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Quentin Jerome Vicens

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Biography 
    Collapse awards and honors
    2019Faculty Member of the Year (Chemical Biology) , Faculty Opinions
    2013Distinguished Educator, Turning Technologies

    Collapse Overview 
    Collapse overview
    Current research focuses on viral structured elements, as well as on cellular targets of the deaminase ADAR1, using collaborative strategies that integrate several molecular and structural biology approaches.

    Collapse Research 
    Collapse research activities and funding
    R21AI157244     (VICENS, QUENTIN)Dec 15, 2020 - Nov 30, 2022
    NIH
    Structural determinants of viral RNAs resistant to exoribonucleases in the alphavirus supergroup
    Role: Principal Investigator
    RBI 2020 RNA-seq Pilot Award     (Vicens)Jan 1, 2021 - Dec 31, 2021
    RNA Bioscience Initiative
    Using RNA-seq to determine the biological role of the Z-RNA binding domain of ADAR1 during the interferon response
    Role Description: This award from the RNA Bioscience Initiative (RBI) at the University of Colorado Anschutz Medical Campus supports the use of RNA-seq and its analysis to enhance basic science, translational, and clinical studies.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nichols PJ, Bevers S, Henen M, Kieft JS, Vicens Q, Vögeli B. Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions. Nat Commun. 2021 02 04; 12(1):793. PMID: 33542240.
      View in: PubMed
    2. Vicens Q, Bochler A, Jobe A, Frank J, Hashem Y. Interaction Networks of Ribosomal Expansion Segments in Kinetoplastids. Subcell Biochem. 2021; 96:433-450. PMID: 33252739.
      View in: PubMed
    3. Abaeva IS, Vicens Q, Bochler A, Soufari H, Simonetti A, Pestova TV, Hashem Y, Hellen CUT. The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism. Cell Rep. 2020 Dec 08; 33(10):108476. PMID: 33296660.
      View in: PubMed
    4. Vicens Q. Special Issue: Frontiers in RNA Structure. Molecules. 2020 Oct 21; 25(20). PMID: 33096601.
      View in: PubMed
    5. Jones RA, Steckelberg AL, Vicens Q, Szucs MJ, Akiyama BM, Kieft JS. Different tertiary interactions create the same important 3D features in a distinct flavivirus xrRNA. RNA. 2021 Jan; 27(1):54-65. PMID: 33004436.
      View in: PubMed
    6. Szucs MJ, Nichols PJ, Jones RA, Vicens Q, Kieft JS. A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of Flaviviridae. mBio. 2020 09 29; 11(5). PMID: 32994331.
      View in: PubMed
    7. Steckelberg AL, Vicens Q, Costantino DA, Nix JC, Kieft JS. The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold. RNA. 2020 12; 26(12):1767-1776. PMID: 32848042.
      View in: PubMed
    8. Vicens, Q. Kim, Y. Harrowfield, J. Jacques Vicens: an obituary. J Incl Phenom Macrocycl Chem. 2020; 98:123-125.
      View Publication
    9. Vicens Q, Coumoul X, Souciet JL. A forum where french-speaking faculty can exchange research on teaching. Biochem Mol Biol Educ. 2019 09; 47(5):599-606. PMID: 31141270.
      View in: PubMed
    10. Steckelberg AL, Vicens Q, Kieft JS. Exoribonuclease-Resistant RNAs Exist within both Coding and Noncoding Subgenomic RNAs. mBio. 2018 12 18; 9(6). PMID: 30563900.
      View in: PubMed
    11. Vicens Q, Kieft JS, Rissland OS. Revisiting the Closed-Loop Model and the Nature of mRNA 5'-3' Communication. Mol Cell. 2018 12 06; 72(5):805-812. PMID: 30526871.
