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Slobodan Milenko Todorovic

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Anesthesiology

    Collapse Research 
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    K08DA000428     (TODOROVIC, SLOBODAN M)Aug 16, 2000 - Jul 31, 2005
    NIH/NIDA
    MULTIPLE CLASSES OF CA2+ CHANNELS - SENSORY TRANSMISSION
    Role: Principal Investigator

    R01GM070726     (TODOROVIC, SLOBODAN M)Mar 1, 2005 - Feb 28, 2011
    NIH/NIGMS
    Anesthetics block neuronal voltage-gated Ca2+ currents
    Role: Principal Investigator

    R01GM075229     (TODOROVIC, SLOBODAN M)Jun 1, 2006 - May 31, 2011
    NIH/NIGMS
    REDOX PHARMACOLOGY OF T CHANNELS IN DRG NEURONS
    Role: Principal Investigator

    R21DA029342     (TODOROVIC, SLOBODAN M)May 1, 2010 - Apr 30, 2013
    NIH/NIDA
    Validation of voltage-dependent T-channel blockers in treatment of neuropathic pa
    Role: Principal Investigator

    R21DA034448     (TODOROVIC, SLOBODAN M.)Apr 1, 2013 - Mar 31, 2015
    NIH/NIDA
    The role of trace metals and T-channels in pain
    Role: Principal Investigator

    R01GM102525     (TODOROVIC, SLOBODAN M.)Jan 1, 2014 - Dec 31, 2017
    NIH/NIGMS
    Effects of anesthetics on thalamic excitability
    Role: Principal Investigator

    R01NS091353     (JEVTOVIC-TODOROVIC, VESNA)Jun 1, 2016 - Apr 30, 2021
    NIH/NINDS
    Molecular mechanisms of glycosylation of Cav3.2 channels in pain pathway
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dalla Massara L, Osuru HP, Oklopcic A, Milanovic D, Joksimovic SM, Caputo V, DiGruccio MR, Ori C, Wang G, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus. Anesthesiology. 2016 Jun; 124(6):1311-27. PMID: 27028464; PMCID: PMC4870171 [Available on 06/01/17].
    2. Todorovic SM. Is Diabetic Nerve Pain Caused by Dysregulated Ion Channels in Sensory Neurons? Diabetes. 2015 Dec; 64(12):3987-9. PMID: 26604173.
      View in: PubMed
    3. Evans JG, Todorovic SM. Redox and trace metal regulation of ion channels in the pain pathway. Biochem J. 2015 Sep 15; 470(3):275-80. PMID: 26341484; PMCID: PMC4613504.
    4. Obradovic AL, Scarpa J, Osuru HP, Weaver JL, Park JY, Pathirathna S, Peterkin A, Lim Y, Jagodic MM, Todorovic SM, Jevtovic-Todorovic V. Silencing the a2 subunit of ?-aminobutyric acid type A receptors in rat dorsal root ganglia reveals its major role in antinociception posttraumatic nerve injury. Anesthesiology. 2015 Sep; 123(3):654-67. PMID: 26164299; PMCID: PMC4568754.
    5. Brkušanin M, Kosac A, Jovanovic V, Pešovic J, Brajuškovic G, Dimitrijevic N, Todorovic S, Romac S, Milic Rašic V, Savic-Pavicevic D. Joint effect of the SMN2 and SERF1A genes on childhood-onset types of spinal muscular atrophy in Serbian patients. J Hum Genet. 2015 Nov; 60(11):723-8. PMID: 26311540.
      View in: PubMed
    6. Wang G, Bochorishvili G, Chen Y, Salvati KA, Zhang P, Dubel SJ, Perez-Reyes E, Snutch TP, Stornetta RL, Deisseroth K, Erisir A, Todorovic SM, Luo JH, Kapur J, Beenhakker MP, Zhu JJ. CaV3.2 calcium channels control NMDA receptor-mediated transmission: a new mechanism for absence epilepsy. Genes Dev. 2015 Jul 15; 29(14):1535-51. PMID: 26220996; PMCID: PMC4526737.
