Quentin Jerome Vicens
Title | Asst Professor-Research |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-BioChem&Molecular Genetics |
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Biography 2019 | Faculty Member of the Year (Chemical Biology) , Faculty Opinions | 2013 | Distinguished Educator, Turning Technologies |
Overview Current research focuses on viral structured elements, as well as on cellular targets of the deaminase ADAR1, using collaborative strategies that integrate several molecular and structural biology approaches.
Research RBI 2020 RNA-seq Pilot Award (Vicens)Jan 1, 2021 - Dec 31, 2021 RNA Bioscience Initiative Using RNA-seq to determine the biological role of the Z-RNA binding domain of ADAR1 during the interferon response Role Description: This award from the RNA Bioscience Initiative (RBI) at the University of Colorado Anschutz Medical Campus supports the use of RNA-seq and its analysis to enhance basic science, translational, and clinical studies. Role: PI |
| R21AI157244 (VICENS, QUENTIN)Dec 15, 2020 - Nov 30, 2022 NIH Structural determinants of viral RNAs resistant to exoribonucleases in the alphavirus supergroup Role: Principal Investigator |
Bibliographic
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Vicens Q, Kieft JS. Thoughts on how to think (and talk) about RNA structure. Proc Natl Acad Sci U S A. 2022 04 26; 119(17):e2112677119. PMID: 35439059.
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Vicens Q, Kieft JS. Shared properties and singularities of exoribonuclease-resistant RNAs in viruses. Comput Struct Biotechnol J. 2021; 19:4373-4380. PMID: 34471487.
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Herbert A, Karapetyan S, Poptsova M, Vasquez KM, Vicens Q, Vögeli B. Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA. Int J Mol Sci. 2021 Jul 19; 22(14). PMID: 34299306.
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Nichols PJ, Henen MA, Vicens Q, Vögeli B. Solution NMR backbone assignments of the N-terminal Za-linker-Zß segment from Homo sapiens ADAR1p150. Biomol NMR Assign. 2021 10; 15(2):273-279. PMID: 33742389.
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Nichols PJ, Bevers S, Henen M, Kieft JS, Vicens Q, Vögeli B. Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions. Nat Commun. 2021 02 04; 12(1):793. PMID: 33542240.
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Abaeva IS, Vicens Q, Bochler A, Soufari H, Simonetti A, Pestova TV, Hashem Y, Hellen CUT. The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism. Cell Rep. 2020 12 08; 33(10):108476. PMID: 33296660.
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Vicens Q. Special Issue: Frontiers in RNA Structure. Molecules. 2020 Oct 21; 25(20). PMID: 33096601.
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Jones RA, Steckelberg AL, Vicens Q, Szucs MJ, Akiyama BM, Kieft JS. Different tertiary interactions create the same important 3D features in a distinct flavivirus xrRNA. RNA. 2021 01; 27(1):54-65. PMID: 33004436.
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Szucs MJ, Nichols PJ, Jones RA, Vicens Q, Kieft JS. A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of Flaviviridae. mBio. 2020 09 29; 11(5). PMID: 32994331.
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Steckelberg AL, Vicens Q, Costantino DA, Nix JC, Kieft JS. The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold. RNA. 2020 12; 26(12):1767-1776. PMID: 32848042.
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Vicens, Q.
Kim, Y.
Harrowfield, J. Jacques Vicens: an obituary. J Incl Phenom Macrocycl Chem. 2020; 98:123-125.
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Vicens Q, Coumoul X, Souciet JL. A forum where french-speaking faculty can exchange research on teaching. Biochem Mol Biol Educ. 2019 09; 47(5):599-606. PMID: 31141270.
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Steckelberg AL, Vicens Q, Kieft JS. Exoribonuclease-Resistant RNAs Exist within both Coding and Noncoding Subgenomic RNAs. mBio. 2018 12 18; 9(6). PMID: 30563900.
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Vicens Q, Mondragón E, Reyes FE, Coish P, Aristoff P, Berman J, Kaur H, Kells KW, Wickens P, Wilson J, Gadwood RC, Schostarez HJ, Suto RK, Blount KF, Batey RT. Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch. ACS Chem Biol. 2018 10 19; 13(10):2908-2919. PMID: 30107111.
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D'Ascenzo L, Vicens Q, Auffinger P. Identification of receptors for UNCG and GNRA Z-turns and their occurrence in rRNA. Nucleic Acids Res. 2018 09 06; 46(15):7989-7997. PMID: 29986118.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 30526871.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33252739.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11587639.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12925992.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18772866.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21123692.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18768647.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21745821.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19390598.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12589761.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 17397252.
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Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27151194.
