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Matthew J Sikora

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Pathology
Phone303/724-4301

    Collapse Research 
    Collapse research activities and funding
    R01CA285446     (SIKORA, MATTHEW J)Sep 21, 2023 - Aug 31, 2028
    NIH
    Elucidating a novel WNT4 regulatory axis as a driver of gynecologic cancer health disparities
    Role: Principal Investigator
    R01CA251621     (SIKORA, MATTHEW J)Sep 1, 2022 - Aug 31, 2027
    NIH
    MDC1: central regulator of estrogen receptor function and therapy response in lobular carcinoma
    Role: Principal Investigator
    R00CA193734     (SIKORA, MATTHEW J)Dec 7, 2016 - Nov 30, 2019
    NIH
    WNT4 IN ENDOCRINE RESPONSE AND RESISTANCE IN INVASIVE LOBULAR CARCINOMA
    Role: Principal Investigator
    R13CA195982     (SIKORA, MATTHEW J)May 1, 2015 - Sep 30, 2015
    NIH
    2015 Hormone-Dependent Cancers Gordon Research Conference and Gordon Research Seminar
    Role: Principal Investigator
    K99CA193734     (SIKORA, MATTHEW J)Apr 1, 2015 - Mar 31, 2017
    NIH
    Elucidating the function of WNT4 in endocrine response and resistance in invasive lobular carcinoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sottnik JL, Shackleford MT, Robinson SK, Villagomez FR, Bahnassy S, Oesterreich S, Hu J, Madak-Erdogan Z, Riggins RB, Corr BR, Cook LS, Trevi?o LS, Bitler BG, Sikora MJ. WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers. Cancer Res Commun. 2024 01 17; 4(1):134-151. PMID: 38112643.
      View in: PubMed
    2. Sikora MJ, Ostrander JH. A Path to Precision Metabolic Treatment in Breast Cancer: Riluzole, Glutamate Signaling, and Invasive Lobular Carcinoma. J Endocr Soc. 2024 Jan 05; 8(2):bvad171. PMID: 38193025.
      View in: PubMed
    3. Li Z, Li T, Yates ME, Wu Y, Ferber A, Chen L, Brown DD, Carroll JS, Sikora MJ, Tseng GC, Oesterreich S, Lee AV. The EstroGene Database Reveals Diverse Temporal, Context-Dependent, and Bidirectional Estrogen Receptor Regulomes in Breast Cancer. Cancer Res. 2023 08 15; 83(16):2656-2674. PMID: 37272757.
      View in: PubMed
    4. Li Z, Li T, Yates ME, Wu Y, Ferber A, Chen L, Brown DD, Carroll JS, Sikora MJ, Tseng GC, Oesterreich S, Lee AV. EstroGene database reveals diverse temporal, context-dependent and directional estrogen receptor regulomes in breast cancer. bioRxiv. 2023 Feb 02. PMID: 36778377.
      View in: PubMed
    5. Bahnassy S, Sikora MJ, Riggins RB. Unlocking the Mysteries of Lobular Breast Cancer Biology Needs the Right Combination of Preclinical Models. Mol Cancer Res. 2022 06 03; 20(6):837-840. PMID: 35276005.
      View in: PubMed
    6. Li Z, Spoelstra NS, Sikora MJ, Sams SB, Elias A, Richer JK, Lee AV, Oesterreich S. Mutual exclusivity of ESR1 and TP53 mutations in endocrine resistant metastatic breast cancer. NPJ Breast Cancer. 2022 May 10; 8(1):62. PMID: 35538119.
      View in: PubMed
    7. Almosnino G, Sikora MJ, Farrokhi FR, Schwartz SR, Zeitler DM. Tumor-Related and Patient-Related Variables Affecting Length of Hospital Stay Following Vestibular Schwannoma Microsurgery. Ann Otol Rhinol Laryngol. 2022 May; 131(5):535-543. PMID: 34210194.
      View in: PubMed
    8. Pitzer LM, Moroney MR, Nokoff NJ, Sikora MJ. WNT4 Balances Development vs Disease in Gynecologic Tissues and Women's Health. Endocrinology. 2021 07 01; 162(7). PMID: 33963381.
      View in: PubMed
    9. Sottnik JL, Bordeaux EK, Mehrotra S, Ferrara SE, Goodspeed AE, Costello JC, Sikora MJ. Mediator of DNA Damage Checkpoint 1 (MDC1) Is a Novel Estrogen Receptor Coregulator in Invasive Lobular Carcinoma of the Breast. Mol Cancer Res. 2021 08; 19(8):1270-1282. PMID: 33947745.
