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Alexander J. Barker

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-RAD General Operations

    Collapse Research 
    Collapse research activities and funding
    F31EB006695     (BARKER, ALEXANDER J)Jun 1, 2007 - May 31, 2008
    NIH/NIBIB
    Improved Molecular Contrast Agent for MRI Imaging
    Role: Principal Investigator

    K25HL119608     (BARKER, ALEX J.)May 1, 2014 - Apr 30, 2019
    NIH/NHLBI
    Hemodynamic Loading of the Left Ventricle and Aorta in Aortic Valve Disease
    Role: Principal Investigator

    R01HL133504     (BARKER, ALEX J.)May 1, 2017 - Apr 30, 2022
    NIH/NHLBI
    Role of Valve-Mediated Hemodynamics on Bicuspid Aortopathy
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Suwa K, Rahman OA, Bollache E, Rose MJ, Rahsepar AA, Carr JC, Collins JD, Barker AJ, Markl M. Effect of Aortic Valve Disease on 3D Hemodynamics in Patients With Aortic Dilation and Trileaflet Aortic Valve Morphology. J Magn Reson Imaging. 2019 Jun 06. PMID: 31169969.
      View in: PubMed
    2. Rahman O, Scott M, Bollache E, Suwa K, Collins J, Carr J, Fedak P, McCarthy P, Malaisrie C, Barker AJ, Markl M. Interval changes in aortic peak velocity and wall shear stress in patients with bicuspid aortic valve disease. Int J Cardiovasc Imaging. 2019 May 29. PMID: 31144256.
      View in: PubMed
    3. Chandrabose S, Chen K, Barker AJ, Sutton JJ, Prasad SKK, Zhu J, Zhou J, Gordon KC, Xie Z, Zhan X, Hodgkiss JM. High Exciton Diffusion Coefficients in Fused Ring Electron Acceptor Films. J Am Chem Soc. 2019 May 01; 141(17):6922-6929. PMID: 30964678.
      View in: PubMed
    4. McLennan D, Schäfer M, Mitchell MB, Morgan GJ, Ivy D, Barker AJ, Jacobsen R. Usefulness of 4D-Flow MRI in Mapping Flow Distribution Through Failing Fontan Circulation Prior to Cardiac Intervention. Pediatr Cardiol. 2019 Jun; 40(5):1093-1096. PMID: 30982076.
      View in: PubMed
    5. Irde G, Pietralunga SM, Sala V, Zani M, Ball JM, Barker AJ, Petrozza A, Lanzani G, Tagliaferri A. Imaging photoinduced surface potentials on hybrid perovskites by real-time Scanning Electron Microscopy. Micron. 2019 Jun; 121:53-65. PMID: 30947034.
      View in: PubMed
    6. Schäfer M, Ivy DD, Abman SH, Stenmark K, Browne LP, Barker AJ, Mitchell MB, Morgan GJ, Wilson N, Shah A, Kollengode M, Naresh N, Fonseca B, DiMaria M, Buckner JK, Hunter KS, Kheyfets V, Fenster BE, Truong U. Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies. Am J Physiol Heart Circ Physiol. 2019 May 01; 316(5):H1091-H1104. PMID: 30822118.
      View in: PubMed
    7. Shan Y, Li J, Wang Y, Wu B, Barker AJ, Markl M, Wang C, Wang X, Shu X. Aortic stenosis exacerbates flow aberrations related to the bicuspid aortic valve fusion pattern and the aortopathy phenotype. Eur J Cardiothorac Surg. 2019 Mar 01; 55(3):534-542. PMID: 30215695.
      View in: PubMed
    8. Ma LE, Markl M, Chow K, Huh H, Forman C, Vali A, Greiser A, Carr J, Schnell S, Barker AJ, Jin N. Aortic 4D flow MRI in 2 minutes using compressed sensing, respiratory controlled adaptive k-space reordering, and inline reconstruction. Magn Reson Med. 2019 Jun; 81(6):3675-3690. PMID: 30803006.
      View in: PubMed
    9. Garcia J, Barker AJ, Markl M. The Role of Imaging of Flow Patterns by 4D Flow MRI in Aortic Stenosis. JACC Cardiovasc Imaging. 2019 Feb; 12(2):252-266. PMID: 30732721.
      View in: PubMed
    10. Friesen RM, Schäfer M, Ivy DD, Abman SH, Stenmark K, Browne LP, Barker AJ, Hunter KS, Truong U. Proximal pulmonary vascular stiffness as a prognostic factor in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2019 02 01; 20(2):209-217. PMID: 29788051.
      View in: PubMed
    11. Robinson JD, Rose MJ, Joh M, Jarvis K, Schnell S, Barker AJ, Rigsby CK, Markl M. 4-D flow magnetic-resonance-imaging-derived energetic biomarkers are abnormal in children with repaired tetralogy of Fallot and associated with disease severity. Pediatr Radiol. 2019 03; 49(3):308-317. PMID: 30506329.
      View in: PubMed
    12. Schäfer M, Frank BS, Ivy DD, Wilson N, Morgan GJ, Barker AJ, Browne LP, Mitchell MB, Truong U. Close look at the Potts shunt flow hemodynamics in a patient with severe pulmonary hypertension: 4D-flow MRI evaluation. J Magn Reson Imaging. 2019 Jun; 49(6):1800-1802. PMID: 30451346.
