 Tryptophan Hydroxylase
"Tryptophan Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
| Descriptor ID |
D014365
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| MeSH Number(s) |
D08.811.682.690.708.870
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| Concept/Terms |
Tryptophan Hydroxylase- Tryptophan Hydroxylase
- Hydroxylase, Tryptophan
- Tryptophan Monooxygenase
- Monooxygenase, Tryptophan
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Below are MeSH descriptors whose meaning is more general than "Tryptophan Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Tryptophan Hydroxylase".
This graph shows the total number of publications written about "Tryptophan Hydroxylase" by people in this website by year, and whether "Tryptophan Hydroxylase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2005 | 1 | 3 | 4 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 3 | 3 | | 2009 | 2 | 0 | 2 | | 2010 | 0 | 3 | 3 | | 2011 | 3 | 2 | 5 | | 2012 | 2 | 1 | 3 | | 2013 | 1 | 2 | 3 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 2 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 2 | 3 | | 2018 | 1 | 1 | 2 | | 2019 | 3 | 0 | 3 | | 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tryptophan Hydroxylase" by people in Profiles.
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Russo AM, Payet JM, Kent S, Lesku JA, Lowry CA, Hale MW. Acute treatment with 5-hydroxytryptophan increases social approach behaviour but does not activate serotonergic neurons in the dorsal raphe nucleus in juvenile male BALB/c mice: A model of human disorders with deficits of sociability. J Psychopharmacol. 2022 07; 36(7):806-818.
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Jin B, Ha SE, Wei L, Singh R, Zogg H, Clemmensen B, Heredia DJ, Gould TW, Sanders KM, Ro S. Colonic Motility Is Improved by the Activation of 5-HT2B Receptors on Interstitial Cells of Cajal in Diabetic Mice. Gastroenterology. 2021 08; 161(2):608-622.e7.
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Arnold MR, Greenwood BN, McArthur JA, Clark PJ, Fleshner M, Lowry CA. Effects of repeated voluntary or forced exercise on brainstem serotonergic systems in rats. Behav Brain Res. 2020 01 27; 378:112237.
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Donner NC, Davies SM, Fitz SD, Kienzle DM, Shekhar A, Lowry CA. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. Prog Neuropsychopharmacol Biol Psychiatry. 2020 01 10; 96:109730.
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Lieb MW, Weidner M, Arnold MR, Loupy KM, Nguyen KT, Hassell JE, Schnabel KS, Kern R, Day HEW, Lesch KP, Waider J, Lowry CA. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behav Brain Res. 2019 11 05; 373:112086.
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Arnold MR, Williams PH, McArthur JA, Archuleta AR, O'Neill CE, Hassell JE, Smith DG, Bachtell RK, Lowry CA. Effects of chronic caffeine exposure during adolescence and subsequent acute caffeine challenge during adulthood on rat brain serotonergic systems. Neuropharmacology. 2019 04; 148:257-271.
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Russo AM, Lawther AJ, Prior BM, Isbel L, Somers WG, Lesku JA, Richdale AL, Dissanayake C, Kent S, Lowry CA, Hale MW. Social approach, anxiety, and altered tryptophan hydroxylase 2 activity in juvenile BALB/c and C57BL/6J mice. Behav Brain Res. 2019 02 01; 359:918-926.
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Vincent MY, Donner NC, Smith DG, Lowry CA, Jacobson L. Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice. Neurosci Lett. 2018 02 05; 665:48-53.
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Waider J, Popp S, Lange MD, Kern R, Kolter JF, Kobler J, Donner NC, Lowe KR, Malzbender JH, Brazell CJ, Arnold MR, Aboagye B, Schmitt-Böhrer A, Lowry CA, Pape HC, Lesch KP. Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice. Transl Psychiatry. 2017 10 03; 7(10):e1246.
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Fox JH, Hassell JE, Siebler PH, Arnold MR, Lamb AK, Smith DG, Day HEW, Smith TM, Simmerman EM, Outzen AA, Holmes KS, Brazell CJ, Lowry CA. Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm. Brain Behav Immun. 2017 Nov; 66:70-84.
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