      View in: PubMed
    10. Sikora MJ, Riggins RB, Madak-Erdogan Z. Making an IMPACT on career development for early- and mid-career faculty. Endocrinology. 2021 Jan 07. PMID: 33411889.
      View in: PubMed
    11. Shackleford MT, Rao DM, Bordeaux EK, Hicks HM, Towers CG, Sottnik JL, Oesterreich S, Sikora MJ. Estrogen Regulation of mTOR Signaling and Mitochondrial Function in Invasive Lobular Carcinoma Cell Lines Requires WNT4. Cancers (Basel). 2020 Oct 12; 12(10). PMID: 33053661.
      View in: PubMed
    12. Jordan KR, Sikora MJ, Slansky JE, Minic A, Richer JK, Moroney MR, Hu J, Wolsky RJ, Watson ZL, Yamamoto TM, Costello JC, Clauset A, Behbakht K, Kumar TR, Bitler BG. The Capacity of the Ovarian Cancer Tumor Microenvironment to Integrate Inflammation Signaling Conveys a Shorter Disease-free Interval. Clin Cancer Res. 2020 12 01; 26(23):6362-6373. PMID: 32928797.
      View in: PubMed
    13. Sreekumar S, Levine KM, Sikora MJ, Chen J, Tasdemir N, Carter D, Dabbs DJ, Meier C, Basudan A, Boone D, McAuliffe PF, Jankowitz RC, Lee AV, Atkinson JM, Oesterreich S. Differential Regulation and Targeting of Estrogen Receptor a Turnover in Invasive Lobular Breast Carcinoma. Endocrinology. 2020 09 01; 161(9). PMID: 32609836.
      View in: PubMed
    14. Buchlak QD, Farrokhi F, Sikora M, Esmaili N, Marsans M, McLeod P, Mark J, Cox E, Bennett C, Carlson J. In Reply to the Letter to the Editor Regarding "Investigating Risk Factors and Predicting Complications in Deep Brain Stimulation Surgery with Machine Learning Algorithms". World Neurosurg. 2020 05; 137:497-499. PMID: 32365451.
      View in: PubMed
    15. Rao DM, Shackleford MT, Bordeaux EK, Sottnik JL, Ferguson RL, Yamamoto TM, Wellberg EA, Bitler BG, Sikora MJ. Wnt family member 4 (WNT4) and WNT3A activate cell-autonomous Wnt signaling independent of porcupine O-acyltransferase or Wnt secretion. J Biol Chem. 2019 12 27; 294(52):19950-19966. PMID: 31740580.
      View in: PubMed
    16. Farrokhi F, Buchlak QD, Sikora M, Esmaili N, Marsans M, McLeod P, Mark J, Cox E, Bennett C, Carlson J. Investigating Risk Factors and Predicting Complications in Deep Brain Stimulation Surgery with Machine Learning Algorithms. World Neurosurg. 2020 Feb; 134:e325-e338. PMID: 31634625.
      View in: PubMed
    17. Farrokhi FR, Marsans MT, Sikora M, Monsell SE, Wright AK, Palmer M, Hoefer A, McLeod P, Mark J, Carlson J. Pre-operative smoking history increases risk of infection in deep brain stimulation surgery. J Clin Neurosci. 2019 Nov; 69:88-92. PMID: 31445813.
      View in: PubMed
    18. Levine KM, Priedigkeit N, Basudan A, Tasdemir N, Sikora MJ, Sokol ES, Hartmaier RJ, Ding K, Ahmad NZ, Watters RJ, Weiss KR, Blohmer JU, Denkert C, Machleidt A, Karsten MM, Boisen MM, Elishaev E, Lucas PC, Lee AV, Oesterreich S. FGFR4 overexpression and hotspot mutations in metastatic ER+ breast cancer are enriched in the lobular subtype. NPJ Breast Cancer. 2019; 5:19. PMID: 31263748.
      View in: PubMed
    19. Cao L, Basudan A, Sikora MJ, Bahreini A, Tasdemir N, Levine KM, Jankowitz RC, McAuliffe PF, Dabbs D, Haupt S, Haupt Y, Lucas PC, Lee AV, Oesterreich S, Atkinson JM. Frequent amplifications of ESR1, ERBB2 and MDM4 in primary invasive lobular breast carcinoma. Cancer Lett. 2019 Oct 01; 461:21-30. PMID: 31229512.
      View in: PubMed
    20. Yamamoto TM, McMellen A, Watson ZL, Aguilera J, Ferguson R, Nurmemmedov E, Thakar T, Moldovan GL, Kim H, Cittelly DM, Joglar AM, Brennecke EP, Wilson H, Behbakht K, Sikora MJ, Bitler BG. Activation of Wnt signaling promotes olaparib resistant ovarian cancer. Mol Carcinog. 2019 10; 58(10):1770-1782. PMID: 31219654.
