 Receptor, Melanocortin, Type 1
"Receptor, Melanocortin, Type 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A melanocortin receptor subtype found primarily in MELANOCYTES. It shows specificity for ALPHA-MSH and ADRENOCORTICOTROPIC HORMONE. Loss of function mutations of the type 1 melanocortin receptor account for the majority of red hair and fair skin recessive traits in human.
| Descriptor ID |
D044102
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| MeSH Number(s) |
D12.776.543.750.695.430.500 D12.776.543.750.720.600.285.500.500 D12.776.543.750.750.555.285.500.500 D12.776.543.750.750.660.285.500.500
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| Concept/Terms |
Receptor, Melanocortin, Type 1- Receptor, Melanocortin, Type 1
- Receptor, Melanocortin-1
- Receptor, Melanocortin 1
- Melanocortin Receptor 1
- Receptor 1, Melanocortin
- Melanocyte Melanocortin Receptor
- Melanocortin Receptor, Melanocyte
- Receptor, Melanocyte Melanocortin
- MC1 Receptor
- Receptor, MC1
- Melanocortin-1 Receptor
- Melanocortin 1 Receptor
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Below are MeSH descriptors whose meaning is more general than "Receptor, Melanocortin, Type 1".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.695]
- Receptors, Melanocortin [D12.776.543.750.695.430]
- Receptor, Melanocortin, Type 1 [D12.776.543.750.695.430.500]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Neuropeptide [D12.776.543.750.720.600]
- Receptors, Corticotropin [D12.776.543.750.720.600.285]
- Receptors, Melanocortin [D12.776.543.750.720.600.285.500]
- Receptor, Melanocortin, Type 1 [D12.776.543.750.720.600.285.500.500]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Neuropeptide [D12.776.543.750.750.555]
- Receptors, Corticotropin [D12.776.543.750.750.555.285]
- Receptors, Melanocortin [D12.776.543.750.750.555.285.500]
- Receptor, Melanocortin, Type 1 [D12.776.543.750.750.555.285.500.500]
- Receptors, Pituitary Hormone [D12.776.543.750.750.660]
- Receptors, Corticotropin [D12.776.543.750.750.660.285]
- Receptors, Melanocortin [D12.776.543.750.750.660.285.500]
- Receptor, Melanocortin, Type 1 [D12.776.543.750.750.660.285.500.500]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Melanocortin, Type 1".
This graph shows the total number of publications written about "Receptor, Melanocortin, Type 1" by people in this website by year, and whether "Receptor, Melanocortin, Type 1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2005 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 4 | 4 | | 2012 | 0 | 1 | 1 | | 2014 | 1 | 1 | 2 | | 2015 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptor, Melanocortin, Type 1" by people in Profiles.
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Qiao Z, Xu J, Gonzalez R, Miao Y. Novel [99mTc]-Tricarbonyl-NOTA-Conjugated Lactam-Cyclized Alpha-MSH Peptide with Enhanced Melanoma Uptake and Reduced Renal Uptake. Mol Pharm. 2020 09 08; 17(9):3581-3588.
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Yang J, Xu J, Gonzalez R, Lindner T, Kratochwil C, Miao Y. 68Ga-DOTA-GGNle-CycMSHhex targets the melanocortin-1 receptor for melanoma imaging. Sci Transl Med. 2018 11 07; 10(466).
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Yang J, Hu CA, Miao Y. Tc-99m-labeled RGD-conjugated alpha-melanocyte stimulating hormone hybrid peptides with reduced renal uptake. Amino Acids. 2015 Apr; 47(4):813-23.
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Barón AE, Asdigian NL, Gonzalez V, Aalborg J, Terzian T, Stiegmann RA, Torchia EC, Berwick M, Dellavalle RP, Morelli JG, Mokrohisky ST, Crane LA, Box NF. Interactions between ultraviolet light and MC1R and OCA2 variants are determinants of childhood nevus and freckle phenotypes. Cancer Epidemiol Biomarkers Prev. 2014 Dec; 23(12):2829-39.
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Flook AM, Yang J, Miao Y. Substitution of the Lys linker with the ß-Ala linker dramatically decreased the renal uptake of 99mTc-labeled Arg-X-Asp-conjugated and X-Ala-Asp-conjugated a-melanocyte stimulating hormone peptides. J Med Chem. 2014 Nov 13; 57(21):9010-8.
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Guo H, Gallazzi F, Miao Y. Gallium-67-labeled lactam bridge-cyclized alpha-MSH peptides with enhanced melanoma uptake and reduced renal uptake. Bioconjug Chem. 2012 Jun 20; 23(6):1341-8.
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Zhang C, Song Y, Thompson DA, Madonna MA, Millhauser GL, Toro S, Varga Z, Westerfield M, Gamse J, Chen W, Cone RD. Pineal-specific agouti protein regulates teleost background adaptation. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20164-71.
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Yang J, Guo H, Miao Y. Technetium-99m-labeled Arg-Gly-Asp-conjugated alpha-melanocyte stimulating hormone hybrid peptides for human melanoma imaging. Nucl Med Biol. 2010 Nov; 37(8):873-83.
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Quinn T, Zhang X, Miao Y. Targeted melanoma imaging and therapy with radiolabeled alpha-melanocyte stimulating hormone peptide analogues. G Ital Dermatol Venereol. 2010 Apr; 145(2):245-58.
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Guo H, Yang J, Gallazzi F, Miao Y. Reduction of the ring size of radiolabeled lactam bridge-cyclized alpha-MSH peptide, resulting in enhanced melanoma uptake. J Nucl Med. 2010 Mar; 51(3):418-26.
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