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Slobodan Milenko Todorovic

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Anesthesiology

    Collapse Research 
    Collapse research activities and funding
    K08DA000428     (TODOROVIC, SLOBODAN M)Aug 16, 2000 - Jul 31, 2005
    NIH/NIDA
    MULTIPLE CLASSES OF CA2+ CHANNELS - SENSORY TRANSMISSION
    Role: Principal Investigator
    R01GM070726     (TODOROVIC, SLOBODAN M)Mar 1, 2005 - Feb 28, 2011
    NIH/NIGMS
    Anesthetics block neuronal voltage-gated Ca2+ currents
    Role: Principal Investigator
    R01GM075229     (TODOROVIC, SLOBODAN M)Jun 1, 2006 - May 31, 2011
    NIH/NIGMS
    REDOX PHARMACOLOGY OF T CHANNELS IN DRG NEURONS
    Role: Principal Investigator
    R21DA029342     (TODOROVIC, SLOBODAN M)May 1, 2010 - Apr 30, 2013
    NIH/NIDA
    Validation of voltage-dependent T-channel blockers in treatment of neuropathic pa
    Role: Principal Investigator
    R21DA034448     (TODOROVIC, SLOBODAN M.)Apr 1, 2013 - Mar 31, 2015
    NIH/NIDA
    The role of trace metals and T-channels in pain
    Role: Principal Investigator
    R01GM102525     (TODOROVIC, SLOBODAN M.)Jan 1, 2014 - Dec 31, 2017
    NIH/NIGMS
    Effects of anesthetics on thalamic excitability
    Role: Principal Investigator
    R01NS091353     (TODOROVIC, SLOBODAN M.)Jun 1, 2016 - Apr 30, 2021
    NIH/NINDS
    Molecular mechanisms of glycosylation of Cav3.2 channels in pain pathway
    Role: Principal Investigator
    R01GM123746     (TODOROVIC, SLOBODAN M.)Sep 1, 2017 - May 31, 2021
    NIH/NIGMS
    Novel neurosteroid anesthetics and perioperative analgesia
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Joksimovic SL, Joksimovic SM, Tesic V, García-Caballero A, Feseha S, Zamponi GW, Jevtovic-Todorovic V, Todorovic SM. Selective inhibition of CaV3.2 channels reverses hyperexcitability of peripheral nociceptors and alleviates postsurgical pain. Sci Signal. 2018 Aug 28; 11(545). PMID: 30154101.
      View in: PubMed
    2. Tracy ME, Tesic V, Stamenic TT, Joksimovic SM, Busquet N, Jevtovic-Todorovic V, Todorovic SM. CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology. 2018 Jun; 135:343-354. PMID: 29578032.
      View in: PubMed
    3. Stamenic TT, Todorovic SM. Cytosolic ATP Relieves Voltage-Dependent Inactivation of T-Type Calcium Channels and Facilitates Excitability of Neurons in the Rat Central Medial Thalamus. eNeuro. 2018 Jan-Feb; 5(1). PMID: 29468189.
      View in: PubMed
    4. Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. Br J Anaesth. 2018 Apr; 120(4):768-778. PMID: 29576117.
      View in: PubMed
    5. Joksimovic SM, Osuru HP, Oklopcic A, Beenhakker MP, Jevtovic-Todorovic V, Todorovic SM. Histone Deacetylase Inhibitor Entinostat (MS-275) Restores Anesthesia-induced Alteration of Inhibitory Synaptic Transmission in the Developing Rat Hippocampus. Mol Neurobiol. 2018 01; 55(1):222-228. PMID: 28840475.
      View in: PubMed
    6. Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM. The role of T-type calcium channels in the subiculum: to burst or not to burst? J Physiol. 2017 Oct 01; 595(19):6327-6348. PMID: 28744923.
      View in: PubMed
    7. Todorovic SM. Painful Diabetic Neuropathy: Prevention or Suppression? Int Rev Neurobiol. 2016; 127:211-25. PMID: 27133151.
