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Bruce E. Maryanoff

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhao Y, Leman LJ, Search DJ, Garcia RA, Gordon DA, Maryanoff BE, Ghadiri MR. Self-Assembling Cyclic d,l-a-Peptides as Modulators of Plasma HDL Function. A Supramolecular Approach toward Antiatherosclerotic Agents. ACS Cent Sci. 2017 Jun 28; 3(6):639-646. PMID: 28691076.
      View in: PubMed
    2. Maryanoff BE. Phenotypic Assessment and the Discovery of Topiramate. ACS Med Chem Lett. 2016 Jul 14; 7(7):662-5. PMID: 27437073; PMCID: PMC4948003.
    3. Maryanoff BE, Huryn DM. Our scope expansion to include biologics. ACS Med Chem Lett. 2015 Mar 12; 6(3):227. PMID: 25941543; PMCID: PMC4416428.
    4. Zhao Y, Black AS, Bonnet DJ, Maryanoff BE, Curtiss LK, Leman LJ, Ghadiri MR. In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I. J Lipid Res. 2014 Oct; 55(10):2053-63. PMID: 24975585; PMCID: PMC4173998.
    5. McComsey DF, Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, Maryanoff BE. Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112). J Med Chem. 2013 Nov 27; 56(22):9019-30. PMID: 24205976; PMCID: PMC4004761.
    6. Leman LJ, Maryanoff BE, Ghadiri MR. Molecules that mimic apolipoprotein A-I: potential agents for treating atherosclerosis. J Med Chem. 2014 Mar 27; 57(6):2169-96. PMID: 24168751; PMCID: PMC3969399.
    7. Zhao Y, Imura T, Leman LJ, Curtiss LK, Maryanoff BE, Ghadiri MR. Mimicry of high-density lipoprotein: functional peptide-lipid nanoparticles based on multivalent peptide constructs. J Am Chem Soc. 2013 Sep 11; 135(36):13414-24. PMID: 23978057; PMCID: PMC3839580.
    8. Maryanoff BE, O'Neill JC, McComsey DF, Yabut SC, Luci DK, Gibbs AC, Connelly MA. Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. Bioorg Med Chem Lett. 2012 Aug 15; 22(16):5326-9. PMID: 22795331.
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    9. Hutt DM, Olsen CA, Vickers CJ, Herman D, Chalfant M, Montero A, Leman LJ, Burkle R, Maryanoff BE, Balch WE, Ghadiri MR. Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ?F508-CFTR. ACS Med Chem Lett. 2011 Jul 21; 2(9):703-707. PMID: 21984958.
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    10. Maryanoff BE, O'Neill JC, McComsey DF, Yabut SC, Luci DK, Jordan AD, Masucci JA, Jones WJ, Abad MC, Gibbs AC, Petrounia I. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Jul 14; 2(7):538-43. PMID: 24900346; PMCID: PMC4018111.
    11. Kervinen J, Crysler C, Bayoumy S, Abad MC, Spurlino J, Deckman I, Greco MN, Maryanoff BE, de Garavilla L. Potency variation of small-molecule chymase inhibitors across species. Biochem Pharmacol. 2010 Oct 01; 80(7):1033-41. PMID: 20599788.
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    12. Maryanoff BE, Kinney WA. Urotensin-II receptor modulators as potential drugs. J Med Chem. 2010 Apr 08; 53(7):2695-708. PMID: 20043680.
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    13. Giardino EC, Haertlein BJ, de Garavilla L, Costanzo MJ, Damiano BP, Andrade-Gordon P, Maryanoff BE. Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa. Blood Coagul Fibrinolysis. 2010 Mar; 21(2):128-34. PMID: 20010091.
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    14. Lu T, Markotan T, Ballentine SK, Giardino EC, Spurlino J, Crysler CS, Brown K, Maryanoff BE, Tomczuk BE, Damiano BP, Shukla U, End D, Andrade-Gordon P, Bone RF, Player MR. Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif. J Med Chem. 2010 Feb 25; 53(4):1843-56. PMID: 20102150.
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    15. Lawson EC, Luci DK, Ghosh S, Kinney WA, Reynolds CH, Qi J, Smith CE, Wang Y, Minor LK, Haertlein BJ, Parry TJ, Damiano BP, Maryanoff BE. Nonpeptide urotensin-II receptor antagonists: a new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits. J Med Chem. 2009 Dec 10; 52(23):7432-45. PMID: 19731961.
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    16. Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, Leclercq L, Cuyckens F, Reitz AB, Maryanoff BE. Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. J Med Chem. 2009 Dec 10; 52(23):7528-36. PMID: 19388676.
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    17. Maryanoff BE, de Garavilla L, Greco MN, Haertlein BJ, Wells GI, Andrade-Gordon P, Abraham WM. Dual inhibition of cathepsin G and chymase is effective in animal models of pulmonary inflammation. Am J Respir Crit Care Med. 2010 Feb 01; 181(3):247-53. PMID: 19875688.
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    18. Maryanoff BE. 2009 Edward E Smissman Award. Pharmaceutical "gold" from neurostabilizing agents: topiramate and successor molecules. J Med Chem. 2009 Jun 11; 52(11):3431-40. PMID: 19385640.
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    19. Maryanoff BE. Drug discovery and the medicinal chemist. Future Med Chem. 2009 Apr; 1(1):11-5. PMID: 21426067.
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    20. Maryanoff BE. Sugar sulfamates for seizure control: discovery and development of topiramate, a structurally unique antiepileptic drug. Curr Top Med Chem. 2009; 9(11):1049-62. PMID: 19860705.