      View in: PubMed
    12. Vicens Q, Mondragón E, Reyes FE, Coish P, Aristoff P, Berman J, Kaur H, Kells KW, Wickens P, Wilson J, Gadwood RC, Schostarez HJ, Suto RK, Blount KF, Batey RT. Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch. ACS Chem Biol. 2018 10 19; 13(10):2908-2919. PMID: 30107111.
      View in: PubMed
    13. D'Ascenzo L, Vicens Q, Auffinger P. Identification of receptors for UNCG and GNRA Z-turns and their occurrence in rRNA. Nucleic Acids Res. 2018 09 06; 46(15):7989-7997. PMID: 29986118.
      View in: PubMed
    14. Brito Querido J, Mancera-Martínez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y. The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein. Structure. 2017 12 05; 25(12):1785-1794.e3. PMID: 29107485.
      View in: PubMed
    15. Gross L, Vicens Q, Einhorn E, Noireterre A, Schaeffer L, Kuhn L, Imler JL, Eriani G, Meignin C, Martin F. The IRES5'UTR of the dicistrovirus cricket paralysis virus is a type III IRES containing an essential pseudoknot structure. Nucleic Acids Res. 2017 Sep 06; 45(15):8993-9004. PMID: 28911115.
      View in: PubMed
    16. Khusainov I, Vicens Q, Ayupov R, Usachev K, Myasnikov A, Simonetti A, Validov S, Kieffer B, Yusupova G, Yusupov M, Hashem Y. Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF. EMBO J. 2017 07 14; 36(14):2073-2087. PMID: 28645916.
      View in: PubMed
    17. D'Ascenzo L, Leonarski F, Vicens Q, Auffinger P. Revisiting GNRA and UNCG folds: U-turns versus Z-turns in RNA hairpin loops. RNA. 2017 03; 23(3):259-269. PMID: 27999116.
      View in: PubMed
    18. Khusainov I, Vicens Q, Bochler A, Grosse F, Myasnikov A, Ménétret JF, Chicher J, Marzi S, Romby P, Yusupova G, Yusupov M, Hashem Y. Structure of the 70S ribosome from human pathogen Staphylococcus aureus. Nucleic Acids Res. 2017 01 25; 45(2):1026. PMID: 28123039.
      View in: PubMed
    19. Khusainov I, Vicens Q, Bochler A, Grosse F, Myasnikov A, Ménétret JF, Chicher J, Marzi S, Romby P, Yusupova G, Yusupov M, Hashem Y. Structure of the 70S ribosome from human pathogen Staphylococcus aureus. Nucleic Acids Res. 2016 12 01; 44(21):10491-10504. PMID: 27906650.
      View in: PubMed
    20. Martin F, Ménétret JF, Simonetti A, Myasnikov AG, Vicens Q, Prongidi-Fix L, Natchiar SK, Klaholz BP, Eriani G. Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation. Nat Commun. 2016 08 24; 7:12622. PMID: 27554013.
      View in: PubMed
    21. D'Ascenzo L, Leonarski F, Vicens Q, Auffinger P. 'Z-DNA like' fragments in RNA: a recurring structural motif with implications for folding, RNA/protein recognition and immune response. Nucleic Acids Res. 2016 07 08; 44(12):5944-56. PMID: 27151194.
      View in: PubMed
    22. Vicens Q, Westhof E. Biogenesis of Circular RNAs. Cell. 2014 Sep 25; 159(1):13-14. PMID: 25259915.
      View in: PubMed
    23. Vicens Q, Mondragón E, Batey RT. Molecular sensing by the aptamer domain of the FMN riboswitch: a general model for ligand binding by conformational selection. Nucleic Acids Res. 2011 Oct; 39(19):8586-98. PMID: 21745821.
      View in: PubMed
    24. Shi J, Wood WB, Martin JM, Guild NA, Vicens Q, Knight JK. A diagnostic assessment for introductory molecular and cell biology. CBE Life Sci Educ. 2010; 9(4):453-61. PMID: 21123692.