    7. Joksovic PM, Lunardi N, Jevtovic-Todorovic V, Todorovic SM. Early Exposure to General Anesthesia with Isoflurane Downregulates Inhibitory Synaptic Neurotransmission in the Rat Thalamus. Mol Neurobiol. 2015 Oct; 52(2):952-8. PMID: 26048671; PMCID: PMC4558348 [Available on 10/01/16].
    8. DiGruccio MR, Joksimovic S, Joksovic PM, Lunardi N, Salajegheh R, Jevtovic-Todorovic V, Beenhakker MP, Goodkin HP, Todorovic SM. Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development. J Neurosci. 2015 Jan 28; 35(4):1481-92. PMID: 25632125; PMCID: PMC4308595.
    9. Ayoola C, Hwang SM, Hong SJ, Rose KE, Boyd C, Bozic N, Park JY, Osuru HP, DiGruccio MR, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone. Psychopharmacology (Berl). 2014 Sep; 231(17):3503-15. PMID: 24800894; PMCID: PMC4135044.
    10. Obradovic ALj, Hwang SM, Scarpa J, Hong SJ, Todorovic SM, Jevtovic-Todorovic V. CaV3.2 T-type calcium channels in peripheral sensory neurons are important for mibefradil-induced reversal of hyperalgesia and allodynia in rats with painful diabetic neuropathy. PLoS One. 2014; 9(4):e91467. PMID: 24705276; PMCID: PMC3976247.
    11. Todorovic SM, Jevtovic-Todorovic V. Targeting of CaV3.2 T-type calcium channels in peripheral sensory neurons for the treatment of painful diabetic neuropathy. Pflugers Arch. 2014 Apr; 466(4):701-6. PMID: 24482063.
      View in: PubMed
    12. Todorovic SM, Jevtovic-Todorovic V. Redox regulation of neuronal voltage-gated calcium channels. Antioxid Redox Signal. 2014 Aug 20; 21(6):880-91. PMID: 24161125; PMCID: PMC4116091.
    13. Rose KE, Lunardi N, Boscolo A, Dong X, Erisir A, Jevtovic-Todorovic V, Todorovic SM. Immunohistological demonstration of CaV3.2 T-type voltage-gated calcium channel expression in soma of dorsal root ganglion neurons and peripheral axons of rat and mouse. Neuroscience. 2013 Oct 10; 250:263-74. PMID: 23867767; PMCID: PMC3796369.
    14. Orestes P, Osuru HP, McIntire WE, Jacus MO, Salajegheh R, Jagodic MM, Choe W, Lee J, Lee SS, Rose KE, Poiro N, Digruccio MR, Krishnan K, Covey DF, Lee JH, Barrett PQ, Jevtovic-Todorovic V, Todorovic SM. Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes. 2013 Nov; 62(11):3828-38. PMID: 23835327; PMCID: PMC3806612.
    15. Todorovic SM, Jevtovic-Todorovic V. Neuropathic pain: role for presynaptic T-type channels in nociceptive signaling. Pflugers Arch. 2013 Jul; 465(7):921-7. PMID: 23322114.
      View in: PubMed
    16. Jacus MO, Uebele VN, Renger JJ, Todorovic SM. Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons. J Neurosci. 2012 Jul 04; 32(27):9374-82. PMID: 22764245; PMCID: PMC3398424.
    17. Eckle VS, Digruccio MR, Uebele VN, Renger JJ, Todorovic SM. Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane. Neuropharmacology. 2012 Aug; 63(2):266-73. PMID: 22491022; PMCID: PMC3372673.
    18. Shcheglovitov A, Vitko I, Lazarenko RM, Orestes P, Todorovic SM, Perez-Reyes E. Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels. J Gen Physiol. 2012 Mar; 139(3):219-34. PMID: 22371363; PMCID: PMC3289959.
    19. Sanchez V, Feinstein SD, Lunardi N, Joksovic PM, Boscolo A, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain. Anesthesiology. 2011 Nov; 115(5):992-1002. PMID: 21909020; PMCID: PMC3203321.