      View in: PubMed
    8. Obradovic AL, Scarpa J, Osuru HP, Weaver JL, Park JY, Pathirathna S, Peterkin A, Lim Y, Jagodic MM, Todorovic SM, Jevtovic-Todorovic V. Silencing the a2 subunit of ?-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury. Anesthesiology. 2015 Sep; 123(3):654-67. PMID: 26164299; PMCID: PMC4568754.
      View in: PubMed, PubMed Central
    9. Wang G, Bochorishvili G, Chen Y, Salvati KA, Zhang P, Dubel SJ, Perez-Reyes E, Snutch TP, Stornetta RL, Deisseroth K, Erisir A, Todorovic SM, Luo JH, Kapur J, Beenhakker MP, Zhu JJ. CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy. Genes Dev. 2015 Jul 15; 29(14):1535-51. PMID: 26220996; PMCID: PMC4526737.
      View in: PubMed, PubMed Central
    10. Joksovic PM, Lunardi N, Jevtovic-Todorovic V, Todorovic SM. Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus. Mol Neurobiol. 2015 Oct; 52(2):952-8. PMID: 26048671; PMCID: PMC4558348 [Available on 10/01/16].
      View in: PubMed, PubMed Central
    11. DiGruccio MR, Joksimovic S, Joksovic PM, Lunardi N, Salajegheh R, Jevtovic-Todorovic V, Beenhakker MP, Goodkin HP, Todorovic SM. Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development. J Neurosci. 2015 Jan 28; 35(4):1481-92. PMID: 25632125; PMCID: PMC4308595.
      View in: PubMed, PubMed Central
    12. Ayoola C, Hwang SM, Hong SJ, Rose KE, Boyd C, Bozic N, Park JY, Osuru HP, DiGruccio MR, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone. Psychopharmacology (Berl). 2014 Sep; 231(17):3503-3515. PMID: 24800894; PMCID: PMC4135044.
      View in: PubMed, PubMed Central
    13. Obradovic ALj, Hwang SM, Scarpa J, Hong SJ, Todorovic SM, Jevtovic-Todorovic V. CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy. PLoS One. 2014; 9(4):e91467. PMID: 24705276; PMCID: PMC3976247.
      View in: PubMed, PubMed Central
    14. Todorovic SM, Jevtovic-Todorovic V. Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy. Pflugers Arch. 2014 Apr; 466(4):701-6. PMID: 24482063.
      View in: PubMed
    15. Todorovic SM, Jevtovic-Todorovic V. Redox regulation of neuronal voltage-gated calcium channels. Antioxid Redox Signal. 2014 Aug 20; 21(6):880-91. PMID: 24161125; PMCID: PMC4116091.
      View in: PubMed, PubMed Central
    16. Rose KE, Lunardi N, Boscolo A, Dong X, Erisir A, Jevtovic-Todorovic V, Todorovic SM. Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse. Neuroscience. 2013 Oct 10; 250:263-74. PMID: 23867767; PMCID: PMC3796369.
      View in: PubMed, PubMed Central
    17. Orestes P, Osuru HP, McIntire WE, Jacus MO, Salajegheh R, Jagodic MM, Choe W, Lee J, Lee SS, Rose KE, Poiro N, Digruccio MR, Krishnan K, Covey DF, Lee JH, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes. 2013 Nov; 62(11):3828-38. PMID: 23835327; PMCID: PMC3806612.
      View in: PubMed, PubMed Central
    18. Lee J, Nelson MT, Rose KE, Todorovic SM. Redox mechanism of S-nitrosothiol modulation of neuronal CaV3.2 T-type calcium channels. Mol Neurobiol. 2013 Oct; 48(2):274-80. PMID: 23813099; PMCID: PMC3779485.
