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Rebecca L O'brien

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology

    Collapse Research 
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    R01AI031588     (O'BRIEN, REBECCA L.)Aug 1, 1991 - Jul 31, 1994
    NIH/NIAID
    HEAT SHOCK PROTEIN RECOGNITION/GAMMA-DELTA T CELL SUBSET
    Role: Principal Investigator

    K04AI001291     (O'BRIEN, REBECCA L.)Sep 30, 1994 - Aug 31, 1999
    NIH/NIAID
    ANTIGEN RECOGNITION BY GAMMA/DELTA T CELLS
    Role: Principal Investigator

    R01AI044920     (O'BRIEN, REBECCA L.)Apr 1, 1999 - Mar 31, 2010
    NIH/NIAID
    The Basis of Functional Variation in Gamma/Delta T cells
    Role: Principal Investigator

    R03EY015840     (O'BRIEN, REBECCA L.)Sep 30, 2004 - Aug 31, 2007
    NIH/NEI
    Spontaneous Corneal Inflammation in gd T cell absence
    Role: Principal Investigator

    R21AI063400     (O'BRIEN, REBECCA L.)Jul 1, 2005 - Jun 30, 2008
    NIH/NIAID
    Identifying Ligands with Soluble Gamma/Delta TCRs
    Role: Principal Investigator

    R21EY019328     (O'BRIEN, REBECCA L.)Apr 1, 2010 - Mar 31, 2013
    NIH/NEI
    Spontaneous Keratitis in T-Cell Deficient Female Mice
    Role: Principal Investigator

    R56AI077594     (O'BRIEN, REBECCA L.)Jul 19, 2010 - Jun 30, 2012
    NIH/NIAID
    Discovery and Investigation of Gamma/Delta TCR Ligands
    Role: Principal Investigator

    R21AI097962     (O'BRIEN, REBECCA L.)Mar 1, 2012 - Feb 28, 2014
    NIH/NIAID
    The role of gamma/delta T cells in type 1 diabetes
    Role: Principal Investigator

    R01EY021199     (O'BRIEN, REBECCA L.)Aug 1, 2012 - Jul 31, 2016
    NIH/NEI
    Gamma/delta T cells in autoimmune keratitis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liang D, Zuo A, Zhao R, Shao H, Born WK, O'Brien RL, Kaplan HJ, Sun D. Correction: CD73 Expressed on ?d T Cells Shapes Their Regulatory Effect in Experimental Autoimmune Uveitis. PLoS One. 2016; 11(10):e0164502. PMID: 27701472.
      View in: PubMed
    2. Luria SR, O'Brien RL, Kaufman JC. Creativity in gifted identification: increasing accuracy and diversity. Ann N Y Acad Sci. 2016 Aug; 1377(1):44-52. PMID: 27434531.
      View in: PubMed
    3. Born WK, Huang Y, Zeng W, Torres RM, O'Brien RL. A Special Connection between ?d T Cells and Natural Antibodies? Arch Immunol Ther Exp (Warsz). 2016 Dec; 64(6):455-462. PMID: 27235134.
      View in: PubMed
    4. Born WK, O'Brien RL. Discovery of the ?d TCR: Act II. J Immunol. 2016 May 01; 196(9):3507-8. PMID: 27183646.
      View in: PubMed
    5. Liang D, Zuo A, Zhao R, Shao H, Born WK, O'Brien RL, Kaplan HJ, Sun D. CD73 Expressed on ?d T Cells Shapes Their Regulatory Effect in Experimental Autoimmune Uveitis. PLoS One. 2016; 11(2):e0150078. PMID: 26919582; PMCID: PMC4769068.
    6. Huang Y, Getahun A, Heiser RA, Detanico TO, Aviszus K, Kirchenbaum GA, Casper TL, Huang C, Aydintug MK, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, O'Brien RL, Born WK. ?d T Cells Shape Preimmune Peripheral B Cell Populations. J Immunol. 2016 Jan 01; 196(1):217-31. PMID: 26582947; PMCID: PMC4684964 [Available on 01/01/17].
    7. Huang Y, Yang Z, Huang C, McGowan J, Casper T, Sun D, Born WK, O'Brien RL. ?d T Cell-Dependent Regulatory T Cells Prevent the Development of Autoimmune Keratitis. J Immunol. 2015 Dec 15; 195(12):5572-81. PMID: 26566677; PMCID: PMC4670787 [Available on 12/15/16].