      View in: PubMed
    13. Schäfer M, Browne LP, Truong U, Jaggers JJ, Mitchell MB, Malone L, Morgan G, Chatfield K, McLennan D, Turbendian H, Vargas D, Fonseca B, DiMaria M, Shah A, Ivy MP, Barker AJ, Hunter KS, Wilson N, Ivy DD, Campbell DN. Aortic stiffness in adolescent Turner and Marfan syndrome patients. Eur J Cardiothorac Surg. 2018 11 01; 54(5):926-932. PMID: 29684119.
      View in: PubMed
    14. Schäfer M, Browne LP, Morgan GJ, Barker AJ, Fonseca B, Ivy DD, Mitchell MB. Reduced proximal aortic compliance and elevated wall shear stress after early repair of tetralogy of Fallot. J Thorac Cardiovasc Surg. 2018 Dec; 156(6):2239-2249. PMID: 30449579.
      View in: PubMed
    15. Jarvis K, Schnell S, Barker AJ, Rose M, Robinson JD, Rigsby CK, Markl M. Caval to pulmonary 3D flow distribution in patients with Fontan circulation and impact of potential 4D flow MRI error sources. Magn Reson Med. 2019 02; 81(2):1205-1218. PMID: 30277276.
      View in: PubMed
    16. Rose MJ, Rigsby CK, Berhane H, Bollache E, Jarvis K, Barker AJ, Schnell S, Allen BD, Robinson JD, Markl M. 4-D flow MRI aortic 3-D hemodynamics and wall shear stress remain stable over short-term follow-up in pediatric and young adult patients with bicuspid aortic valve. Pediatr Radiol. 2019 01; 49(1):57-67. PMID: 30203126.
      View in: PubMed
    17. Ma LE, Vali A, Blanken C, Barker AJ, Malaisrie C, McCarthy P, Collins JD, Carr JC, Schnell S, Markl M. Altered Aortic 3-Dimensional Hemodynamics in Patients With Functionally Unicuspid Aortic Valves. Circ Cardiovasc Imaging. 2018 Aug; 11(8):e007915. PMID: 30354500.
      View in: PubMed
    18. Borger MA, Fedak PWM, Stephens EH, Gleason TG, Girdauskas E, Ikonomidis JS, Khoynezhad A, Siu SC, Verma S, Hope MD, Cameron DE, Hammer DF, Coselli JS, Moon MR, Sundt TM, Barker AJ, Markl M, Della Corte A, Michelena HI, Elefteriades JA. The American Association for Thoracic Surgery consensus guidelines on bicuspid aortic valve-related aortopathy: Full online-only version. J Thorac Cardiovasc Surg. 2018 Aug; 156(2):e41-e74. PMID: 30011777.
      View in: PubMed
    19. Borger MA, Fedak PWM, Stephens EH, Gleason TG, Girdauskas E, Ikonomidis JS, Khoynezhad A, Siu SC, Verma S, Hope MD, Cameron DE, Hammer DF, Coselli JS, Moon MR, Sundt TM, Barker AJ, Markl M, Della Corte A, Michelena HI, Elefteriades JA. The American Association for Thoracic Surgery consensus guidelines on bicuspid aortic valve-related aortopathy: Executive summary. J Thorac Cardiovasc Surg. 2018 Aug; 156(2):473-480. PMID: 30011756.
      View in: PubMed
    20. Schäfer M, Wilson N, Ivy DD, Ing R, Abman S, Browne LP, Morgan G, Ross M, McLennan D, Barker AJ, Fonseca B, Di Maria M, Hunter KS, Truong U. Noninvasive wave intensity analysis predicts functional worsening in children with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol. 2018 Oct 01; 315(4):H968-H977. PMID: 30004811.
      View in: PubMed
    21. Bollache E, Guzzardi DG, Sattari S, Olsen KE, Di Martino ES, Malaisrie SC, van Ooij P, Collins J, Carr J, McCarthy PM, Markl M, Barker AJ, Fedak PWM. Aortic valve-mediated wall shear stress is heterogeneous and predicts regional aortic elastic fiber thinning in bicuspid aortic valve-associated aortopathy. J Thorac Cardiovasc Surg. 2018 Dec; 156(6):2112-2120.e2. PMID: 30060930.
      View in: PubMed
    22. Schäfer M, Truong U, Ivy DD, Fonseca B, Malone L, DiMaria M, Barker AJ, Vargas D, Hunter KS, Jone PN, Browne LP. Children with kawasaki disease present elevated stiffness of great arteries: Phase-contrast MRI study. J Magn Reson Imaging. 2018 11; 48(5):1228-1236. PMID: 29707843.
      View in: PubMed
    23. Schäfer M, Morgan GJ, Mitchell MB, Ross M, Barker AJ, Hunter KS, Fonseca B, DiMaria M, Vargas D, Ivy DD, Wilson N, Browne LP. Impact of different coarctation therapies on aortic stiffness: phase-contrast MRI study. Int J Cardiovasc Imaging. 2018 Sep; 34(9):1459-1469. PMID: 29667078.
      View in: PubMed
    24. Barker AJ, Markl M, Fedak PWM. Assessing wall stresses in bicuspid aortic valve-associated aortopathy: Forecasting the perfect storm? J Thorac Cardiovasc Surg. 2018 Aug; 156(2):471-472. PMID: 29666014.
      View in: PubMed
    25. Schäfer M, Barker AJ, Kheyfets V, Stenmark KR, Crapo J, Yeager ME, Truong U, Buckner JK, Fenster BE, Hunter KS. Helicity and Vorticity of Pulmonary Arterial Flow in Patients With Pulmonary Hypertension: Quantitative Analysis of Flow Formations. J Am Heart Assoc. 2017 Dec 20; 6(12). PMID: 29263034.
