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Melanie Koenigshoff

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Overview 
    Collapse overview
    Lung disease researcher Melanie Königshoff, MD, PhD joined CU in
    November 2016 as a Professor in the Division of Pulmonary Sciences and Critical Care Medicine. She will build a new Fibrosis and Regeneration Program at CU with a focus on interdisciplinary and translational research. Her own multi-disciplinary research team – representing clinical medicine, molecular and cell biology, pharmacology, and bioengineering – aims to understand how the lung repairs itself, and to create new approaches to repairing and regenerating lung tissue.


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Skronska-Wasek W, Mutze K, Baarsma HA, Bracke KR, Alsafadi HN, Lehmann M, Costa R, Stornaiuolo M, Novellino E, Brusselle GG, Wagner DE, Yildirim AÖ, Königshoff M. Reduced Frizzled Receptor 4 Expression Prevents WNT/ß-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 Jul 15; 196(2):172-185. PMID: 28245136.
      View in: PubMed
    2. Costa R, Königshoff M. Linking Wnt Signaling to Mucosal Inflammation. Am J Respir Cell Mol Biol. 2017 May; 56(5):551-552. PMID: 28459386.
      View in: PubMed
    3. Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES. An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2017 May; 56(5):667-679. PMID: 28459387.
      View in: PubMed
    4. Baarsma HA, Königshoff M. 'WNT-er is coming': WNT signalling in chronic lung diseases. Thorax. 2017 Aug; 72(8):746-759. PMID: 28416592.
      View in: PubMed
    5. Kneidinger N, Milger K, Janitza S, Ceelen F, Leuschner G, Dinkel J, Königshoff M, Weig T, Schramm R, Winter H, Behr J, Neurohr C. Lung volumes predict survival in patients with chronic lung allograft dysfunction. Eur Respir J. 2017 Apr; 49(4). PMID: 28404648.
      View in: PubMed
    6. Alsafadi HN, Staab-Weijnitz CA, Lehmann M, Lindner M, Peschel B, Königshoff M, Wagner DE. An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2017 Jun 01; 312(6):L896-L902. PMID: 28314802.
      View in: PubMed
    7. Poobalasingam T, Yates LL, Walker SA, Pereira M, Gross NY, Ali A, Kolatsi-Joannou M, Jarvelin MR, Pekkanen J, Papakrivopoulou E, Long DA, Griffiths M, Wagner D, Königshoff M, Hind M, Minelli C, Lloyd CM, Dean CH. Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair. Dis Model Mech. 2017 Apr 01; 10(4):409-423. PMID: 28237967.
      View in: PubMed
    8. Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M. Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD. J Exp Med. 2017 Feb; 214(2):565. PMID: 28069639.
      View in: PubMed
    9. Mossina A, Lukas C, Merl-Pham J, Uhl FE, Mutze K, Schamberger A, Staab-Weijnitz C, Jia J, Yildirim AÖ, Königshoff M, Hauck SM, Eickelberg O, Meiners S. Cigarette smoke alters the secretome of lung epithelial cells. Proteomics. 2017 Jan; 17(1-2). PMID: 27891773.
      View in: PubMed
    10. Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD. J Exp Med. 2017 Jan; 214(1):143-163. PMID: 27979969.
      View in: PubMed
    11. Ge L, Habiel DM, Hansbro PM, Kim RY, Gharib SA, Edelman JD, Königshoff M, Parimon T, Brauer R, Huang Y, Allen J, Jiang D, Kurkciyan AA, Mizuno T, Stripp BR, Noble PW, Hogaboam CM, Chen P. miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways. JCI Insight. 2016 Dec 08; 1(20):e90301. PMID: 27942594.
      View in: PubMed
    12. Hofmann K, Fiedler S, Vierkotten S, Weber J, Klee S, Jia J, Zwickenpflug W, Flockerzi V, Storch U, Yildirim AÖ, Gudermann T, Königshoff M, Dietrich A. Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis. Biochim Biophys Acta. 2017 Feb; 1863(2):560-568. PMID: 27932059.