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    21. Cejas MA, Kinney WA, Chen C, Vinter JG, Almond HR, Balss KM, Maryanoff CA, Schmidt U, Breslav M, Mahan A, Lacy E, Maryanoff BE. Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions. Proc Natl Acad Sci U S A. 2008 Jun 24; 105(25):8513-8. PMID: 18559857; PMCID: PMC2438399.
    22. Gunnet JW, Wines P, Xiang M, Rybczynski P, Andrade-Gordon P, de Garavilla L, Parry TJ, Cheung WM, Minor L, Demarest KT, Maryanoff BE, Damiano BP. Pharmacological characterization of RWJ-676070, a dual vasopressin V(1A)/V(2) receptor antagonist. Eur J Pharmacol. 2008 Aug 20; 590(1-3):333-42. PMID: 18599033.
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    23. Ye H, Chen C, Zhang HC, Haertlein B, Parry TJ, Damiano BP, Maryanoff BE. Carba-nucleosides as potent antagonists of the adenosine 5'-diphosphate (ADP) purinergic receptor (P2Y12 on human platelets. ChemMedChem. 2008 May; 3(5):732-6. PMID: 18224705.
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    24. Aluisio L, Lord B, Barbier AJ, Fraser IC, Wilson SJ, Boggs J, Dvorak LK, Letavic MA, Maryanoff BE, Carruthers NI, Bonaventure P, Lovenberg TW. In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor. Eur J Pharmacol. 2008 Jun 10; 587(1-3):141-6. PMID: 18499098.
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    25. Kreutter KD, Lu T, Lee L, Giardino EC, Patel S, Huang H, Xu G, Fitzgerald M, Haertlein BJ, Mohan V, Crysler C, Eisennagel S, Dasgupta M, McMillan M, Spurlino JC, Huebert ND, Maryanoff BE, Tomczuk BE, Damiano BP, Player MR. Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif. Bioorg Med Chem Lett. 2008 May 01; 18(9):2865-70. PMID: 18420408.
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    26. Shank RP, Smith-Swintosky VL, Maryanoff BE. Carbonic anhydrase inhibition. Insight into the characteristics of zonisamide, topiramate, and the sulfamide cognate of topiramate. J Enzyme Inhib Med Chem. 2008 Apr; 23(2):271-6. PMID: 18343915.
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    27. Maryanoff BE, McComsey DF, Lee J, Smith-Swintosky VL, Wang Y, Minor LK, Todd MJ. Carbonic anhydrase-II inhibition. what are the true enzyme-inhibitory properties of the sulfamide cognate of topiramate? J Med Chem. 2008 Apr 24; 51(8):2518-21. PMID: 18363349.
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    28. Kinney WA, Teleha CA, Thompson AS, Newport M, Hansen R, Ballentine S, Ghosh S, Mahan A, Grasa G, Zanotti-Gerosa A, Dingenen J, Schubert C, Zhou Y, Leo GC, McComsey DF, Santulli RJ, Maryanoff BE. Suzuki-Miyaura approach to JNJ-26076713, an orally active tetrahydroquinoline-containing alphaVbeta3/alphaVbeta5 integrin antagonist. enantioselective synthesis and stereochemical studies. J Org Chem. 2008 Mar 21; 73(6):2302-10. PMID: 18278942.
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    29. Costanzo MJ, Yabut SC, Zhang HC, White KB, de Garavilla L, Wang Y, Minor LK, Tounge BA, Barnakov AN, Lewandowski F, Milligan C, Spurlino JC, Abraham WM, Boswell-Smith V, Page CP, Maryanoff BE. Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives. Bioorg Med Chem Lett. 2008 Mar 15; 18(6):2114-21. PMID: 18272363.
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    30. Shank RP, Maryanoff BE. Molecular pharmacodynamics, clinical therapeutics, and pharmacokinetics of topiramate. CNS Neurosci Ther. 2008; 14(2):120-42. PMID: 18482025.
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    31. Lee YK, Parks DJ, Lu T, Thieu TV, Markotan T, Pan W, McComsey DF, Milkiewicz KL, Crysler CS, Ninan N, Abad MC, Giardino EC, Maryanoff BE, Damiano BP, Player MR. 7-fluoroindazoles as potent and selective inhibitors of factor Xa. J Med Chem. 2008 Jan 24; 51(2):282-97. PMID: 18159923.
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    32. Santulli RJ, Kinney WA, Ghosh S, Decorte BL, Liu L, Tuman RW, Zhou Z, Huebert N, Bursell SE, Clermont AC, Grant MB, Shaw LC, Mousa SA, Galemmo RA, Johnson DL, Maryanoff BE, Damiano BP. Studies with an orally bioavailable alpha V integrin antagonist in animal models of ocular vasculopathy: retinal neovascularization in mice and retinal vascular permeability in diabetic rats. J Pharmacol Exp Ther. 2008 Mar; 324(3):894-901. PMID: 18083913.
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    33. Maryanoff BE, Costanzo MJ. Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. Bioorg Med Chem. 2008 Feb 15; 16(4):1562-95. PMID: 18053726.
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    34. Luci DK, Ghosh S, Smith CE, Qi J, Wang Y, Haertlein B, Parry TJ, Li J, Almond HR, Minor LK, Damiano BP, Kinney WA, Maryanoff BE, Lawson EC. Phenylpiperidine-benzoxazinones as urotensin-II receptor antagonists: synthesis, SAR, and in vivo assessment. Bioorg Med Chem Lett. 2007 Dec 01; 17(23):6489-92. PMID: 17933531.