      View in: PubMed
    26. Geiger J, Rahsepar AA, Suwa K, Powell A, Ghasemiesfe A, Barker AJ, Collins JD, Carr JC, Markl M. 4D flow MRI, cardiac function, and T1 -mapping: Association of valve-mediated changes in aortic hemodynamics with left ventricular remodeling. J Magn Reson Imaging. 2018 07; 48(1):121-131. PMID: 29206322.
      View in: PubMed
    27. Bollache E, Fedak PWM, van Ooij P, Rahman O, Malaisrie SC, McCarthy PM, Carr JC, Powell A, Collins JD, Markl M, Barker AJ. Perioperative evaluation of regional aortic wall shear stress patterns in patients undergoing aortic valve and/or proximal thoracic aortic replacement. J Thorac Cardiovasc Surg. 2018 Jun; 155(6):2277-2286.e2. PMID: 29248286.
      View in: PubMed
    28. Keenan KE, Ainslie M, Barker AJ, Boss MA, Cecil KM, Charles C, Chenevert TL, Clarke L, Evelhoch JL, Finn P, Gembris D, Gunter JL, Hill DLG, Jack CR, Jackson EF, Liu G, Russek SE, Sharma SD, Steckner M, Stupic KF, Trzasko JD, Yuan C, Zheng J. Quantitative magnetic resonance imaging phantoms: A review and the need for a system phantom. Magn Reson Med. 2018 Jan; 79(1):48-61. PMID: 29083101.
      View in: PubMed
    29. Schäfer M, Kheyfets VO, Barker AJ, Stenmark K, Hunter KS, McClatchey PM, Buckner JK, Reece TB, Jazaeri O, Fenster BE. Reduced shear stress and associated aortic deformation in the thoracic aorta of patients with chronic obstructive pulmonary disease. J Vasc Surg. 2018 07; 68(1):246-253. PMID: 28986100.
      View in: PubMed
    30. Shen X, Schnell S, Barker AJ, Suwa K, Tashakkor L, Jarvis K, Carr JC, Collins JD, Prabhakaran S, Markl M. Voxel-by-voxel 4D flow MRI-based assessment of regional reverse flow in the aorta. J Magn Reson Imaging. 2018 05; 47(5):1276-1286. PMID: 28925047.
      View in: PubMed
    31. Condemi F, Campisi S, Viallon M, Troalen T, Xuexin G, Barker AJ, Markl M, Croisille P, Trabelsi O, Cavinato C, Duprey A, Avril S. Fluid- and Biomechanical Analysis of Ascending Thoracic Aorta Aneurysm with Concomitant Aortic Insufficiency. Ann Biomed Eng. 2017 12; 45(12):2921-2932. PMID: 28905268.
      View in: PubMed
    32. van Ooij P, Markl M, Collins JD, Carr JC, Rigsby C, Bonow RO, Malaisrie SC, McCarthy PM, Fedak PWM, Barker AJ. Aortic Valve Stenosis Alters Expression of Regional Aortic Wall Shear Stress: New Insights From a 4-Dimensional Flow Magnetic Resonance Imaging Study of 571 Subjects. J Am Heart Assoc. 2017 Sep 13; 6(9). PMID: 28903936.
      View in: PubMed
    33. Fatehi Hassanabad A, Barker AJ, Guzzardi D, Markl M, Malaisrie C, McCarthy PM, Fedak PWM. Evolution of Precision Medicine and Surgical Strategies for Bicuspid Aortic Valve-Associated Aortopathy. Front Physiol. 2017; 8:475. PMID: 28740468.
      View in: PubMed
    34. Garcia J, van der Palen RLF, Bollache E, Jarvis K, Rose MJ, Barker AJ, Collins JD, Carr JC, Robinson J, Rigsby CK, Markl M. Distribution of blood flow velocity in the normal aorta: Effect of age and gender. J Magn Reson Imaging. 2018 02; 47(2):487-498. PMID: 28556277.
      View in: PubMed
    35. Beretta D, Barker AJ, Maqueira-Albo I, Calloni A, Bussetti G, Dell'Erba G, Luzio A, Duò L, Petrozza A, Lanzani G, Caironi M. Thermoelectric Properties of Highly Conductive Poly(3,4-ethylenedioxythiophene) Polystyrene Sulfonate Printed Thin Films. ACS Appl Mater Interfaces. 2017 May 31; 9(21):18151-18160. PMID: 28466635.
      View in: PubMed
    36. Gurung A, Gates PE, Mazzaro L, Fulford J, Zhang F, Barker AJ, Hertzberg J, Aizawa K, Strain WD, Elyas S, Shore AC, Shandas R. Echo Particle Image Velocimetry for Estimation of Carotid Artery Wall Shear Stress: Repeatability, Reproducibility and Comparison with Phase-Contrast Magnetic Resonance Imaging. Ultrasound Med Biol. 2017 08; 43(8):1618-1627. PMID: 28501327.
      View in: PubMed
    37. Raghav V, Barker AJ, Mangiameli D, Mirabella L, Markl M, Yoganathan AP. Valve mediated hemodynamics and their association with distal ascending aortic diameter in bicuspid aortic valve subjects. J Magn Reson Imaging. 2018 01; 47(1):246-254. PMID: 28390180.
