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Slobodan Milenko Todorovic

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-AN General Operations

    Collapse Research 
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    K08DA000428     (TODOROVIC, SLOBODAN M)Aug 16, 2000 - Aug 31, 2001
    NIH
    MULTIPLE CLASSES OF CA2+ CHANNELS - SENSORY TRANSMISSION
    Role: Principal Investigator
    R01GM070726     (TODOROVIC, SLOBODAN M.)Mar 1, 2005 - Feb 28, 2011
    NIH
    Anesthetics block neuronal voltage-gated Ca2+ currents
    Role: Principal Investigator
    R01GM075229     (TODOROVIC, SLOBODAN M.)Jun 1, 2006 - May 31, 2011
    NIH
    REDOX PHARMACOLOGY OF T CHANNELS IN DRG NEURONS
    Role: Principal Investigator
    R21DA029342     (TODOROVIC, SLOBODAN M)May 1, 2010 - Apr 30, 2013
    NIH
    Validation of voltage-dependent T-channel blockers in treatment of neuropathic pa
    Role: Principal Investigator
    R21DA034448     (TODOROVIC, SLOBODAN M.)Apr 1, 2013 - Jun 30, 2015
    NIH
    The role of trace metals and T-channels in pain
    Role: Principal Investigator
    R01GM102525     (TODOROVIC, SLOBODAN M.)Jan 1, 2014 - Jun 30, 2023
    NIH
    Effects of anesthetics on thalamic excitability
    Role: Principal Investigator
    R01NS091353     (TODOROVIC, SLOBODAN M.)Jun 1, 2016 - Apr 30, 2021
    NIH
    Molecular mechanisms of glycosylation of Cav3.2 channels in pain pathway
    Role: Principal Investigator
    R01GM123746     (TODOROVIC, SLOBODAN M.)Sep 1, 2017 - May 31, 2021
    NIH
    Novel neurosteroid anesthetics and perioperative analgesia
    Role: Principal Investigator
    I01BX004763     (TODOROVIC, SLOBODAN M.)Apr 1, 2020 - Mar 31, 2024
    NIH
    T-type calcium channel inhibitors and alpha lipoic acid as novel therapies for treating pain post-surgery
    Role: Principal Investigator
    R35GM141802     (TODOROVIC, SLOBODAN M.)Jun 1, 2021 - May 31, 2026
    NIH
    Voltage-gated calcium channels as target for anesthetics
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Joksimovic SL, Lamborn N, Jevtovic-Todorovic V, Todorovic SM. Alpha lipoic acid attenuates evoked and spontaneous pain following surgical skin incision in rats. Channels (Austin). 2021 12; 15(1):398-407. PMID: 33843451.
      View in: PubMed
    2. Joksimovic SM, Sampath D, Krishnan K, Covey DF, Jevtovic-Todorovic V, Raol YH, Todorovic SM. Differential effects of the novel neurosteroid hypnotic (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats. Br J Anaesth. 2021 Sep; 127(3):435-446. PMID: 33972091.
      View in: PubMed
    3. Joksimovic SL, Evans JG, McIntire WE, Orestes P, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Glycosylation of CaV3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes. Front Cell Neurosci. 2020; 14:605312. PMID: 33384586.
      View in: PubMed
    4. Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells. 2020 12 12; 9(12). PMID: 33322727.
      View in: PubMed
    5. Feseha S, Timic Stamenic T, Wallace D, Tamag C, Yang L, Pan JQ, Todorovic SM. Global genetic deletion of CaV3.3 channels facilitates anaesthetic induction and enhances isoflurane-sparing effects of T-type calcium channel blockers. Sci Rep. 2020 12 09; 10(1):21510. PMID: 33299036.
      View in: PubMed
    6. Raol YH, Joksimovic SM, Sampath D, Matter BA, Lam PM, Kompella UB, Todorovic SM, González MI. The role of KCC2 in hyperexcitability of the neonatal brain. Neurosci Lett. 2020 11 01; 738:135324. PMID: 32860887.
      View in: PubMed
    7. Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Cav3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3ß,5ß,17ß)-3-hydroxyandrostane-17-carbonitrile. Br J Anaesth. 2021 01; 126(1):245-255. PMID: 32859366.
      View in: PubMed
    8. Manzella FM, Joksimovic SM, Orfila JE, Fine BR, Dietz RM, Sampath D, Fiedler HK, Tesic V, Atluri N, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats. Front Syst Neurosci. 2020; 14:26. PMID: 32528257.
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    9. Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABAA currents, but are not neurotoxic to the developing rat brain. Br J Anaesth. 2020 05; 124(5):603-613. PMID: 32151384.
