 SRS-A
"SRS-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed)
| Descriptor ID |
D013189
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| MeSH Number(s) |
D10.251.355.255.100.450.855 D10.251.355.310.166.887.855 D23.469.050.175.450.725
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| Concept/Terms |
SRS-A- SRS-A
- Slow Reacting Substance of Anaphylaxis
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Below are MeSH descriptors whose meaning is more general than "SRS-A".
Below are MeSH descriptors whose meaning is more specific than "SRS-A".
This graph shows the total number of publications written about "SRS-A" by people in this website by year, and whether "SRS-A" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
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Below are the most recent publications written about "SRS-A" by people in Profiles.
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Di Gennaro A, Carnini C, Buccellati C, Ballerio R, Zarini S, Fumagalli F, Viappiani S, Librizzi L, Hernandez A, Murphy RC, Constantin G, De Curtis M, Folco G, Sala A. Cysteinyl-leukotrienes receptor activation in brain inflammatory reactions and cerebral edema formation: a role for transcellular biosynthesis of cysteinyl-leukotrienes. FASEB J. 2004 May; 18(7):842-4.
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Antoine C, Murphy RC, Henson PM, Maclouf J. Time-dependent utilization of platelet arachidonic acid by the neutrophil in formation of 5-lipoxygenase products in platelet-neutrophil co-incubations. Biochim Biophys Acta. 1992 Oct 30; 1128(2-3):139-46.
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Morelli JG, Hake SS, Murphy RC, Norris DA. Leukotriene B4-induced human melanocyte pigmentation and leukotriene C4-induced human melanocyte growth are inhibited by different isoquinolinesulfonamides. J Invest Dermatol. 1992 Jan; 98(1):55-8.
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Lew DB, Leslie CC, Henson PM, Riches DW. Role of endogenously derived leukotrienes in the regulation of lysosomal enzyme expression in macrophages exposed to beta 1,3-glucan. J Leukoc Biol. 1991 Mar; 49(3):266-76.
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Murphy RC, Maclouf J, Henson PM. Interaction of platelets and neutrophils in the generation of sulfidopeptide leukotrienes. Adv Exp Med Biol. 1991; 314:91-101.
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Graham LM, Vasil A, Vasil ML, Voelkel NF, Stenmark KR. Decreased pulmonary vasoreactivity in an animal model of chronic Pseudomonas pneumonia. Am Rev Respir Dis. 1990 Jul; 142(1):221-9.
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Cassin S, Stenmark KR, Gause G, Zapp LM, Kuck H, Westcott JY. Leukotrienes and prostaglandins in fetal lung liquid. J Appl Physiol (1985). 1990 May; 68(5):2214-22.
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Morelli JG, Norris DA, Lyons MB, Murphy RC. Metabolism of exogenous leukotrienes by cultured human keratinocytes. J Invest Dermatol. 1990 May; 94(5):681-4.
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Morelli JG, Yohn JJ, Lyons MB, Murphy RC, Norris DA. Leukotrienes C4 and D4 as potent mitogens for cultured human neonatal melanocytes. J Invest Dermatol. 1989 Dec; 93(6):719-22.
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Maclouf J, Murphy RC, Henson PM. Transcellular sulfidopeptide leukotriene biosynthetic capacity of vascular cells. Blood. 1989 Aug 01; 74(2):703-7.
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