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Christina C Leslie

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

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    R01HL032015     (LESLIE, CHRISTINA CARROLL)Sep 1, 1983 - Aug 31, 1986
    Role: Principal Investigator

    P01HL034303     (LESLIE, CHRISTINA CARROLL)Sep 30, 1985 - Jan 31, 2016
    Ether Lipids, Elcosanoids, and Lung Cell Pathophysiology
    Role: Principal Investigator

    R13GM058004     (LESLIE, CHRISTINA CARROLL)Jul 20, 1998 - Jan 19, 1999
    Role: Principal Investigator

    R01HL061378     (LESLIE, CHRISTINA CARROLL)Jan 1, 1999 - Jul 31, 2013
    Regulation and Function of Cytosolic Phospholipases A2 in Lung Cells
    Role: Principal Investigator

    S10RR029218     (LESLIE, CHRISTINA CARROLL)Apr 1, 2011 - Mar 31, 2012
    Request for Spinning Disc Confocal Microscopy System
    Role: Principal Investigator

    R21ES025015     (LESLIE, CHRISTINA CARROLL)Jul 15, 2015 - Jun 30, 2017
    Identity of a serine hydrolase that controls mitochondrial calcium and cell death
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yun B, Lee H, Powell R, Reisdorph N, Ewing H, Gelb MH, Hsu KL, Cravatt BF, Leslie CC. Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2. Biochem Biophys Res Commun. 2017 09 02; 490(4):1226-1231. PMID: 28684316.
      View in: PubMed
    2. Vu LP, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, Chou T, Chow A, Minuesa G, Park SM, Barlowe TS, Taggart J, Tivnan P, Deering RP, Chu LP, Kwon JA, Meydan C, Perales-Paton J, Arshi A, Gönen M, Famulare C, Patel M, Paietta E, Tallman MS, Lu Y, Glass J, Garret-Bakelman FE, Melnick A, Levine R, Al-Shahrour F, Järås M, Hacohen N, Hwang A, Garippa R, Lengner CJ, Armstrong SA, Cerchietti L, Cowley GS, Root D, Doench J, Leslie C, Ebert BL, Kharas MG. Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells. Nat Genet. 2017 Jun; 49(6):866-875. PMID: 28436985.
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    3. Yun B, Lee H, Ewing H, Gelb MH, Leslie CC. Off-target effect of the cPLA2a inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum. Biochem Biophys Res Commun. 2016 10 07; 479(1):61-6. PMID: 27620490.
      View in: PubMed
    4. Jayaraja S, Dakhama A, Yun B, Ghosh M, Lee H, Redente EF, Uhlson CL, Murphy RC, Leslie CC. Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infection. BMC Immunol. 2016 08 08; 17(1):27. PMID: 27501951; PMCID: PMC4977843.
    5. Kandasamy P, Numata M, Berry KZ, Fickes R, Leslie CC, Murphy RC, Voelker DR. Structural analogs of pulmonary surfactant phosphatidylglycerol inhibit toll-like receptor 2 and 4 signaling. J Lipid Res. 2016 06; 57(6):993-1005. PMID: 27095543.
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    6. Taggart J, Ho TC, Amin E, Xu H, Barlowe TS, Perez AR, Durham BH, Tivnan P, Okabe R, Chow A, Vu L, Park SM, Prieto C, Famulare C, Patel M, Lengner CJ, Verma A, Roboz G, Guzman M, Klimek VM, Abdel-Wahab O, Leslie C, Nimer SD, Kharas MG. MSI2 is required for maintaining activated myelodysplastic syndrome stem cells. Nat Commun. 2016 Feb 22; 7:10739. PMID: 26898884; PMCID: PMC4764878.
    7. Yun B, Lee H, Jayaraja S, Suram S, Murphy RC, Leslie CC. Prostaglandins from Cytosolic Phospholipase A2a/Cyclooxygenase-1 Pathway and Mitogen-activated Protein Kinases Regulate Gene Expression in Candida albicans-infected Macrophages. J Biol Chem. 2016 Mar 25; 291(13):7070-86. PMID: 26841868; PMCID: PMC4807289 [Available on 03/25/17].
