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Sean Lee Hammond

TitlePost-Doctoral Fellow
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

    Collapse Research 
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    F31NS096841     (HAMMOND, SEAN)Apr 1, 2016 - Mar 31, 2018
    Cell-specific expression of AAV-Nurr1 in a model of Parkinson's Disease
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kirkley KS, Popichak KA, Hammond SL, Davies C, Hunt L, Tjalkens RB. Genetic suppression of IKK2/NF-?B in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease. Neurobiol Dis. 2019 Feb 25; 127:193-209. PMID: 30818064.
      View in: PubMed
    2. Popichak KA, Hammond SL, Moreno JA, Afzali MF, Backos DS, Slayden RD, Safe S, Tjalkens RB. Compensatory Expression of Nur77 and Nurr1 Regulates NF-?B-Dependent Inflammatory Signaling in Astrocytes. Mol Pharmacol. 2018 Oct; 94(4):1174-1186. PMID: 30111648.
      View in: PubMed
    3. Hammond SL, Popichak KA, Li X, Hunt LG, Richman EH, Damale PU, Chong EKP, Backos DS, Safe S, Tjalkens RB. The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism. J Pharmacol Exp Ther. 2018 Jun; 365(3):636-651. PMID: 29626009.
      View in: PubMed
    4. Hammond SL, Leek AN, Richman EH, Tjalkens RB. Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection. PLoS One. 2017; 12(12):e0188830. PMID: 29244806.
      View in: PubMed
    5. Phillips AT, Rico AB, Stauft CB, Hammond SL, Aboellail TA, Tjalkens RB, Olson KE. Entry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection. J Virol. 2016 06 15; 90(12):5785-96. PMID: 27053560; PMCID: PMC4886771 [Available on 11/27/16].
    6. Hammond SL, Safe S, Tjalkens RB. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neurosci Lett. 2015 Oct 21; 607:83-89. PMID: 26383113; PMCID: PMC4631643 [Available on 10/21/16].
    7. Li W, Liu J, Hammond SL, Tjalkens RB, Saifudeen Z, Feng Y. Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein. Am J Physiol Regul Integr Comp Physiol. 2015 Jul 15; 309(2):R138-47. PMID: 25994957; PMCID: PMC4504960.
    8. De Miranda BR, Popichak KA, Hammond SL, Jorgensen BA, Phillips AT, Safe S, Tjalkens RB. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor ?B. Mol Pharmacol. 2015 Jun; 87(6):1021-34. PMID: 25858541; PMCID: PMC4429718.
    9. De Miranda BR, Popichak KA, Hammond SL, Miller JA, Safe S, Tjalkens RB. Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease. Toxicol Sci. 2015 Feb; 143(2):360-73. PMID: 25406165; PMCID: PMC4306720.
    10. Subbaram S, Lyons SP, Svenson KB, Hammond SL, McCabe LG, Chittur SV, DiPersio CM. Integrin a3ß1 controls mRNA splicing that determines Cox-2 mRNA stability in breast cancer cells. J Cell Sci. 2014 Mar 15; 127(Pt 6):1179-89. PMID: 24434582; PMCID: PMC3953813.
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