    8. Beck BH, Kim H, O'Brien R, Jadus MR, Gillespie GY, Cloud GA, Hoa NT, Langford CP, Lopez RD, Harkins LE, Lamb LS. Dynamics of Circulating ?d T Cell Activity in an Immunocompetent Mouse Model of High-Grade Glioma. PLoS One. 2015; 10(5):e0122387. PMID: 25955158; PMCID: PMC4425513.
    9. Huang Y, Yang Z, McGowan J, Huang H, O'Brien RL, Born WK. Regulation of IgE Responses by ?d T Cells. Curr Allergy Asthma Rep. 2015 Apr; 15(4):13. PMID: 26130476.
      View in: PubMed
    10. O'Brien RL, Born WK. Dermal ?d T cells--What have we learned? Cell Immunol. 2015 Jul; 296(1):62-9. PMID: 25649119; PMCID: PMC4466165.
    11. Huang Y, Heiser RA, Detanico TO, Getahun A, Kirchenbaum GA, Casper TL, Aydintug MK, Carding SR, Ikuta K, Huang H, Cambier JC, Wysocki LJ, O'Brien RL, Born WK. ?d T cells affect IL-4 production and B-cell tolerance. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):E39-48. PMID: 25535377; PMCID: PMC4291655.
    12. Zhang J, Wang J, Pang L, Xie G, Welte T, Saxena V, Wicker J, Mann B, Soong L, Barrett A, Born W, O'Brien R, Wang T. The co-stimulatory effects of MyD88-dependent Toll-like receptor signaling on activation of murine ?d T cells. PLoS One. 2014; 9(9):e108156. PMID: 25232836; PMCID: PMC4169491.
    13. Aydintug MK, Zhang L, Wang C, Liang D, Wands JM, Michels AW, Hirsch B, Day BJ, Zhang G, Sun D, Eisenbarth GS, O'Brien RL, Born WK. ?d T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation. Mol Immunol. 2014 Aug; 60(2):116-28. PMID: 24853397; PMCID: PMC4091716.
    14. Liang D, Zuo A, Shao H, Born WK, O'Brien RL, Kaplan HJ, Sun D. IL-23 receptor expression on ?d T cells correlates with their enhancing or suppressive effects on autoreactive T cells in experimental autoimmune uveitis. J Immunol. 2013 Aug 01; 191(3):1118-25. PMID: 23797670; PMCID: PMC3720691.
    15. Liang D, Zuo A, Shao H, Born WK, O'Brien RL, Kaplan HJ, Sun D. Retinoic acid inhibits CD25+ dendritic cell expansion and ?d T-cell activation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2013 May 01; 54(5):3493-503. PMID: 23611991; PMCID: PMC3665306.
    16. Roark CL, Huang Y, Jin N, Aydintug MK, Casper T, Sun D, Born WK, O'Brien RL. A canonical V?4Vd4+ ?d T cell population with distinct stimulation requirements which promotes the Th17 response. Immunol Res. 2013 Mar; 55(1-3):217-30. PMID: 22961659; PMCID: PMC3543513.
    17. Huang Y, Aydintug MK, Loomis J, Macleod MK, McKee AS, Kirchenbaum G, Jakubzick CV, Kedl RM, Sun D, Jacobelli J, O'Brien RL, Born WK. Antigen-specific regulation of IgE antibodies by non-antigen-specific ?d T cells. J Immunol. 2013 Feb 01; 190(3):913-21. PMID: 23275606; PMCID: PMC3552125.
    18. Born WK, Kemal Aydintug M, O'Brien RL. Diversity of ?d T-cell antigens. Cell Mol Immunol. 2013 Jan; 10(1):13-20. PMID: 23085946; PMCID: PMC4003174.
    19. Liang D, Zuo A, Shao H, Born WK, O'Brien RL, Kaplan HJ, Sun D. Role of CD25+ dendritic cells in the generation of Th17 autoreactive T cells in autoimmune experimental uveitis. J Immunol. 2012 Jun 01; 188(11):5785-91. PMID: 22539790; PMCID: PMC3358586.
    20. O'Brien RL, Chain JL, Aydintug MK, Bohrer-Kunter D, Huang Y, Hardy IR, Cambier JC, Lahmers K, Nuhsbaum T, Davidson R, Sun D, Born WK. aß TCR? T cells, but not B cells, promote autoimmune keratitis in b10 mice lacking ?d T cells. Invest Ophthalmol Vis Sci. 2012 Jan 25; 53(1):301-8. PMID: 22199243; PMCID: PMC3292366.