      View in: PubMed, PubMed Central
    19. Todorovic SM, Jevtovic-Todorovic V. Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling. Pflugers Arch. 2013 Jul; 465(7):921-7. PMID: 23322114.
      View in: PubMed
    20. Jacus MO, Uebele VN, Renger JJ, Todorovic SM. Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons. J Neurosci. 2012 Jul 04; 32(27):9374-82. PMID: 22764245; PMCID: PMC3398424.
      View in: PubMed, PubMed Central
    21. Sanchez V, Feinstein SD, Lunardi N, Joksovic PM, Boscolo A, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain. Anesthesiology. 2011 Nov; 115(5):992-1002. PMID: 21909020; PMCID: PMC3203321.
      View in: PubMed, PubMed Central
    22. Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011 Nov; 80(5):900-10. PMID: 21821734; PMCID: PMC3198916.
      View in: PubMed, PubMed Central
    23. Todorovic SM, Jevtovic-Todorovic V. T-type voltage-gated calcium channels as targets for the development of novel pain therapies. Br J Pharmacol. 2011 Jun; 163(3):484-95. PMID: 21306582; PMCID: PMC3101611.
      View in: PubMed, PubMed Central
    24. Orestes P, Bojadzic D, Lee J, Leach E, Salajegheh R, Digruccio MR, Nelson MT, Todorovic SM. Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol. 2011 Jan 01; 589(Pt 1):135-48. PMID: 21059758; PMCID: PMC3039265.
      View in: PubMed, PubMed Central
    25. Jevtovic-Todorovic V, Covey DF, Todorovic SM. Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain? Psychoneuroendocrinology. 2009 Dec; 34 Suppl 1:S178-85. PMID: 19577375; PMCID: PMC2795041.
      View in: PubMed, PubMed Central
    26. Latham JR, Pathirathna S, Jagodic MM, Choe WJ, Levin ME, Nelson MT, Lee WY, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes. 2009 Nov; 58(11):2656-65. PMID: 19651818; PMCID: PMC2768156.
      View in: PubMed, PubMed Central
    27. Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SM. Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. J Neurosci. 2009 Jul 29; 29(30):9500-9. PMID: 19641113; PMCID: PMC3073510.
      View in: PubMed, PubMed Central
    28. Messinger RB, Naik AK, Jagodic MM, Nelson MT, Lee WY, Choe WJ, Orestes P, Latham JR, Todorovic SM, Jevtovic-Todorovic V. In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy. Pain. 2009 Sep; 145(1-2):184-95. PMID: 19577366; PMCID: PMC2735619.
      View in: PubMed, PubMed Central
    29. Zamponi GW, Lewis RJ, Todorovic SM, Arneric SP, Snutch TP. Role of voltage-gated calcium channels in ascending pain pathways. Brain Res Rev. 2009 Apr; 60(1):84-9. PMID: 19162069; PMCID: PMC2692704.
      View in: PubMed, PubMed Central
    30. Jagodic MM, Pathirathna S, Joksovic PM, Lee W, Nelson MT, Naik AK, Su P, Jevtovic-Todorovic V, Todorovic SM. Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J Neurophysiol. 2008 Jun; 99(6):3151-6. PMID: 18417624; PMCID: PMC2667888.
      View in: PubMed, PubMed Central
    31. Todorovic SM, Jevtovic-Todorovic V. Regulation of T-type calcium channels in the peripheral pain pathway. Channels (Austin). 2007 Jul-Aug; 1(4):238-45. PMID: 18708751.
      View in: PubMed
    32. Nelson MT, Woo J, Kang HW, Vitko I, Barrett PQ, Perez-Reyes E, Lee JH, Shin HS, Todorovic SM. Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. J Neurosci. 2007 Aug 01; 27(31):8250-60. PMID: 17670971.
      View in: PubMed
    33. Jagodic MM, Pathirathna S, Nelson MT, Mancuso S, Joksovic PM, Rosenberg ER, Bayliss DA, Jevtovic-Todorovic V, Todorovic SM. Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J Neurosci. 2007 Mar 21; 27(12):3305-16. PMID: 17376991.
