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Holger Andreas Russ

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BDC Basic Research
Phone303/724-8544

    Collapse Research 
    Collapse research activities and funding
    R21AI140044     (DAVIDSON, HOWARD W)Jan 15, 2019 - Dec 31, 2021
    NIH
    Stress induced changes to the human beta cell proteome
    Role: Co-Principal Investigator
    R01DK120444     (RUSS, HOLGER A.)Sep 30, 2018 - Jul 31, 2022
    NIH
    Improving human pluripotent stem cell derived beta cell transplantation using genetic lineage tracing.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Basile G, Qadir MMF, Mauvais-Jarvis F, Vetere A, Shoba V, Modell AE, Pastori RL, Russ HA, Wagner BK, Dominguez-Bendala J. Emerging diabetes therapies: Bringing back the ß-cells. Mol Metab. 2022 06; 60:101477. PMID: 35331962.
      View in: PubMed
    2. Russ HA, Shilleh AH, Sussel L. From the dish to humans: A stem cell recipe for success. Cell Metab. 2022 02 01; 34(2):193-196. PMID: 35108510.
      View in: PubMed
    3. Armitage LH, Stimpson SE, Santostefano KE, Sui L, Ogundare S, Newby BN, Castro-Gutierrez R, Huber MK, Taylor JP, Sharma P, Radichev IA, Perry DJ, Fredette NC, Savinov AY, Wallet MA, Terada N, Brusko TM, Russ HA, Chen J, Egli D, Mathews CE. Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes. Front Endocrinol (Lausanne). 2021; 12:737276. PMID: 34858326.
      View in: PubMed
    4. Russ HA, Davidson HW. Found in Translation: Novel Insights Into Type 1 Diabetes and ß-Cell Biology. Diabetes. 2021 10; 70(10):2185-2186. PMID: 34593539.
      View in: PubMed
    5. Docherty FM, Riemondy KA, Castro-Gutierrez R, Dwulet JM, Shilleh AH, Hansen MS, Williams SPM, Armitage LH, Santostefano KE, Wallet MA, Mathews CE, Triolo TM, Benninger RKP, Russ HA. ENTPD3 Marks Mature Stem Cell-Derived ß-Cells Formed by Self-Aggregation In Vitro. Diabetes. 2021 11; 70(11):2554-2567. PMID: 34380694.
      View in: PubMed
    6. Brusko TM, Russ HA, Stabler CL. Strategies for durable ß cell replacement in type 1 diabetes. Science. 2021 07 30; 373(6554):516-522. PMID: 34326233.
      View in: PubMed
    7. Ramos SA, Morton JJ, Yadav P, Reed B, Alizadeh SI, Shilleh AH, Perrenoud L, Jaggers J, Kappler J, Jimeno A, Russ HA. Generation of functional human thymic cells from induced pluripotent stem cells. J Allergy Clin Immunol. 2022 02; 149(2):767-781.e6. PMID: 34331993.
      View in: PubMed
    8. Castro-Gutierrez R, Alkanani A, Mathews CE, Michels A, Russ HA. Protecting Stem Cell Derived Pancreatic Beta-Like Cells From Diabetogenic T Cell Recognition. Front Endocrinol (Lausanne). 2021; 12:707881. PMID: 34305820.
      View in: PubMed
    9. Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System. Stem Cell Reports. 2021 Apr 13; 16(4):1009. PMID: 33852882.
      View in: PubMed
    10. Santini-González J, Simonovich JA, Castro-Gutiérrez R, González-Vargas Y, Abuid NJ, Stabler CL, Russ HA, Phelps EA. In vitro generation of peri-islet basement membrane-like structures. Biomaterials. 2021 06; 273:120808. PMID: 33895491.
      View in: PubMed
    11. Bubak AN, Beseler C, Como CN, Coughlan CM, Johnson NR, Hassell JE, Burnet AM, Mescher T, Schmid DS, Coleman C, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Shilleh AH, Russ HA, Nagel MA. Amylin, Aß42, and Amyloid in Varicella Zoster Virus Vasculopathy Cerebrospinal Fluid and Infected Vascular Cells. J Infect Dis. 2021 04 08; 223(7):1284-1294. PMID: 32809013.
