Lawrence J Wysocki
Title | Affiliate - NJH |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-IMM MICRO GENERAL OPER |
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Research R21AI033613 (WYSOCKI, LAWRENCE J.)Sep 1, 1993 - Aug 31, 2001 NIH/NIAID IMMUNE RECOGNITION AND TOLERANCE OF ANTIBODY DIVERSITY Role: Principal Investigator |
| R01AI033613 (WYSOCKI, LAWRENCE J.)Sep 1, 1993 - Mar 31, 2011 NIH/NIAID Immune Recognition and Tolerance of Antibody Diversity Role: Principal Investigator |
| R01AI039563 (WYSOCKI, LAWRENCE J.)Apr 1, 1996 - Mar 31, 2002 NIH/NIAID SOMATIC MUTAGENESIS AND DEVELOPMENT OF B CELL MEMORY Role: Principal Investigator |
| R01AI048108 (WYSOCKI, LAWRENCE J.)Apr 1, 2001 - Mar 31, 2007 NIH/NIAID ORIGIN OF T CELL HELP FOR AUTOREACTIVE B CELLS Role: Principal Investigator |
| R01AI073945 (WYSOCKI, LAWRENCE J.)Dec 15, 2007 - Nov 30, 2013 NIH/NIAID Functional Anergy in B Cells Role: Principal Investigator |
| R03AI088408 (WYSOCKI, LAWRENCE J.)Feb 15, 2010 - Jan 31, 2013 NIH/NIAID A Reporter for Mutant Autoreactive B Cells Role: Principal Investigator |
| R03AI092358 (WYSOCKI, LAWRENCE J.)Aug 4, 2011 - Jul 31, 2014 NIH/NIAID An Advanced Model to Analyze CD4T Cel Reactions to Antibody and BCR V Regions Role: Principal Investigator |
| R01AI093822 (WYSOCKI, LAWRENCE J.)Dec 1, 2011 - Nov 30, 2016 NIH/NIAID Somatic Hypermutation in SLE Role: Principal Investigator |
| R21AI113122 (WYSOCKI, LAWRENCE J.)Jun 1, 2014 - May 31, 2016 NIH/NIAID Somatic Mutagenesis in Autoimmunity Role: Principal Investigator |
| R21AI121980 (WYSOCKI, LAWRENCE J)Jan 1, 2016 - Dec 31, 2017 NIH/NIAID A Universal Strategy for Inducing Tolerance to Therapeutic Mab Role: Principal Investigator |
Bibliographic
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St Clair JB, Detanico T, Aviszus K, Kirchenbaum GA, Christie M, Carpenter JF, Wysocki LJ. Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes. PLoS One. 2017; 12(1):e0170556. PMID: 28114383.
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Detanico T, Phillips M, Wysocki LJ. Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes. Front Immunol. 2016; 7:525. PMID: 27920779.
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Huang Y, Getahun A, Heiser RA, Detanico TO, Aviszus K, Kirchenbaum GA, Casper TL, Huang C, Aydintug MK, Carding SR, Ikuta K, Huang H, Wysocki LJ, Cambier JC, O'Brien RL, Born WK. ?d T Cells Shape Preimmune Peripheral B Cell Populations. J Immunol. 2016 Jan 01; 196(1):217-31. PMID: 26582947.
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Detanico T, Guo W, Wysocki LJ. Predominant role for activation-induced cytidine deaminase in generating IgG anti-nucleosomal antibodies of murine SLE. J Autoimmun. 2015 Apr; 58:67-77. PMID: 25634361.
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Huang Y, Heiser RA, Detanico TO, Getahun A, Kirchenbaum GA, Casper TL, Aydintug MK, Carding SR, Ikuta K, Huang H, Cambier JC, Wysocki LJ, O'Brien RL, Born WK. ?d T cells affect IL-4 production and B-cell tolerance. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):E39-48. PMID: 25535377.
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Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15; 193(10):4757-60. PMID: 25381356.
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Kirchenbaum GA, St Clair JB, Detanico T, Aviszus K, Wysocki LJ. Functionally responsive self-reactive B cells of low affinity express reduced levels of surface IgM. Eur J Immunol. 2014 Apr; 44(4):970-82. PMID: 24375379.
