Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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ENERGY METABOLISM IN REDUCED-OBESE SUBJECTS


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Collapse Overview 
Collapse abstract
The 2-yr proposed project is aimed at understanding whether or not energy metabolism is altered in reduced-obese subjects as compared to never-obese control subjects. A major hypothesis of the proposal is that the reduced-obese do not constitute a homogeneous group and that energy metabolism may be altered in some but not all reduced- obese subjects. Using the NWCR, the project will begin by examining determinants of resting metabolic rate in reduced-obese subjects. A foil ow-up study will examine total energy expenditure (using doubly labeled water) in subjects who have maintained short (1-2 year ) versus long (greater than 5 year) weight reduction. Finally, the project will assess fat oxidation in response to dietary manipulation in reduced-obese subjects. No previous studies of energy expenditure in reduced obese subjects have used subjects with who have maintained their weight loss for longer than 5 years. in fact, most previously reduced-obese subjects were studied within 6 months of their weight loss. Substantial weight loss can likely produce perturbation in energy metabolism that may last for long periods of time.
Collapse sponsor award id
F32DK009705

Collapse Time 
Collapse start date
1998-01-01
Collapse end date
1900-01-01

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