      View in: PubMed
    21. Bossart EA, Tasdemir N, Sikora MJ, Bahreini A, Levine KM, Chen J, Basudan A, Jacobsen BM, Burns TF, Oesterreich S. SNAIL is induced by tamoxifen and leads to growth inhibition in invasive lobular breast carcinoma. Breast Cancer Res Treat. 2019 Jun; 175(2):327-337. PMID: 30798422.
      View in: PubMed
    22. Andersen CL, Boisen MM, Sikora MJ, Ma T, Tseng G, Suryawanshi S, Vlad A, Elishaev E, Edwards RP, Oesterreich S. The Evolution of Estrogen Receptor Signaling in the Progression of Endometriosis to Endometriosis-Associated Ovarian Cancer. Horm Cancer. 2018 12; 9(6):399-407. PMID: 30302736.
      View in: PubMed
    23. Tasdemir N, Bossart EA, Li Z, Zhu L, Sikora MJ, Levine KM, Jacobsen BM, Tseng GC, Davidson NE, Oesterreich S. Comprehensive Phenotypic Characterization of Human Invasive Lobular Carcinoma Cell Lines in 2D and 3D Cultures. Cancer Res. 2018 11 01; 78(21):6209-6222. PMID: 30228172.
      View in: PubMed
    24. Du T, Sikora MJ, Levine KM, Tasdemir N, Riggins RB, Wendell SG, Van Houten B, Oesterreich S. Key regulators of lipid metabolism drive endocrine resistance in invasive lobular breast cancer. Breast Cancer Res. 2018 09 04; 20(1):106. PMID: 30180878.
      View in: PubMed
    25. Martin LA, Ribas R, Simigdala N, Schuster E, Pancholi S, Tenev T, Gellert P, Buluwela L, Harrod A, Thornhill A, Nikitorowicz-Buniak J, Bhamra A, Turgeon MO, Poulogiannis G, Gao Q, Martins V, Hills M, Garcia-Murillas I, Fribbens C, Patani N, Li Z, Sikora MJ, Turner N, Zwart W, Oesterreich S, Carroll J, Ali S, Dowsett M. Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance. Nat Commun. 2017 11 30; 8(1):1865. PMID: 29192207.
      View in: PubMed
    26. Hertz DL, Kidwell KM, Hilsenbeck SG, Oesterreich S, Osborne CK, Philips S, Chenault C, Hartmaier RJ, Skaar TC, Sikora MJ, Rae JM. CYP2D6 genotype is not associated with survival in breast cancer patients treated with tamoxifen: results from a population-based study. Breast Cancer Res Treat. 2017 Nov; 166(1):277-287. PMID: 28730340.
      View in: PubMed
    27. Hsu JY, Sikora MJ. CRISPR Fish Reel in Novel Roles for Estrogen Receptors in Reproduction. Endocrinology. 2017 07 01; 158(7):2082-2083. PMID: 28881866.
      View in: PubMed
    28. Andersen CL, Sikora MJ, Boisen MM, Ma T, Christie A, Tseng G, Park Y, Luthra S, Chandran U, Haluska P, Mantia-Smaldone GM, Odunsi K, McLean K, Lee AV, Elishaev E, Edwards RP, Oesterreich S. Active Estrogen Receptor-alpha Signaling in Ovarian Cancer Models and Clinical Specimens. Clin Cancer Res. 2017 Jul 15; 23(14):3802-3812. PMID: 28073843.
      View in: PubMed
    29. Sikora MJ. Family Matters: Collaboration and Conflict Among the Steroid Receptors Raises a Need for Group Therapy. Endocrinology. 2016 Dec; 157(12):4553-4560. PMID: 27835038.
      View in: PubMed
    30. Sikora MJ, Jacobsen BM, Levine K, Chen J, Davidson NE, Lee AV, Alexander CM, Oesterreich S. WNT4 mediates estrogen receptor signaling and endocrine resistance in invasive lobular carcinoma cell lines. Breast Cancer Res. 2016 09 20; 18(1):92. PMID: 27650553.
      View in: PubMed
    31. Sikora MJ, Johnson MD, Lee AV, Oesterreich S. Endocrine Response Phenotypes Are Altered by Charcoal-Stripped Serum Variability. Endocrinology. 2016 Oct; 157(10):3760-3766. PMID: 27459541.
      View in: PubMed
    32. Dennison JB, Shahmoradgoli M, Liu W, Ju Z, Meric-Bernstam F, Perou CM, Sahin AA, Welm A, Oesterreich S, Sikora MJ, Brown RE, Mills GB. High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype. Clin Cancer Res. 2016 Oct 15; 22(20):5068-5078. PMID: 27172895.