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    10. Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Novel neuroactive steroid with hypnotic and T-type calcium channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. Br J Pharmacol. 2020 04; 177(8):1735-1753. PMID: 31732978.
      View in: PubMed
    11. Timic Stamenic T, Feseha S, Valdez R, Zhao W, Klawitter J, Todorovic SM. Alterations in Oscillatory Behavior of Central Medial Thalamic Neurons Demonstrate a Key Role of CaV3.1 Isoform of T-Channels During Isoflurane-Induced Anesthesia. Cereb Cortex. 2019 12 17; 29(11):4679-4696. PMID: 30715245.
      View in: PubMed
    12. Joksimovic SL, Donald RR, Park JY, Todorovic SM. Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision. Channels (Austin). 2019 12; 13(1):48-61. PMID: 30672394.
      View in: PubMed
    13. Woodward TJ, Tesic V, Stamenic TT, Jevtovic-Todorovic V, Todorovic SM. Pharmacological Antagonism of T-Type Calcium Channels Constrains Rebound Burst Firing in Two Distinct Subpopulations of GABA Neurons in the Rat Ventral Tegmental Area: Implications for a-Lipoic Acid. Front Pharmacol. 2019; 10:1402. PMID: 31849661.
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    14. Chemin J, Stamenic TT, Cazade M, Llinares J, Blesneac I, Todorovic SM, Lory P. A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels. Sci Rep. 2019 10 30; 9(1):15642. PMID: 31666636.
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    15. Joksimovic SM, DiGruccio MR, Boscolo A, Jevtovic-Todorovic V, Todorovic SM. The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development. Mol Neurobiol. 2020 Jan; 57(1):208-216. PMID: 31493241.
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    16. Oury J, Liu Y, Töpf A, Todorovic S, Hoedt E, Preethish-Kumar V, Neubert TA, Lin W, Lochmüller H, Burden SJ. MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses. J Cell Biol. 2019 05 06; 218(5):1686-1705. PMID: 30842214.
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    17. Woodward TJ, Timic Stamenic T, Todorovic SM. Neonatal general anesthesia causes lasting alterations in excitatory and inhibitory synaptic transmission in the ventrobasal thalamus of adolescent female rats. Neurobiol Dis. 2019 07; 127:472-481. PMID: 30825640.
      View in: PubMed
    18. Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM. Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. Br J Anaesth. 2019 May; 122(5):643-651. PMID: 30916017.
      View in: PubMed
    19. Joksimovic SL, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Neurosteroids in Pain Management: A New Perspective on an Old Player. Front Pharmacol. 2018; 9:1127. PMID: 30333753.
      View in: PubMed
    20. Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM. Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain. Sci Signal. 2018 08 28; 11(545). PMID: 30154101.
      View in: PubMed
    21. Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM. CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology. 2018 06; 135:343-354. PMID: 29578032.
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    22. Stamenic TT, Todorovic SM. Cytosolic ATP Relieves Voltage-Dependent Inactivation of T-Type Calcium Channels and Facilitates Excitability of Neurons in the Rat Central Medial Thalamus. eNeuro. 2018 Jan-Feb; 5(1). PMID: 29468189.
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    23. Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018 04; 120(4):768-778. PMID: 29576117.
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    24. Joksimovic SM, Osuru HP, Oklopcic A, Beenhakker MP, Jevtovic-Todorovic V, Todorovic SM. Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus. Mol Neurobiol. 2018 01; 55(1):222-228. PMID: 28840475.
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    25. Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM. The role of T-type calcium channels in the subiculum: to burst or not to burst? J Physiol. 2017 10 01; 595(19):6327-6348. PMID: 28744923.
      View in: PubMed
    26. Todorovic SM. Painful Diabetic Neuropathy: Prevention or Suppression? Int Rev Neurobiol. 2016; 127:211-25. PMID: 27133151.
      View in: PubMed
    27. Evans JG, Todorovic SM. Redox and trace metal regulation of ion channels in the pain pathway. Biochem J. 2015 Sep 15; 470(3):275-80. PMID: 26341484.
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    28. Obradovic AL, Scarpa J, Osuru HP, Weaver JL, Park JY, Pathirathna S, Peterkin A, Lim Y, Jagodic MM, Todorovic SM, Jevtovic-Todorovic V. Silencing the a2 subunit of ?-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury. Anesthesiology. 2015 Sep; 123(3):654-67. PMID: 26164299.