      View in: PubMed
    13. Lehmann M, Baarsma HA, Königshoff M. WNT Signaling in Lung Aging and Disease. Ann Am Thorac Soc. 2016 Dec; 13(Supplement_5):S411-S416. PMID: 28005418.
      View in: PubMed
    14. Ota C, Baarsma HA, Wagner DE, Hilgendorff A, Königshoff M. Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling. Mol Cell Pediatr. 2016 Dec; 3(1):34. PMID: 27718180.
      View in: PubMed
    15. Liu X, Baarsma HA, Thiam CH, Montrone C, Brauner B, Fobo G, Heier JS, Duscha S, Königshoff M, Angeli V, Ruepp A, Campillos M. Systematic Identification of Pharmacological Targets from Small-Molecule Phenotypic Screens. Cell Chem Biol. 2016 Oct 20; 23(10):1302-1313. PMID: 27667560.
      View in: PubMed
    16. Dietz K, de Los Reyes Jiménez M, Gollwitzer ES, Chaker AM, Zissler UM, Rådmark OP, Baarsma HA, Königshoff M, Schmidt-Weber CB, Marsland BJ, Esser-von Bieren J. Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways. J Allergy Clin Immunol. 2017 Apr; 139(4):1343-1354.e6. PMID: 27554815.
      View in: PubMed
    17. Chen S, Yin R, Mutze K, Yu Y, Takenaka S, Königshoff M, Stoeger T. No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice. Part Fibre Toxicol. 2016 06 21; 13(1):33. PMID: 27328634; PMCID: PMC4915176.
    18. Kammerl IE, Dann A, Mossina A, Brech D, Lukas C, Vosyka O, Nathan P, Conlon TM, Wagner DE, Overkleeft HS, Prasse A, Rosas IO, Straub T, Krauss-Etschmann S, Königshoff M, Preissler G, Winter H, Lindner M, Hatz R, Behr J, Heinzelmann K, Yildirim AÖ, Noessner E, Eickelberg O, Meiners S. Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 Jun 01; 193(11):1230-41. PMID: 26756824.
      View in: PubMed
    19. Bardou O, Menou A, François C, Duitman JW, von der Thüsen JH, Borie R, Sales KU, Mutze K, Castier Y, Sage E, Liu L, Bugge TH, Fairlie DP, Königshoff M, Crestani B, Borensztajn KS. Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis. Am J Respir Crit Care Med. 2016 Apr 15; 193(8):847-60. PMID: 26599507; PMCID: PMC4849177 [Available on 04/15/17].
    20. Fernandez IE, Amarie OV, Mutze K, Königshoff M, Yildirim AÖ, Eickelberg O. Systematic phenotyping and correlation of biomarkers with lung function and histology in lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2016 May 15; 310(10):L919-27. PMID: 26993522.
      View in: PubMed
    21. Klee S, Lehmann M, Wagner DE, Baarsma HA, Königshoff M. WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts. Sci Rep. 2016 Feb 12; 6:20547. PMID: 26867691; PMCID: PMC4751539.
    22. Spanjer AI, Baarsma HA, Oostenbrink LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M. TGF-ß-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8. FASEB J. 2016 May; 30(5):1823-35. PMID: 26849959.
      View in: PubMed
    23. Sarker RS, John-Schuster G, Bohla A, Mutze K, Burgstaller G, Bedford MT, Königshoff M, Eickelberg O, Yildirim AÖ. Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility. Am J Respir Cell Mol Biol. 2015 Dec; 53(6):769-81. PMID: 25906418.
      View in: PubMed
    24. André PA, Prêle CM, Vierkotten S, Carnesecchi S, Donati Y, Chambers RC, Pache JC, Crestani B, Barazzone-Argiroffo C, Königshoff M, Laurent GJ, Irminger-Finger I. BARD1 mediates TGF-ß signaling in pulmonary fibrosis. Respir Res. 2015 Sep 29; 16:118. PMID: 26415510; PMCID: PMC4587901.
