 Cyclin-Dependent Kinase 8
"Cyclin-Dependent Kinase 8" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CYCLIN C dependent kinase that is an important component of the mediator complex. The enzyme is activated by its interaction with CYCLIN C and plays a role in transcriptional regulation by phosphorylating RNA POLYMERASE II.
| Descriptor ID |
D056850
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| MeSH Number(s) |
D05.500.374.500 D08.811.913.696.620.682.700.646.500.968 D12.644.360.024.309.500 D12.644.360.250.547 D12.776.157.057.072.500 D12.776.167.200.548 D12.776.476.024.388.500 D12.776.476.250.548 D12.776.660.551.500
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| Concept/Terms |
Cyclin-Dependent Kinase 8- Cyclin-Dependent Kinase 8
- Cyclin Dependent Kinase 8
- Cdk8 Cyclin-Dependent Kinase
- Cdk8 Cyclin Dependent Kinase
- Cyclin-Dependent Kinase, Cdk8
- Kinase, Cdk8 Cyclin-Dependent
- Cdk8 Protein Kinase
- Kinase, Cdk8 Protein
- Protein Kinase, Cdk8
- Cell Division Protein Kinase 8
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Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase 8".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase 8".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase 8" by people in this website by year, and whether "Cyclin-Dependent Kinase 8" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2013 | 3 | 0 | 3 | | 2016 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2022 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase 8" by people in Profiles.
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Luyties O, Taatjes DJ. The Mediator kinase module: an interface between cell signaling and transcription. Trends Biochem Sci. 2022 04; 47(4):314-327.
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Andrysik Z, Bender H, Galbraith MD, Espinosa JM. Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response. Nat Commun. 2021 03 02; 12(1):1375.
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Steinparzer I, Sedlyarov V, Rubin JD, Eislmayr K, Galbraith MD, Levandowski CB, Vcelkova T, Sneezum L, Wascher F, Amman F, Kleinova R, Bender H, Andrysik Z, Espinosa JM, Superti-Furga G, Dowell RD, Taatjes DJ, Kovarik P. Transcriptional Responses to IFN-? Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions. Mol Cell. 2019 11 07; 76(3):485-499.e8.
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Snijders Blok L, Hiatt SM, Bowling KM, Prokop JW, Engel KL, Cochran JN, Bebin EM, Bijlsma EK, Ruivenkamp CAL, Terhal P, Simon MEH, Smith R, Hurst JA, McLaughlin H, Person R, Crunk A, Wangler MF, Streff H, Symonds JD, Zuberi SM, Elliott KS, Sanders VR, Masunga A, Hopkin RJ, Dubbs HA, Ortiz-Gonzalez XR, Pfundt R, Brunner HG, Fisher SE, Kleefstra T, Cooper GM. De novo mutations in MED13, a component of the Mediator complex, are associated with a novel neurodevelopmental disorder. Hum Genet. 2018 May; 137(5):375-388.
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Galbraith MD, Andrysik Z, Pandey A, Hoh M, Bonner EA, Hill AA, Sullivan KD, Espinosa JM. CDK8 Kinase Activity Promotes Glycolysis. Cell Rep. 2017 Nov 07; 21(6):1495-1506.
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Perez-Perri JI, Dengler VL, Audetat KA, Pandey A, Bonner EA, Urh M, Mendez J, Daniels DL, Wappner P, Galbraith MD, Espinosa JM. The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Rep. 2016 06 28; 16(1):37-47.
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Poss ZC, Ebmeier CC, Taatjes DJ. The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48(6):575-608.
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Galbraith MD, Allen MA, Bensard CL, Wang X, Schwinn MK, Qin B, Long HW, Daniels DL, Hahn WC, Dowell RD, Espinosa JM. HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia. Cell. 2013 Jun 06; 153(6):1327-39.
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Bancerek J, Poss ZC, Steinparzer I, Sedlyarov V, Pfaffenwimmer T, Mikulic I, Dölken L, Strobl B, Müller M, Taatjes DJ, Kovarik P. CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity. 2013 Feb 21; 38(2):250-62.
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Ebmeier CC, Taatjes DJ. Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11283-8.
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