      View in: PubMed
    12. Landry LG, Anderson AM, Russ HA, Yu L, Kent SC, Atkinson MA, Mathews CE, Michels AW, Nakayama M. Proinsulin-Reactive CD4 T Cells in the Islets of Type 1 Diabetes Organ Donors. Front Endocrinol (Lausanne). 2021; 12:622647. PMID: 33841327.
      View in: PubMed
    13. Goering R, Hudish LI, Guzman BB, Raj N, Bassell GJ, Russ HA, Dominguez D, Taliaferro JM. FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences. Elife. 2020 06 08; 9. PMID: 32510328.
      View in: PubMed
    14. Russell R, Carnese PP, Hennings TG, Walker EM, Russ HA, Liu JS, Giacometti S, Stein R, Hebrok M. Loss of the transcription factor MAFB limits ß-cell derivation from human PSCs. Nat Commun. 2020 06 02; 11(1):2742. PMID: 32488111.
      View in: PubMed
    15. Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System. Stem Cell Reports. 2020 06 09; 14(6):1033-1043. PMID: 32386561.
      View in: PubMed
    16. Bubak AN, Como CN, Coughlan CM, Johnson NR, Hassell JE, Mescher T, Niemeyer CS, Mahalingam R, Cohrs RJ, Boyd TD, Potter H, Russ HA, Nagel MA. Varicella-Zoster Virus Infection of Primary Human Spinal Astrocytes Produces Intracellular Amylin, Amyloid-ß, and an Amyloidogenic Extracellular Environment. J Infect Dis. 2020 03 16; 221(7):1088-1097. PMID: 31665341.
      View in: PubMed
    17. Zhou X, Nair GG, Russ HA, Belair CD, Li ML, Shveygert M, Hebrok M, Blelloch R. LIN28B Impairs the Transition of hESC-Derived ß Cells from the Juvenile to Adult State. Stem Cell Reports. 2020 01 14; 14(1):9-20. PMID: 31883920.
      View in: PubMed
    18. Liebau S, Russ HA, Kleger A. Stem Cell Derived Organoids in Human Disease and Development. Stem Cells Int. 2019; 2019:7919427. PMID: 31827533.
      View in: PubMed
    19. Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M. Author Correction: Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived ß cells. Nat Cell Biol. 2019 06; 21(6):792. PMID: 30914825.
      View in: PubMed
    20. Nair GG, Liu JS, Russ HA, Tran S, Saxton MS, Chen R, Juang C, Li ML, Nguyen VQ, Giacometti S, Puri S, Xing Y, Wang Y, Szot GL, Oberholzer J, Bhushan A, Hebrok M. Recapitulating endocrine cell clustering in culture promotes maturation of human stem-cell-derived ß cells. Nat Cell Biol. 2019 02; 21(2):263-274. PMID: 30710150.
      View in: PubMed
    21. Castro-Gutierrez R, Michels AW, Russ HA. ß Cell replacement: improving on the design. Curr Opin Endocrinol Diabetes Obes. 2018 08; 25(4):251-257. PMID: 29846237.
      View in: PubMed
    22. Puri S, Roy N, Russ HA, Leonhardt L, French EK, Roy R, Bengtsson H, Scott DK, Stewart AF, Hebrok M. Replication confers ß cell immaturity. Nat Commun. 2018 02 02; 9(1):485. PMID: 29396395.
      View in: PubMed
    23. Faleo G, Russ HA, Wisel S, Parent AV, Nguyen V, Nair GG, Freise JE, Villanueva KE, Szot GL, Hebrok M, Tang Q. Mitigating Ischemic Injury of Stem Cell-Derived Insulin-Producing Cells after Transplant. Stem Cell Reports. 2017 09 12; 9(3):807-819. PMID: 28803916.
      View in: PubMed
    24. Chang R, Faleo G, Russ HA, Parent AV, Elledge SK, Bernards DA, Allen JL, Villanueva K, Hebrok M, Tang Q, Desai TA. Nanoporous Immunoprotective Device for Stem-Cell-Derived ß-Cell Replacement Therapy. ACS Nano. 2017 08 22; 11(8):7747-7757. PMID: 28763191.
      View in: PubMed
    25. Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M. Human islets contain four distinct subtypes of ß cells. Nat Commun. 2016 07 11; 7:11756. PMID: 27399229.