    25. Semren N, Habel-Ungewitter NC, Fernandez IE, Königshoff M, Eickelberg O, Stöger T, Meiners S. Validation of the 2nd Generation Proteasome Inhibitor Oprozomib for Local Therapy of Pulmonary Fibrosis. PLoS One. 2015; 10(9):e0136188. PMID: 26340365; PMCID: PMC4560391.
    26. Burgstaller G, Vierkotten S, Lindner M, Königshoff M, Eickelberg O. Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue. Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15; 309(4):L323-32. PMID: 26092995; PMCID: PMC4538231.
    27. Mutze K, Vierkotten S, Milosevic J, Eickelberg O, Königshoff M. Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/ß-catenin-driven trans-differentiation of murine alveolar epithelial cells. Dis Model Mech. 2015 Aug 01; 8(8):877-90. PMID: 26035385; PMCID: PMC4527283.
    28. Uhl FE, Vierkotten S, Wagner DE, Burgstaller G, Costa R, Koch I, Lindner M, Meiners S, Eickelberg O, Königshoff M. Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures. Eur Respir J. 2015 Oct; 46(4):1150-66. PMID: 25929950.
      View in: PubMed
    29. MacKenzie B, Henneke I, Hezel S, Al Alam D, El Agha E, Chao CM, Quantius J, Wilhelm J, Jones M, Goth K, Li X, Seeger W, Königshoff M, Herold S, Rizvanov AA, Günther A, Bellusci S. Attenuating endogenous Fgfr2b ligands during bleomycin-induced lung fibrosis does not compromise murine lung repair. Am J Physiol Lung Cell Mol Physiol. 2015 May 15; 308(10):L1014-24. PMID: 25820524; PMCID: PMC4437006.
    30. van Rijt SH, Bölükbas DA, Argyo C, Datz S, Lindner M, Eickelberg O, Königshoff M, Bein T, Meiners S. Protease-mediated release of chemotherapeutics from mesoporous silica nanoparticles to ex vivo human and mouse lung tumors. ACS Nano. 2015 Mar 24; 9(3):2377-89. PMID: 25703655.
      View in: PubMed
    31. Meiners S, Eickelberg O, Königshoff M. Hallmarks of the ageing lung. Eur Respir J. 2015 Mar; 45(3):807-27. PMID: 25657021.
      View in: PubMed
    32. Königshoff M, Bonniaud P. Live and let die: targeting alveolar epithelial cell proliferation in pulmonary fibrosis. Am J Respir Crit Care Med. 2014 Dec 15; 190(12):1339-41. PMID: 25496102.
      View in: PubMed
    33. Ballweg K, Mutze K, Königshoff M, Eickelberg O, Meiners S. Cigarette smoke extract affects mitochondrial function in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 01; 307(11):L895-907. PMID: 25326581.
      View in: PubMed
    34. Königshoff M. The new Back to Basics section: emerging concepts in basic and translational medicine. Eur Respir J. 2014 Aug; 44(2):297-8. PMID: 25082908.
      View in: PubMed
    35. Berschneider B, Ellwanger DC, Baarsma HA, Thiel C, Shimbori C, White ES, Kolb M, Neth P, Königshoff M. miR-92a regulates TGF-ß1-induced WISP1 expression in pulmonary fibrosis. Int J Biochem Cell Biol. 2014 Aug; 53:432-41. PMID: 24953558.
      View in: PubMed
    36. Banon-Maneus E, Rovira J, Ramirez-Bajo MJ, Moya-Rull D, Hierro-Garcia N, Takenaka S, Diekmann F, Eickelberg O, Königshoff M, Campistol JM. Wnt pathway activation in long term remnant rat model. Biomed Res Int. 2014; 2014:324713. PMID: 24995284; PMCID: PMC4066683.
    37. Aumiller V, Balsara N, Wilhelm J, Günther A, Königshoff M. WNT/ß-catenin signaling induces IL-1ß expression by alveolar epithelial cells in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):96-104. PMID: 23526221.