    8. Han YC, Vidigal JA, Mu P, Yao E, Singh I, González AJ, Concepcion CP, Bonetti C, Ogrodowski P, Carver B, Selleri L, Betel D, Leslie C, Ventura A. An allelic series of miR-17 ~ 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jul; 47(7):766-75. PMID: 26029871; PMCID: PMC4485521.
    9. Ito Y, Correll K, Zemans RL, Leslie CC, Murphy RC, Mason RJ. Influenza induces IL-8 and GM-CSF secretion by human alveolar epithelial cells through HGF/c-Met and TGF-a/EGFR signaling. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1178-88. PMID: 26033355; PMCID: PMC4451400.
    10. Leslie CC. Cytosolic phospholipase A2: physiological function and role in disease. J Lipid Res. 2015 Aug; 56(8):1386-402. PMID: 25838312; PMCID: PMC4513982.
    11. Macdonald DJ, Boyle RM, Glen AC, Leslie CC, Glen AI, Horrobin DF. The development of an ELISA for group IVA phospholipase A2 in human red blood cells. Prostaglandins Leukot Essent Fatty Acids. 2015 Mar; 94:43-8. PMID: 25547672.
      View in: PubMed
    12. Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG. Musashi-2 controls cell fate, lineage bias, and TGF-ß signaling in HSCs. J Exp Med. 2014 Jan 13; 211(1):71-87. PMID: 24395885; PMCID: PMC3892968.
    13. Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J Biol Chem. 2014 Jan 17; 289(3):1491-504. PMID: 24297180; PMCID: PMC3894331.
    14. Suram S, Silveira LJ, Mahaffey S, Brown GD, Bonventre JV, Williams DL, Gow NA, Bratton DL, Murphy RC, Leslie CC. Cytosolic phospholipase A(2)a and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. PLoS One. 2013; 8(7):e69002. PMID: 23950842.
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    15. Kobos R, Nagai M, Tsuda M, Merl MY, Saito T, Laé M, Mo Q, Olshen A, Lianoglou S, Leslie C, Ostrovnaya I, Antczak C, Djaballah H, Ladanyi M. Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein. J Pathol. 2013 Apr; 229(5):743-754. PMID: 23288701; PMCID: PMC4083568.
    16. Frasch SC, Fernandez-Boyanapalli RF, Berry KA, Murphy RC, Leslie CC, Nick JA, Henson PM, Bratton DL. Neutrophils regulate tissue Neutrophilia in inflammation via the oxidant-modified lipid lysophosphatidylserine. J Biol Chem. 2013 Feb 15; 288(7):4583-93. PMID: 23293064; PMCID: PMC3576064.
    17. Basso K, Schneider C, Shen Q, Holmes AB, Setty M, Leslie C, Dalla-Favera R. BCL6 positively regulates AID and germinal center gene expression via repression of miR-155. J Exp Med. 2012 Dec 17; 209(13):2455-65. PMID: 23166356; PMCID: PMC3526356.
    18. Arvey A, Agius P, Noble WS, Leslie C. Sequence and chromatin determinants of cell-type-specific transcription factor binding. Genome Res. 2012 Sep; 22(9):1723-34. PMID: 22955984; PMCID: PMC3431489.
    19. Pastar I, Khan AA, Stojadinovic O, Lebrun EA, Medina MC, Brem H, Kirsner RS, Jimenez JJ, Leslie C, Tomic-Canic M. Induction of specific microRNAs inhibits cutaneous wound healing. J Biol Chem. 2012 Aug 24; 287(35):29324-35. PMID: 22773832; PMCID: PMC3436197.
    20. Zizza P, Iurisci C, Bonazzi M, Cossart P, Leslie CC, Corda D, Mariggiò S. Phospholipase A2IVa regulates phagocytosis independent of its enzymatic activity. J Biol Chem. 2012 May 11; 287(20):16849-59. PMID: 22393044; PMCID: PMC3351341.
