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Owen Vaughan

TitlePost-Doctoral Fellow
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-OB/GYN BRS

    Collapse Overview 
    Collapse overview
    I conduct research in pregnancy, fetal physiology and the developmental programming of metabolic and cardiovascular disease. My work focuses on the role of the placenta in mediating the effects of environmental factors like maternal nutrition, stress, obesity and hypoxia on intrauterine development. The findings will help to inform clinical practice, for example in the use of synthetic glucocorticoids during pregnancy, and to develop prenatal interventions to ameliorate postnatal cardiometabolic disease programmed before birth. I received my PhD from the University of Cambridge and undertook postdoctoral training both in Cambridge and University College London.

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Vaughan OR, Rosario FJ, Powell TL, Jansson T. Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring. Int J Obes (Lond). 2019 May 10. PMID: 31076636.
      View in: PubMed
    2. Vaughan OR, Powell TL, Jansson T. Apelin is a novel regulator of human trophoblast amino acid transport. Am J Physiol Endocrinol Metab. 2019 May 01; 316(5):E810-E816. PMID: 30835509.
      View in: PubMed
    3. Sferruzzi-Perri AN, Higgins JS, Vaughan OR, Murray AJ, Fowden AL. Placental mitochondria adapt developmentally and in response to hypoxia to support fetal growth. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1621-1626. PMID: 30655345.
      View in: PubMed
    4. Vaughan OR, Rossi CA, Ginsberg Y, White A, Hristova M, Sebire NJ, Martin J, Zachary IC, Peebles DM, David AL. Perinatal and long-term effects of maternal uterine artery adenoviral VEGF-A165 gene therapy in the growth-restricted guinea pig fetus. Am J Physiol Regul Integr Comp Physiol. 2018 Aug 01; 315(2):R344-R353. PMID: 29847165.
      View in: PubMed
    5. Vaughan OR, De Blasio MJ, Fowden AL. Ovine uteroplacental and fetal metabolism during and after fetal cortisol overexposure in late gestation. Am J Physiol Regul Integr Comp Physiol. 2018 06 01; 314(6):R791-R801. PMID: 29443545.
      View in: PubMed
    6. Musial B, Vaughan OR, Fernandez-Twinn DS, Voshol P, Ozanne SE, Fowden AL, Sferruzzi-Perri AN. A Western-style obesogenic diet alters maternal metabolic physiology with consequences for fetal nutrient acquisition in mice. J Physiol. 2017 07 15; 595(14):4875-4892. PMID: 28382681.
      View in: PubMed
    7. Vaughan OR, Rosario FJ, Powell TL, Jansson T. Regulation of Placental Amino Acid Transport and Fetal Growth. Prog Mol Biol Transl Sci. 2017; 145:217-251. PMID: 28110752.
      View in: PubMed
    8. Vaughan OR, Fowden AL. Placental metabolism: substrate requirements and the response to stress. Reprod Domest Anim. 2016 Oct; 51 Suppl 2:25-35. PMID: 27762057.
      View in: PubMed
    9. Swanson AM, Rossi CA, Ofir K, Mehta V, Boyd M, Barker H, Ledwozyw A, Vaughan O, Martin J, Zachary I, Sebire N, Peebles DM, David AL. Maternal Therapy with Ad.VEGF-A165 Increases Fetal Weight at Term in a Guinea-Pig Model of Fetal Growth Restriction. Hum Gene Ther. 2016 12; 27(12):997-1007. PMID: 27530140.
      View in: PubMed
    10. Vaughan OR, Davies KL, Ward JW, de Blasio MJ, Fowden AL. A physiological increase in maternal cortisol alters uteroplacental metabolism in the pregnant ewe. J Physiol. 2016 11 01; 594(21):6407-6418. PMID: 27292274.
      View in: PubMed
    11. Fowden AL, Valenzuela OA, Vaughan OR, Jellyman JK, Forhead AJ. Glucocorticoid programming of intrauterine development. Domest Anim Endocrinol. 2016 07; 56 Suppl:S121-32. PMID: 27345310.
      View in: PubMed
    12. Higgins JS, Vaughan OR, Fernandez de Liger E, Fowden AL, Sferruzzi-Perri AN. Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy. J Physiol. 2016 Mar 01; 594(5):1341-56. PMID: 26377136.
      View in: PubMed
    13. Vaughan OR, Phillips HM, Everden AJ, Sferruzzi-Perri AN, Fowden AL. Dexamethasone treatment of pregnant F0 mice leads to parent of origin-specific changes in placental function of the F2 generation. Reprod Fertil Dev. 2015 May; 27(4):704-11. PMID: 25674796.
      View in: PubMed
    14. Vaughan OR, Fisher HM, Dionelis KN, Jeffreys EC, Higgins JS, Musial B, Sferruzzi-Perri AN, Fowden AL. Corticosterone alters materno-fetal glucose partitioning and insulin signalling in pregnant mice. J Physiol. 2015 03 01; 593(5):1307-21. PMID: 25625347.
      View in: PubMed
    15. Vaughan OR, Sferruzzi-Perri AN, Coan PM, Fowden AL. Adaptations in placental phenotype depend on route and timing of maternal dexamethasone administration in mice. Biol Reprod. 2013 Oct; 89(4):80. PMID: 23986571.
      View in: PubMed
    16. Vaughan OR, Sferruzzi-Perri AN, Fowden AL. Maternal corticosterone regulates nutrient allocation to fetal growth in mice. J Physiol. 2012 Nov 01; 590(21):5529-40. PMID: 22930269.
      View in: PubMed
    17. Vaughan OR, Sferruzzi-Perri AN, Coan PM, Fowden AL. Environmental regulation of placental phenotype: implications for fetal growth. Reprod Fertil Dev. 2011; 24(1):80-96. PMID: 22394720.
      View in: PubMed
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