      View in: PubMed
    33. Capper CP, Larios JM, Sikora MJ, Johnson MD, Rae JM. The CYP17A1 inhibitor abiraterone exhibits estrogen receptor agonist activity in breast cancer. Breast Cancer Res Treat. 2016 05; 157(1):23-30. PMID: 27083183.
      View in: PubMed
    34. Delgado E, Boisen MM, Laskey R, Chen R, Song C, Sallit J, Yochum ZA, Andersen CL, Sikora MJ, Wagner J, Safe S, Elishaev E, Lee A, Edwards RP, Haluska P, Tseng G, Schurdak M, Oesterreich S. High expression of orphan nuclear receptor NR4A1 in a subset of ovarian tumors with worse outcome. Gynecol Oncol. 2016 05; 141(2):348-356. PMID: 26946093.
      View in: PubMed
    35. Sikora MJ, Cooper KL, Bahreini A, Luthra S, Wang G, Chandran UR, Davidson NE, Dabbs DJ, Welm AL, Oesterreich S. Invasive lobular carcinoma cell lines are characterized by unique estrogen-mediated gene expression patterns and altered tamoxifen response. Cancer Res. 2014 Mar 01; 74(5):1463-74. PMID: 24425047.
      View in: PubMed
    36. Sikora MJ, Jankowitz RC, Dabbs DJ, Oesterreich S. Invasive lobular carcinoma of the breast: patient response to systemic endocrine therapy and hormone response in model systems. Steroids. 2013 Jun; 78(6):568-75. PMID: 23178159.
      View in: PubMed
    37. Sikora MJ, Strumba V, Lippman ME, Johnson MD, Rae JM. Mechanisms of estrogen-independent breast cancer growth driven by low estrogen concentrations are unique versus complete estrogen deprivation. Breast Cancer Res Treat. 2012 Aug; 134(3):1027-39. PMID: 22456984.
      View in: PubMed
    38. Anderson MA, Brenner DE, Scheiman JM, Simeone DM, Singh N, Sikora MJ, Zhao L, Mertens AN, Rae JM. Reliable gene expression measurements from fine needle aspirates of pancreatic tumors: effect of amplicon length and quality assessment. J Mol Diagn. 2010 Sep; 12(5):566-75. PMID: 20709792.
      View in: PubMed
    39. Sikora MJ, Rae JM, Johnson MD, Desta Z. Efavirenz directly modulates the oestrogen receptor and induces breast cancer cell growth. HIV Med. 2010 Oct 01; 11(9):603-7. PMID: 20408889.
      View in: PubMed
    40. Sikora MJ, Thibert JN, Salter J, Dowsett M, Johnson MD, Rae JM. High-efficiency genotype analysis from formalin-fixed, paraffin-embedded tumor tissues. Pharmacogenomics J. 2011 Oct; 11(5):348-58. PMID: 20548328.
      View in: PubMed
    41. Rae JM, Sikora MJ, Henry NL, Li L, Kim S, Oesterreich S, Skaar TC, Nguyen AT, Desta Z, Storniolo AM, Flockhart DA, Hayes DF, Stearns V. Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients. Pharmacogenomics J. 2009 Aug; 9(4):258-64. PMID: 19421167.
      View in: PubMed
    42. Henry NL, Rae JM, Li L, Azzouz F, Skaar TC, Desta Z, Sikora MJ, Philips S, Nguyen AT, Storniolo AM, Hayes DF, Flockhart DA, Stearns V. Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. Breast Cancer Res Treat. 2009 Oct; 117(3):571-5. PMID: 19153830.
      View in: PubMed
    43. Snider NT, Sikora MJ, Sridar C, Feuerstein TJ, Rae JM, Hollenberg PF. The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. J Pharmacol Exp Ther. 2008 Nov; 327(2):538-45. PMID: 18698000.
      View in: PubMed
    44. Sikora MJ, Cordero KE, Larios JM, Johnson MD, Lippman ME, Rae JM. The androgen metabolite 5alpha-androstane-3beta,17beta-diol (3betaAdiol) induces breast cancer growth via estrogen receptor: implications for aromatase inhibitor resistance. Breast Cancer Res Treat. 2009 May; 115(2):289-96. PMID: 18521740.
      View in: PubMed
    45. Sikora MJ, Bauer JA, Verhaegen M, Belbin TJ, Prystowsky MB, Taylor JC, Brenner JC, Wang S, Soengas MS, Bradford CR, Carey TE. Anti-oxidant treatment enhances anti-tumor cytotoxicity of (-)-gossypol. Cancer Biol Ther. 2008 May; 7(5):767-76. PMID: 18376141.
      View in: PubMed
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