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Brito Querido J, Mancera-Martínez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y. The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein. Structure. 2017 12 05; 25(12):1785-1794.e3. PMID: 29107485.
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Gross L, Vicens Q, Einhorn E, Noireterre A, Schaeffer L, Kuhn L, Imler JL, Eriani G, Meignin C, Martin F. The IRES5'UTR of the dicistrovirus cricket paralysis virus is a type III IRES containing an essential pseudoknot structure. Nucleic Acids Res. 2017 Sep 06; 45(15):8993-9004. PMID: 28911115.
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Khusainov I, Vicens Q, Ayupov R, Usachev K, Myasnikov A, Simonetti A, Validov S, Kieffer B, Yusupova G, Yusupov M, Hashem Y. Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF. EMBO J. 2017 07 14; 36(14):2073-2087. PMID: 28645916.
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D'Ascenzo L, Leonarski F, Vicens Q, Auffinger P. Revisiting GNRA and UNCG folds: U-turns versus Z-turns in RNA hairpin loops. RNA. 2017 03; 23(3):259-269. PMID: 27999116.
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Khusainov I, Vicens Q, Bochler A, Grosse F, Myasnikov A, Ménétret JF, Chicher J, Marzi S, Romby P, Yusupova G, Yusupov M, Hashem Y. Structure of the 70S ribosome from human pathogen Staphylococcus aureus. Nucleic Acids Res. 2017 01 25; 45(2):1026. PMID: 28123039.
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Khusainov I, Vicens Q, Bochler A, Grosse F, Myasnikov A, Ménétret JF, Chicher J, Marzi S, Romby P, Yusupova G, Yusupov M, Hashem Y. Structure of the 70S ribosome from human pathogen Staphylococcus aureus. Nucleic Acids Res. 2016 12 01; 44(21):10491-10504. PMID: 27906650.
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Martin F, Ménétret JF, Simonetti A, Myasnikov AG, Vicens Q, Prongidi-Fix L, Natchiar SK, Klaholz BP, Eriani G. Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation. Nat Commun. 2016 08 24; 7:12622. PMID: 27554013.
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Vicens Q, Westhof E. Biogenesis of Circular RNAs. Cell. 2014 Sep 25; 159(1):13-14. PMID: 25259915.
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Vicens Q, Gooding AR, Duarte LF, Batey RT. Preparation of group I introns for biochemical studies and crystallization assays by native affinity purification. PLoS One. 2009 Aug 27; 4(8):e6740. PMID: 19710925.
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Vicens Q, Cech TR. A natural ribozyme with 3',5' RNA ligase activity. Nat Chem Biol. 2009 Feb; 5(2):97-9. PMID: 19125157.
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Vicens Q, Allen MA, Gilbert SD, Reznik B, Gooding AR, Batey RT. The Cech Symposium: a celebration of 25 years of ribozymes, 10 years of TERT, and 60 years of Tom. RNA. 2008 Mar; 14(3):397-403. PMID: 18203922.
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Vicens Q, Gooding AR, Laederach A, Cech TR. Local RNA structural changes induced by crystallization are revealed by SHAPE. RNA. 2007 Apr; 13(4):536-48. PMID: 17299128.
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Vicens Q, Cech TR. Atomic level architecture of group I introns revealed. Trends Biochem Sci. 2006 Jan; 31(1):41-51. PMID: 16356725.
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François B, Russell RJ, Murray JB, Aboul-ela F, Masquida B, Vicens Q, Westhof E. Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding. Nucleic Acids Res. 2005; 33(17):5677-90. PMID: 16214802.
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Vicens Q, Westhof E. RNA as a drug target: the case of aminoglycosides. Chembiochem. 2003 Oct 06; 4(10):1018-23. PMID: 14523919.
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Pfister P, Hobbie S, Vicens Q, Böttger EC, Westhof E. The molecular basis for A-site mutations conferring aminoglycoside resistance: relationship between ribosomal susceptibility and X-ray crystal structures. Chembiochem. 2003 Oct 06; 4(10):1078-88. PMID: 14523926.
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Vicens Q, Westhof E. Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site. Chem Biol. 2002 Jun; 9(6):747-55. PMID: 12079787.
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Walter F, Vicens Q, Westhof E. Aminoglycoside-RNA interactions. Curr Opin Chem Biol. 1999 Dec; 3(6):694-704. PMID: 10600721.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1999 | 1 | 2002 | 1 | 2003 | 2 | 2005 | 2 | 2007 | 1 | 2008 | 1 | 2009 | 2 | 2014 | 1 | 2016 | 4 | 2017 | 3 | 2018 | 15 | 2019 | 1 | 2020 | 6 | 2021 | 4 | 2022 | 1 |
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