    20. Choe W, Messinger RB, Leach E, Eckle VS, Obradovic A, Salajegheh R, Jevtovic-Todorovic V, Todorovic SM. TTA-P2 is a potent and selective blocker of T-type calcium channels in rat sensory neurons and a novel antinociceptive agent. Mol Pharmacol. 2011 Nov; 80(5):900-10. PMID: 21821734; PMCID: PMC3198916.
    21. Todorovic SM, Jevtovic-Todorovic V. T-type voltage-gated calcium channels as targets for the development of novel pain therapies. Br J Pharmacol. 2011 Jun; 163(3):484-95. PMID: 21306582; PMCID: PMC3101611.
    22. Orestes P, Bojadzic D, Lee J, Leach E, Salajegheh R, Digruccio MR, Nelson MT, Todorovic SM. Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol. 2011 Jan 01; 589(Pt 1):135-48. PMID: 21059758; PMCID: PMC3039265.
    23. Orestes P, Todorovic SM. Are neuronal voltage-gated calcium channels valid cellular targets for general anesthetics? Channels (Austin). 2010 Nov-Dec; 4(6):518-22. PMID: 21164281; PMCID: PMC3021099.
    24. Joksovic PM, Todorovic SM. Isoflurane modulates neuronal excitability of the nucleus reticularis thalami in vitro. Ann N Y Acad Sci. 2010 Jun; 1199:36-42. PMID: 20633107; PMCID: PMC2906252.
    25. Eckle VS, Todorovic SM. Mechanisms of inhibition of CaV3.1 T-type calcium current by aliphatic alcohols. Neuropharmacology. 2010 Jul-Aug; 59(1-2):58-69. PMID: 20363234; PMCID: PMC2879975.
    26. Nelson MT, Milescu LS, Todorovic SM, Scroggs RS. A modeling study of T-type Ca2+ channel gating and modulation by L-cysteine in rat nociceptors. Biophys J. 2010 Jan 20; 98(2):197-206. PMID: 20338841; PMCID: PMC2808491.
    27. Jevtovic-Todorovic V, Covey DF, Todorovic SM. Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain? Psychoneuroendocrinology. 2009 Dec; 34 Suppl 1:S178-85. PMID: 19577375; PMCID: PMC2795041.
    28. Eckle VS, Hucklenbruch C, Todorovic SM. [What do we know about anesthetic mechanisms?: hypnosis, unresponsiveness to surgical incision and amnesia]. Anaesthesist. 2009 Nov; 58(11):1144-9. PMID: 19760252; PMCID: PMC2823130.
    29. Joksovic PM, Choe WJ, Nelson MT, Orestes P, Brimelow BC, Todorovic SM. Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway. Mol Pharmacol. 2010 Jan; 77(1):87-94. PMID: 19846748; PMCID: PMC2802428.
    30. Latham JR, Pathirathna S, Jagodic MM, Choe WJ, Levin ME, Nelson MT, Lee WY, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes. 2009 Nov; 58(11):2656-65. PMID: 19651818; PMCID: PMC2768156.
    31. Lee WY, Orestes P, Latham J, Naik AK, Nelson MT, Vitko I, Perez-Reyes E, Jevtovic-Todorovic V, Todorovic SM. Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway. J Neurosci. 2009 Jul 29; 29(30):9500-9. PMID: 19641113; PMCID: PMC3073510.
    32. Messinger RB, Naik AK, Jagodic MM, Nelson MT, Lee WY, Choe WJ, Orestes P, Latham JR, Todorovic SM, Jevtovic-Todorovic V. In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy. Pain. 2009 Sep; 145(1-2):184-95. PMID: 19577366; PMCID: PMC2735619.
    33. Joksovic PM, Weiergräber M, Lee W, Struck H, Schneider T, Todorovic SM. Isoflurane-sensitive presynaptic R-type calcium channels contribute to inhibitory synaptic transmission in the rat thalamus. J Neurosci. 2009 Feb 04; 29(5):1434-45. PMID: 19193890; PMCID: PMC2659547.
    34. Orestes P, Bojadzic D, Chow RM, Todorovic SM. Mechanisms and functional significance of inhibition of neuronal T-type calcium channels by isoflurane. Mol Pharmacol. 2009 Mar; 75(3):542-54. PMID: 19038845; PMCID: PMC2645928.