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    35. Xiang MA, Rybczynski PJ, Patel M, Chen RH, McComsey DF, Zhang HC, Gunnet JW, Look R, Wang Y, Minor LK, Zhong HM, Villani FJ, Demarest KT, Damiano BP, Maryanoff BE. Next-generation spirobenzazepines: identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies. Bioorg Med Chem Lett. 2007 Dec 01; 17(23):6623-8. PMID: 17942308.
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    36. Cejas MA, Chen C, Kinney WA, Maryanoff BE. Nanoparticles that display short collagen-related peptides. Potent stimulation of human platelet aggregation by triple helical motifs. Bioconjug Chem. 2007 Jul-Aug; 18(4):1025-7. PMID: 17583929.
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    37. Greco MN, Hawkins MJ, Powell ET, Almond HR, de Garavilla L, Hall J, Minor LK, Wang Y, Corcoran TW, Di Cera E, Cantwell AM, Savvides SN, Damiano BP, Maryanoff BE. Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19; 50(8):1727-30. PMID: 17361995.
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    38. Zhang HC, Boñaga LV, Ye H, Derian CK, Damiano BP, Maryanoff BE. Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3. Bioorg Med Chem Lett. 2007 May 15; 17(10):2863-8. PMID: 17350261.
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    39. Cejas MA, Kinney WA, Chen C, Leo GC, Tounge BA, Vinter JG, Joshi PP, Maryanoff BE. Collagen-related peptides: self-assembly of short, single strands into a functional biomaterial of micrometer scale. J Am Chem Soc. 2007 Feb 28; 129(8):2202-3. PMID: 17269769.
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    40. Maryanoff BE. Adventures in drug discovery: potent agents based on ligands for cell-surface receptors. Acc Chem Res. 2006 Nov; 39(11):831-40. PMID: 17115723.
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    41. Hawkins MJ, Powell ET, Leo GC, Gauthier DA, Greco MN, Maryanoff B. Facile dephosphonylation of beta-ketophosphonic acids: mechanistic studies. Org Lett. 2006 Aug 03; 8(16):3429-31. PMID: 16869627.
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    42. Shank RP, McComsey DF, Smith-Swintosky VL, Maryanoff BE. Examination of two independent kinetic assays for determining the inhibition of carbonic anhydrases I and II: structure-activity comparison of sulfamates and sulfamides. Chem Biol Drug Des. 2006 Aug; 68(2):113-9. PMID: 16999776.
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    43. Maryanoff BE, McComsey DF, Costanzo MJ, Yabut SC, Lu T, Player MR, Giardino EC, Damiano BP. Exploration of potential prodrugs of RWJ-445167, an oxyguanidine-based dual inhibitor of thrombin and factor Xa. Chem Biol Drug Des. 2006 Jul; 68(1):29-36. PMID: 16923023.
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    44. Klinger AL, McComsey DF, Smith-Swintosky V, Shank RP, Maryanoff BE. Inhibition of carbonic anhydrase-II by sulfamate and sulfamide groups: an investigation involving direct thermodynamic binding measurements. J Med Chem. 2006 Jun 15; 49(12):3496-500. PMID: 16759092.
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    45. Gong Y, Barbay JK, Dyatkin AB, Miskowski TA, Kimball ES, Prouty SM, Fisher MC, Santulli RJ, Schneider CR, Wallace NH, Ballentine SA, Hageman WE, Masucci JA, Maryanoff BE, Damiano BP, Andrade-Gordon P, Hlasta DJ, Hornby PJ, He W. Synthesis and biological evaluation of novel pyridazinone-based alpha4 integrin receptor antagonists. J Med Chem. 2006 Jun 01; 49(11):3402-11. PMID: 16722660.
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    46. Gunnet JW, Matthews JM, Maryanoff BE, de Garavilla L, Andrade-Gordon P, Damiano B, Hageman W, Look R, Stahle P, Streeter AJ, Wines PG, Demarest KT. Characterization of RWJ-351647, a novel nonpeptide vasopressin V2 receptor antagonist. Clin Exp Pharmacol Physiol. 2006 Apr; 33(4):320-6. PMID: 16620295.
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    47. Lawson EC, Santulli RJ, Dyatkin AB, Ballentine SA, Abraham WM, Rudman S, Page CP, de Garavilla L, Damiano BP, Kinney WA, Maryanoff BE. Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent. Bioorg Med Chem. 2006 Jun 15; 14(12):4208-16. PMID: 16495061.
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    48. Dyatkin AB, Gong Y, Miskowski TA, Kimball ES, Prouty SM, Fisher MC, Santulli RJ, Schneider CR, Wallace NH, Hornby PJ, Diamond C, Kinney WA, Maryanoff BE, Damiano BP, He W. Aza-bicyclic amino acid carboxamides as alpha4beta1/alpha4beta7 integrin receptor antagonists. Bioorg Med Chem. 2005 Dec 15; 13(24):6693-702. PMID: 16112583.
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    49. Caldwell GW, Wu WN, Masucci JA, McKown LA, Gauthier D, Jones WJ, Leo GC, Maryanoff BE. Metabolism and excretion of the antiepileptic/antimigraine drug, Topiramate in animals and humans. Eur J Drug Metab Pharmacokinet. 2005 Jul-Sep; 30(3):151-64. PMID: 16250251.
