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Quentin Jerome Vicens

TitleAsst Professor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BioChem&Molecular Genetics

    Collapse Biography 
    Collapse awards and honors
    2019Faculty Member of the Year (Chemical Biology) , Faculty Opinions
    2013Distinguished Educator, Turning Technologies

    Collapse Overview 
    Collapse overview
    Current research focuses on viral structured elements, as well as on cellular targets of the deaminase ADAR1, using collaborative strategies that integrate several molecular and structural biology approaches.

    Collapse Research 
    Collapse research activities and funding
    RBI 2020 RNA-seq Pilot Award     (Vicens)Jan 1, 2021 - Dec 31, 2021
    RNA Bioscience Initiative
    Using RNA-seq to determine the biological role of the Z-RNA binding domain of ADAR1 during the interferon response
    Role Description: This award from the RNA Bioscience Initiative (RBI) at the University of Colorado Anschutz Medical Campus supports the use of RNA-seq and its analysis to enhance basic science, translational, and clinical studies.
    Role: PI

    R21AI157244     (VICENS, QUENTIN)Dec 15, 2020 - Nov 30, 2022
    NIH
    Structural determinants of viral RNAs resistant to exoribonucleases in the alphavirus supergroup
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Vicens Q, Kieft JS. Thoughts on how to think (and talk) about RNA structure. Proc Natl Acad Sci U S A. 2022 04 26; 119(17):e2112677119. PMID: 35439059.
      View in: PubMed
    2. Vicens Q, Kieft JS. Shared properties and singularities of exoribonuclease-resistant RNAs in viruses. Comput Struct Biotechnol J. 2021; 19:4373-4380. PMID: 34471487.
      View in: PubMed
    3. Herbert A, Karapetyan S, Poptsova M, Vasquez KM, Vicens Q, Vögeli B. Special Issue: A, B and Z: The Structure, Function and Genetics of Z-DNA and Z-RNA. Int J Mol Sci. 2021 Jul 19; 22(14). PMID: 34299306.
      View in: PubMed
    4. Nichols PJ, Henen MA, Vicens Q, Vögeli B. Solution NMR backbone assignments of the N-terminal Za-linker-Zß segment from Homo sapiens ADAR1p150. Biomol NMR Assign. 2021 10; 15(2):273-279. PMID: 33742389.
      View in: PubMed
    5. Nichols PJ, Bevers S, Henen M, Kieft JS, Vicens Q, Vögeli B. Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions. Nat Commun. 2021 02 04; 12(1):793. PMID: 33542240.
      View in: PubMed
    6. Abaeva IS, Vicens Q, Bochler A, Soufari H, Simonetti A, Pestova TV, Hashem Y, Hellen CUT. The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism. Cell Rep. 2020 12 08; 33(10):108476. PMID: 33296660.
      View in: PubMed
    7. Vicens Q. Special Issue: Frontiers in RNA Structure. Molecules. 2020 Oct 21; 25(20). PMID: 33096601.
      View in: PubMed
    8. Jones RA, Steckelberg AL, Vicens Q, Szucs MJ, Akiyama BM, Kieft JS. Different tertiary interactions create the same important 3D features in a distinct flavivirus xrRNA. RNA. 2021 01; 27(1):54-65. PMID: 33004436.
      View in: PubMed
    9. Szucs MJ, Nichols PJ, Jones RA, Vicens Q, Kieft JS. A New Subclass of Exoribonuclease-Resistant RNA Found in Multiple Genera of Flaviviridae. mBio. 2020 09 29; 11(5). PMID: 32994331.
      View in: PubMed
    10. Steckelberg AL, Vicens Q, Costantino DA, Nix JC, Kieft JS. The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold. RNA. 2020 12; 26(12):1767-1776. PMID: 32848042.
      View in: PubMed
    11. Vicens, Q. Kim, Y. Harrowfield, J. Jacques Vicens: an obituary. J Incl Phenom Macrocycl Chem. 2020; 98:123-125.
    12. Vicens Q, Coumoul X, Souciet JL. A forum where french-speaking faculty can exchange research on teaching. Biochem Mol Biol Educ. 2019 09; 47(5):599-606. PMID: 31141270.
      View in: PubMed
    13. Steckelberg AL, Vicens Q, Kieft JS. Exoribonuclease-Resistant RNAs Exist within both Coding and Noncoding Subgenomic RNAs. mBio. 2018 12 18; 9(6). PMID: 30563900.
      View in: PubMed
    14. Vicens Q, Mondragón E, Reyes FE, Coish P, Aristoff P, Berman J, Kaur H, Kells KW, Wickens P, Wilson J, Gadwood RC, Schostarez HJ, Suto RK, Blount KF, Batey RT. Structure-Activity Relationship of Flavin Analogues That Target the Flavin Mononucleotide Riboswitch. ACS Chem Biol. 2018 10 19; 13(10):2908-2919. PMID: 30107111.
      View in: PubMed
    15. D'Ascenzo L, Vicens Q, Auffinger P. Identification of receptors for UNCG and GNRA Z-turns and their occurrence in rRNA. Nucleic Acids Res. 2018 09 06; 46(15):7989-7997. PMID: 29986118.
      View in: PubMed
    16. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 30526871.
      View in: PubMed
    17. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33252739.
      View in: PubMed
    18. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11587639.
      View in: PubMed
    19. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12925992.
      View in: PubMed