    21. Sanford SD, Yun BG, Leslie CC, Murphy RC, Pfenninger KH. Group IVA phospholipase A2 is necessary for growth cone repulsion and collapse. J Neurochem. 2012 Mar; 120(6):974-84. PMID: 22220903; PMCID: PMC3296835.
    22. Yang JS, Valente C, Polishchuk RS, Turacchio G, Layre E, Moody DB, Leslie CC, Gelb MH, Brown WJ, Corda D, Luini A, Hsu VW. COPI acts in both vesicular and tubular transport. Nat Cell Biol. 2011 Jul 03; 13(8):996-1003. PMID: 21725317; PMCID: PMC3149785.
    23. Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi F, Gelb MH, Leslie CC, Oates JA, Boutaud O. Functional characterization of mutations in inherited human cPLA2 deficiency. Biochemistry. 2011 Mar 15; 50(10):1731-8. PMID: 21247147; PMCID: PMC3051024.
    24. Frasch SC, Fernandez-Boyanapalli RF, Berry KZ, Leslie CC, Bonventre JV, Murphy RC, Henson PM, Bratton DL. Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity. J Biol Chem. 2011 Apr 08; 286(14):12108-22. PMID: 21297111; PMCID: PMC3069415.
    25. Kandasamy P, Zarini S, Chan ED, Leslie CC, Murphy RC, Voelker DR. Pulmonary surfactant phosphatidylglycerol inhibits Mycoplasma pneumoniae-stimulated eicosanoid production from human and mouse macrophages. J Biol Chem. 2011 Mar 11; 286(10):7841-53. PMID: 21205826.
      View in: PubMed
    26. Tithof PK, Richards SM, Elgayyar MA, Menn FM, Vulava VM, McKay L, Sanseverino J, Sayler G, Tucker DE, Leslie CC, Lu KP, Ramos KS. Activation of group IVC phospholipase A(2) by polycyclic aromatic hydrocarbons induces apoptosis of human coronary artery endothelial cells. Arch Toxicol. 2011 Jun; 85(6):623-34. PMID: 21132278; PMCID: PMC4741309.
    27. Yao X, Balamurugan P, Arvey A, Leslie C, Zhang L. Heme controls the regulation of protein tyrosine kinases Jak2 and Src. Biochem Biophys Res Commun. 2010 Dec 03; 403(1):30-5. PMID: 21036157; PMCID: PMC3038409.
    28. Agius P, Arvey A, Chang W, Noble WS, Leslie C. High resolution models of transcription factor-DNA affinities improve in vitro and in vivo binding predictions. PLoS Comput Biol. 2010 Sep 09; 6(9). PMID: 20838582; PMCID: PMC2936517.
    29. Ghomashchi F, Naika GS, Bollinger JG, Aloulou A, Lehr M, Leslie CC, Gelb MH. Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms. J Biol Chem. 2010 Nov 12; 285(46):36100-11. PMID: 20705608; PMCID: PMC2975232.
    30. Suram S, Gangelhoff TA, Taylor PR, Rosas M, Brown GD, Bonventre JV, Akira S, Uematsu S, Williams DL, Murphy RC, Leslie CC. Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans. J Biol Chem. 2010 Oct 01; 285(40):30676-85. PMID: 20643646.
      View in: PubMed
    31. Leslie CC, Gangelhoff TA, Gelb MH. Localization and function of cytosolic phospholipase A2alpha at the Golgi. Biochimie. 2010 Jun; 92(6):620-6. PMID: 20226226; PMCID: PMC2878860.
    32. San Pietro E, Capestrano M, Polishchuk EV, DiPentima A, Trucco A, Zizza P, Mariggiò S, Pulvirenti T, Sallese M, Tete S, Mironov AA, Leslie CC, Corda D, Luini A, Polishchuk RS. Group IV phospholipase A(2)alpha controls the formation of inter-cisternal continuities involved in intra-Golgi transport. PLoS Biol. 2009 Sep; 7(9):e1000194. PMID: 19753100; PMCID: PMC2732982.