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    50. Mimrod D, Specchio LM, Britzi M, Perucca E, Specchio N, La Neve A, Soback S, Levy RH, Gatti G, Doose DR, Maryanoff BE, Bialer M. A comparative study of the effect of carbamazepine and valproic acid on the pharmacokinetics and metabolic profile of topiramate at steady state in patients with epilepsy. Epilepsia. 2005 Jul; 46(7):1046-54. PMID: 16026556.
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    51. Zhang HC, Derian CK, McComsey DF, White KB, Ye H, Hecker LR, Li J, Addo MF, Croll D, Eckardt AJ, Smith CE, Li Q, Cheung WM, Conway BR, Emanuel S, Demarest KT, Andrade-Gordon P, Damiano BP, Maryanoff BE. Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety. J Med Chem. 2005 Mar 24; 48(6):1725-8. PMID: 15771419.
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    52. Maryanoff BE, McComsey DF, Costanzo MJ, Hochman C, Smith-Swintosky V, Shank RP. Comparison of sulfamate and sulfamide groups for the inhibition of carbonic anhydrase-II by using topiramate as a structural platform. J Med Chem. 2005 Mar 24; 48(6):1941-7. PMID: 15771438.
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    53. Costanzo MJ, Almond HR, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Corcoran TW, Giardino EC, Kauffman JA, Lewis JM, de Garavilla L, Haertlein BJ, Maryanoff BE. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. J Med Chem. 2005 Mar 24; 48(6):1984-2008. PMID: 15771442.
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    54. Boñaga LV, Zhang HC, Moretto AF, Ye H, Gauthier DA, Li J, Leo GC, Maryanoff BE. Synthesis of macrocycles via cobalt-mediated [2 + 2 + 2] cycloadditions. J Am Chem Soc. 2005 Mar 16; 127(10):3473-85. PMID: 15755167.
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    55. Britzi M, Perucca E, Soback S, Levy RH, Fattore C, Crema F, Gatti G, Doose DR, Maryanoff BE, Bialer M. Pharmacokinetic and metabolic investigation of topiramate disposition in healthy subjects in the absence and in the presence of enzyme induction by carbamazepine. Epilepsia. 2005 Mar; 46(3):378-84. PMID: 15730535.
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    56. de Garavilla L, Greco MN, Sukumar N, Chen ZW, Pineda AO, Mathews FS, Di Cera E, Giardino EC, Wells GI, Haertlein BJ, Kauffman JA, Corcoran TW, Derian CK, Eckardt AJ, Damiano BP, Andrade-Gordon P, Maryanoff BE. A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo. J Biol Chem. 2005 May 06; 280(18):18001-7. PMID: 15741158.
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    57. Ghosh S, Santulli RJ, Kinney WA, Decorte BL, Liu L, Lewis JM, Proost JC, Leo GC, Masucci J, Hageman WE, Thompson AS, Chen I, Kawahama R, Tuman RW, Galemmo RA, Johnson DL, Damiano BP, Maryanoff BE. 1,2,3,4-Tetrahydroquinoline-containing alphaVbeta3 integrin antagonists with enhanced oral bioavailability. Bioorg Med Chem Lett. 2004 Dec 06; 14(23):5937-41. PMID: 15501072.
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    58. De Corte BL, Kinney WA, Liu L, Ghosh S, Brunner L, Hoekstra WJ, Santulli RJ, Tuman RW, Baker J, Burns C, Proost JC, Tounge BA, Damiano BP, Maryanoff BE, Johnson DL, Galemmo RA. Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins. Bioorg Med Chem Lett. 2004 Oct 18; 14(20):5227-32. PMID: 15380233.
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    59. Boñaga LV, Zhang HC, Maryanoff BE. Cobalt-mediated cyclotrimerisation of bis-alkynes and cyanamides. Chem Commun (Camb). 2004 Nov 07; (21):2394-5. PMID: 15514782.
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    60. Zhang HC, Ye H, Conway BR, Derian CK, Addo MF, Kuo GH, Hecker LR, Croll DR, Li J, Westover L, Xu JZ, Look R, Demarest KT, Andrade-Gordon P, Damiano BP, Maryanoff BE. 3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3. Bioorg Med Chem Lett. 2004 Jun 21; 14(12):3245-50. PMID: 15149684.
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    61. O'Neill DJ, Shen L, Prouty C, Conway BR, Westover L, Xu JZ, Zhang HC, Maryanoff BE, Murray WV, Demarest KT, Kuo GH. Design, synthesis, and biological evaluation of novel 7-azaindolyl-heteroaryl-maleimides as potent and selective glycogen synthase kinase-3beta (GSK-3beta) inhibitors. Bioorg Med Chem. 2004 Jun 15; 12(12):3167-85. PMID: 15158785.
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    62. Matthews JM, Hoekstra WJ, Dyatkin AB, Hecker LR, Hlasta DJ, Poulter BL, Andrade-Gordon P, de Garavilla L, Demarest KT, Ericson E, Gunnet JW, Hageman W, Look R, Moore JB, Reynolds CH, Maryanoff BE. Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates. Bioorg Med Chem Lett. 2004 Jun 07; 14(11):2747-52. PMID: 15125926.
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    63. Maryanoff BE, Zhang HC, Cohen JH, Turchi IJ, Maryanoff CA. Cyclizations of N-acyliminium ions. Chem Rev. 2004 Mar; 104(3):1431-628. PMID: 15008627.
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    64. Maryanoff BE. Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G. J Med Chem. 2004 Feb 12; 47(4):769-87. PMID: 14761180.
