Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Contact Us
If you have any questions or feedback please contact us.

Lawrence J Wysocki

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Immunology Microbiology

    Collapse Research 
    Collapse research activities and funding
    R21AI033613     (WYSOCKI, LAWRENCE J.)Sep 1, 1993 - Aug 31, 2001
    NIH/NIAID
    IMMUNE RECOGNITION AND TOLERANCE OF ANTIBODY DIVERSITY
    Role: Principal Investigator

    R01AI033613     (WYSOCKI, LAWRENCE J.)Sep 1, 1993 - Mar 31, 2011
    NIH/NIAID
    Immune Recognition and Tolerance of Antibody Diversity
    Role: Principal Investigator

    R01AI039563     (WYSOCKI, LAWRENCE J.)Apr 1, 1996 - Mar 31, 2002
    NIH/NIAID
    SOMATIC MUTAGENESIS AND DEVELOPMENT OF B CELL MEMORY
    Role: Principal Investigator

    R01AI048108     (WYSOCKI, LAWRENCE J.)Apr 1, 2001 - Mar 31, 2007
    NIH/NIAID
    ORIGIN OF T CELL HELP FOR AUTOREACTIVE B CELLS
    Role: Principal Investigator

    R01AI073945     (WYSOCKI, LAWRENCE J.)Dec 15, 2007 - Nov 30, 2013
    NIH/NIAID
    Functional Anergy in B Cells
    Role: Principal Investigator

    R03AI088408     (WYSOCKI, LAWRENCE J.)Feb 15, 2010 - Jan 31, 2013
    NIH/NIAID
    A Reporter for Mutant Autoreactive B Cells
    Role: Principal Investigator

    R03AI092358     (WYSOCKI, LAWRENCE J.)Aug 4, 2011 - Jul 31, 2014
    NIH/NIAID
    An Advanced Model to Analyze CD4T Cel Reactions to Antibody and BCR V Regions
    Role: Principal Investigator

    R01AI093822     (WYSOCKI, LAWRENCE J.)Dec 1, 2011 - Nov 30, 2016
    NIH/NIAID
    Somatic Hypermutation in SLE
    Role: Principal Investigator

    R21AI113122     (WYSOCKI, LAWRENCE J.)Jun 1, 2014 - May 31, 2016
    NIH/NIAID
    Somatic Mutagenesis in Autoimmunity
    Role: Principal Investigator

