yu A, Tang S, Ding L, Foley J, Tang W, Jia H, Panja S, Holbert CE, Hang Y, Stewart TM, Smith LM, Sil D, Casero RA, Oupick? D. Hyaluronate-coated perfluoroalkyl polyamine prodrugs as bioactive siRNA delivery systems for the treatment of peritoneal cancers. Biomater Adv. 2022 May; 136:212755.
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Cable J, Heard E, Hirose T, Prasanth KV, Chen LL, Henninger JE, Quinodoz SA, Spector DL, Diermeier SD, Porman AM, Kumar D, Feinberg MW, Shen X, Unfried JP, Johnson R, Chen CK, Wilusz JE, Lempradl A, McGeary SE, Wahba L, Pyle AM, Hargrove AE, Simon MD, Marcia M, Przanowska RK, Chang HY, Jaffrey SR, Contreras LM, Chen Q, Shi J, Mendell JT, He L, Song E, Rinn JL, Lalwani MK, Kalem MC, Chuong EB, Maquat LE, Liu X. Noncoding RNAs: biology and applications-a Keystone Symposia report. Ann N Y Acad Sci. 2021 12; 1506(1):118-141.
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Shoda T, Wen T, Caldwell JM, Ben-Baruch Morgenstern N, Osswald GA, Rochman M, Mack LE, Felton JM, Abonia JP, Arva NC, Atkins D, Bonis PA, Capocelli KE, Collins MH, Dellon ES, Falk GW, Gonsalves N, Gupta SK, Hirano I, Leung J, Menard-Katcher PA, Mukkada VA, Putnam PE, Rudman Spergel AK, Spergel JM, Wechsler JB, Yang GY, Aceves SS, Furuta GT, Rothenberg ME. Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell-Fibroblast Crosstalk. Gastroenterology. 2022 02; 162(2):439-453.
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Li J, Cai Z, Vaites LP, Shen N, Mitchell DC, Huttlin EL, Paulo JA, Harry BL, Gygi SP. Proteome-wide mapping of short-lived proteins in human cells. Mol Cell. 2021 11 18; 81(22):4722-4735.e5.
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