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Slobodan Milenko Todorovic

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Anesthesiology

    Collapse Research 
    Collapse research activities and funding
    K08DA000428     (TODOROVIC, SLOBODAN M)Aug 16, 2000 - Jul 31, 2005
    NIH/NIDA
    MULTIPLE CLASSES OF CA2+ CHANNELS - SENSORY TRANSMISSION
    Role: Principal Investigator
    R01GM070726     (TODOROVIC, SLOBODAN M)Mar 1, 2005 - Feb 28, 2011
    NIH/NIGMS
    Anesthetics block neuronal voltage-gated Ca2+ currents
    Role: Principal Investigator
    R01GM075229     (TODOROVIC, SLOBODAN M)Jun 1, 2006 - May 31, 2011
    NIH/NIGMS
    REDOX PHARMACOLOGY OF T CHANNELS IN DRG NEURONS
    Role: Principal Investigator
    R21DA029342     (TODOROVIC, SLOBODAN M)May 1, 2010 - Apr 30, 2013
    NIH/NIDA
    Validation of voltage-dependent T-channel blockers in treatment of neuropathic pa
    Role: Principal Investigator
    R21DA034448     (TODOROVIC, SLOBODAN M.)Apr 1, 2013 - Mar 31, 2015
    NIH/NIDA
    The role of trace metals and T-channels in pain
    Role: Principal Investigator
    R01GM102525     (TODOROVIC, SLOBODAN M.)Jan 1, 2014 - Dec 31, 2017
    NIH/NIGMS
    Effects of anesthetics on thalamic excitability
    Role: Principal Investigator
    R01NS091353     (TODOROVIC, SLOBODAN M.)Jun 1, 2016 - Apr 30, 2021
    NIH/NINDS
    Molecular mechanisms of glycosylation of Cav3.2 channels in pain pathway
    Role: Principal Investigator
    R01GM123746     (TODOROVIC, SLOBODAN M.)Sep 1, 2017 - May 31, 2021
    NIH/NIGMS
    Novel neurosteroid anesthetics and perioperative analgesia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM. CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology. 2018 Jun; 135:343-354. PMID: 29578032.
      View in: PubMed
    2. Stamenic TT, Todorovic SM. Cytosolic ATP Relieves Voltage-Dependent Inactivation of T-Type Calcium Channels and Facilitates Excitability of Neurons in the Rat Central Medial Thalamus. eNeuro. 2018 Jan-Feb; 5(1). PMID: 29468189.
      View in: PubMed
    3. Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018 Apr; 120(4):768-778. PMID: 29576117.
      View in: PubMed
    4. Joksimovic SM, Osuru HP, Oklopcic A, Beenhakker MP, Jevtovic-Todorovic V, Todorovic SM. Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus. Mol Neurobiol. 2018 Jan; 55(1):222-228. PMID: 28840475.
      View in: PubMed
    5. Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM. The role of T-type calcium channels in the subiculum: to burst or not to burst? J Physiol. 2017 Oct 01; 595(19):6327-6348. PMID: 28744923.
      View in: PubMed
    6. Todorovic SM. Painful Diabetic Neuropathy: Prevention or Suppression? Int Rev Neurobiol. 2016; 127:211-25. PMID: 27133151.
      View in: PubMed
    7. Ayoola C, Hwang SM, Hong SJ, Rose KE, Boyd C, Bozic N, Park JY, Osuru HP, DiGruccio MR, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone. Psychopharmacology (Berl). 2014 Sep; 231(17):3503-3515. PMID: 24800894; PMCID: PMC4135044.
      View in: PubMed, PubMed Central
    8. Obradovic ALj, Hwang SM, Scarpa J, Hong SJ, Todorovic SM, Jevtovic-Todorovic V. CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy. PLoS One. 2014; 9(4):e91467. PMID: 24705276; PMCID: PMC3976247.
      View in: PubMed, PubMed Central
    9. Todorovic SM, Jevtovic-Todorovic V. Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy. Pflugers Arch. 2014 Apr; 466(4):701-6. PMID: 24482063.
      View in: PubMed
    10. Orestes P, Osuru HP, McIntire WE, Jacus MO, Salajegheh R, Jagodic MM, Choe W, Lee J, Lee SS, Rose KE, Poiro N, Digruccio MR, Krishnan K, Covey DF, Lee JH, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes. 2013 Nov; 62(11):3828-38. PMID: 23835327; PMCID: PMC3806612.
      View in: PubMed, PubMed Central
    11. Jacus MO, Uebele VN, Renger JJ, Todorovic SM. Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons. J Neurosci. 2012 Jul 04; 32(27):9374-82. PMID: 22764245; PMCID: PMC3398424.
      View in: PubMed, PubMed Central
    12. Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011 Nov; 80(5):900-10. PMID: 21821734; PMCID: PMC3198916.