    33. Parti RP, Loper R, Brown GD, Gordon S, Taylor PR, Bonventre JV, Murphy RC, Williams DL, Leslie CC. Cytosolic phospholipase a2 activation by Candida albicans in alveolar macrophages: role of dectin-1. Am J Respir Cell Mol Biol. 2010 Apr; 42(4):415-23. PMID: 19502385.
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    34. Tucker DE, Ghosh M, Ghomashchi F, Loper R, Suram S, John BS, Girotti M, Bollinger JG, Gelb MH, Leslie CC. Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function. J Biol Chem. 2009 Apr 03; 284(14):9596-611. PMID: 19176526; PMCID: PMC2666612.
    35. Giannattasio G, Lai Y, Granata F, Mounier CM, Nallan L, Oslund R, Leslie CC, Marone G, Lambeau G, Gelb MH, Triggiani M. Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. Biochim Biophys Acta. 2009 Feb; 1791(2):92-102. PMID: 19130898; PMCID: PMC2676353.
    36. Frasch SC, Berry KZ, Fernandez-Boyanapalli R, Jin HS, Leslie C, Henson PM, Murphy RC, Bratton DL. NADPH oxidase-dependent generation of lysophosphatidylserine enhances clearance of activated and dying neutrophils via G2A. J Biol Chem. 2008 Nov 28; 283(48):33736-49. PMID: 18824544; PMCID: PMC2586279.
    37. Tucker DE, Gijón MA, Spencer DM, Qiu ZH, Gelb MH, Leslie CC. Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages. J Leukoc Biol. 2008 Sep; 84(3):798-806. PMID: 18550790; PMCID: PMC2516904.
    38. Wooten RE, Willingham MC, Daniel LW, Leslie CC, Rogers LC, Sergeant S, O'Flaherty JT. Novel translocation responses of cytosolic phospholipase A2alpha fluorescent proteins. Biochim Biophys Acta. 2008 Aug; 1783(8):1544-50. PMID: 18406359; PMCID: PMC2474710.
    39. Pavicevic Z, Leslie CC, Malik KU. cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells. J Lipid Res. 2008 Apr; 49(4):724-37. PMID: 18187403.
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    40. Noor S, Goldfine H, Tucker DE, Suram S, Lenz LL, Akira S, Uematsu S, Girotti M, Bonventre JV, Breuel K, Williams DL, Leslie CC. Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2. J Biol Chem. 2008 Feb 22; 283(8):4744-55. PMID: 18083708.
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    41. Melvin I, Ie E, Kuang R, Weston J, Stafford WN, Leslie C. SVM-Fold: a tool for discriminative multi-class protein fold and superfamily recognition. BMC Bioinformatics. 2007 May 22; 8 Suppl 4:S2. PMID: 17570145.
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    42. Ghosh M, Loper R, Ghomashchi F, Tucker DE, Bonventre JV, Gelb MH, Leslie CC. Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. J Biol Chem. 2007 Apr 20; 282(16):11676-86. PMID: 17293613; PMCID: PMC2678067.
    43. Ghosh M, Tucker DE, Burchett SA, Leslie CC. Properties of the Group IV phospholipase A2 family. Prog Lipid Res. 2006 Nov; 45(6):487-510. PMID: 16814865.
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    44. Ghosh M, Loper R, Gelb MH, Leslie CC. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. J Biol Chem. 2006 Jun 16; 281(24):16615-24. PMID: 16617059.
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    45. Suram S, Brown GD, Ghosh M, Gordon S, Loper R, Taylor PR, Akira S, Uematsu S, Williams DL, Leslie CC. Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor. J Biol Chem. 2006 Mar 03; 281(9):5506-14. PMID: 16407295.