    21. Welte T, Aronson J, Gong B, Rachamallu A, Mendell N, Tesh R, Paessler S, Born WK, O'Brien RL, Wang T. V?4+ T cells regulate host immune response to West Nile virus infection. FEMS Immunol Med Microbiol. 2011 Nov; 63(2):183-92. PMID: 22077221; PMCID: PMC3605001.
    22. Hao J, Dong S, Xia S, He W, Jia H, Zhang S, Wei J, O'Brien RL, Born WK, Wu Z, Wang P, Han J, Hong Z, Zhao L, Yin Z. Regulatory role of V?1 ?d T cells in tumor immunity through IL-4 production. J Immunol. 2011 Nov 15; 187(10):4979-86. PMID: 21987661.
      View in: PubMed
    23. Nian H, Shao H, O'Brien RL, Born WK, Kaplan HJ, Sun D. Activated gammadelta T cells promote the activation of uveitogenic T cells and exacerbate EAU development. Invest Ophthalmol Vis Sci. 2011 Jul 29; 52(8):5920-7. PMID: 21296823; PMCID: PMC3262554.
    24. Do JS, Visperas A, O'Brien RL, Min B. CD4 T cells play important roles in maintaining IL-17-producing ?d T-cell subsets in naive animals. Immunol Cell Biol. 2012 Apr; 90(4):396-403. PMID: 21647171; PMCID: PMC3170686.
    25. Born WK, Zhang L, Nakayama M, Jin N, Chain JL, Huang Y, Aydintug MK, O'Brien RL. Peptide antigens for gamma/delta T cells. Cell Mol Life Sci. 2011 Jul; 68(14):2335-43. PMID: 21553233.
      View in: PubMed
    26. Born WK, O'Brien RL. ?d T cells develop, respond and survive - with a little help from CD27. Eur J Immunol. 2011 Jan; 41(1):26-8. PMID: 21182073.
      View in: PubMed
    27. Simonian PL, Wehrmann F, Roark CL, Born WK, O'Brien RL, Fontenot AP. ?d T cells protect against lung fibrosis via IL-22. J Exp Med. 2010 Sep 27; 207(10):2239-53. PMID: 20855496; PMCID: PMC2947077.
    28. Bonneville M, O'Brien RL, Born WK. Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev Immunol. 2010 Jul; 10(7):467-78. PMID: 20539306.
      View in: PubMed
    29. He W, Hao J, Dong S, Gao Y, Tao J, Chi H, Flavell R, O'Brien RL, Born WK, Craft J, Han J, Wang P, Zhao L, Wu J, Yin Z. Naturally activated V gamma 4 gamma delta T cells play a protective role in tumor immunity through expression of eomesodermin. J Immunol. 2010 Jul 01; 185(1):126-33. PMID: 20525896; PMCID: PMC3813958.
    30. O'Brien RL, Born WK. gammadelta T cell subsets: a link between TCR and function? Semin Immunol. 2010 Aug; 22(4):193-8. PMID: 20451408; PMCID: PMC2906689.
    31. Born WK, Yin Z, Hahn YS, Sun D, O'Brien RL. Analysis of gamma delta T cell functions in the mouse. J Immunol. 2010 Apr 15; 184(8):4055-61. PMID: 20368285; PMCID: PMC4476288.
    32. Nian H, Shao H, Zhang G, Born WK, O'Brien RL, Kaplan HJ, Sun D. Regulatory effect of gammadelta T cells on IL-17+ uveitogenic T cells. Invest Ophthalmol Vis Sci. 2010 Sep; 51(9):4661-7. PMID: 20375337; PMCID: PMC2941184.
    33. Okamoto Yoshida Y, Umemura M, Yahagi A, O'Brien RL, Ikuta K, Kishihara K, Hara H, Nakae S, Iwakura Y, Matsuzaki G. Essential role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J Immunol. 2010 Apr 15; 184(8):4414-22. PMID: 20212094.
      View in: PubMed
    34. O'Brien R, Jin N, Huang Y, Aydintug MK, Roark C, Born W. Characteristics of IL-17-producing gammadelta T cells. Immunity. 2010 Jan 29; 32(1):1; author reply 2-4. PMID: 20152161.
