 Interleukin-1
"Interleukin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
| Descriptor ID |
D007375
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| MeSH Number(s) |
D12.644.276.374.465.010 D12.644.276.374.500.400 D12.776.467.374.465.010 D12.776.467.374.500.400 D23.529.374.465.131 D23.529.374.500.400
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| Concept/Terms |
Interleukin-1- Interleukin-1
- Interleukin 1
- IL-1
- T Helper Factor
- Lymphocyte-Activating Factor
- Lymphocyte Activating Factor
- Macrophage Cell Factor
- Epidermal Cell Derived Thymocyte-Activating Factor
- Epidermal Cell Derived Thymocyte Activating Factor
- Interleukin I
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Below are MeSH descriptors whose meaning is more general than "Interleukin-1".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-1".
This graph shows the total number of publications written about "Interleukin-1" by people in this website by year, and whether "Interleukin-1" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1990 | 35 | 5 | 40 | | 1991 | 26 | 6 | 32 | | 1992 | 27 | 11 | 38 | | 1993 | 27 | 13 | 40 | | 1994 | 36 | 7 | 43 | | 1995 | 20 | 14 | 34 | | 1996 | 16 | 9 | 25 | | 1997 | 16 | 6 | 22 | | 1998 | 18 | 8 | 26 | | 1999 | 19 | 10 | 29 | | 2000 | 19 | 11 | 30 | | 2001 | 12 | 10 | 22 | | 2002 | 5 | 15 | 20 | | 2003 | 12 | 12 | 24 | | 2004 | 18 | 10 | 28 | | 2005 | 8 | 9 | 17 | | 2006 | 6 | 6 | 12 | | 2007 | 3 | 1 | 4 | | 2008 | 1 | 2 | 3 | | 2009 | 6 | 2 | 8 | | 2010 | 7 | 5 | 12 | | 2011 | 5 | 4 | 9 | | 2012 | 2 | 5 | 7 | | 2013 | 5 | 2 | 7 | | 2014 | 8 | 3 | 11 | | 2015 | 10 | 3 | 13 | | 2016 | 8 | 1 | 9 | | 2017 | 9 | 1 | 10 | | 2018 | 6 | 2 | 8 | | 2019 | 4 | 1 | 5 |
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Below are the most recent publications written about "Interleukin-1" by people in Profiles.
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Højen JF, Kristensen MLV, McKee AS, Wade MT, Azam T, Lunding LP, de Graaf DM, Swartzwelter BJ, Wegmann M, Tolstrup M, Beckman K, Fujita M, Fischer S, Dinarello CA. IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease. Nat Immunol. 2019 09; 20(9):1138-1149.
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Madonna S, Girolomoni G, Dinarello CA, Albanesi C. The Significance of IL-36 Hyperactivation and IL-36R Targeting in Psoriasis. Int J Mol Sci. 2019 Jul 05; 20(13).
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Osborne DG, Domenico J, Luo Y, Reid AL, Amato C, Zhai Z, Gao D, Ziman M, Dinarello CA, Robinson WA, Fujita M. Interleukin-37 is highly expressed in regulatory T cells of melanoma patients and enhanced by melanoma cell secretome. Mol Carcinog. 2019 09; 58(9):1670-1679.
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Mantovani A, Dinarello CA, Molgora M, Garlanda C. Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity. Immunity. 2019 04 16; 50(4):778-795.
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Eisenmesser EZ, Gottschlich A, Redzic JS, Paukovich N, Nix JC, Azam T, Zhang L, Zhao R, Kieft JS, The E, Meng X, Dinarello CA. Interleukin-37 monomer is the active form for reducing innate immunity. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5514-5522.
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Mercurio L, Morelli M, Scarponi C, Eisenmesser EZ, Doti N, Pagnanelli G, Gubinelli E, Mazzanti C, Cavani A, Ruvo M, Dinarello CA, Albanesi C, Madonna S. IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment. Cell Death Dis. 2018 10 30; 9(11):1104.
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Kuipers EN, van Dam AD, Ballak DB, de Wit EA, Dinarello CA, Stienstra R, van Diepen JA, Rensen PCN, Boon MR. IL-37 Expression Reduces Lean Body Mass in Mice by Reducing Food Intake. Int J Mol Sci. 2018 Aug 02; 19(8).
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Ballak DB, Li S, Cavalli G, Stahl JL, Tengesdal IW, van Diepen JA, Klück V, Swartzwelter B, Azam T, Tack CJ, Stienstra R, Mandrup-Poulsen T, Seals DR, Dinarello CA. Interleukin-37 treatment of mice with metabolic syndrome improves insulin sensitivity and reduces pro-inflammatory cytokine production in adipose tissue. J Biol Chem. 2018 09 14; 293(37):14224-14236.
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Wang Q, Delcorde J, Tang T, Downey GP, McCulloch CA. Regulation of IL-1 signaling through control of focal adhesion assembly. FASEB J. 2018 06; 32(6):3119-3132.
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van de Veerdonk FL, de Graaf DM, Joosten LA, Dinarello CA. Biology of IL-38 and its role in disease. Immunol Rev. 2018 01; 281(1):191-196.
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