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    46. Balestrieri B, Hsu VW, Gilbert H, Leslie CC, Han WK, Bonventre JV, Arm JP. Group V secretory phospholipase A2 translocates to the phagosome after zymosan stimulation of mouse peritoneal macrophages and regulates phagocytosis. J Biol Chem. 2006 Mar 10; 281(10):6691-8. PMID: 16407308; PMCID: PMC1820836.
    47. Evans JH, Murray D, Leslie CC, Falke JJ. Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain. Mol Biol Cell. 2006 Jan; 17(1):56-66. PMID: 16236797.
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    48. Kuang R, Weston J, Noble WS, Leslie C. Motif-based protein ranking by network propagation. Bioinformatics. 2005 Oct 01; 21(19):3711-8. PMID: 16076885.
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    49. Tucker DE, Stewart A, Nallan L, Bendale P, Ghomashchi F, Gelb MH, Leslie CC. Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells. J Lipid Res. 2005 Oct; 46(10):2122-33. PMID: 16061942.
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    50. Kuang R, Ie E, Wang K, Wang K, Siddiqi M, Freund Y, Leslie C. Profile-based string kernels for remote homology detection and motif extraction. J Bioinform Comput Biol. 2005 Jun; 3(3):527-50. PMID: 16108083.
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    51. Leslie CC. Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2. Prostaglandins Leukot Essent Fatty Acids. 2004 Apr; 70(4):373-6. PMID: 15041029.
      View in: PubMed
    52. Girotti M, Evans JH, Burke D, Leslie CC. Cytosolic phospholipase A2 translocates to forming phagosomes during phagocytosis of zymosan in macrophages. J Biol Chem. 2004 Apr 30; 279(18):19113-21. PMID: 14963030.
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    53. Ahmad S, Ahmad A, Ghosh M, Leslie CC, White CW. Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress. J Biol Chem. 2004 Apr 16; 279(16):16317-25. PMID: 14761947.
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    54. Leslie CC. Regulation of arachidonic acid availability for eicosanoid production. Biochem Cell Biol. 2004 Feb; 82(1):1-17. PMID: 15052324.
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    55. Leslie CC, Gelb MH. Assaying phospholipase A2 activity. Methods Mol Biol. 2004; 284:229-42. PMID: 15173620.
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    56. Pettus BJ, Bielawska A, Subramanian P, Wijesinghe DS, Maceyka M, Leslie CC, Evans JH, Freiberg J, Roddy P, Hannun YA, Chalfant CE. Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J Biol Chem. 2004 Mar 19; 279(12):11320-6. PMID: 14676210.
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    57. Leventhal AR, Leslie CC, Tabas I. Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking. J Biol Chem. 2004 Feb 27; 279(9):8084-92. PMID: 14638686.
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    58. Evans JH, Leslie CC. The cytosolic phospholipase A2 catalytic domain modulates association and residence time at Golgi membranes. J Biol Chem. 2004 Feb 13; 279(7):6005-16. PMID: 14623879.
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    59. Evans JH, Gerber SH, Murray D, Leslie CC. The calcium binding loops of the cytosolic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cells. Mol Biol Cell. 2004 Jan; 15(1):371-83. PMID: 13679516.
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    60. Ghosh M, Stewart A, Tucker DE, Bonventre JV, Murphy RC, Leslie CC. Role of cytosolic phospholipase A(2) in prostaglandin E(2) production by lung fibroblasts. Am J Respir Cell Mol Biol. 2004 Jan; 30(1):91-100. PMID: 12842849.
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    61. Evans JH, Fergus DJ, Leslie CC. Regulation of cytosolic phospholipase A(2) translocation. Adv Enzyme Regul. 2003; 43:229-44. PMID: 12791394.
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    62. Evans JH, Fergus DJ, Leslie CC. Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA2 phosphorylation and translocation. BMC Biochem. 2002 Oct 08; 3:30. PMID: 12370087; PMCID: PMC130032.
    63. Stewart A, Ghosh M, Spencer DM, Leslie CC. Enzymatic properties of human cytosolic phospholipase A(2)gamma. J Biol Chem. 2002 Aug 16; 277(33):29526-36. PMID: 12039969.
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