      View in: PubMed
    38. Karo-Atar D, Moshkovits I, Eickelberg O, Königshoff M, Munitz A. Paired immunoglobulin-like receptor-B inhibits pulmonary fibrosis by suppressing profibrogenic properties of alveolar macrophages. Am J Respir Cell Mol Biol. 2013 Apr; 48(4):456-64. PMID: 23258232.
      View in: PubMed
    39. Gottardi CJ, Königshoff M. Considerations for targeting ß-catenin signaling in fibrosis. Am J Respir Crit Care Med. 2013 Mar 15; 187(6):566-8. PMID: 23504360.
      View in: PubMed
    40. Königshoff M, Saglani S, Marsland BJ, Eickelberg O. Rebuilding a diseased lung: repair and regeneration. Eur Respir J. 2013 Mar; 41(3):497-9. PMID: 23456930.
      View in: PubMed
    41. Baarsma HA, Königshoff M, Gosens R. The WNT signaling pathway from ligand secretion to gene transcription: molecular mechanisms and pharmacological targets. Pharmacol Ther. 2013 Apr; 138(1):66-83. PMID: 23328704.
      View in: PubMed
    42. Rock J, Königshoff M. Endogenous lung regeneration: potential and limitations. Am J Respir Crit Care Med. 2012 Dec 15; 186(12):1213-9. PMID: 22997206.
      View in: PubMed
    43. Krauss-Etschmann S, Bush A, Bellusci S, Brusselle GG, Dahlén SE, Dehmel S, Eickelberg O, Gibson G, Hylkema MN, Knaus P, Königshoff M, Lloyd CM, Macciarini P, Mailleux A, Marsland BJ, Postma DS, Roberts G, Samakovlis C, Stocks J, Vandesompele J, Wjst M, Holloway J. Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax. 2013 Apr; 68(4):380-4. PMID: 22781122.
      View in: PubMed
    44. Mittal RA, Hammel M, Schwarz J, Heschl KM, Bretschneider N, Flemmer AW, Herber-Jonat S, Königshoff M, Eickelberg O, Holzinger A. SFTA2--a novel secretory peptide highly expressed in the lung--is modulated by lipopolysaccharide but not hyperoxia. PLoS One. 2012; 7(6):e40011. PMID: 22768197; PMCID: PMC3386909.
    45. Königshoff M, Rojas M. Galectin-3: the bridge over troubled waters. Am J Respir Crit Care Med. 2012 Mar 01; 185(5):473-5. PMID: 22383566.
      View in: PubMed
    46. Marsland BJ, Königshoff M, Saglani S, Eickelberg O. Immune system dysregulation in chronic lung disease. Eur Respir J. 2011 Sep; 38(3):500-1. PMID: 21885411.
      View in: PubMed
    47. Königshoff M, Schwarz J, Eickelberg O. Human lung stem cells: oh, the places you'll go! EMBO Mol Med. 2011 Oct; 3(10):575-7. PMID: 21853530; PMCID: PMC3377101.
    48. Pullamsetti SS, Savai R, Dumitrascu R, Dahal BK, Wilhelm J, Konigshoff M, Zakrzewicz D, Ghofrani HA, Weissmann N, Eickelberg O, Guenther A, Leiper J, Seeger W, Grimminger F, Schermuly RT. The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis. Sci Transl Med. 2011 Jun 15; 3(87):87ra53. PMID: 21677199.
      View in: PubMed
    49. Jenkins G, Blanchard A, Borok Z, Bradding P, Ehrhardt C, Fisher A, Hirani N, Johnson S, Königshoff M, Maher TM, Millar A, Parfrey H, Scotton C, Tetley T, Thickett D, Wolters P. In search of the fibrotic epithelial cell: opportunities for a collaborative network. Thorax. 2012 Feb; 67(2):179-82. PMID: 21680569.
