Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Last Name

Contact Us
If you have any questions or feedback please contact us.

Prafulla Aryal

TitleResearch Associate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM - Physiology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Nematian-Ardestani E, Jarerattanachat V, Aryal P, Sansom MSP, Tucker SJ. The effects of stretch activation on ionic selectivity of the TREK-2 K2P K+ channel. Channels (Austin). 2017 Sep 03; 11(5):482-486. PMID: 28723241.
      View in: PubMed
    2. Lacin E, Aryal P, Glaaser IW, Bodhinathan K, Tsai E, Marsh N, Tucker SJ, Sansom MSP, Slesinger PA. Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel. J Gen Physiol. 2017 Jul 18. PMID: 28720589.
      View in: PubMed
    3. Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike ACW, Carpenter EP, Baukrowitz T, Sansom MSP, Tucker SJ. Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel. Structure. 2017 05 02; 25(5):708-718.e2. PMID: 28392258.
      View in: PubMed
    4. Trick JL, Chelvaniththilan S, Klesse G, Aryal P, Wallace EJ, Tucker SJ, Sansom MSP. Functional Annotation of Ion Channel Structures by Molecular Simulation. Structure. 2016 12 06; 24(12):2207-2216. PMID: 27866853.
      View in: PubMed
    5. McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. J Gen Physiol. 2016 06; 147(6):497-505. PMID: 27241700; PMCID: PMC4886281 [Available on 12/01/16].
    6. Trick JL, Aryal P, Tucker SJ, Sansom MS. Molecular simulation studies of hydrophobic gating in nanopores and ion channels. Biochem Soc Trans. 2015 Apr; 43(2):146-50. PMID: 25849908.
      View in: PubMed
    7. Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP. K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science. 2015 Mar 13; 347(6227):1256-9. PMID: 25766236.
      View in: PubMed
    8. Aryal P, Abd-Wahab F, Bucci G, Sansom MS, Tucker SJ. Influence of lipids on the hydrophobic barrier within the pore of the TWIK-1 K2P channel. Channels (Austin). 2015; 9(1):44-9. PMID: 25487004.
      View in: PubMed
    9. Aryal P, Sansom MS, Tucker SJ. Hydrophobic gating in ion channels. J Mol Biol. 2015 Jan 16; 427(1):121-30. PMID: 25106689.
      View in: PubMed
    10. Aryal P, Abd-Wahab F, Bucci G, Sansom MS, Tucker SJ. A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel. Nat Commun. 2014 Jul 08; 5:4377. PMID: 25001086.
      View in: PubMed
    11. Almeida MC, Hew-Butler T, Soriano RN, Rao S, Wang W, Wang J, Tamayo N, Oliveira DL, Nucci TB, Aryal P, Garami A, Bautista D, Gavva NR, Romanovsky AA. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012 Feb 08; 32(6):2086-99. PMID: 22323721; PMCID: PMC3566779.
    12. An MC, Lin W, Yang J, Dominguez B, Padgett D, Sugiura Y, Aryal P, Gould TW, Oppenheim RW, Hester ME, Kaspar BK, Ko CP, Lee KF. Acetylcholine negatively regulates development of the neuromuscular junction through distinct cellular mechanisms. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10702-7. PMID: 20498043; PMCID: PMC2890820.
    13. Aryal P, Dvir H, Choe S, Slesinger PA. A discrete alcohol pocket involved in GIRK channel activation. Nat Neurosci. 2009 Aug; 12(8):988-95. PMID: 19561601; PMCID: PMC2717173.
    14. Fowler CE, Aryal P, Suen KF, Slesinger PA. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. J Physiol. 2007 Apr 01; 580(Pt 1):51-65. PMID: 17185339; PMCID: PMC2075413.
    15. Lin W, Dominguez B, Yang J, Aryal P, Brandon EP, Gage FH, Lee KF. Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron. 2005 May 19; 46(4):569-79. PMID: 15944126.
      View in: PubMed
    16. Martindale JJ, Wall JA, Martinez-Longoria DM, Aryal P, Rockman HA, Guo Y, Bolli R, Glembotski CC. Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo. J Biol Chem. 2005 Jan 07; 280(1):669-76. PMID: 15492008; PMCID: PMC3691679.
    17. Dance AL, Miller M, Seragaki S, Aryal P, White B, Aschenbrenner L, Hasson T. Regulation of myosin-VI targeting to endocytic compartments. Traffic. 2004 Oct; 5(10):798-813. PMID: 15355515.
      View in: PubMed
    18. Lucas DT, Aryal P, Szweda LI, Koch WJ, Leinwand LA. Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2003 Feb; 284(2):H575-83. PMID: 12414446.
      View in: PubMed
    Aryal's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description
    Physical Neighbors Expand Description

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)