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    65. Dyatkin AB, Hoekstra WJ, Kinney WA, Kontoyianni M, Santulli RJ, Kimball ES, Fisher MC, Carolyn Fisher M, Prouty SM, Abraham WM, de Garavilla L, Andrade-Gordon P, Hlasta DJ, He W, Hornby PJ, Damiano BP, Maryanoff BE. Aza-bicyclic amino acid sulfonamides as alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists. Bioorg Med Chem Lett. 2004 Feb 09; 14(3):591-6. PMID: 14741249.
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    66. Boñaga LV, Zhang HC, Gauthier DA, Reddy I, Maryanoff BE. Cobalt-mediated macrocyclizations. Facile synthesis of 2-oxo pyridinophanes via [2 + 2 + 2] cycloaddition of alpha, omega-diynes and isocyanates. Org Lett. 2003 Nov 27; 5(24):4537-40. PMID: 14627377.
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    67. Zhang HC, White KB, Ye H, McComsey DF, Derian CK, Addo MF, Andrade-Gordon P, Eckardt AJ, Conway BR, Westover L, Xu JZ, Look R, Demarest KT, Emanuel S, Maryanoff BE. Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3. Bioorg Med Chem Lett. 2003 Sep 15; 13(18):3049-53. PMID: 12941331.
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    68. Costanzo MJ, Yabut SC, Almond HR, Andrade-Gordon P, Corcoran TW, De Garavilla L, Kauffman JA, Abraham WM, Recacha R, Chattopadhyay D, Maryanoff BE. Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone. J Med Chem. 2003 Aug 28; 46(18):3865-76. PMID: 12930148.
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    69. Zhang HC, White KB, McComsey DF, Addo MF, Andrade-Gordon P, Derian CK, Oksenberg D, Maryanoff BE. High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus. Bioorg Med Chem Lett. 2003 Jul 07; 13(13):2199-203. PMID: 12798334.
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    70. Britzi M, Soback S, Isoherranen N, Levy RH, Perucca E, Doose DR, Maryanoff BE, Bialer M. Analysis of topiramate and its metabolites in plasma and urine of healthy subjects and patients with epilepsy by use of a novel liquid chromatography-mass spectrometry assay. Ther Drug Monit. 2003 Jun; 25(3):314-22. PMID: 12766560.
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    71. Maryanoff BE, McComsey DF, Dukor RK, Nafie LA, Freedman TB, Cao X, Day VW. Structural studies on McN-5652-X, a high-affinity ligand for the serotonin transporter in mammalian brain. Bioorg Med Chem. 2003 May 29; 11(11):2463-70. PMID: 12735993.
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    72. Maryanoff BE, Zhang HC, Andrade-Gordon P, Derian CK. Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1). Curr Med Chem Cardiovasc Hematol Agents. 2003 Mar; 1(1):13-36. PMID: 15317288.
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    73. Matthews JM, Greco MN, Hecker LR, Hoekstra WJ, Andrade-Gordon P, de Garavilla L, Demarest KT, Ericson E, Gunnet JW, Hageman W, Look R, Moore JB, Maryanoff BE. Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists. Bioorg Med Chem Lett. 2003 Feb 24; 13(4):753-6. PMID: 12639574.
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    74. Derian CK, Damiano BP, Addo MF, Darrow AL, D'Andrea MR, Nedelman M, Zhang HC, Maryanoff BE, Andrade-Gordon P. Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates. J Pharmacol Exp Ther. 2003 Feb; 304(2):855-61. PMID: 12538843.
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    75. Derian CK, Maryanoff BE, Zhang HC, Andrade-Gordon P. Therapeutic potential of protease-activated receptor-1 antagonists. Expert Opin Investig Drugs. 2003 Feb; 12(2):209-21. PMID: 12556215.
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    76. Damiano BP, Derian CK, Maryanoff BE, Zhang HC, Gordon PA. RWJ-58259: a selective antagonist of protease activated receptor-1. Cardiovasc Drug Rev. 2003; 21(4):313-26. PMID: 14647534.
      View in: PubMed
    77. Dyatkin AB, Hoekstra WJ, Hlasta DJ, Andrade-Gordon P, de Garavilla L, Demarest KT, Gunnet JW, Hageman W, Look R, Maryanoff BE. Bridged bicyclic vasopressin receptor antagonists with V(2)-selective or dual V(1a)/V(2) activity. Bioorg Med Chem Lett. 2002 Nov 04; 12(21):3081-4. PMID: 12372506.
      View in: PubMed
    78. Maryanoff BE. Commentary to "The structure of McN-5652" [Bioorg. Med. Chem. 9 (2001) 2105] and to the corrigendum to "The structure of McN-5652" [Bioorg. Med. Chem. 10 (2002) 3368]. Bioorg Med Chem. 2002 Oct; 10(10):3367. PMID: 12150884.
      View in: PubMed
    79. Kinney WA, Almond Jr HR, Qi J, Smith CE, Santulli RJ, de Garavilla L, Andrade-Gordon P, Cho DS, Everson AM, Feinstein MA, Leung PA, Maryanoff BE. Structure-function analysis of urotensin II and its use in the construction of a ligand-receptor working model. Angew Chem Int Ed Engl. 2002 Aug 16; 41(16):2940-4. PMID: 12203418.
      View in: PubMed
    80. Greco MN, Hawkins MJ, Powell ET, Almond HR, Corcoran TW, de Garavilla L, Kauffman JA, Recacha R, Chattopadhyay D, Andrade-Gordon P, Maryanoff BE. Nonpeptide inhibitors of cathepsin G: optimization of a novel beta-ketophosphonic acid lead by structure-based drug design. J Am Chem Soc. 2002 Apr 17; 124(15):3810-1. PMID: 11942800.