      View in: PubMed
    50. Zhou Q, Pardo A, Königshoff M, Eickelberg O, Budinger GR, Thavarajah K, Gottardi CJ, Jones J, Varga J, Selman M, Sznajder JI, Raj JU, Zhou G. Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis. FASEB J. 2011 Sep; 25(9):3032-44. PMID: 21642472; PMCID: PMC3157679.
    51. Königshoff M. Lung cancer in pulmonary fibrosis: tales of epithelial cell plasticity. Respiration. 2011; 81(5):353-8. PMID: 21502777.
      View in: PubMed
    52. Königshoff M, Uhl F, Gosens R. From molecule to man: integrating molecular biology with whole organ physiology in studying respiratory disease. Pulm Pharmacol Ther. 2011 Oct; 24(5):466-70. PMID: 21356323.
      View in: PubMed
    53. Berschneider B, Königshoff M. WNT1 inducible signaling pathway protein 1 (WISP1): a novel mediator linking development and disease. Int J Biochem Cell Biol. 2011 Mar; 43(3):306-9. PMID: 21109017.
      View in: PubMed
    54. Nikolova S, Guenther A, Savai R, Weissmann N, Ghofrani HA, Konigshoff M, Eickelberg O, Klepetko W, Voswinckel R, Seeger W, Grimminger F, Schermuly RT, Pullamsetti SS. Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis. Respir Res. 2010 Oct 27; 11:146. PMID: 20979602; PMCID: PMC2988012.
    55. Dumitrascu R, Kulcke C, Königshoff M, Kouri F, Yang X, Morrell N, Ghofrani HA, Weissmann N, Reiter R, Seeger W, Grimminger F, Eickelberg O, Schermuly RT, Pullamsetti SS. Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats. Eur Respir J. 2011 May; 37(5):1104-18. PMID: 20947677.
      View in: PubMed
    56. Kneidinger N, Yildirim AÖ, Callegari J, Takenaka S, Stein MM, Dumitrascu R, Bohla A, Bracke KR, Morty RE, Brusselle GG, Schermuly RT, Eickelberg O, Königshoff M. Activation of the WNT/ß-catenin pathway attenuates experimental emphysema. Am J Respir Crit Care Med. 2011 Mar 15; 183(6):723-33. PMID: 20889911.
      View in: PubMed
    57. Königshoff M, Dumitrascu R, Udalov S, Amarie OV, Reiter R, Grimminger F, Seeger W, Schermuly RT, Eickelberg O. Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention. Thorax. 2010 Nov; 65(11):949-55. PMID: 20671305.
      View in: PubMed
    58. Pfaff EM, Becker S, Günther A, Königshoff M. Dickkopf proteins influence lung epithelial cell proliferation in idiopathic pulmonary fibrosis. Eur Respir J. 2011 Jan; 37(1):79-87. PMID: 20650998.
      View in: PubMed
    59. Morty RE, Königshoff M, Eickelberg O. Transforming growth factor-beta signaling across ages: from distorted lung development to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2009 Dec 01; 6(7):607-13. PMID: 19934357.
      View in: PubMed
    60. Jayachandran A, Königshoff M, Yu H, Rupniewska E, Hecker M, Klepetko W, Seeger W, Eickelberg O. SNAI transcription factors mediate epithelial-mesenchymal transition in lung fibrosis. Thorax. 2009 Dec; 64(12):1053-61. PMID: 19850962.
      View in: PubMed
    61. Königshoff M, Kneidinger N, Eickelberg O. TGF-beta signaling in COPD: deciphering genetic and cellular susceptibilities for future therapeutic regimen. Swiss Med Wkly. 2009 Oct 03; 139(39-40):554-63. PMID: 19838873.
      View in: PubMed
    62. Scotton CJ, Krupiczojc MA, Königshoff M, Mercer PF, Lee YC, Kaminski N, Morser J, Post JM, Maher TM, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC. Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest. 2009 Sep; 119(9):2550-63. PMID: 19652365; PMCID: PMC2735922.