    35. Jagodic MM, Pathirathna S, Joksovic PM, Lee W, Nelson MT, Naik AK, Su P, Jevtovic-Todorovic V, Todorovic SM. Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve. J Neurophysiol. 2008 Jun; 99(6):3151-6. PMID: 18417624; PMCID: PMC2667888.
    36. Joksovic PM, Covey DF, Todorovic SM. Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid. Ann N Y Acad Sci. 2007 Dec; 1122:83-94. PMID: 18077566.
      View in: PubMed
    37. Nelson MT, Joksovic PM, Su P, Kang HW, Van Deusen A, Baumgart JP, David LS, Snutch TP, Barrett PQ, Lee JH, Zorumski CF, Perez-Reyes E, Todorovic SM. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14; 27(46):12577-83. PMID: 18003836.
      View in: PubMed
    38. Todorovic SM, Jevtovic-Todorovic V. Regulation of T-type calcium channels in the peripheral pain pathway. Channels (Austin). 2007 Jul-Aug; 1(4):238-45. PMID: 18708751.
      View in: PubMed
    39. Nelson MT, Woo J, Kang HW, Vitko I, Barrett PQ, Perez-Reyes E, Lee JH, Shin HS, Todorovic SM. Reducing agents sensitize C-type nociceptors by relieving high-affinity zinc inhibition of T-type calcium channels. J Neurosci. 2007 Aug 01; 27(31):8250-60. PMID: 17670971.
      View in: PubMed
    40. Jagodic MM, Pathirathna S, Nelson MT, Mancuso S, Joksovic PM, Rosenberg ER, Bayliss DA, Jevtovic-Todorovic V, Todorovic SM. Cell-specific alterations of T-type calcium current in painful diabetic neuropathy enhance excitability of sensory neurons. J Neurosci. 2007 Mar 21; 27(12):3305-16. PMID: 17376991.
      View in: PubMed
    41. Joksovic PM, Doctor A, Gaston B, Todorovic SM. Functional regulation of T-type calcium channels by s-nitrosothiols in the rat thalamus. J Neurophysiol. 2007 Apr; 97(4):2712-21. PMID: 17287440.
      View in: PubMed
    42. Nelson MT, Todorovic SM. Is there a role for T-type calcium channels in peripheral and central pain sensitization? Mol Neurobiol. 2006 Dec; 34(3):243-8. PMID: 17308355.
      View in: PubMed
    43. Todorovic SM, Jevtovic-Todorovic V. The role of T-type calcium channels in peripheral and central pain processing. CNS Neurol Disord Drug Targets. 2006 Dec; 5(6):639-53. PMID: 17168748.
      View in: PubMed
    44. Pathirathna S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats. Pain. 2006 Nov; 125(1-2):53-64. PMID: 16782275.
      View in: PubMed
    45. Jevtovic-Todorovic V, Todorovic SM. The role of peripheral T-type calcium channels in pain transmission. Cell Calcium. 2006 Aug; 40(2):197-203. PMID: 16777222.
      View in: PubMed
    46. Mladenovic J, Pekmezovic T, Todorovic S, Rakocevic-Stojanovic V, Savic D, Romac S, Apostolski S. Epidemiology of myotonic dystrophy type 1 (Steinert disease) in Belgrade (Serbia). Clin Neurol Neurosurg. 2006 Dec; 108(8):757-60. PMID: 16713671.
      View in: PubMed
    47. Joksovic PM, Nelson MT, Jevtovic-Todorovic V, Patel MK, Perez-Reyes E, Campbell KP, Chen CC, Todorovic SM. CaV3.2 is the major molecular substrate for redox regulation of T-type Ca2+ channels in the rat and mouse thalamus. J Physiol. 2006 Jul 15; 574(Pt 2):415-30. PMID: 16644797; PMCID: PMC1817755.
    48. Nelson MT, Todorovic SM, Perez-Reyes E. The role of T-type calcium channels in epilepsy and pain. Curr Pharm Des. 2006; 12(18):2189-97. PMID: 16787249.
      View in: PubMed
    49. Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain. 2005 Oct; 117(3):326-39. PMID: 16150542.