      View in: PubMed
    81. Recacha R, Costanzo MJ, Maryanoff BE, Chattopadhyay D. Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate. Biochem J. 2002 Feb 01; 361(Pt 3):437-41. PMID: 11802772; PMCID: PMC1222325.
    82. Dyatkin AB, Freedman TB, Cao X, Dukor RK, Maryanoff BE, Maryanoff CA, Matthews JM, Shah RD, Nafie LA. Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism. Chirality. 2002 Feb-Mar; 14(2-3):215-9. PMID: 11835568.
      View in: PubMed
    83. Damiano BP, Mitchell JA, Giardino E, Corcoran T, Haertlein BJ, de Garavilla L, Kauffman JA, Hoekstra WJ, Maryanoff BE, Andrade-Gordon P. Antiplatelet and antithrombotic activity of RWJ-53308, a novel orally active glycoprotein IIb/IIIa antagonist. Thromb Res. 2001 Oct 15; 104(2):113-26. PMID: 11672755.
      View in: PubMed
    84. Lawson EC, Hoekstra WJ, Addo MF, Andrade-Gordon P, Damiano BP, Kauffman JA, Mitchell JA, Maryanoff BE. 1,2,4-triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists. Bioorg Med Chem Lett. 2001 Oct 08; 11(19):2619-22. PMID: 11551763.
      View in: PubMed
    85. Zhang HC, McComsey DF, White KB, Addo MF, Andrade-Gordon P, Derian CK, Oksenberg D, Maryanoff BE. Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide. Bioorg Med Chem Lett. 2001 Aug 20; 11(16):2105-9. PMID: 11514149.
      View in: PubMed
    86. Andrade-Gordon P, Derian CK, Maryanoff BE, Zhang HC, Addo MF, Damiano BP, D'Andrea MR, Darrow AL, de Garavilla L, Eckardt AJ, Giardino EC, Haertlein BJ, McComsey DF. Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats. J Pharmacol Exp Ther. 2001 Jul; 298(1):34-42. PMID: 11408522.
      View in: PubMed
    87. Elliott JT, Hoekstra WJ, Derian CK, Addo MF, Maryanoff BE, Ahern DG, Prestwich GD. Tritiated photoactivatable analogs of the native human thrombin receptor (PAR-1) agonist peptide, SFLLRN-NH2. J Pept Res. 2001 Jun; 57(6):494-506. PMID: 11437953.
      View in: PubMed
    88. Zhang HC, Derian CK, Andrade-Gordon P, Hoekstra WJ, McComsey DF, White KB, Poulter BL, Addo MF, Cheung WM, Damiano BP, Oksenberg D, Reynolds EE, Pandey A, Scarborough RM, Maryanoff BE. Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates. J Med Chem. 2001 Mar 29; 44(7):1021-4. PMID: 11297447.
      View in: PubMed
    89. Maryanoff BE, Santulli RJ, McComsey DF, Hoekstra WJ, Hoey K, Smith CE, Addo M, Darrow AL, Andrade-Gordon P. Protease-activated receptor-2 (PAR-2): structure-function study of receptor activation by diverse peptides related to tethered-ligand epitopes. Arch Biochem Biophys. 2001 Feb 15; 386(2):195-204. PMID: 11368342.
      View in: PubMed
    90. Recacha R, Costanzo MJ, Maryanoff BE, Carson M, DeLucas L, Chattopadhyay D. Structure of human alpha-thrombin complexed with RWJ-51438 at 1.7 A: unusual perturbation of the 60A-60I insertion loop. Acta Crystallogr D Biol Crystallogr. 2000 Nov; 56(Pt 11):1395-400. PMID: 11053836.
      View in: PubMed
    91. Giardino EC, Costanzo MJ, Kauffman JA, Li QS, Maryanoff BE, Andrade-Gordon P. Antithrombotic properties of RWJ-50353, a potent and novel thrombin inhibitor. Thromb Res. 2000 Apr 01; 98(1):83-93. PMID: 10706936.
      View in: PubMed
    92. Dodgson SJ, Shank RP, Maryanoff BE. Topiramate as an inhibitor of carbonic anhydrase isoenzymes. Epilepsia. 2000; 41 Suppl 1:S35-9. PMID: 10768298.
      View in: PubMed
    93. Shank RP, Gardocki JF, Streeter AJ, Maryanoff BE. An overview of the preclinical aspects of topiramate: pharmacology, pharmacokinetics, and mechanism of action. Epilepsia. 2000; 41 Suppl 1:S3-9. PMID: 10768292.
      View in: PubMed
    94. Hoekstra WJ, Maryanoff BE, Damiano BP, Andrade-Gordon P, Cohen JH, Costanzo MJ, Haertlein BJ, Hecker LR, Hulshizer BL, Kauffman JA, Keane P, McComsey DF, Mitchell JA, Scott L, Shah RD, Yabut SC. Potent, orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure-activity studies leading to the discovery of RWJ-53308. J Med Chem. 1999 Dec 16; 42(25):5254-65. PMID: 10602710.
      View in: PubMed
    95. Ceruso MA, McComsey DF, Leo GC, Andrade-Gordon P, Addo MF, Scarborough RM, Oksenberg D, Maryanoff BE. Thrombin receptor-activating peptides (TRAPs): investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies. Bioorg Med Chem. 1999 Nov; 7(11):2353-71. PMID: 10632045.