      View in: PubMed
    29. Wang G, Bochorishvili G, Chen Y, Salvati KA, Zhang P, Dubel SJ, Perez-Reyes E, Snutch TP, Stornetta RL, Deisseroth K, Erisir A, Todorovic SM, Luo JH, Kapur J, Beenhakker MP, Zhu JJ. CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy. Genes Dev. 2015 Jul 15; 29(14):1535-51. PMID: 26220996.
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    30. Joksovic PM, Lunardi N, Jevtovic-Todorovic V, Todorovic SM. Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus. Mol Neurobiol. 2015 Oct; 52(2):952-8. PMID: 26048671.
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    31. DiGruccio MR, Joksimovic S, Joksovic PM, Lunardi N, Salajegheh R, Jevtovic-Todorovic V, Beenhakker MP, Goodkin HP, Todorovic SM. Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development. J Neurosci. 2015 Jan 28; 35(4):1481-92. PMID: 25632125.
      View in: PubMed
    32. Ayoola C, Hwang SM, Hong SJ, Rose KE, Boyd C, Bozic N, Park JY, Osuru HP, DiGruccio MR, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone. Psychopharmacology (Berl). 2014 Sep; 231(17):3503-3515. PMID: 24800894.
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    33. Obradovic ALj, Hwang SM, Scarpa J, Hong SJ, Todorovic SM, Jevtovic-Todorovic V. CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy. PLoS One. 2014; 9(4):e91467. PMID: 24705276.
      View in: PubMed
    34. Todorovic SM, Jevtovic-Todorovic V. Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy. Pflugers Arch. 2014 Apr; 466(4):701-6. PMID: 24482063.
      View in: PubMed
    35. Todorovic SM, Jevtovic-Todorovic V. Redox regulation of neuronal voltage-gated calcium channels. Antioxid Redox Signal. 2014 Aug 20; 21(6):880-91. PMID: 24161125.
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    36. Rose KE, Lunardi N, Boscolo A, Dong X, Erisir A, Jevtovic-Todorovic V, Todorovic SM. Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse. Neuroscience. 2013 Oct 10; 250:263-74. PMID: 23867767.
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    37. Orestes P, Osuru HP, McIntire WE, Jacus MO, Salajegheh R, Jagodic MM, Choe W, Lee J, Lee SS, Rose KE, Poiro N, Digruccio MR, Krishnan K, Covey DF, Lee JH, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes. 2013 Nov; 62(11):3828-38. PMID: 23835327.
      View in: PubMed
    38. Lee J, Nelson MT, Rose KE, Todorovic SM. Redox mechanism of S-nitrosothiol modulation of neuronal CaV3.2 T-type calcium channels. Mol Neurobiol. 2013 Oct; 48(2):274-80. PMID: 23813099.
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    39. Todorovic SM, Jevtovic-Todorovic V. Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling. Pflugers Arch. 2013 Jul; 465(7):921-7. PMID: 23322114.
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    40. Jacus MO, Uebele VN, Renger JJ, Todorovic SM. Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons. J Neurosci. 2012 Jul 04; 32(27):9374-82. PMID: 22764245.
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    41. Eckle VS, Digruccio MR, Uebele VN, Renger JJ, Todorovic SM. Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane. Neuropharmacology. 2012 Aug; 63(2):266-73. PMID: 22491022.
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    42. Shcheglovitov A, Vitko I, Lazarenko RM, Orestes P, Todorovic SM, Perez-Reyes E. Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels. J Gen Physiol. 2012 Mar; 139(3):219-34. PMID: 22371363.
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    43. Sanchez V, Feinstein SD, Lunardi N, Joksovic PM, Boscolo A, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain. Anesthesiology. 2011 Nov; 115(5):992-1002. PMID: 21909020.
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    44. Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011 Nov; 80(5):900-10. PMID: 21821734.
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    45. Todorovic SM, Jevtovic-Todorovic V. T-type voltage-gated calcium channels as targets for the development of novel pain therapies. Br J Pharmacol. 2011 Jun; 163(3):484-95. PMID: 21306582.
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    46. Orestes P, Bojadzic D, Lee J, Leach E, Salajegheh R, Digruccio MR, Nelson MT, Todorovic SM. Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol. 2011 Jan 01; 589(Pt 1):135-48. PMID: 21059758.
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    47. Orestes P, Todorovic SM. Are neuronal voltage-gated calcium channels valid cellular targets for general anesthetics? Channels (Austin). 2010 Nov-Dec; 4(6):518-22. PMID: 21164281.
      View in: PubMed
    48. Eckle VS, Todorovic SM. Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols. Neuropharmacology. 2010 Jul-Aug; 59(1-2):58-69. PMID: 20363234.