      View in: PubMed
    38. Trinh B, Dubin I, Rahman O, Ferreira Botelho MP, Naro N, Carr JC, Collins JD, Barker AJ. Aortic Volumetry at Contrast-Enhanced Magnetic Resonance Angiography: Feasibility as a Sensitive Method for Monitoring Bicuspid Aortic Valve Aortopathy. Invest Radiol. 2017 04; 52(4):216-222. PMID: 27861233.
      View in: PubMed
    39. Schäfer M, Ivy DD, Barker AJ, Kheyfets V, Shandas R, Abman SH, Hunter KS, Truong U. Characterization of CMR-derived haemodynamic data in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2017 Apr 01; 18(4):424-431. PMID: 27444679.
      View in: PubMed
    40. Geiger J, Hirtler D, Gottfried K, Rahman O, Bollache E, Barker AJ, Markl M, Stiller B. Longitudinal Evaluation of Aortic Hemodynamics in Marfan Syndrome: New Insights from a 4D Flow Cardiovascular Magnetic Resonance Multi-Year Follow-Up Study. J Cardiovasc Magn Reson. 2017 Mar 22; 19(1):33. PMID: 28327193.
      View in: PubMed
    41. van der Palen RL, Barker AJ, Bollache E, Garcia J, Rose MJ, van Ooij P, Young LT, Roest AA, Markl M, Robinson JD, Rigsby CK. Altered aortic 3D hemodynamics and geometry in pediatric Marfan syndrome patients. J Cardiovasc Magn Reson. 2017 Mar 17; 19(1):30. PMID: 28302143.
      View in: PubMed
    42. Murphy IG, Collins J, Powell A, Markl M, McCarthy P, Malaisrie SC, Carr JC, Barker AJ. Comprehensive 4-stage categorization of bicuspid aortic valve leaflet morphology by cardiac MRI in 386 patients. Int J Cardiovasc Imaging. 2017 Aug; 33(8):1213-1221. PMID: 28299607.
      View in: PubMed
    43. Bollache E, Barker AJ, Dolan RS, Carr JC, van Ooij P, Ahmadian R, Powell A, Collins JD, Geiger J, Markl M. k-t accelerated aortic 4D flow MRI in under two minutes: Feasibility and impact of resolution, k-space sampling patterns, and respiratory navigator gating on hemodynamic measurements. Magn Reson Med. 2018 Jan; 79(1):195-207. PMID: 28266062.
      View in: PubMed
    44. Disha K, Dubslaff G, Rouman M, Fey B, Borger MA, Barker AJ, Kuntze T, Girdauskas E. Evidence of subannular and left ventricular morphological differences in patients with bicuspid versus tricuspid aortic valve stenosis: magnetic resonance imaging-based analysis. Interact Cardiovasc Thorac Surg. 2017 03 01; 24(3):369-376. PMID: 28040769.
      View in: PubMed
    45. Shan Y, Li J, Wang Y, Wu B, Barker AJ, Markl M, Wang C, Wang X, Shu X. Aortic shear stress in patients with bicuspid aortic valve with stenosis and insufficiency. J Thorac Cardiovasc Surg. 2017 Jun; 153(6):1263-1272.e1. PMID: 28268004.
      View in: PubMed
    46. Schäfer M, Ivy DD, Abman SH, Barker AJ, Browne LP, Fonseca B, Kheyfets V, Hunter KS, Truong U. Apparent Aortic Stiffness in Children With Pulmonary Arterial Hypertension: Existence of Vascular Interdependency? Circ Cardiovasc Imaging. 2017 02; 10(2). PMID: 28193613.
      View in: PubMed
    47. McCormick ME, Manduchi E, Witschey WRT, Gorman RC, Gorman JH, Jiang YZ, Stoeckert CJ, Barker AJ, Yoon S, Markl M, Davies PF. Spatial phenotyping of the endocardial endothelium as a function of intracardiac hemodynamic shear stress. J Biomech. 2017 01 04; 50:11-19. PMID: 27916240.
      View in: PubMed
    48. Jarvis K, Vonder M, Barker AJ, Schnell S, Rose M, Carr J, Robinson JD, Markl M, Rigsby CK. Hemodynamic evaluation in patients with transposition of the great arteries after the arterial switch operation: 4D flow and 2D phase contrast cardiovascular magnetic resonance compared with Doppler echocardiography. J Cardiovasc Magn Reson. 2016 Sep 22; 18(1):59. PMID: 27659876.
      View in: PubMed
    49. Garcia J, Barker AJ, Collins JD, Carr JC, Markl M. Volumetric quantification of absolute local normalized helicity in patients with bicuspid aortic valve and aortic dilatation. Magn Reson Med. 2017 08; 78(2):689-701. PMID: 27539068.
      View in: PubMed
    50. Schnell S, Smith DA, Barker AJ, Entezari P, Honarmand AR, Carr ML, Malaisrie SC, McCarthy PM, Collins J, Carr JC, Markl M. Altered aortic shape in bicuspid aortic valve relatives influences blood flow patterns. Eur Heart J Cardiovasc Imaging. 2016 Nov; 17(11):1239-1247. PMID: 27461208.
      View in: PubMed
    51. Bollache E, van Ooij P, Powell A, Carr J, Markl M, Barker AJ. Comparison of 4D flow and 2D velocity-encoded phase contrast MRI sequences for the evaluation of aortic hemodynamics. Int J Cardiovasc Imaging. 2016 Oct; 32(10):1529-41. PMID: 27435230.