      View in: PubMed
    96. Andrade-Gordon P, Maryanoff BE, Derian CK, Zhang HC, Addo MF, Darrow AL, Eckardt AJ, Hoekstra WJ, McComsey DF, Oksenberg D, Reynolds EE, Santulli RJ, Scarborough RM, Smith CE, White KB. Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12257-62. PMID: 10535908; PMCID: PMC22903.
    97. Maryanoff BE, Nortey SO, McNally JJ, Sanfilippo PJ, McComsey DF, Dubinsky B, Shank RP, Reitz AB. Potential anxiolytic agents. 3. Novel A-ring modified pyrido[1,2-a]benzimidazoles. Bioorg Med Chem Lett. 1999 Jun 07; 9(11):1547-52. PMID: 10386933.
      View in: PubMed
    98. McComsey DF, Hawkins MJ, Andrade-Gordon P, Addo MF, Oksenberg D, Maryanoff BE. Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1). Bioorg Med Chem Lett. 1999 May 17; 9(10):1423-8. PMID: 10360749.
      View in: PubMed
    99. Elliott JT, Hoekstra WJ, Maryanoff BE, Prestwich GD. Photoactivatable peptides based on BMS-197525: a potent antagonist of the human thrombin receptor (PAR-1). Bioorg Med Chem Lett. 1999 Jan 18; 9(2):279-84. PMID: 10021945.
      View in: PubMed
    100. McComsey DF, Hecker LR, Andrade-Gordon P, Addo MF, Maryanoff BE. Macrocyclic hexapeptide analogues of the thrombin receptor (PAR-1) activation motif SFLLRN. Bioorg Med Chem Lett. 1999 Jan 18; 9(2):255-60. PMID: 10021940.
      View in: PubMed
    101. Hoekstra WJ, Hulshizer BL, McComsey DF, Andrade-Gordon P, Kauffman JA, Addo MF, Oksenberg D, Scarborough RM, Maryanoff BE. Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif. Bioorg Med Chem Lett. 1998 Jul 07; 8(13):1649-54. PMID: 9873407.
      View in: PubMed
    102. Reitz AB, Baxter EW, Codd EE, Davis CB, Jordan AD, Maryanoff BE, Maryanoff CA, McDonnell ME, Powell ET, Renzi MJ, Schott MR, Scott MK, Shank RP, Vaught JL. Orally active benzamide antipsychotic agents with affinity for dopamine D2, serotonin 5-HT1A, and adrenergic alpha1 receptors. J Med Chem. 1998 Jun 04; 41(12):1997-2009. PMID: 9622541.
      View in: PubMed
    103. Maryanoff BE, McComsey DF, Martin GE, Shank RP. Azepinoindole derivatives with high affinity for brain dopamine and serotonin receptors. Bioorg Med Chem Lett. 1998 Apr 21; 8(8):983-8. PMID: 9871525.
      View in: PubMed
    104. Maryanoff BE, Costanzo MJ, Nortey SO, Greco MN, Shank RP, Schupsky JJ, Ortegon MP, Vaught JL. Structure-activity studies on anticonvulsant sugar sulfamates related to topiramate. Enhanced potency with cyclic sulfate derivatives. J Med Chem. 1998 Apr 09; 41(8):1315-43. PMID: 9548821.
      View in: PubMed
    105. Nortey SO, Wu WN, Maryanoff BE. Synthesis of hydroxylated derivatives of topiramate, a novel antiepileptic drug based on D-fructose: investigation of oxidative metabolites. Carbohydr Res. 1997 Oct 28; 304(1):29-38. PMID: 9490196.
      View in: PubMed
    106. Matthews JH, Krishnan R, Costanzo MJ, Maryanoff BE, Tulinsky A. Crystal structures of thrombin with thiazole-containing inhibitors: probes of the S1' binding site. Biophys J. 1996 Nov; 71(5):2830-9. PMID: 8913620; PMCID: PMC1233769.
    107. Costanzo MJ, Maryanoff BE, Hecker LR, Schott MR, Yabut SC, Zhang HC, Andrade-Gordon P, Kauffman JA, Lewis JM, Krishnan R, Tulinsky A. Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group. J Med Chem. 1996 Aug 02; 39(16):3039-43. PMID: 8759623.
      View in: PubMed
    108. Reitz AB, Baxter EW, Bennett DJ, Codd EE, Jordan AD, Malloy EA, Maryanoff BE, McDonnell ME, Ortegon ME, Renzi MJ, et al. N-aryl-N'-benzylpiperazines as potential antipsychotic agents. J Med Chem. 1995 Oct 13; 38(21):4211-22. PMID: 7473548.
      View in: PubMed
    109. Scott MK, Baxter EW, Bennett DJ, Boyd RE, Blum PS, Codd EE, Kukla MJ, Malloy E, Maryanoff BE, Maryanoff CA, et al. Piperazinylalkyl heterocycles as potential antipsychotic agents. J Med Chem. 1995 Oct 13; 38(21):4198-210. PMID: 7473547.
      View in: PubMed
    110. Maryanoff BE, Zhang HC, Greco MN, Glover KA, Kauffman JA, Andrade-Gordon P. Cyclotheonamide derivatives: synthesis and thrombin inhibition. Exploration of specific structure-function issues. Bioorg Med Chem. 1995 Aug; 3(8):1025-38. PMID: 7582977.