    63. Königshoff M, Eickelberg O. WNT signaling in lung disease: a failure or a regeneration signal? Am J Respir Cell Mol Biol. 2010 Jan; 42(1):21-31. PMID: 19329555.
      View in: PubMed
    64. Königshoff M, Kramer M, Balsara N, Wilhelm J, Amarie OV, Jahn A, Rose F, Fink L, Seeger W, Schaefer L, Günther A, Eickelberg O. WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest. 2009 Apr; 119(4):772-87. PMID: 19287097; PMCID: PMC2662540.
    65. Mercer PF, Johns RH, Scotton CJ, Krupiczojc MA, Königshoff M, Howell DC, McAnulty RJ, Das A, Thorley AJ, Tetley TD, Eickelberg O, Chambers RC. Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis. Am J Respir Crit Care Med. 2009 Mar 01; 179(5):414-25. PMID: 19060230; PMCID: PMC2648910.
    66. Sevilla-Pérez J, Königshoff M, Kwapiszewska G, Amarie OV, Seeger W, Weissmann N, Schermuly RT, Morty RE, Eickelberg O. Shroom expression is attenuated in pulmonary arterial hypertension. Eur Respir J. 2008 Oct; 32(4):871-80. PMID: 18550613.
      View in: PubMed
    67. Königshoff M, Balsara N, Pfaff EM, Kramer M, Chrobak I, Seeger W, Eickelberg O. Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS One. 2008 May 14; 3(5):e2142. PMID: 18478089; PMCID: PMC2374879.
    68. Costello CM, Howell K, Cahill E, McBryan J, Konigshoff M, Eickelberg O, Gaine S, Martin F, McLoughlin P. Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Aug; 295(2):L272-84. PMID: 18469115.
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    69. Queisser MA, Kouri FM, Königshoff M, Wygrecka M, Schubert U, Eickelberg O, Preissner KT. Loss of RAGE in pulmonary fibrosis: molecular relations to functional changes in pulmonary cell types. Am J Respir Cell Mol Biol. 2008 Sep; 39(3):337-45. PMID: 18421017.
      View in: PubMed
    70. Kouri FM, Queisser MA, Königshoff M, Chrobak I, Preissner KT, Seeger W, Eickelberg O. Plasminogen activator inhibitor type 1 inhibits smooth muscle cell proliferation in pulmonary arterial hypertension. Int J Biochem Cell Biol. 2008; 40(9):1872-82. PMID: 18337154.
      View in: PubMed
    71. Yu H, Königshoff M, Jayachandran A, Handley D, Seeger W, Kaminski N, Eickelberg O. Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis. FASEB J. 2008 Jun; 22(6):1778-89. PMID: 18245174.
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    72. Kitowska K, Zakrzewicz D, Königshoff M, Chrobak I, Grimminger F, Seeger W, Bulau P, Eickelberg O. Functional role and species-specific contribution of arginases in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008 Jan; 294(1):L34-45. PMID: 17934065.
      View in: PubMed
    73. Königshoff M, Wilhelm A, Jahn A, Sedding D, Amarie OV, Eul B, Seeger W, Fink L, Günther A, Eickelberg O, Rose F. The angiotensin II receptor 2 is expressed and mediates angiotensin II signaling in lung fibrosis. Am J Respir Cell Mol Biol. 2007 Dec; 37(6):640-50. PMID: 17630322.
      View in: PubMed
    74. Vadász I, Morty RE, Olschewski A, Königshoff M, Kohstall MG, Ghofrani HA, Grimminger F, Seeger W. Thrombin impairs alveolar fluid clearance by promoting endocytosis of Na+,K+-ATPase. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):343-54. PMID: 16014898.
      View in: PubMed
    75. Königshoff M, Wilhelm J, Bohle RM, Pingoud A, Hahn M. HER-2/neu gene copy number quantified by real-time PCR: comparison of gene amplification, heterozygosity, and immunohistochemical status in breast cancer tissue. Clin Chem. 2003 Feb; 49(2):219-29. PMID: 12560343.
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