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Detanico T, St Clair JB, Aviszus K, Kirchenbaum G, Guo W, Wysocki LJ. Somatic mutagenesis in autoimmunity. Autoimmunity. 2013 Mar; 46(2):102-14. PMID: 23249093.
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Aviszus K, Macleod MK, Kirchenbaum GA, Detanico TO, Heiser RA, St Clair JB, Guo W, Wysocki LJ. Antigen-specific suppression of humoral immunity by anergic Ars/A1 B cells. J Immunol. 2012 Nov 01; 189(9):4275-83. PMID: 23008448.
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Heiser RA, Snyder CM, St Clair J, Wysocki LJ. Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide. J Immunol. 2011 Jul 01; 187(1):212-21. PMID: 21622866.
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Detanico T, Heiser RA, Aviszus K, Bonorino C, Wysocki LJ. Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor. J Immunol. 2011 Jul 01; 187(1):82-91. PMID: 21622865.
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Guo W, Smith D, Aviszus K, Detanico T, Heiser RA, Wysocki LJ. Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity. J Exp Med. 2010 Sep 27; 207(10):2225-37. PMID: 20805563.
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Aviszus K, Zhang X, Wysocki LJ. Silent development of memory progenitor B cells. J Immunol. 2007 Oct 15; 179(8):5181-90. PMID: 17911603.
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Kilmon MA, Wagner NJ, Garland AL, Lin L, Aviszus K, Wysocki LJ, Vilen BJ. Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6. Blood. 2007 Sep 01; 110(5):1595-602. PMID: 17712049.
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Liu X, Wysocki LJ, Manser T. Autoantigen-B cell antigen receptor interactions that regulate expression of B cell antigen receptor Loci. J Immunol. 2007 Apr 15; 178(8):5035-47. PMID: 17404286.
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Merrell KT, Benschop RJ, Gauld SB, Aviszus K, Decote-Ricardo D, Wysocki LJ, Cambier JC. Identification of anergic B cells within a wild-type repertoire. Immunity. 2006 Dec; 25(6):953-62. PMID: 17174121.
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Guo W, Smith D, Guth A, Aviszus K, Wysocki LJ. T cell tolerance to germline-encoded antibody sequences in a lupus-prone mouse. J Immunol. 2005 Aug 15; 175(4):2184-90. PMID: 16081785.
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Snyder CM, Aviszus K, Heiser RA, Tonkin DR, Guth AM, Wysocki LJ. Activation and tolerance in CD4(+) T cells reactive to an immunoglobulin variable region. J Exp Med. 2004 Jul 05; 200(1):1-11. PMID: 15226360.
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Guth AM, Zhang X, Smith D, Detanico T, Wysocki LJ. Chromatin specificity of anti-double-stranded DNA antibodies and a role for Arg residues in the third complementarity-determining region of the heavy chain. J Immunol. 2003 Dec 01; 171(11):6260-6. PMID: 14634143.
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Shapiro GS, Ellison MC, Wysocki LJ. Sequence-specific targeting of two bases on both DNA strands by the somatic hypermutation mechanism. Mol Immunol. 2003 Sep; 40(5):287-95. PMID: 12943801.
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Jena PK, Smith DS, Zhang X, Aviszus K, Durdik JM, Wysocki LJ. Somatic translocation and differential expression of Ig mu transgene copies implicate a role for the Igh locus in memory B cell development. Mol Immunol. 2003 May; 39(14):885-97. PMID: 12686505.
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Snyder CM, Zhang X, Wysocki LJ. Negligible class II MHC presentation of B cell receptor-derived peptides by high density resting B cells. J Immunol. 2002 Apr 15; 168(8):3865-73. PMID: 11937540.
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Shapiro GS, Aviszus K, Murphy J, Wysocki LJ. Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation. J Immunol. 2002 Mar 01; 168(5):2302-6. PMID: 11859119.
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Shapiro GS, Wysocki LJ. DNA target motifs of somatic mutagenesis in antibody genes. Crit Rev Immunol. 2002; 22(3):183-200. PMID: 12498382.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2002 | 3 | 2003 | 3 | 2004 | 1 | 2005 | 1 | 2006 | 1 | 2007 | 3 | 2010 | 1 | 2011 | 2 | 2012 | 1 | 2013 | 1 | 2014 | 3 | 2015 | 2 | 2016 | 1 | 2017 | 1 |
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