    R21AI121980     (WYSOCKI, LAWRENCE J)Jan 1, 2016 - Dec 31, 2017
    NIH/NIAID
    A Universal Strategy for Inducing Tolerance to Therapeutic Mab
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. St Clair JB, Detanico T, Aviszus K, Kirchenbaum GA, Christie M, Carpenter JF, Wysocki LJ. Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes. PLoS One. 2017; 12(1):e0170556. PMID: 28114383.
      View in: PubMed
    2. Detanico T, Phillips M, Wysocki LJ. Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes. Front Immunol. 2016; 7:525. PMID: 27920779.
      View in: PubMed
    3. Huang Y, Getahun A, Heiser RA, Detanico TO, Aviszus K, Kirchenbaum GA, Casper TL, Huang C, Aydintug MK, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, O'Brien RL, Born WK. ?d T Cells Shape Preimmune Peripheral B Cell Populations. J Immunol. 2016 Jan 01; 196(1):217-31. PMID: 26582947; PMCID: PMC4684964 [Available on 01/01/17].
    4. Detanico T, Guo W, Wysocki LJ. Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE. J Autoimmun. 2015 Apr; 58:67-77. PMID: 25634361; PMCID: PMC4492439.
    5. Huang Y, Heiser RA, Detanico TO, Getahun A, Kirchenbaum GA, Casper TL, Aydintug MK, Carding SR, Ikuta K, Huang H, Cambier JC, Wysocki LJ, O'Brien RL, Born WK. ?d T cells affect IL-4 production and B-cell tolerance. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):E39-48. PMID: 25535377; PMCID: PMC4291655.
    6. Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15; 193(10):4757-60. PMID: 25381356; PMCID: PMC4440340.
    7. Kirchenbaum GA, St Clair JB, Detanico T, Aviszus K, Wysocki LJ. Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM. Eur J Immunol. 2014 Apr; 44(4):970-82. PMID: 24375379; PMCID: PMC3984621.
    8. Detanico T, St Clair JB, Aviszus K, Kirchenbaum G, Guo W, Wysocki LJ. Somatic mutagenesis in autoimmunity. Autoimmunity. 2013 Mar; 46(2):102-14. PMID: 23249093; PMCID: PMC3743419.
    9. Aviszus K, Macleod MK, Kirchenbaum GA, Detanico TO, Heiser RA, St Clair JB, Guo W, Wysocki LJ. Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells. J Immunol. 2012 Nov 01; 189(9):4275-83. PMID: 23008448; PMCID: PMC3478495.
    10. Detanico T, Heiser RA, Aviszus K, Bonorino C, Wysocki LJ. Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor. J Immunol. 2011 Jul 01; 187(1):82-91. PMID: 21622865; PMCID: PMC3124280.
    11. Heiser RA, Snyder CM, St Clair J, Wysocki LJ. Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide. J Immunol. 2011 Jul 01; 187(1):212-21. PMID: 21622866; PMCID: PMC3133611.
    12. Guo W, Smith D, Aviszus K, Detanico T, Heiser RA, Wysocki LJ. Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity. J Exp Med. 2010 Sep 27; 207(10):2225-37. PMID: 20805563; PMCID: PMC2947070.
    13. Aviszus K, Zhang X, Wysocki LJ. Silent development of memory progenitor B cells. J Immunol. 2007 Oct 15; 179(8):5181-90. PMID: 17911603; PMCID: PMC2896480.
    14. Kilmon MA, Wagner NJ, Garland AL, Lin L, Aviszus K, Wysocki LJ, Vilen BJ. Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6. Blood. 2007 Sep 01; 110(5):1595-602. PMID: 17712049; PMCID: PMC1952615.
    15. Liu X, Wysocki LJ, Manser T. Autoantigen-B cell antigen receptor interactions that regulate expression of B cell antigen receptor Loci. J Immunol. 2007 Apr 15; 178(8):5035-47. PMID: 17404286.
      View in: PubMed
    16. Merrell KT, Benschop RJ, Gauld SB, Aviszus K, Decote-Ricardo D, Wysocki LJ, Cambier JC. Identification of anergic B cells within a wild-type repertoire. Immunity. 2006 Dec; 25(6):953-62. PMID: 17174121.
      View in: PubMed
    17. Guo W, Smith D, Guth A, Aviszus K, Wysocki LJ. T cell tolerance to germline-encoded antibody sequences in a lupus-prone mouse. J Immunol. 2005 Aug 15; 175(4):2184-90. PMID: 16081785.
      View in: PubMed
    18. Snyder CM, Aviszus K, Heiser RA, Tonkin DR, Guth AM, Wysocki LJ. Activation and tolerance in CD4(+) T cells reactive to an immunoglobulin variable region. J Exp Med. 2004 Jul 05; 200(1):1-11. PMID: 15226360; PMCID: PMC2213315.
    19. Guth AM, Zhang X, Smith D, Detanico T, Wysocki LJ. Chromatin specificity of anti-double-stranded DNA antibodies and a role for Arg residues in the third complementarity-determining region of the heavy chain. J Immunol. 2003 Dec 01; 171(11):6260-6. PMID: 14634143.
      View in: PubMed
    20. Shapiro GS, Ellison MC, Wysocki LJ. Sequence-specific targeting of two bases on both DNA strands by the somatic hypermutation mechanism. Mol Immunol. 2003 Sep; 40(5):287-95. PMID: 12943801.
      View in: PubMed
    21. Jena PK, Smith DS, Zhang X, Aviszus K, Durdik JM, Wysocki LJ. Somatic translocation and differential expression of Ig mu transgene copies implicate a role for the Igh locus in memory B cell development. Mol Immunol. 2003 May; 39(14):885-97. PMID: 12686505.
      View in: PubMed
    22. Snyder CM, Zhang X, Wysocki LJ. Negligible class II MHC presentation of B cell receptor-derived peptides by high density resting B cells. J Immunol. 2002 Apr 15; 168(8):3865-73. PMID: 11937540.
      View in: PubMed
    23. Shapiro GS, Aviszus K, Murphy J, Wysocki LJ. Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation. J Immunol. 2002 Mar 01; 168(5):2302-6. PMID: 11859119.
      View in: PubMed
    24. Shapiro GS, Wysocki LJ. DNA target motifs of somatic mutagenesis in antibody genes. Crit Rev Immunol. 2002; 22(3):183-200. PMID: 12498382.
      View in: PubMed
    Wysocki's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description
    Physical Neighbors Expand Description
    _

    Copyright © 2017 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.10.0)