      View in: PubMed
    35. Born WK, Huang Y, Jin N, Huang H, O'Brien RL. Balanced approach of gammadelta T cells to type 2 immunity. Immunol Cell Biol. 2010 Mar-Apr; 88(3):269-74. PMID: 20101253.
      View in: PubMed
    36. Zhang L, Jin N, Nakayama M, O'Brien RL, Eisenbarth GS, Born WK. Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23. J Autoimmun. 2010 Jun; 34(4):478-84. PMID: 20080388; PMCID: PMC2860027.
    37. Born WK, Roark CL, Jin N, Wands JM, Kemal Aydintug M, Huang Y, Chain JL, Hahn YS, Simonian PL, Fontenot AP, O'Brien RL. Role of ?d T Cells in Lung Inflammation. Open Immunol J. 2009; 2:143-150. PMID: 26550059.
      View in: PubMed
    38. Simonian PL, Roark CL, Born WK, O'Brien RL, Fontenot AP. Gammadelta T cells and Th17 cytokines in hypersensitivity pneumonitis and lung fibrosis. Transl Res. 2009 Nov; 154(5):222-7. PMID: 19840763; PMCID: PMC2766087.
    39. Cui Y, Shao H, Lan C, Nian H, O'Brien RL, Born WK, Kaplan HJ, Sun D. Major role of gamma delta T cells in the generation of IL-17+ uveitogenic T cells. J Immunol. 2009 Jul 01; 183(1):560-7. PMID: 19542467; PMCID: PMC4077214.
    40. Huang Y, Jin N, Roark CL, Aydintug MK, Wands JM, Huang H, O'Brien RL, Born WK. The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin. J Immunol. 2009 Jul 15; 183(2):849-55. PMID: 19542369; PMCID: PMC2712735.
    41. Simonian PL, Roark CL, Wehrmann F, Lanham AM, Born WK, O'Brien RL, Fontenot AP. IL-17A-expressing T cells are essential for bacterial clearance in a murine model of hypersensitivity pneumonitis. J Immunol. 2009 May 15; 182(10):6540-9. PMID: 19414809; PMCID: PMC2766088.
    42. Born WK, O'Brien RL. Antigen-restricted gammadelta T-cell receptors? Arch Immunol Ther Exp (Warsz). 2009 Mar-Apr; 57(2):129-35. PMID: 19333730.
      View in: PubMed
    43. O'Brien RL, Roark CL, Born WK. IL-17-producing gammadelta T cells. Eur J Immunol. 2009 Mar; 39(3):662-6. PMID: 19283718; PMCID: PMC2698711.
    44. Jin N, Roark CL, Miyahara N, Taube C, Aydintug MK, Wands JM, Huang Y, Hahn YS, Gelfand EW, O'Brien RL, Born WK. Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells. J Immunol. 2009 Feb 15; 182(4):2002-10. PMID: 19201853; PMCID: PMC2688721.
    45. French JD, Roark CL, Born WK, O'Brien RL. Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin. J Immunol. 2009 Feb 15; 182(4):1892-900. PMID: 19201842; PMCID: PMC2703819.
    46. O'Brien RL, Taylor MA, Hartley J, Nuhsbaum T, Dugan S, Lahmers K, Aydintug MK, Wands JM, Roark CL, Born WK. Protective role of gammadelta T cells in spontaneous ocular inflammation. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3266-74. PMID: 19151391; PMCID: PMC2701479.
    47. Wang S, Welte T, Fang H, Chang GJ, Born WK, O'Brien RL, Sun B, Fujii H, Kosuna K, Wang T. Oral administration of active hexose correlated compound enhances host resistance to West Nile encephalitis in mice. J Nutr. 2009 Mar; 139(3):598-602. PMID: 19141700; PMCID: PMC2646222.
    48. Simonian PL, Roark CL, Wehrmann F, Lanham AK, Diaz del Valle F, Born WK, O'Brien RL, Fontenot AP. Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis. J Immunol. 2009 Jan 01; 182(1):657-65. PMID: 19109199; PMCID: PMC2766086.
    49. Matsubara S, Takeda K, Jin N, Okamoto M, Matsuda H, Shiraishi Y, Park JW, McConville G, Joetham A, O'Brien RL, Dakhama A, Born WK, Gelfand EW. Vgamma1+ T cells and tumor necrosis factor-alpha in ozone-induced airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2009 Apr; 40(4):454-63. PMID: 18927346; PMCID: PMC2660562.
