 Kruppel-Like Transcription Factors
"Kruppel-Like Transcription Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.
| Descriptor ID |
D051741
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| MeSH Number(s) |
D12.776.260.522 D12.776.930.375
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| Concept/Terms |
Kruppel-Like Transcription Factors- Kruppel-Like Transcription Factors
- Kruppel Like Transcription Factors
- Transcription Factors, Kruppel-Like
- Kruppel-Like Factors
- Kruppel Like Factors
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Below are MeSH descriptors whose meaning is more general than "Kruppel-Like Transcription Factors".
Below are MeSH descriptors whose meaning is more specific than "Kruppel-Like Transcription Factors".
This graph shows the total number of publications written about "Kruppel-Like Transcription Factors" by people in this website by year, and whether "Kruppel-Like Transcription Factors" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2000 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 2 | 3 | | 2010 | 1 | 0 | 1 | | 2011 | 2 | 1 | 3 | | 2012 | 2 | 0 | 2 | | 2013 | 1 | 2 | 3 | | 2014 | 1 | 6 | 7 | | 2015 | 1 | 2 | 3 | | 2016 | 1 | 0 | 1 | | 2017 | 4 | 1 | 5 | | 2020 | 4 | 0 | 4 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Kruppel-Like Transcription Factors" by people in Profiles.
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Brooks EP, Casey MR, Wells KL, Liu TY, Van Orman M, Sussel L. NKX2.2 and KLF4 cooperate to regulate a-cell identity. Genes Dev. 2025 Feb 03; 39(3-4):242-260.
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McCoy MG, Jamaiyar A, Sausen G, Cheng HS, P?rez-Cremades D, Zhuang R, Chen J, Goodney PP, Creager MA, Sabatine MS, Bonaca MP, Feinberg MW. MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia. Angiogenesis. 2023 02; 26(1):107-127.
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Jo JR, Lee SE, An S, Nedumaran B, Ghosh S, Park KG, Kim YD. Gluconeogenic signals regulate hepcidin gene expression via a CRBN-KLF15 axis. BMB Rep. 2021 04; 54(4):221-226.
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Lu S, Jolly AJ, Strand KA, Dubner AM, Mutryn MF, Moulton KS, Nemenoff RA, Majesky MW, Weiser-Evans MC. Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis. JCI Insight. 2020 12 03; 5(23).
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Mostafa MM, Bansal A, Michi AN, Sasse SK, Proud D, Gerber AN, Newton R. Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells. J Biol Chem. 2021 Jan-Jun; 296:100065.
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Yu Y, Tencer A, Xuan H, Kutateladze TG, Shi X. ZZEF1 is a Histone Reader and Transcriptional Coregulator of Kr?ppel-Like Factors. J Mol Biol. 2021 01 22; 433(2):166722.
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Do-Umehara HC, Chen C, Zhang Q, Misharin AV, Abdala-Valencia H, Casalino-Matsuda SM, Reyfman PA, Anekalla KR, Gonzalez-Gonzalez FJ, Sala MA, Peng C, Wu P, Wong CCL, Kalhan R, Bharat A, Perlman H, Ridge KM, Sznajder JI, Sporn PHS, Chandel NS, Yu J, Fu X, Petrache I, Tuder R, Budinger GRS, Liu J. Epithelial cell-specific loss of function of Miz1 causes a spontaneous COPD-like phenotype and up-regulates Ace2 expression in mice. Sci Adv. 2020 08; 6(33):eabb7238.
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Kim YD, Hwang SL, Jeon HJ, Jeon YH, Nedumaran B, Kim K, Lee SE. B-cell translocation gene 2 enhances fibroblast growth factor 21 production by inducing Kruppel-like factor 15. Sci Rep. 2019 03 06; 9(1):3730.
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Bagati A, Moparthy S, Fink EE, Bianchi-Smiraglia A, Yun DH, Kolesnikova M, Udartseva OO, Wolff DW, Roll MV, Lipchick BC, Han Z, Kozlova NI, Jowdy P, Berman AE, Box NF, Rodriguez C, Bshara W, Kandel ES, Soengas MS, Paragh G, Nikiforov MA. KLF9-dependent ROS regulate melanoma progression in stage-specific manner. Oncogene. 2019 05; 38(19):3585-3597.
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Andrabi SBA, Tripathi SK, Dirasantha O, Kanduri K, Rautio S, Gross CC, Lehtim?ki S, Bala K, Tuomisto J, Bhatia U, Chakroborty D, Elo LL, L?hdesm?ki H, Wiendl H, Rasool O, Lahesmaa R. Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells. Cell Rep. 2018 02 20; 22(8):2094-2106.
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