      View in: PubMed
    25. Vicens Q, Gooding AR, Duarte LF, Batey RT. Preparation of group I introns for biochemical studies and crystallization assays by native affinity purification. PLoS One. 2009 Aug 27; 4(8):e6740. PMID: 19710925.
      View in: PubMed
    26. Vicens Q, Bourne PE. Ten simple rules to combine teaching and research. PLoS Comput Biol. 2009 Apr; 5(4):e1000358. PMID: 19390598.
      View in: PubMed
    27. Vicens Q, Cech TR. A natural ribozyme with 3',5' RNA ligase activity. Nat Chem Biol. 2009 Feb; 5(2):97-9. PMID: 19125157.
      View in: PubMed
    28. Vicens Q, Paukstelis PJ, Westhof E, Lambowitz AM, Cech TR. Toward predicting self-splicing and protein-facilitated splicing of group I introns. RNA. 2008 Oct; 14(10):2013-29. PMID: 18768647.
      View in: PubMed
    29. Vicens Q, Allen MA, Gilbert SD, Reznik B, Gooding AR, Batey RT. The Cech Symposium: a celebration of 25 years of ribozymes, 10 years of TERT, and 60 years of Tom. RNA. 2008 Mar; 14(3):397-403. PMID: 18203922.
      View in: PubMed
    30. Laederach A, Das R, Vicens Q, Pearlman SM, Brenowitz M, Herschlag D, Altman RB. Semiautomated and rapid quantification of nucleic acid footprinting and structure mapping experiments. Nat Protoc. 2008; 3(9):1395-401. PMID: 18772866.
      View in: PubMed
    31. Vicens Q, Bourne PE. Ten simple rules for a successful collaboration. PLoS Comput Biol. 2007 Mar 30; 3(3):e44. PMID: 17397252.
      View in: PubMed
    32. Vicens Q, Gooding AR, Laederach A, Cech TR. Local RNA structural changes induced by crystallization are revealed by SHAPE. RNA. 2007 Apr; 13(4):536-48. PMID: 17299128.
      View in: PubMed
    33. Vicens Q, Cech TR. Atomic level architecture of group I introns revealed. Trends Biochem Sci. 2006 Jan; 31(1):41-51. PMID: 16356725.
      View in: PubMed
    34. François B, Russell RJ, Murray JB, Aboul-ela F, Masquida B, Vicens Q, Westhof E. Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding. Nucleic Acids Res. 2005; 33(17):5677-90. PMID: 16214802.
      View in: PubMed
    35. Pfister P, Hobbie S, Vicens Q, Böttger EC, Westhof E. The molecular basis for A-site mutations conferring aminoglycoside resistance: relationship between ribosomal susceptibility and X-ray crystal structures. Chembiochem. 2003 Oct 06; 4(10):1078-88. PMID: 14523926.
      View in: PubMed
    36. Vicens Q, Westhof E. RNA as a drug target: the case of aminoglycosides. Chembiochem. 2003 Oct 06; 4(10):1018-23. PMID: 14523919.
      View in: PubMed
    37. Vicens Q, Westhof E. Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: an analysis of x-ray crystal structures. Biopolymers. 2003 Sep; 70(1):42-57. PMID: 12925992.
      View in: PubMed
    38. Vicens Q, Westhof E. Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide. J Mol Biol. 2003 Feb 28; 326(4):1175-88. PMID: 12589761.
      View in: PubMed
    39. Vicens Q, Westhof E. Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site. Chem Biol. 2002 Jun; 9(6):747-55. PMID: 12079787.
      View in: PubMed
    40. Vicens Q, Westhof E. Crystal structure of paromomycin docked into the eubacterial ribosomal decoding A site. Structure. 2001 Aug; 9(8):647-58. PMID: 11587639.
      View in: PubMed
    41. Walter F, Vicens Q, Westhof E. Aminoglycoside-RNA interactions. Curr Opin Chem Biol. 1999 Dec; 3(6):694-704. PMID: 10600721.
      View in: PubMed
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