    50. Cheng L, Cui Y, Shao H, Han G, Zhu L, Huang Y, O'Brien RL, Born WK, Kaplan HJ, Sun D. Mouse gammadelta T cells are capable of expressing MHC class II molecules, and of functioning as antigen-presenting cells. J Neuroimmunol. 2008 Oct 15; 203(1):3-11. PMID: 18774183; PMCID: PMC2612736.
    51. Hahn YS, Ji XY, Woo SI, Choi YK, Song MS, Shin KS, Jin N, O'Brien RL, Born WK. V?1+ ?d T cells reduce IL-10-producing CD4+CD25+ T cells in the lung of ovalbumin-sensitized and challenged mice. Immunol Lett. 2008 Dec 22; 121(2):87-92. PMID: 18840468; PMCID: PMC4500091.
    52. Hamada S, Umemura M, Shiono T, Tanaka K, Yahagi A, Begum MD, Oshiro K, Okamoto Y, Watanabe H, Kawakami K, Roark C, Born WK, O'Brien R, Ikuta K, Ishikawa H, Nakae S, Iwakura Y, Ohta T, Matsuzaki G. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver. J Immunol. 2008 Sep 01; 181(5):3456-63. PMID: 18714018; PMCID: PMC2859669.
    53. Cook L, Miyahara N, Jin N, Wands JM, Taube C, Roark CL, Potter TA, Gelfand EW, O'Brien RL, Born WK. Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness. J Immunol. 2008 Jul 01; 181(1):309-19. PMID: 18566396; PMCID: PMC2493442.
    54. Welte T, Lamb J, Anderson JF, Born WK, O'Brien RL, Wang T. Role of two distinct gammadelta T cell subsets during West Nile virus infection. FEMS Immunol Med Microbiol. 2008 Jul; 53(2):275-83. PMID: 18513355; PMCID: PMC2755494.
    55. Aydintug MK, Roark CL, Chain JL, Born WK, O'Brien RL. Macrophages express multiple ligands for gammadelta TCRs. Mol Immunol. 2008 Jun; 45(11):3253-63. PMID: 18455236; PMCID: PMC2600894.
    56. Roark CL, Simonian PL, Fontenot AP, Born WK, O'Brien RL. gammadelta T cells: an important source of IL-17. Curr Opin Immunol. 2008 Jun; 20(3):353-7. PMID: 18439808; PMCID: PMC2601685.
    57. Roark CL, French JD, Taylor MA, Bendele AM, Born WK, O'Brien RL. Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells. J Immunol. 2007 Oct 15; 179(8):5576-83. PMID: 17911645; PMCID: PMC2768546.
    58. Jin N, Miyahara N, Roark CL, French JD, Aydintug MK, Matsuda JL, Gapin L, O'Brien RL, Gelfand EW, Born WK. Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cells. J Immunol. 2007 Sep 01; 179(5):2961-8. PMID: 17709511; PMCID: PMC4480876.
    59. Born WK, Jin N, Aydintug MK, Wands JM, French JD, Roark CL, O'Brien RL. gammadelta T lymphocytes-selectable cells within the innate system? J Clin Immunol. 2007 Mar; 27(2):133-44. PMID: 17333410.
      View in: PubMed
    60. O'Brien RL, Roark CL, Jin N, Aydintug MK, French JD, Chain JL, Wands JM, Johnston M, Born WK. gammadelta T-cell receptors: functional correlations. Immunol Rev. 2007 Feb; 215:77-88. PMID: 17291280.
      View in: PubMed
    61. Nakasone C, Yamamoto N, Nakamatsu M, Kinjo T, Miyagi K, Uezu K, Nakamura K, Higa F, Ishikawa H, O'brien RL, Ikuta K, Kaku M, Fujita J, Kawakami K. Accumulation of gamma/delta T cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infection. Microbes Infect. 2007 Mar; 9(3):251-8. PMID: 17306586.
      View in: PubMed
    62. Simonian PL, Roark CL, Diaz del Valle F, Palmer BE, Douglas IS, Ikuta K, Born WK, O'Brien RL, Fontenot AP. Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis. J Immunol. 2006 Oct 01; 177(7):4436-43. PMID: 16982878.
      View in: PubMed
    63. Reardon CL, Hu LJ, Yin X, Born WK, Arden B, O'Brien R. A new mechanism for generating TCR diversity: A TCR Jalpha-like gene that inserts partial nucleotide sequences in a D-gene manner. Mol Immunol. 2007 Feb; 44(5):906-15. PMID: 16793139.