      View in: PubMed
    26. Zhu S, Russ HA, Wang X, Zhang M, Ma T, Xu T, Tang S, Hebrok M, Ding S. Human pancreatic beta-like cells converted from fibroblasts. Nat Commun. 2016 Jan 06; 7:10080. PMID: 26733021.
      View in: PubMed
    27. Russ HA, Landsman L, Moss CL, Higdon R, Greer RL, Kaihara K, Salamon R, Kolker E, Hebrok M. Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation. Stem Cells Int. 2016; 2016:6183562. PMID: 26681951.
      View in: PubMed
    28. Sintov E, Nathan G, Knoller S, Pasmanik-Chor M, Russ HA, Efrat S. Inhibition of ZEB1 expression induces redifferentiation of adult human ß cells expanded in vitro. Sci Rep. 2015 Aug 12; 5:13024. PMID: 26264186.
      View in: PubMed
    29. Russ HA, Parent AV, Ringler JJ, Hennings TG, Nair GG, Shveygert M, Guo T, Puri S, Haataja L, Cirulli V, Blelloch R, Szot GL, Arvan P, Hebrok M. Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro. EMBO J. 2015 Jul 02; 34(13):1759-72. PMID: 25908839.
      View in: PubMed
    30. Russ HA, Hebrok M. Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors. EMBO J. 2014 Oct 01; 33(19):2135-6. PMID: 25154606.
      View in: PubMed
    31. Morris JP, Greer R, Russ HA, von Figura G, Kim GE, Busch A, Lee J, Hertel KJ, Kim S, McManus M, Hebrok M. Dicer regulates differentiation and viability during mouse pancreatic cancer initiation. PLoS One. 2014; 9(5):e95486. PMID: 24788257.
      View in: PubMed
    32. von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol. 2014 Mar; 16(3):255-67. PMID: 24561622.
      View in: PubMed
    33. Li K, Zhu S, Russ HA, Xu S, Xu T, Zhang Y, Ma T, Hebrok M, Ding S. Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell. 2014 Feb 06; 14(2):228-36. PMID: 24506886.
      View in: PubMed
    34. Parent AV, Russ HA, Khan IS, LaFlam TN, Metzger TC, Anderson MS, Hebrok M. Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development. Cell Stem Cell. 2013 Aug 01; 13(2):219-29. PMID: 23684540.
      View in: PubMed
    35. Efrat S, Russ HA. Making ß cells from adult tissues. Trends Endocrinol Metab. 2012 Jun; 23(6):278-85. PMID: 22537825.
      View in: PubMed
    36. Bar Y, Russ HA, Sintov E, Anker-Kitai L, Knoller S, Efrat S. Redifferentiation of expanded human pancreatic ß-cell-derived cells by inhibition of the NOTCH pathway. J Biol Chem. 2012 May 18; 287(21):17269-17280. PMID: 22457355.
      View in: PubMed
    37. Russ HA, Efrat S. Development of human insulin-producing cells for cell therapy of diabetes. Pediatr Endocrinol Rev. 2011 Dec; 9(2):590-7. PMID: 22397143.
      View in: PubMed
    38. Russ HA, Sintov E, Anker-Kitai L, Friedman O, Lenz A, Toren G, Farhy C, Pasmanik-Chor M, Oron-Karni V, Ravassard P, Efrat S. Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS One. 2011; 6(9):e25566. PMID: 21984932.
      View in: PubMed
    39. Bar-Nur O, Russ HA, Efrat S, Benvenisty N. Epigenetic memory and preferential lineage-specific differentiation in induced pluripotent stem cells derived from human pancreatic islet beta cells. Cell Stem Cell. 2011 Jul 08; 9(1):17-23. PMID: 21726830.
      View in: PubMed
    40. Russ HA, Ravassard P, Kerr-Conte J, Pattou F, Efrat S. Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells. PLoS One. 2009 Jul 29; 4(7):e6417. PMID: 19641613.
      View in: PubMed
    41. Bar Y, Russ HA, Knoller S, Ouziel-Yahalom L, Efrat S. HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro. Diabetes. 2008 Sep; 57(9):2413-20. PMID: 18599525.
      View in: PubMed
    42. Russ HA, Bar Y, Ravassard P, Efrat S. In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing. Diabetes. 2008 Jun; 57(6):1575-83. PMID: 18316362.
      View in: PubMed
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