      View in: PubMed, PubMed Central
    13. Todorovic SM, Jevtovic-Todorovic V. T-type voltage-gated calcium channels as targets for the development of novel pain therapies. Br J Pharmacol. 2011 Jun; 163(3):484-95. PMID: 21306582; PMCID: PMC3101611.
      View in: PubMed, PubMed Central
    14. Orestes P, Bojadzic D, Lee J, Leach E, Salajegheh R, Digruccio MR, Nelson MT, Todorovic SM. Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol. 2011 Jan 01; 589(Pt 1):135-48. PMID: 21059758; PMCID: PMC3039265.
      View in: PubMed, PubMed Central
    15. Jevtovic-Todorovic V, Covey DF, Todorovic SM. Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain? Psychoneuroendocrinology. 2009 Dec; 34 Suppl 1:S178-85. PMID: 19577375; PMCID: PMC2795041.
      View in: PubMed, PubMed Central
    16. Latham JR, Pathirathna S, Jagodic MM, Choe WJ, Levin ME, Nelson MT, Lee WY, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes. 2009 Nov; 58(11):2656-65. PMID: 19651818; PMCID: PMC2768156.
      View in: PubMed, PubMed Central
    17. Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SM. Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. J Neurosci. 2009 Jul 29; 29(30):9500-9. PMID: 19641113; PMCID: PMC3073510.
      View in: PubMed, PubMed Central
    18. Messinger RB, Naik AK, Jagodic MM, Nelson MT, Lee WY, Choe WJ, Orestes P, Latham JR, Todorovic SM, Jevtovic-Todorovic V. In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy. Pain. 2009 Sep; 145(1-2):184-95. PMID: 19577366; PMCID: PMC2735619.
      View in: PubMed, PubMed Central
    19. Zamponi GW, Lewis RJ, Todorovic SM, Arneric SP, Snutch TP. Role of voltage-gated calcium channels in ascending pain pathways. Brain Res Rev. 2009 Apr; 60(1):84-9. PMID: 19162069; PMCID: PMC2692704.
      View in: PubMed, PubMed Central
    20. Todorovic SM, Jevtovic-Todorovic V. Regulation of T-type calcium channels in the peripheral pain pathway. Channels (Austin). 2007 Jul-Aug; 1(4):238-45. PMID: 18708751.
      View in: PubMed
    21. Jagodic MM, Pathirathna S, Nelson MT, Mancuso S, Joksovic PM, Rosenberg ER, Bayliss DA, Jevtovic-Todorovic V, Todorovic SM. Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J Neurosci. 2007 Mar 21; 27(12):3305-16. PMID: 17376991.
      View in: PubMed
    22. Nelson MT, Todorovic SM. Is there a role for T-type calcium channels in peripheral and central pain sensitization? Mol Neurobiol. 2006 Dec; 34(3):243-8. PMID: 17308355.
      View in: PubMed
    23. Todorovic SM, Jevtovic-Todorovic V. The role of T-type calcium channels in peripheral and central pain processing. CNS Neurol Disord Drug Targets. 2006 Dec; 5(6):639-53. PMID: 17168748.
      View in: PubMed
    24. Pathirathna S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats. Pain. 2006 Nov; 125(1-2):53-64. PMID: 16782275.
      View in: PubMed
    25. Jevtovic-Todorovic V, Todorovic SM. The role of peripheral T-type calcium channels in pain transmission. Cell Calcium. 2006 Aug; 40(2):197-203. PMID: 16777222.
      View in: PubMed
    26. Nelson MT, Todorovic SM, Perez-Reyes E. The role of T-type calcium channels in epilepsy and pain. Curr Pharm Des. 2006; 12(18):2189-97. PMID: 16787249.
      View in: PubMed
    27. Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain. 2005 Oct; 117(3):326-39. PMID: 16150542.
      View in: PubMed
    28. Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V. 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Mol Pharmacol. 2004 Nov; 66(5):1223-35. PMID: 15280444.
      View in: PubMed
    29. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia. Pain. 2004 Jun; 109(3):328-39. PMID: 15157694.
      View in: PubMed
    30. Todorovic SM, Rastogi AJ, Jevtovic-Todorovic V. Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats. Br J Pharmacol. 2003 Sep; 140(2):255-60. PMID: 12970103; PMCID: PMC1574030.
      View in: PubMed, PubMed Central
    31. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res. 2002 Oct 04; 951(2):336-40. PMID: 12270514.
      View in: PubMed
    32. Todorovic SM, Jevtovic-Todorovic V, Meyenburg A, Mennerick S, Perez-Reyes E, Romano C, Olney JW, Zorumski CF. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron. 2001 Jul 19; 31(1):75-85. PMID: 11498052.
      View in: PubMed
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