 Tryptophan Hydroxylase
"Tryptophan Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
| Descriptor ID |
D014365
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| MeSH Number(s) |
D08.811.682.690.708.870
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| Concept/Terms |
Tryptophan Hydroxylase- Tryptophan Hydroxylase
- Hydroxylase, Tryptophan
- Tryptophan Monooxygenase
- Monooxygenase, Tryptophan
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Below are MeSH descriptors whose meaning is more general than "Tryptophan Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Tryptophan Hydroxylase".
This graph shows the total number of publications written about "Tryptophan Hydroxylase" by people in this website by year, and whether "Tryptophan Hydroxylase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2005 | 1 | 3 | 4 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2009 | 2 | 0 | 2 | | 2010 | 0 | 2 | 2 | | 2011 | 3 | 2 | 5 | | 2012 | 2 | 1 | 3 | | 2013 | 1 | 2 | 3 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 2 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 1 | 2 | 3 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tryptophan Hydroxylase" by people in Profiles.
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Russo AM, Lawther AJ, Prior BM, Isbel L, Somers WG, Lesku JA, Richdale AL, Dissanayake C, Kent S, Lowry CA, Hale MW. Social approach, anxiety, and altered tryptophan hydroxylase 2 activity in juvenile BALB/c and C57BL/6J mice. Behav Brain Res. 2019 02 01; 359:918-926.
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Vincent MY, Donner NC, Smith DG, Lowry CA, Jacobson L. Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice. Neurosci Lett. 2018 02 05; 665:48-53.
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Waider J, Popp S, Lange MD, Kern R, Kolter JF, Kobler J, Donner NC, Lowe KR, Malzbender JH, Brazell CJ, Arnold MR, Aboagye B, Schmitt-Böhrer A, Lowry CA, Pape HC, Lesch KP. Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice. Transl Psychiatry. 2017 10 03; 7(10):e1246.
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Fox JH, Hassell JE, Siebler PH, Arnold MR, Lamb AK, Smith DG, Day HEW, Smith TM, Simmerman EM, Outzen AA, Holmes KS, Brazell CJ, Lowry CA. Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm. Brain Behav Immun. 2017 Nov; 66:70-84.
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Aiello RJ, Bourassa PA, Zhang Q, Dubins J, Goldberg DR, De Lombaert S, Humbert M, Guignabert C, Cavasin MA, McKinsey TA, Paralkar V. Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension. J Pharmacol Exp Ther. 2017 Feb; 360(2):267-279.
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Donner NC, Siebler PH, Johnson DT, Villarreal MD, Mani S, Matti AJ, Lowry CA. Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Psychoneuroendocrinology. 2016 Jan; 63:178-90.
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Lawther AJ, Clissold ML, Ma S, Kent S, Lowry CA, Gundlach AL, Hale MW. Anxiogenic drug administration and elevated plus-maze exposure in rats activate populations of relaxin-3 neurons in the nucleus incertus and serotonergic neurons in the dorsal raphe nucleus. Neuroscience. 2015 Sep 10; 303:270-84.
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Brooks LR, Enix CL, Rich SC, Magno JA, Lowry CA, Tsai PS. Fibroblast growth factor deficiencies impact anxiety-like behavior and the serotonergic system. Behav Brain Res. 2014 May 01; 264:74-81.
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Drugan RC, Hibl PT, Kelly KJ, Dady KF, Hale MW, Lowry CA. Prior cold water swim stress alters immobility in the forced swim test and associated activation of serotonergic neurons in the rat dorsal raphe nucleus. Neuroscience. 2013 Dec 03; 253:221-34.
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Delaney C, Gien J, Roe G, Isenberg N, Kailey J, Abman SH. Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15; 304(12):L894-901.
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