      View in: PubMed
    52. Jarvis K, Schnell S, Barker AJ, Garcia J, Lorenz R, Rose M, Chowdhary V, Carr J, Robinson JD, Rigsby CK, Markl M. Evaluation of blood flow distribution asymmetry and vascular geometry in patients with Fontan circulation using 4-D flow MRI. Pediatr Radiol. 2016 Oct; 46(11):1507-19. PMID: 27350377.
      View in: PubMed
    53. Freed BH, Collins JD, François CJ, Barker AJ, Cuttica MJ, Chesler NC, Markl M, Shah SJ. MR and CT Imaging for the Evaluation of Pulmonary Hypertension. JACC Cardiovasc Imaging. 2016 06; 9(6):715-32. PMID: 27282439.
      View in: PubMed
    54. Keller EJ, Malaisrie SC, Kruse J, McCarthy PM, Carr JC, Markl M, Barker AJ, Collins JD. Reduction of aberrant aortic haemodynamics following aortic root replacement with a mechanical valved conduit. Interact Cardiovasc Thorac Surg. 2016 09; 23(3):416-23. PMID: 27245620.
      View in: PubMed
    55. Rose MJ, Jarvis K, Chowdhary V, Barker AJ, Allen BD, Robinson JD, Markl M, Rigsby CK, Schnell S. Efficient method for volumetric assessment of peak blood flow velocity using 4D flow MRI. J Magn Reson Imaging. 2016 12; 44(6):1673-1682. PMID: 27192153.
      View in: PubMed
    56. Fedak PWM, Barker AJ. Is Concomitant Aortopathy Unique With Bicuspid Aortic Valve Stenosis? J Am Coll Cardiol. 2016 Apr 19; 67(15):1797-1799. PMID: 27081019.
      View in: PubMed
    57. McCormick ME, Manduchi E, Witschey WR, Gorman RC, Gorman JH, Jiang YZ, Stoeckert CJ, Barker AJ, Markl M, Davies PF. Integrated Regional Cardiac Hemodynamic Imaging and RNA Sequencing Reveal Corresponding Heterogeneity of Ventricular Wall Shear Stress and Endocardial Transcriptome. J Am Heart Assoc. 2016 Apr 18; 5(4):e003170. PMID: 27091183.
      View in: PubMed
    58. Barker AJ, Guzzardi D, Markl M, Fedak PW. Reply: Importance of Stress Mapping of Aortic Wall in Aortic Valve Disease. J Am Coll Cardiol. 2016 Apr 12; 67(14):1756-7. PMID: 27056787.
      View in: PubMed
    59. Markl M, Schnell S, Wu C, Bollache E, Jarvis K, Barker AJ, Robinson JD, Rigsby CK. Advanced flow MRI: emerging techniques and applications. Clin Radiol. 2016 Aug; 71(8):779-95. PMID: 26944696.
      View in: PubMed
    60. von Knobelsdorff-Brenkenhoff F, Karunaharamoorthy A, Trauzeddel RF, Barker AJ, Blaszczyk E, Markl M, Schulz-Menger J. Evaluation of Aortic Blood Flow and Wall Shear Stress in Aortic Stenosis and Its Association With Left Ventricular Remodeling. Circ Cardiovasc Imaging. 2016 Mar; 9(3):e004038. PMID: 26917824.
      View in: PubMed
    61. Fedak PW, Barker AJ, Verma S. Year in review: bicuspid aortopathy. Curr Opin Cardiol. 2016 Mar; 31(2):132-8. PMID: 26808007.
      View in: PubMed
    62. Guzzardi DG, Barker AJ, Markl M, Fedak PWM. Reply: Final Common Pathway of Aortic Dilation?: Heterogeneity of Aortic Wall Property Causes the Aneurysmal Change. J Am Coll Cardiol. 2016 Feb 16; 67(6):735-736. PMID: 26868701.
      View in: PubMed
    63. Markl M, Wagner GJ, Barker AJ. Re: Blood flow analysis of the aortic arch using computational fluid dynamics. Eur J Cardiothorac Surg. 2016 06; 49(6):1586-7. PMID: 26819284.
      View in: PubMed
    64. Allen BD, Markl M, Barker AJ, van Ooij P, Carr JC, Malaisrie SC, McCarthy P, Bonow RO, Kansal P. Influence of beta-blocker therapy on aortic blood flow in patients with bicuspid aortic valve. Int J Cardiovasc Imaging. 2016 Apr; 32(4):621-8. PMID: 26817758.
      View in: PubMed
    65. Hirtler D, Garcia J, Barker AJ, Geiger J. Assessment of intracardiac flow and vorticity in the right heart of patients after repair of tetralogy of Fallot by flow-sensitive 4D MRI. Eur Radiol. 2016 Oct; 26(10):3598-607. PMID: 26747260.
      View in: PubMed
    66. Trauzeddel RF, Löbe U, Barker AJ, Gelsinger C, Butter C, Markl M, Schulz-Menger J, von Knobelsdorff-Brenkenhoff F. Blood flow characteristics in the ascending aorta after TAVI compared to surgical aortic valve replacement. Int J Cardiovasc Imaging. 2016 Mar; 32(3):461-7. PMID: 26493195.
      View in: PubMed
    67. van Ooij P, Garcia J, Potters WV, Malaisrie SC, Collins JD, Carr JC, Markl M, Barker AJ. Age-related changes in aortic 3D blood flow velocities and wall shear stress: Implications for the identification of altered hemodynamics in patients with aortic valve disease. J Magn Reson Imaging. 2016 May; 43(5):1239-49. PMID: 26477691.