      View in: PubMed
    34. Nelson MT, Todorovic SM. Is there a role for T-type calcium channels in peripheral and central pain sensitization? Mol Neurobiol. 2006 Dec; 34(3):243-8. PMID: 17308355.
      View in: PubMed
    35. Todorovic SM, Jevtovic-Todorovic V. The role of T-type calcium channels in peripheral and central pain processing. CNS Neurol Disord Drug Targets. 2006 Dec; 5(6):639-53. PMID: 17168748.
      View in: PubMed
    36. Pathirathna S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats. Pain. 2006 Nov; 125(1-2):53-64. PMID: 16782275.
      View in: PubMed
    37. Jevtovic-Todorovic V, Todorovic SM. The role of peripheral T-type calcium channels in pain transmission. Cell Calcium. 2006 Aug; 40(2):197-203. PMID: 16777222.
      View in: PubMed
    38. Joksovic PM, Nelson MT, Jevtovic-Todorovic V, Patel MK, Perez-Reyes E, Campbell KP, Chen CC, Todorovic SM. CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus. J Physiol. 2006 Jul 15; 574(Pt 2):415-30. PMID: 16644797; PMCID: PMC1817755.
      View in: PubMed, PubMed Central
    39. Nelson MT, Todorovic SM, Perez-Reyes E. The role of T-type calcium channels in epilepsy and pain. Curr Pharm Des. 2006; 12(18):2189-97. PMID: 16787249.
      View in: PubMed
    40. Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain. 2005 Oct; 117(3):326-39. PMID: 16150542.
      View in: PubMed
    41. Pathirathna S, Brimelow BC, Jagodic MM, Krishnan K, Jiang X, Zorumski CF, Mennerick S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain. 2005 Apr; 114(3):429-43. PMID: 15777868.
      View in: PubMed
    42. Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V. 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Mol Pharmacol. 2004 Nov; 66(5):1223-35. PMID: 15280444.
      View in: PubMed
    43. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia. Pain. 2004 Jun; 109(3):328-39. PMID: 15157694.
      View in: PubMed
    44. Todorovic SM, Pathirathna S, Meyenburg A, Jevtovic-Todorovic V. Mechanical and thermal anti-nociception in rats after systemic administration of verapamil. Neurosci Lett. 2004 Apr 22; 360(1-2):57-60. PMID: 15082178.
      View in: PubMed
    45. Todorovic SM, Rastogi AJ, Jevtovic-Todorovic V. Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats. Br J Pharmacol. 2003 Sep; 140(2):255-60. PMID: 12970103; PMCID: PMC1574030.
      View in: PubMed, PubMed Central
    46. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res. 2002 Oct 04; 951(2):336-40. PMID: 12270514.
      View in: PubMed
    47. Todorovic SM, Jevtovic-Todorovic V, Mennerick S, Perez-Reyes E, Zorumski CF. Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide. Mol Pharmacol. 2001 Sep; 60(3):603-10. PMID: 11502893.
      View in: PubMed
    48. Todorovic SM, Jevtovic-Todorovic V, Meyenburg A, Mennerick S, Perez-Reyes E, Romano C, Olney JW, Zorumski CF. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron. 2001 Jul 19; 31(1):75-85. PMID: 11498052.
      View in: PubMed
    49. Mennerick S, Jevtovic-Todorovic V, Todorovic SM, Shen W, Olney JW, Zorumski CF. Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures. J Neurosci. 1998 Dec 01; 18(23):9716-26. PMID: 9822732.
      View in: PubMed
    50. Jevtovic-Todorovic V, Todorovic SM, Mennerick S, Powell S, Dikranian K, Benshoff N, Zorumski CF, Olney JW. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med. 1998 Apr; 4(4):460-3. PMID: 9546794.
      View in: PubMed
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