      View in: PubMed
    64. Born WK, Reardon CL, O'Brien RL. The function of gammadelta T cells in innate immunity. Curr Opin Immunol. 2006 Feb; 18(1):31-8. PMID: 16337364.
      View in: PubMed
    65. Meeh PF, King M, O'Brien RL, Muga S, Buckhalts P, Neuberg R, Lamb LS. Characterization of the gammadelta T cell response to acute leukemia. Cancer Immunol Immunother. 2006 Sep; 55(9):1072-80. PMID: 16328383.
      View in: PubMed
    66. Wands JM, Roark CL, Aydintug MK, Jin N, Hahn YS, Cook L, Yin X, Dal Porto J, Lahn M, Hyde DM, Gelfand EW, Mason RJ, O'Brien RL, Born WK. Distribution and leukocyte contacts of gammadelta T cells in the lung. J Leukoc Biol. 2005 Nov; 78(5):1086-96. PMID: 16204632.
      View in: PubMed
    67. French JD, Roark CL, Born WK, O'brien RL. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14741-6. PMID: 16203967; PMCID: PMC1239947.
    68. Reardon C, Born WK, O'Brien RL. A unique Vgamma5-T-cell population in the murine mammary gland. Mol Immunol. 2006 Mar; 43(7):1057-61. PMID: 16045990.
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    69. Jin N, Taube C, Sharp L, Hahn YS, Yin X, Wands JM, Roark CL, O'brien RL, Gelfand EW, Born WK. Mismatched antigen prepares gamma delta T cells for suppression of airway hyperresponsiveness. J Immunol. 2005 Mar 01; 174(5):2671-9. PMID: 15728474.
      View in: PubMed
    70. Huber SA, Born W, O'Brien R. Dual functions of murine gammadelta cells in inflammation and autoimmunity in coxsackievirus B3-induced myocarditis: role of Vgamma1+ and Vgamma4+ cells. Microbes Infect. 2005 Mar; 7(3):537-43. PMID: 15777711.
      View in: PubMed
    71. Aydintug MK, Roark CL, Yin X, Wands JM, Born WK, O'Brien RL. Detection of cell surface ligands for the gamma delta TCR using soluble TCRs. J Immunol. 2004 Apr 01; 172(7):4167-75. PMID: 15034029.
      View in: PubMed
    72. Lahn M, Kanehiro A, Hahn YS, Wands JM, Aydintug MK, O'Brien RL, Gelfand EW, Born WK. Aerosolized anti-T-cell-receptor antibodies are effective against airway inflammation and hyperreactivity. Int Arch Allergy Immunol. 2004 May; 134(1):49-55. PMID: 15051940.
      View in: PubMed
    73. Hahn YS, Taube C, Jin N, Sharp L, Wands JM, Aydintug MK, Lahn M, Huber SA, O'Brien RL, Gelfand EW, Born WK. Different potentials of gamma delta T cell subsets in regulating airway responsiveness: V gamma 1+ cells, but not V gamma 4+ cells, promote airway hyperreactivity, Th2 cytokines, and airway inflammation. J Immunol. 2004 Mar 01; 172(5):2894-902. PMID: 14978091.
      View in: PubMed
    74. Roark CL, Aydintug MK, Lewis J, Yin X, Lahn M, Hahn YS, Born WK, Tigelaar RE, O'Brien RL. Subset-specific, uniform activation among V gamma 6/V delta 1+ gamma delta T cells elicited by inflammation. J Leukoc Biol. 2004 Jan; 75(1):68-75. PMID: 14525969.
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    75. Hahn YS, Taube C, Jin N, Takeda K, Park JW, Wands JM, Aydintug MK, Roark CL, Lahn M, O'Brien RL, Gelfand EW, Born WK. V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice. J Immunol. 2003 Sep 15; 171(6):3170-8. PMID: 12960345.
      View in: PubMed
    76. Lahn M, Kanehiro A, Takeda K, Terry J, Hahn YS, Aydintug MK, Konowal A, Ikuta K, O'Brien RL, Gelfand EW, Born WK. MHC class I-dependent Vgamma4+ pulmonary T cells regulate alpha beta T cell-independent airway responsiveness. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8850-5. PMID: 12070351; PMCID: PMC124387.
    77. Born WK, O'Brien RL. The healing touch of epidermal T cells. Nat Med. 2002 Jun; 8(6):560-1. PMID: 12042801.
      View in: PubMed
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