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Kaori Oshima

TitleResearch Instructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
ORCID ORCID Icon0000-0002-0882-056X Additional info

    Collapse Biography 
    Collapse education and training
    University of Colorado, Aurora, COPostdoctoral Fellow09/2019Pulmonary Sciences
    University of South Alabama, Mobile, ALPh.D.07/2016Pharmacology
    University of South Alabama, Mobile, ALB.S.05/2010Biological Sciences

    Collapse Research 
    Collapse research activities and funding
    932840     (Kaori Oshima)Apr 1, 2022 - Mar 31, 2025
    AHA
    Endothelial glycocalyx heparan sulfate regulates systemic hemostasis
    Role Description: The goal of this project is to investigate how vascular glycocalyx, sugar-rich layer that lines all vascular surface, controls coagulation in health and disease.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Siddiqui N, Oshima K, Hippensteel JA. Proteoglycans and glycosaminoglycans in central nervous system injury. Am J Physiol Cell Physiol. 2022 07 01; 323(1):C46-C55. PMID: 35613357.
      View in: PubMed
    2. Rizzo AN, Haeger SM, Oshima K, Yang Y, Wallbank AM, Jin Y, Lettau M, McCaig LA, Wickersham NE, McNeil JB, Zakharevich I, McMurtry SA, Langouët-Astrié CJ, Kopf KW, Voelker DR, Hansen KC, Shaver CM, Kerchberger VE, Peterson RA, Kuebler WM, Ochs M, Veldhuizen RA, Smith BJ, Ware LB, Bastarache JA, Schmidt EP. Alveolar epithelial glycocalyx degradation mediates surfactant dysfunction and contributes to acute respiratory distress syndrome. JCI Insight. 2022 01 25; 7(2). PMID: 34874923.
      View in: PubMed
    3. Bauer C, Piani F, Banks M, Ordoñez FA, de Lucas-Collantes C, Oshima K, Schmidt EP, Zakharevich I, Segarra A, Martinez C, Roncal-Jimenez C, Satchell SC, Bjornstad P, Lucia MS, Blaine J, Thurman JM, Johnson RJ, Cara-Fuentes G. Minimal Change Disease Is Associated With Endothelial Glycocalyx Degradation and Endothelial Activation. Kidney Int Rep. 2022 Apr; 7(4):797-809. PMID: 35497798.
      View in: PubMed
    4. Oshima K, King SI, McMurtry SA, Schmidt EP. Endothelial Heparan Sulfate Proteoglycans in Sepsis: The Role of the Glycocalyx. Semin Thromb Hemost. 2021 Apr; 47(3):274-282. PMID: 33794552.
      View in: PubMed
    5. LaRiviere WB, Han X, Oshima K, McMurtry SA, Linhardt RJ, Schmidt EP. Detection of Glycosaminoglycans by Polyacrylamide Gel Electrophoresis and Silver Staining. J Vis Exp. 2021 02 25; (168). PMID: 33720131.
      View in: PubMed
    6. LaRivière WB, Liao S, McMurtry SA, Oshima K, Han X, Zhang F, Yan S, Haeger SM, Ransom M, Bastarache JA, Linhardt RJ, Schmidt EP, Yang Y. Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2020 06 01; 318(6):L1198-L1210. PMID: 32320623.
      View in: PubMed
    7. Oshima K, Crockett ES, Joshi SR, McLendon JM, Matsumoto Y, McMurtry IF, Abe K, Oka M. Aneurysm-type plexiform lesions form in supernumerary arteries in pulmonary arterial hypertension: potential therapeutic implications. Am J Physiol Lung Cell Mol Physiol. 2019 12 01; 317(6):L805-L815. PMID: 31577161.
      View in: PubMed
    8. Oshima K, Han X, Ouyang Y, El Masri R, Yang Y, Haeger SM, McMurtry SA, Lane TC, Davizon-Castillo P, Zhang F, Yue X, Vivès RR, Linhardt RJ, Schmidt EP. Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses. Am J Physiol Lung Cell Mol Physiol. 2019 11 01; 317(5):L667-L677. PMID: 31461325.
      View in: PubMed
    9. Zhang X, Han X, Xia K, Xu Y, Yang Y, Oshima K, Haeger SM, Perez MJ, McMurtry SA, Hippensteel JA, Ford JA, Herson PS, Liu J, Schmidt EP, Linhardt RJ. Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9208-9213. PMID: 31010931.
      View in: PubMed
    10. Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP. Circulating heparan sulfate fragments mediate septic cognitive dysfunction. J Clin Invest. 2019 04 01; 129(4):1779-1784. PMID: 30720464.
      View in: PubMed
    11. Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Am J Respir Cell Mol Biol. 2018 09; 59(3):363-374. PMID: 29584451.
      View in: PubMed
    12. Oshima K, Haeger SM, Hippensteel JA, Herson PS, Schmidt EP. More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar; 8(1):2045893217745786. PMID: 29199903.
      View in: PubMed
    13. Oka M, McMurtry IF, Oshima K. How does pulmonary endarterectomy cure CTEPH: A clue to cure PAH? Am J Physiol Lung Cell Mol Physiol. 2016 10; 311(4):L766-L769. PMID: 27591244.
      View in: PubMed
    14. Joshi SR, Lakhkar A, Dhagia V, Zias AL, Soldatos V, Oshima K, Jiang H, Gotlinger K, Capdevila JH, Schwartzman ML, McMurtry IF, Gupte SA. Cyp2c44 gene disruption exacerbated pulmonary hypertension and heart failure in female but not male mice. Pulm Circ. 2016 Sep; 6(3):360-8. PMID: 27683613.
      View in: PubMed
    15. Oshima K, McLendon JM, Wagner WW, McMurtry IF, Oka M. Chronic hypoxia does not cause wall thickening of intra-acinar pulmonary supernumerary arteries. Physiol Rep. 2016 Feb; 4(2). PMID: 26811053.
      View in: PubMed
    16. Toba M, Alzoubi A, O'Neill KD, Gairhe S, Matsumoto Y, Oshima K, Abe K, Oka M, McMurtry IF. Temporal hemodynamic and histological progression in Sugen5416/hypoxia/normoxia-exposed pulmonary arterial hypertensive rats. Am J Physiol Heart Circ Physiol. 2014 Jan 15; 306(2):H243-50. PMID: 24240870.
      View in: PubMed
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