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    49. Nelson MT, Milescu LS, Todorovic SM, Scroggs RS. A modeling study of T-type Ca2+ channel gating and modulation by L-cysteine in rat nociceptors. Biophys J. 2010 Jan 20; 98(2):197-206. PMID: 20338841.
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    50. Jevtovic-Todorovic V, Covey DF, Todorovic SM. Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain? Psychoneuroendocrinology. 2009 Dec; 34 Suppl 1:S178-85. PMID: 19577375.
      View in: PubMed
    51. Joksovic PM, Choe WJ, Nelson MT, Orestes P, Brimelow BC, Todorovic SM. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan; 77(1):87-94. PMID: 19846748.
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    52. Latham JR, Pathirathna S, Jagodic MM, Choe WJ, Levin ME, Nelson MT, Lee WY, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes. 2009 Nov; 58(11):2656-65. PMID: 19651818.
      View in: PubMed
    53. Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SM. Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. J Neurosci. 2009 Jul 29; 29(30):9500-9. PMID: 19641113.
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    54. Messinger RB, Naik AK, Jagodic MM, Nelson MT, Lee WY, Choe WJ, Orestes P, Latham JR, Todorovic SM, Jevtovic-Todorovic V. In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy. Pain. 2009 Sep; 145(1-2):184-95. PMID: 19577366.
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    55. Joksovic PM, Weiergräber M, Lee W, Struck H, Schneider T, Todorovic SM. Isoflurane-sensitive presynaptic R-type calcium channels contribute to inhibitory synaptic transmission in the rat thalamus. J Neurosci. 2009 Feb 04; 29(5):1434-45. PMID: 19193890.
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    56. Zamponi GW, Lewis RJ, Todorovic SM, Arneric SP, Snutch TP. Role of voltage-gated calcium channels in ascending pain pathways. Brain Res Rev. 2009 Apr; 60(1):84-9. PMID: 19162069.
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    57. Orestes P, Bojadzic D, Chow RM, Todorovic SM. Mechanisms and functional significance of inhibition of neuronal T-type calcium channels by isoflurane. Mol Pharmacol. 2009 Mar; 75(3):542-54. PMID: 19038845.
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    58. Jagodic MM, Pathirathna S, Joksovic PM, Lee W, Nelson MT, Naik AK, Su P, Jevtovic-Todorovic V, Todorovic SM. Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J Neurophysiol. 2008 Jun; 99(6):3151-6. PMID: 18417624.
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    59. Joksovic PM, Covey DF, Todorovic SM. Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid. Ann N Y Acad Sci. 2007 Dec; 1122:83-94. PMID: 18077566.
      View in: PubMed
    60. Nelson MT, Joksovic PM, Su P, Kang HW, Van Deusen A, Baumgart JP, David LS, Snutch TP, Barrett PQ, Lee JH, Zorumski CF, Perez-Reyes E, Todorovic SM. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14; 27(46):12577-83. PMID: 18003836.
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    61. Todorovic SM, Jevtovic-Todorovic V. Regulation of T-type calcium channels in the peripheral pain pathway. Channels (Austin). 2007 Jul-Aug; 1(4):238-45. PMID: 18708751.
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    62. Nelson MT, Woo J, Kang HW, Vitko I, Barrett PQ, Perez-Reyes E, Lee JH, Shin HS, Todorovic SM. Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. J Neurosci. 2007 Aug 01; 27(31):8250-60. PMID: 17670971.
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    63. Jagodic MM, Pathirathna S, Nelson MT, Mancuso S, Joksovic PM, Rosenberg ER, Bayliss DA, Jevtovic-Todorovic V, Todorovic SM. Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J Neurosci. 2007 Mar 21; 27(12):3305-16. PMID: 17376991.
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    64. Joksovic PM, Doctor A, Gaston B, Todorovic SM. Functional regulation of T-type calcium channels by s-nitrosothiols in the rat thalamus. J Neurophysiol. 2007 Apr; 97(4):2712-21. PMID: 17287440.
      View in: PubMed
    65. Nelson MT, Todorovic SM. Is there a role for T-type calcium channels in peripheral and central pain sensitization? Mol Neurobiol. 2006 Dec; 34(3):243-8. PMID: 17308355.
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    66. Todorovic SM, Jevtovic-Todorovic V. The role of T-type calcium channels in peripheral and central pain processing. CNS Neurol Disord Drug Targets. 2006 Dec; 5(6):639-53. PMID: 17168748.
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    67. Pathirathna S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats. Pain. 2006 Nov; 125(1-2):53-64. PMID: 16782275.