      View in: PubMed
    111. Maryanoff BE, Ho W, McComsey DF, Reitz AB, Grous PP, Nortey SO, Shank RP, Dubinsky B, Taylor RJ, Gardocki JF. Potential anxiolytic agents. Pyrido[1,2-a]benzimidazoles: a new structural class of ligands for the benzodiazepine binding site on GABA-A receptors. J Med Chem. 1995 Jan 06; 38(1):16-20. PMID: 7837226.
      View in: PubMed
    112. Shank RP, Gardocki JF, Vaught JL, Davis CB, Schupsky JJ, Raffa RB, Dodgson SJ, Nortey SO, Maryanoff BE. Topiramate: preclinical evaluation of structurally novel anticonvulsant. Epilepsia. 1994 Mar-Apr; 35(2):450-60. PMID: 8156972.
      View in: PubMed
    113. Maryanoff BE, Qiu X, Padmanabhan KP, Tulinsky A, Almond HR, Andrade-Gordon P, Greco MN, Kauffman JA, Nicolaou KC, Liu A, et al. Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. Proc Natl Acad Sci U S A. 1993 Sep 01; 90(17):8048-52. PMID: 8367461; PMCID: PMC47285.
    114. Maryanoff BE, Vaught JL, Shank RP, McComsey DF, Costanzo MJ, Nortey SO. Pyrroloisoquinoline antidepressants. 3. A focus on serotonin. J Med Chem. 1990 Oct; 33(10):2793-7. PMID: 2213832.
      View in: PubMed
    115. Reitz AB, Tuman RW, Marchione CS, Jordan AD, Bowden CR, Maryanoff BE. Carbohydrate biguanides as potential hypoglycemic agents. J Med Chem. 1989 Sep; 32(9):2110-6. PMID: 2769683.
      View in: PubMed
    116. Shank RP, Vaught JL, Pelley KA, Setler PE, McComsey DF, Maryanoff BE. McN-5652: a highly potent inhibitor of serotonin uptake. J Pharmacol Exp Ther. 1988 Dec; 247(3):1032-8. PMID: 2905001.
      View in: PubMed
    117. McKenna JI, Schlicksupp L, Natale NR, Willett RD, Maryanoff BE, Flaim SF. Cardioactivity and solid-state structure of two 4-isoxazolyldihydropyridines related to the 4-aryldihydropyridine calcium-channel blockers. J Med Chem. 1988 Feb; 31(2):473-6. PMID: 3339618.
      View in: PubMed
    118. Maryanoff BE, McComsey DF, Gardocki JF, Shank RP, Costanzo MJ, Nortey SO, Schneider CR, Setler PE. Pyrroloisoquinoline antidepressants. 2. In-depth exploration of structure-activity relationships. J Med Chem. 1987 Aug; 30(8):1433-54. PMID: 3039136.
      View in: PubMed
    119. Shank RP, Gardocki JF, Schneider CR, Vaught JL, Setler PE, Maryanoff BE, McComsey DF. Preclinical evaluation of McN-5707 as a potential antidepressant. J Pharmacol Exp Ther. 1987 Jul; 242(1):74-84. PMID: 3039115.
      View in: PubMed
    120. Maryanoff BE, Nortey SO, Gardocki JF, Shank RP, Dodgson SP. Anticonvulsant O-alkyl sulfamates. 2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate and related compounds. J Med Chem. 1987 May; 30(5):880-7. PMID: 3572976.
      View in: PubMed
    121. Maryanoff BE, Reitz AB, Mutter MS, Whittle RR, Olofson RA. Stereochemistry and mechanism of the Wittig reaction. Diasteromeric reaction intermediates and analysis of the reaction course. J Am Chem Soc. 1986 Nov 01; 108(24):7664-78. PMID: 22283272.
      View in: PubMed
    122. Pilkis SJ, McGrane MM, Kountz PD, el-Maghrabi MR, Pilkis J, Maryanoff BE, Reitz AB, Benkovic SJ. The effect of arabinose 1,5-bisphosphate on rat hepatic 6-phosphofructo-1-kinase and fructose-1,6-bisphosphatase. Biochem Biophys Res Commun. 1986 Jul 16; 138(1):159-66. PMID: 3017313.
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    123. Maryanoff BE, Reitz AB, Duhl-Emswiler BA. Correction. stereochemistry of the wittig reaction. Effect of nucleophillic groups in phosphonium ylide. J Am Chem Soc. 1986 Feb 01; 108(3):557. PMID: 22175505.
      View in: PubMed
    124. Maryanoff BE, McComsey DF, Castanzo MJ, Setler PE, Gardocki JF, Shank RP, Schneider CR. Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin. J Med Chem. 1984 Aug; 27(8):943-6. PMID: 6747993.
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    125. Maryanoff BE, Keeley SL, Persico FJ. Replacement of aromatic or heteroaromatic groups in nonsteroidal antiinflammatory agents with the ferrocene group. J Med Chem. 1983 Feb; 26(2):226-9. PMID: 6827541.
      View in: PubMed
    126. Zelesko MJ, McComsey DF, Hageman WE, Nortey SO, Baker CA, Maryanoff BE. Cardiac-slowing amidines containing the 3-thioindone group. Potential antianginal agents. J Med Chem. 1983 Feb; 26(2):230-7. PMID: 6687480.
      View in: PubMed
    127. Maryanoff BE, McComsey DF, Taylor RJ, Gardocki JF. Synthesis and stereochemistry of 7-phenyl-2-propionanilidobenzo[a]quinolizidine derivatives. Structural probes of fentanyl analgesics. J Med Chem. 1981 Jan; 24(1):79-88. PMID: 6259354.
      View in: PubMed
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