    20. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18772866.
      View in: PubMed
    21. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21123692.
      View in: PubMed
    22. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 18768647.
      View in: PubMed
    23. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 21745821.
      View in: PubMed
    24. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19390598.
      View in: PubMed
    25. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12589761.
      View in: PubMed
    26. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 17397252.
      View in: PubMed
    27. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27151194.
      View in: PubMed
    28. Brito Querido J, Mancera-Martínez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y. The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein. Structure. 2017 12 05; 25(12):1785-1794.e3. PMID: 29107485.
      View in: PubMed
    29. Gross L, Vicens Q, Einhorn E, Noireterre A, Schaeffer L, Kuhn L, Imler JL, Eriani G, Meignin C, Martin F. The IRES5'UTR of the dicistrovirus cricket paralysis virus is a type III IRES containing an essential pseudoknot structure. Nucleic Acids Res. 2017 Sep 06; 45(15):8993-9004. PMID: 28911115.
      View in: PubMed
    30. Khusainov I, Vicens Q, Ayupov R, Usachev K, Myasnikov A, Simonetti A, Validov S, Kieffer B, Yusupova G, Yusupov M, Hashem Y. Structures and dynamics of hibernating ribosomes from Staphylococcus aureus mediated by intermolecular interactions of HPF. EMBO J. 2017 07 14; 36(14):2073-2087. PMID: 28645916.
      View in: PubMed
    31. D'Ascenzo L, Leonarski F, Vicens Q, Auffinger P. Revisiting GNRA and UNCG folds: U-turns versus Z-turns in RNA hairpin loops. RNA. 2017 03; 23(3):259-269. PMID: 27999116.
      View in: PubMed
    32. Khusainov I, Vicens Q, Bochler A, Grosse F, Myasnikov A, Ménétret JF, Chicher J, Marzi S, Romby P, Yusupova G, Yusupov M, Hashem Y. Structure of the 70S ribosome from human pathogen Staphylococcus aureus. Nucleic Acids Res. 2017 01 25; 45(2):1026. PMID: 28123039.
      View in: PubMed
    33. Khusainov I, Vicens Q, Bochler A, Grosse F, Myasnikov A, Ménétret JF, Chicher J, Marzi S, Romby P, Yusupova G, Yusupov M, Hashem Y. Structure of the 70S ribosome from human pathogen Staphylococcus aureus. Nucleic Acids Res. 2016 12 01; 44(21):10491-10504. PMID: 27906650.
      View in: PubMed
    34. Martin F, Ménétret JF, Simonetti A, Myasnikov AG, Vicens Q, Prongidi-Fix L, Natchiar SK, Klaholz BP, Eriani G. Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation. Nat Commun. 2016 08 24; 7:12622. PMID: 27554013.
      View in: PubMed
    35. Vicens Q, Westhof E. Biogenesis of Circular RNAs. Cell. 2014 Sep 25; 159(1):13-14. PMID: 25259915.
      View in: PubMed
    36. Vicens Q, Gooding AR, Duarte LF, Batey RT. Preparation of group I introns for biochemical studies and crystallization assays by native affinity purification. PLoS One. 2009 Aug 27; 4(8):e6740. PMID: 19710925.
      View in: PubMed
    37. Vicens Q, Cech TR. A natural ribozyme with 3',5' RNA ligase activity. Nat Chem Biol. 2009 Feb; 5(2):97-9. PMID: 19125157.
      View in: PubMed
    38. Vicens Q, Allen MA, Gilbert SD, Reznik B, Gooding AR, Batey RT. The Cech Symposium: a celebration of 25 years of ribozymes, 10 years of TERT, and 60 years of Tom. RNA. 2008 Mar; 14(3):397-403. PMID: 18203922.
      View in: PubMed
    39. Vicens Q, Gooding AR, Laederach A, Cech TR. Local RNA structural changes induced by crystallization are revealed by SHAPE. RNA. 2007 Apr; 13(4):536-48. PMID: 17299128.
      View in: PubMed
    40. Vicens Q, Cech TR. Atomic level architecture of group I introns revealed. Trends Biochem Sci. 2006 Jan; 31(1):41-51. PMID: 16356725.
      View in: PubMed
    41. François B, Russell RJ, Murray JB, Aboul-ela F, Masquida B, Vicens Q, Westhof E. Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding. Nucleic Acids Res. 2005; 33(17):5677-90. PMID: 16214802.
      View in: PubMed
    42. Vicens Q, Westhof E. RNA as a drug target: the case of aminoglycosides. Chembiochem. 2003 Oct 06; 4(10):1018-23. PMID: 14523919.
      View in: PubMed
    43. Pfister P, Hobbie S, Vicens Q, Böttger EC, Westhof E. The molecular basis for A-site mutations conferring aminoglycoside resistance: relationship between ribosomal susceptibility and X-ray crystal structures. Chembiochem. 2003 Oct 06; 4(10):1078-88. PMID: 14523926.
      View in: PubMed
    44. Vicens Q, Westhof E. Crystal structure of a complex between the aminoglycoside tobramycin and an oligonucleotide containing the ribosomal decoding a site. Chem Biol. 2002 Jun; 9(6):747-55. PMID: 12079787.
      View in: PubMed
    45. Walter F, Vicens Q, Westhof E. Aminoglycoside-RNA interactions. Curr Opin Chem Biol. 1999 Dec; 3(6):694-704. PMID: 10600721.
      View in: PubMed
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