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Kambez Benam

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Overview 
    Collapse overview
    Our lab applies a multidisciplinary approach to design and develop bio-inspired technologies that enable us to elucidate cellular and molecular mechanisms that govern tissue pathology or offer protection during lung injury. Our research lies at the intersection of respiratory medicine, immuno-microbiology, tissue engineering, and systems and synthetic biology. Ultimately, our goal is to discover novel druggable targets and personalized diagnostics using microengineered systems that recreate complex human organ pathophysiology in vitro.


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Benam KH, Denney L, Ho LP. How the Respiratory Epithelium Senses and Reacts to Influenza Virus. Am J Respir Cell Mol Biol. 2018 Oct 29. PMID: 30372120.
      View in: PubMed
    2. Kambez H. Benam. Disrupting Experimental Strategies for Inhalation Toxicology: The Emergence of Microengineered Breathing-Smoking Human Lung-on-a-Chip. 2018; 4(2).
    3. Benam KH, Königshoff M, Eickelberg O. Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond. Am J Respir Crit Care Med. 2018 Apr 01; 197(7):869-875. PMID: 29262260.
      View in: PubMed
    4. Niemeyer BF, Zhao P, Tuder RM, Benam KH. Advanced Microengineered Lung Models for Translational Drug Discovery. SLAS Discov. 2018 Sep; 23(8):777-789. PMID: 29447055.
      View in: PubMed
    5. Cole SL, Dunning J, Kok WL, Benam KH, Benlahrech A, Repapi E, Martinez FO, Drumright L, Powell TJ, Bennett M, Elderfield R, Thomas C, Dong T, McCauley J, Liew FY, Taylor S, Zambon M, Barclay W, Cerundolo V, Openshaw PJ, McMichael AJ, Ho LP. M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI Insight. 2017 Apr 06; 2(7):e91868. PMID: 28405622.
      View in: PubMed
    6. Cole SL, Dunning J, Kok WL, Benam KH, Benlahrech A, Repapi E, Martinez FO, Drumright L, Powell TJ, Bennett M, Elderfield R, Thomas C, Dong T, McCauley J, Liew FY, Taylor S, Zambon M, Barclay W, Cerundolo V, Openshaw PJ, McMichael AJ, Ho LP. M1-like monocytes are a major immunological determinant of severity in previously healthy adults with life-threatening influenza. JCI Insight. 2017 Apr 06; 2(7). PMID: 28406797.
      View in: PubMed
    7. Benam KH, Mazur M, Choe Y, Ferrante TC, Novak R, Ingber DE. Human Lung Small Airway-on-a-Chip Protocol. Methods Mol Biol. 2017; 1612:345-365. PMID: 28634955.
      View in: PubMed
    8. Benam KH, Ingber DE. Commendation for Exposing Key Advantage of Organ Chip Approach. Cell Syst. 2016 11 23; 3(5):411. PMID: 27883885.
      View in: PubMed
    9. Benam KH, Novak R, Nawroth J, Hirano-Kobayashi M, Ferrante TC, Choe Y, Prantil-Baun R, Weaver JC, Bahinski A, Parker KK, Ingber DE. Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip. Cell Syst. 2016 11 23; 3(5):456-466.e4. PMID: 27894999.
      View in: PubMed
    10. Benam KH, Villenave R, Lucchesi C, Varone A, Hubeau C, Lee HH, Alves SE, Salmon M, Ferrante TC, Weaver JC, Bahinski A, Hamilton GA, Ingber DE. Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro. Nat Methods. 2016 Feb; 13(2):151-7. PMID: 26689262.
      View in: PubMed
    11. Benam KH, Dauth S, Hassell B, Herland A, Jain A, Jang KJ, Karalis K, Kim HJ, MacQueen L, Mahmoodian R, Musah S, Torisawa YS, van der Meer AD, Villenave R, Yadid M, Parker KK, Ingber DE. Engineered in vitro disease models. Annu Rev Pathol. 2015; 10:195-262. PMID: 25621660.
      View in: PubMed
    12. Cole SL, Benam KH, McMichael AJ, Ho LP. Involvement of the 4-1BB/4-1BBL pathway in control of monocyte numbers by invariant NKT cells. J Immunol. 2014 Apr 15; 192(8):3898-907. PMID: 24639347.
      View in: PubMed
    13. Kok WL, Denney L, Benam K, Cole S, Clelland C, McMichael AJ, Ho LP. Pivotal Advance: Invariant NKT cells reduce accumulation of inflammatory monocytes in the lungs and decrease immune-pathology during severe influenza A virus infection. J Leukoc Biol. 2012 Mar; 91(3):357-68. PMID: 22003207.
      View in: PubMed
    14. Benam KH, Kok WL, McMichael AJ, Ho LP. Alternative spliced CD1d transcripts in human bronchial epithelial cells. PLoS One. 2011; 6(8):e22726. PMID: 21853044; PMCID: PMC3154910.
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