      View in: PubMed
    68. Grancini G, Srimath Kandada AR, Frost JM, Barker AJ, De Bastiani M, Gandini M, Marras S, Lanzani G, Walsh A, Petrozza A. Role of Microstructure in the Electron-Hole Interaction of Hybrid Lead-Halide Perovskites. Nat Photonics. 2015 Oct 01; 9(10):695-701. PMID: 26442125.
      View in: PubMed
    69. Han QJ, Witschey WR, Fang-Yen CM, Arkles JS, Barker AJ, Forfia PR, Han Y. Altered Right Ventricular Kinetic Energy Work Density and Viscous Energy Dissipation in Patients with Pulmonary Arterial Hypertension: A Pilot Study Using 4D Flow MRI. PLoS One. 2015; 10(9):e0138365. PMID: 26418553.
      View in: PubMed
    70. Truong U, Patel S, Kheyfets V, Dunning J, Fonseca B, Barker AJ, Ivy D, Shandas R, Hunter K. Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension. J Cardiovasc Magn Reson. 2015 Sep 16; 17:81. PMID: 26376972.
      View in: PubMed
    71. Garcia J, Barker AJ, Murphy I, Jarvis K, Schnell S, Collins JD, Carr JC, Malaisrie SC, Markl M. Four-dimensional flow magnetic resonance imaging-based characterization of aortic morphometry and haemodynamics: impact of age, aortic diameter, and valve morphology. Eur Heart J Cardiovasc Imaging. 2016 Aug; 17(8):877-84. PMID: 26377908.
      View in: PubMed
    72. Guzzardi DG, Barker AJ, van Ooij P, Malaisrie SC, Puthumana JJ, Belke DD, Mewhort HE, Svystonyuk DA, Kang S, Verma S, Collins J, Carr J, Bonow RO, Markl M, Thomas JD, McCarthy PM, Fedak PW. Valve-Related Hemodynamics Mediate Human Bicuspid Aortopathy: Insights From Wall Shear Stress Mapping. J Am Coll Cardiol. 2015 Aug 25; 66(8):892-900. PMID: 26293758.
      View in: PubMed
    73. Cibis M, Jarvis K, Markl M, Rose M, Rigsby C, Barker AJ, Wentzel JJ. The effect of resolution on viscous dissipation measured with 4D flow MRI in patients with Fontan circulation: Evaluation using computational fluid dynamics. J Biomech. 2015 Sep 18; 48(12):2984-9. PMID: 26298492.
      View in: PubMed
    74. Dyverfeldt P, Bissell M, Barker AJ, Bolger AF, Carlhäll CJ, Ebbers T, Francios CJ, Frydrychowicz A, Geiger J, Giese D, Hope MD, Kilner PJ, Kozerke S, Myerson S, Neubauer S, Wieben O, Markl M. 4D flow cardiovascular magnetic resonance consensus statement. J Cardiovasc Magn Reson. 2015 Aug 10; 17:72. PMID: 26257141.
      View in: PubMed
    75. van Ooij P, Allen BD, Contaldi C, Garcia J, Collins J, Carr J, Choudhury L, Bonow RO, Barker AJ, Markl M. 4D flow MRI and T1 -Mapping: Assessment of altered cardiac hemodynamics and extracellular volume fraction in hypertrophic cardiomyopathy. J Magn Reson Imaging. 2016 Jan; 43(1):107-14. PMID: 26227419.
      View in: PubMed
    76. van Ooij P, Powell AL, Potters WV, Carr JC, Markl M, Barker AJ. Reproducibility and interobserver variability of systolic blood flow velocity and 3D wall shear stress derived from 4D flow MRI in the healthy aorta. J Magn Reson Imaging. 2016 Jan; 43(1):236-48. PMID: 26140480.
      View in: PubMed
    77. Witschey WR, Zhang D, Contijoch F, McGarvey JR, Lee M, Takebayashi S, Aoki C, Han Y, Han J, Barker AJ, Pilla JJ, Gorman RC, Gorman JH. The Influence of Mitral Annuloplasty on Left Ventricular Flow Dynamics. Ann Thorac Surg. 2015 Jul; 100(1):114-121. PMID: 25975941.
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    78. van Ooij P, Semaan E, Schnell S, Giri S, Stankovic Z, Carr J, Barker AJ, Markl M. Improved respiratory navigator gating for thoracic 4D flow MRI. Magn Reson Imaging. 2015 Oct; 33(8):992-9. PMID: 25940391.
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    79. Allen BD, van Ooij P, Barker AJ, Carr M, Gabbour M, Schnell S, Jarvis KB, Carr JC, Markl M, Rigsby C, Robinson JD. Thoracic aorta 3D hemodynamics in pediatric and young adult patients with bicuspid aortic valve. J Magn Reson Imaging. 2015 Oct; 42(4):954-63. PMID: 25644073.
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    80. Mirabella L, Barker AJ, Saikrishnan N, Coco ER, Mangiameli DJ, Markl M, Yoganathan AP. MRI-based Protocol to Characterize the Relationship Between Bicuspid Aortic Valve Morphology and Hemodynamics. Ann Biomed Eng. 2015 Aug; 43(8):1815-27. PMID: 25533768.
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    81. Chen K, Barker AJ, Morgan FL, Halpert JE, Hodgkiss JM. Effect of Carrier Thermalization Dynamics on Light Emission and Amplification in Organometal Halide Perovskites. J Phys Chem Lett. 2015 Jan 02; 6(1):153-8. PMID: 26263104.