      View in: PubMed
    50. Nelson MT, Joksovic PM, Perez-Reyes E, Todorovic SM. The endogenous redox agent L-cysteine induces T-type Ca2+ channel-dependent sensitization of a novel subpopulation of rat peripheral nociceptors. J Neurosci. 2005 Sep 21; 25(38):8766-75. PMID: 16177046.
      View in: PubMed
    51. Novakovic I, Bojic D, Todorovic S, Apostolski S, Lukovic L, Stefanovic D, Milasin J. Proximal dystrophin gene deletions and protein alterations in becker muscular dystrophy. Ann N Y Acad Sci. 2005 Jun; 1048:406-10. PMID: 16154963.
      View in: PubMed
    52. Joksovic PM, Bayliss DA, Todorovic SM. Different kinetic properties of two T-type Ca2+ currents of rat reticular thalamic neurones and their modulation by enflurane. J Physiol. 2005 Jul 01; 566(Pt 1):125-42. PMID: 15845580; PMCID: PMC1464735.
    53. Pathirathna S, Brimelow BC, Jagodic MM, Krishnan K, Jiang X, Zorumski CF, Mennerick S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain. 2005 Apr; 114(3):429-43. PMID: 15777868.
      View in: PubMed
    54. Joksovic PM, Brimelow BC, Murbartián J, Perez-Reyes E, Todorovic SM. Contrasting anesthetic sensitivities of T-type Ca2+ channels of reticular thalamic neurons and recombinant Ca(v)3.3 channels. Br J Pharmacol. 2005 Jan; 144(1):59-70. PMID: 15644869; PMCID: PMC1575974.
    55. Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V. 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Mol Pharmacol. 2004 Nov; 66(5):1223-35. PMID: 15280444.
      View in: PubMed
    56. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia. Pain. 2004 Jun; 109(3):328-39. PMID: 15157694.
      View in: PubMed
    57. Brankovic-Sreckovic V, Milic-Rasic V, Jovic N, Milic N, Todorovic S. The recurrence risk of ischemic stroke in childhood. Med Princ Pract. 2004 May-Jun; 13(3):153-8. PMID: 15073428.
      View in: PubMed
    58. Todorovic SM, Pathirathna S, Meyenburg A, Jevtovic-Todorovic V. Mechanical and thermal anti-nociception in rats after systemic administration of verapamil. Neurosci Lett. 2004 Apr 22; 360(1-2):57-60. PMID: 15082178.
      View in: PubMed
    59. Todorovic SM, Rastogi AJ, Jevtovic-Todorovic V. Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats. Br J Pharmacol. 2003 Sep; 140(2):255-60. PMID: 12970103; PMCID: PMC1574030.
    60. Todorovic SM, Meyenburg A, Jevtovic-Todorovic V. Mechanical and thermal antinociception in rats following systemic administration of mibefradil, a T-type calcium channel blocker. Brain Res. 2002 Oct 04; 951(2):336-40. PMID: 12270514.
      View in: PubMed
    61. Todorovic SM, Jevtovic-Todorovic V, Mennerick S, Perez-Reyes E, Zorumski CF. Ca(v)3.2 channel is a molecular substrate for inhibition of T-type calcium currents in rat sensory neurons by nitrous oxide. Mol Pharmacol. 2001 Sep; 60(3):603-10. PMID: 11502893.
      View in: PubMed
    62. Todorovic SM, Jevtovic-Todorovic V, Meyenburg A, Mennerick S, Perez-Reyes E, Romano C, Olney JW, Zorumski CF. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron. 2001 Jul 19; 31(1):75-85. PMID: 11498052.
      View in: PubMed
    63. Mennerick S, Jevtovic-Todorovic V, Todorovic SM, Shen W, Olney JW, Zorumski CF. Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures. J Neurosci. 1998 Dec 01; 18(23):9716-26. PMID: 9822732.
      View in: PubMed
    64. Jevtovic-Todorovic V, Todorovic SM, Mennerick S, Powell S, Dikranian K, Benshoff N, Zorumski CF, Olney JW. Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med. 1998 Apr; 4(4):460-3. PMID: 9546794.
      View in: PubMed
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