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    68. Jevtovic-Todorovic V, Todorovic SM. The role of peripheral T-type calcium channels in pain transmission. Cell Calcium. 2006 Aug; 40(2):197-203. PMID: 16777222.
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    69. Joksovic PM, Nelson MT, Jevtovic-Todorovic V, Patel MK, Perez-Reyes E, Campbell KP, Chen CC, Todorovic SM. CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus. J Physiol. 2006 Jul 15; 574(Pt 2):415-30. PMID: 16644797.
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    70. Nelson MT, Todorovic SM, Perez-Reyes E. The role of T-type calcium channels in epilepsy and pain. Curr Pharm Des. 2006; 12(18):2189-97. PMID: 16787249.
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    71. Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain. 2005 Oct; 117(3):326-339. PMID: 16150542.
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    72. Nelson MT, Joksovic PM, Perez-Reyes E, Todorovic SM. The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors. J Neurosci. 2005 Sep 21; 25(38):8766-75. PMID: 16177046.
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    73. Joksovic PM, Bayliss DA, Todorovic SM. Different kinetic properties of two T-type Ca2+ currents of rat reticular thalamic neurones and their modulation by enflurane. J Physiol. 2005 Jul 01; 566(Pt 1):125-42. PMID: 15845580.
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    74. Pathirathna S, Brimelow BC, Jagodic MM, Krishnan K, Jiang X, Zorumski CF, Mennerick S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain. 2005 Apr; 114(3):429-443. PMID: 15777868.
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    75. Joksovic PM, Brimelow BC, Murbartián J, Perez-Reyes E, Todorovic SM. Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels. Br J Pharmacol. 2005 Jan; 144(1):59-70. PMID: 15644869.
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    76. Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V. 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Mol Pharmacol. 2004 Nov; 66(5):1223-35. PMID: 15280444.
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    77. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia. Pain. 2004 Jun; 109(3):328-339. PMID: 15157694.
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    78. Todorovic SM, Pathirathna S, Meyenburg A, Jevtovic-Todorovic V. Mechanical and thermal anti-nociception in rats after systemic administration of verapamil. Neurosci Lett. 2004 Apr 22; 360(1-2):57-60. PMID: 15082178.
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    79. Todorovic SM, Rastogi AJ, Jevtovic-Todorovic V. Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats. Br J Pharmacol. 2003 Sep; 140(2):255-60. PMID: 12970103.
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    80. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res. 2002 Oct 04; 951(2):336-40. PMID: 12270514.
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    81. Todorovic SM, Jevtovic-Todorovic V, Mennerick S, Perez-Reyes E, Zorumski CF. Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide. Mol Pharmacol. 2001 Sep; 60(3):603-10. PMID: 11502893.
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    82. Todorovic SM, Jevtovic-Todorovic V, Meyenburg A, Mennerick S, Perez-Reyes E, Romano C, Olney JW, Zorumski CF. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron. 2001 Jul 19; 31(1):75-85. PMID: 11498052.
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    83. Todorovic SM, Perez-Reyes E, Lingle CJ. Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants. Mol Pharmacol. 2000 Jul; 58(1):98-108. PMID: 10860931.
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    84. Mennerick S, Jevtovic-Todorovic V, Todorovic SM, Shen W, Olney JW, Zorumski CF. Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures. J Neurosci. 1998 Dec 01; 18(23):9716-26. PMID: 9822732.
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    85. Todorovic SM, Prakriya M, Nakashima YM, Nilsson KR, Han M, Zorumski CF, Covey DF, Lingle CJ. Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity. Mol Pharmacol. 1998 Nov; 54(5):918-27. PMID: 9804627.
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    86. Nakashima YM, Todorovic SM, Covey DF, Lingle CJ. The anesthetic steroid (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocks N-, Q-, and R-type, but not L- and P-type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat. Mol Pharmacol. 1998 Sep; 54(3):559-68. PMID: 9730915.
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    87. Jevtovic-Todorovic V, Todorovic SM, Mennerick S, Powell S, Dikranian K, Benshoff N, Zorumski CF, Olney JW. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med. 1998 Apr; 4(4):460-3. PMID: 9546794.
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    88. Todorovic SM, Lingle CJ. Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. J Neurophysiol. 1998 Jan; 79(1):240-52. PMID: 9425195.
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    89. Scroggs RS, Todorovic SM, Anderson EG, Fox AP. Variation in IH, IIR, and ILEAK between acutely isolated adult rat dorsal root ganglion neurons of different size. J Neurophysiol. 1994 Jan; 71(1):271-9. PMID: 7512627.
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