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    82. Mahadevia R, Barker AJ, Schnell S, Entezari P, Kansal P, Fedak PW, Malaisrie SC, McCarthy P, Collins J, Carr J, Markl M. Response to letter regarding article, "Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy". Circulation. 2014 Nov 04; 130(19):e171. PMID: 25366843.
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    83. Garcia J, Barker AJ, van Ooij P, Schnell S, Puthumana J, Bonow RO, Collins JD, Carr JC, Markl M. Assessment of altered three-dimensional blood characteristics in aortic disease by velocity distribution analysis. Magn Reson Med. 2015 Sep; 74(3):817-25. PMID: 25252029.
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    84. Barker AJ, Chen K, Hodgkiss JM. Distance distributions of photogenerated charge pairs in organic photovoltaic cells. J Am Chem Soc. 2014 Aug 27; 136(34):12018-26. PMID: 25102389.
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    85. van Ooij P, Potters WV, Collins J, Carr M, Carr J, Malaisrie SC, Fedak PW, McCarthy PM, Markl M, Barker AJ. Characterization of abnormal wall shear stress using 4D flow MRI in human bicuspid aortopathy. Ann Biomed Eng. 2015 Jun; 43(6):1385-97. PMID: 25118671.
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    86. Allen BD, Choudhury L, Barker AJ, van Ooij P, Collins JD, Bonow RO, Carr JC, Markl M. Three-dimensional haemodynamics in patients with obstructive and non-obstructive hypertrophic cardiomyopathy assessed by cardiac magnetic resonance. Eur Heart J Cardiovasc Imaging. 2015 Jan; 16(1):29-36. PMID: 25108915.
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    87. Barker AJ, Roldán-Alzate A, Entezari P, Shah SJ, Chesler NC, Wieben O, Markl M, François CJ. Four-dimensional flow assessment of pulmonary artery flow and wall shear stress in adult pulmonary arterial hypertension: results from two institutions. Magn Reson Med. 2015 May; 73(5):1904-13. PMID: 24974951.
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    88. Chen K, Gallaher JK, Barker AJ, Hodgkiss JM. Transient Grating Photoluminescence Spectroscopy: An Ultrafast Method of Gating Broadband Spectra. J Phys Chem Lett. 2014 May 15; 5(10):1732-7. PMID: 26270375.
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    89. Markl M, Schnell S, Barker AJ. 4D flow imaging: current status to future clinical applications. Curr Cardiol Rep. 2014 May; 16(5):481. PMID: 24700368.
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    90. Garcia J, Markl M, Schnell S, Allen B, Entezari P, Mahadevia R, Chris Malaisrie S, Pibarot P, Carr J, Barker AJ. Evaluation of aortic stenosis severity using 4D flow jet shear layer detection for the measurement of valve effective orifice area. Magn Reson Imaging. 2014 Sep; 32(7):891-8. PMID: 24865143.
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    91. van Ooij P, Potters WV, Nederveen AJ, Allen BD, Collins J, Carr J, Malaisrie SC, Markl M, Barker AJ. A methodology to detect abnormal relative wall shear stress on the full surface of the thoracic aorta using four-dimensional flow MRI. Magn Reson Med. 2015 Mar; 73(3):1216-27. PMID: 24753241.
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    92. Bissell MM, Hess AT, Biasiolli L, Glaze SJ, Loudon M, Pitcher A, Davis A, Prendergast B, Markl M, Barker AJ, Neubauer S, Myerson SG. Response to letter regarding article, "Aortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type". Circ Cardiovasc Imaging. 2014 Jan; 7(1):214. PMID: 24449556.
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    93. Mahadevia R, Barker AJ, Schnell S, Entezari P, Kansal P, Fedak PW, Malaisrie SC, McCarthy P, Collins J, Carr J, Markl M. Bicuspid aortic cusp fusion morphology alters aortic three-dimensional outflow patterns, wall shear stress, and expression of aortopathy. Circulation. 2014 Feb 11; 129(6):673-82. PMID: 24345403.
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    94. von Knobelsdorff-Brenkenhoff F, Trauzeddel RF, Barker AJ, Gruettner H, Markl M, Schulz-Menger J. Blood flow characteristics in the ascending aorta after aortic valve replacement--a pilot study using 4D-flow MRI. Int J Cardiol. 2014 Jan 01; 170(3):426-33. PMID: 24315151.
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    95. Chen K, Barker AJ, Reish ME, Gordon KC, Hodgkiss JM. Broadband ultrafast photoluminescence spectroscopy resolves charge photogeneration via delocalized hot excitons in polymer:fullerene photovoltaic blends. J Am Chem Soc. 2013 Dec 11; 135(49):18502-12. PMID: 24206394.
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    96. Entezari P, Schnell S, Mahadevia R, Malaisrie C, McCarthy P, Mendelson M, Collins J, Carr JC, Markl M, Barker AJ. From unicuspid to quadricuspid: influence of aortic valve morphology on aortic three-dimensional hemodynamics. J Magn Reson Imaging. 2014 Dec; 40(6):1342-6. PMID: 24265266.
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    97. Lamata P, Pitcher A, Krittian S, Nordsletten D, Bissell MM, Cassar T, Barker AJ, Markl M, Neubauer S, Smith NP. Aortic relative pressure components derived from four-dimensional flow cardiovascular magnetic resonance. Magn Reson Med. 2014 Oct; 72(4):1162-9. PMID: 24243444.
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    98. Allen BD, Barker AJ, Kansal P, Collins JD, Carr JC, Malaisrie SC, Markl M. Impact of aneurysm repair on thoracic aorta hemodynamics. Circulation. 2013 Oct 22; 128(17):e341-3. PMID: 24146124.
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    99. Barker AJ, van Ooij P, Bandi K, Garcia J, Albaghdadi M, McCarthy P, Bonow RO, Carr J, Collins J, Malaisrie SC, Markl M. Viscous energy loss in the presence of abnormal aortic flow. Magn Reson Med. 2014 Sep; 72(3):620-8. PMID: 24122967.
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    100. Truong U, Fonseca B, Dunning J, Burgett S, Lanning C, Ivy DD, Shandas R, Hunter K, Barker AJ. Wall shear stress measured by phase contrast cardiovascular magnetic resonance in children and adolescents with pulmonary arterial hypertension. J Cardiovasc Magn Reson. 2013 Sep 13; 15:81. PMID: 24034144.
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    101. Barker AJ, Robinson JD, Markl M. Bicuspid aortic valve phenotype and aortopathy: nomenclature and role of aortic hemodynamics. JACC Cardiovasc Imaging. 2013 Aug; 6(8):921. PMID: 23948381.
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    102. Harloff A, Berg S, Barker AJ, Schöllhorn J, Schumacher M, Weiller C, Markl M. Wall shear stress distribution at the carotid bifurcation: influence of eversion carotid endarterectomy. Eur Radiol. 2013 Dec; 23(12):3361-9. PMID: 23812310.
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    103. McGarvey JR, Kondo N, Takebe M, Koomalsingh KJ, Witschey WR, Barker AJ, Markl M, Takebayashi S, Shimaoka T, Gorman JH, Gorman RC, Pilla JJ. Directed epicardial assistance in ischemic cardiomyopathy: flow and function using cardiac magnetic resonance imaging. Ann Thorac Surg. 2013 Aug; 96(2):577-85. PMID: 23810178.
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    104. Markl M, Brendecke SM, Simon J, Barker AJ, Weiller C, Harloff A. Co-registration of the distribution of wall shear stress and 140 complex plaques of the aorta. Magn Reson Imaging. 2013 Sep; 31(7):1156-62. PMID: 23773622.
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    105. Bissell MM, Hess AT, Biasiolli L, Glaze SJ, Loudon M, Pitcher A, Davis A, Prendergast B, Markl M, Barker AJ, Neubauer S, Myerson SG. Aortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type. Circ Cardiovasc Imaging. 2013 Jul; 6(4):499-507. PMID: 23771987.
      View in: PubMed
    106. Lorenz R, Bock J, Barker AJ, von Knobelsdorff-Brenkenhoff F, Wallis W, Korvink JG, Bissell MM, Schulz-Menger J, Markl M. 4D flow magnetic resonance imaging in bicuspid aortic valve disease demonstrates altered distribution of aortic blood flow helicity. Magn Reson Med. 2014 Apr; 71(4):1542-53. PMID: 23716466.
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    107. Allen BD, Barker AJ, Carr JC, Silverberg RA, Markl M. Time-resolved three-dimensional phase contrast MRI evaluation of bicuspid aortic valve and coarctation of the aorta. Eur Heart J Cardiovasc Imaging. 2013 Apr; 14(4):399. PMID: 23111692.
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    108. Barker AJ, Markl M, Bürk J, Lorenz R, Bock J, Bauer S, Schulz-Menger J, von Knobelsdorff-Brenkenhoff F. Bicuspid aortic valve is associated with altered wall shear stress in the ascending aorta. Circ Cardiovasc Imaging. 2012 Jul; 5(4):457-66. PMID: 22730420.
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    109. Barker AJ, Staehle F, Bock J, Jung BA, Markl M. Analysis of complex cardiovascular flow with three-component acceleration-encoded MRI. Magn Reson Med. 2012 Jan; 67(1):50-61. PMID: 21590722.
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    110. Bock J, Frydrychowicz A, Lorenz R, Hirtler D, Barker AJ, Johnson KM, Arnold R, Burkhardt H, Hennig J, Markl M. In vivo noninvasive 4D pressure difference mapping in the human aorta: phantom comparison and application in healthy volunteers and patients. Magn Reson Med. 2011 Oct; 66(4):1079-88. PMID: 21437978.
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    111. Zhang F, Lanning C, Mazzaro L, Barker AJ, Gates PE, Strain WD, Fulford J, Gosling OE, Shore AC, Bellenger NG, Rech B, Chen J, Chen J, Shandas R. In vitro and preliminary in vivo validation of echo particle image velocimetry in carotid vascular imaging. Ultrasound Med Biol. 2011 Mar; 37(3):450-64. PMID: 21316562.
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    112. Barker AJ, Markl M. The role of hemodynamics in bicuspid aortic valve disease. Eur J Cardiothorac Surg. 2011 Jun; 39(6):805-6. PMID: 21339071.
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    113. Barker AJ, Lanning C, Shandas R. Quantification of hemodynamic wall shear stress in patients with bicuspid aortic valve using phase-contrast MRI. Ann Biomed Eng. 2010 Mar; 38(3):788-800. PMID: 19953319.
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    114. Zheng H, Barker A, Shandas R. Predicting backscatter characteristics from micron- and submicron-scale ultrasound contrast agents using a size-integration technique. IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Mar; 53(3):639-44. PMID: 16555773.
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