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Brian Alberto Aguado

TitleAffiliate
InstitutionUniversity of Colorado Boulder
DepartmentChemical & Biological Engin

    Collapse Research 
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    R00HL148542     (AGUADO, BRIAN ALBERTO)Sep 5, 2021 - Aug 31, 2024
    NIH
    Investigating sex differences in persistent valvular myofibroblast activation using hydrogel culture substrates
    Role: Principal Investigator
    K99HL148542     (AGUADO, BRIAN ALBERTO)Aug 1, 2019 - Jul 31, 2021
    NIH
    Investigating sex differences in persistent valvular myofibroblast activation using hydrogel culture substrates
    Role: Principal Investigator
    F32HL137256     (AGUADO, BRIAN ALBERTO)Jul 1, 2017 - Jun 30, 2020
    NIH
    Development of a nanotherapy for aortic valve stenosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Vogt BJ, Peters DK, Anseth KS, Aguado BA. Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation. Biomater Sci. 2022 Nov 08; 10(22):6341-6353. PMID: 36226463.
      View in: PubMed
    2. Vogt BJ, Anseth KS, Aguado BA. Correction: Inflammatory serum factors from aortic valve stenosis patients modulate sex differences in valvular myofibroblast activation and osteoblast-like differentiation. Biomater Sci. 2022 Nov 08; 10(22):6627. PMID: 36281803.
      View in: PubMed
    3. F?lix V?lez NE, Gorashi RM, Aguado BA. Chemical and molecular tools to probe biological sex differences at multiple length scales. J Mater Chem B. 2022 09 28; 10(37):7089-7098. PMID: 36043366.
      View in: PubMed
    4. Walker CJ, Batan D, Bishop CT, Ramirez D, Aguado BA, Schroeder ME, Crocini C, Schwisow J, Moulton K, Macdougall L, Weiss RM, Allen MA, Dowell R, Leinwand LA, Anseth KS. Extracellular matrix stiffness controls cardiac valve myofibroblast activation through epigenetic remodeling. Bioeng Transl Med. 2022 Sep; 7(3):e10394. PMID: 36176599.
      View in: PubMed
    5. Schroeder ME, Batan D, Gonzalez Rodriguez A, Speckl KF, Peters DK, Kirkpatrick BE, Hach GK, Walker CJ, Grim JC, Aguado BA, Weiss RM, Anseth KS. Osteopontin activity modulates sex-specific calcification in engineered valve tissue mimics. Bioeng Transl Med. 2023 Jan; 8(1):e10358. PMID: 36684107.
      View in: PubMed
    6. Batan D, Peters DK, Schroeder ME, Aguado BA, Young MW, Weiss RM, Anseth KS. Hydrogel cultures reveal Transient Receptor Potential Vanilloid 4 regulation of myofibroblast activation and proliferation in valvular interstitial cells. FASEB J. 2022 05; 36(5):e22306. PMID: 35385164.
      View in: PubMed
    7. Rogers JD, Aguado BA, Watts KM, Anseth KS, Richardson WJ. Network modeling predicts personalized gene expression and drug responses in valve myofibroblasts cultured with patient sera. Proc Natl Acad Sci U S A. 2022 02 22; 119(8). PMID: 35181609.
      View in: PubMed
    8. Aguado BA, Walker CJ, Grim JC, Schroeder ME, Batan D, Vogt BJ, Rodriguez AG, Schwisow JA, Moulton KS, Weiss RM, Heistad DD, Leinwand LA, Anseth KS. Genes That Escape X Chromosome Inactivation Modulate Sex Differences in Valve Myofibroblasts. Circulation. 2022 02 15; 145(7):513-530. PMID: 35000411.
      View in: PubMed
    9. Walker CJ, Crocini C, Ramirez D, Killaars AR, Grim JC, Aguado BA, Clark K, Allen MA, Dowell RD, Leinwand LA, Anseth KS. Author Correction: Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts. Nat Biomed Eng. 2021 Dec; 5(12):1517-1518. PMID: 34050334.
      View in: PubMed
    10. Walker CJ, Schroeder ME, Aguado BA, Anseth KS, Leinwand LA. Matters of the heart: Cellular sex differences. J Mol Cell Cardiol. 2021 11; 160:42-55. PMID: 34166708.
      View in: PubMed
    11. Walker CJ, Crocini C, Ramirez D, Killaars AR, Grim JC, Aguado BA, Clark K, Allen MA, Dowell RD, Leinwand LA, Anseth KS. Nuclear mechanosensing drives chromatin remodelling in persistently activated fibroblasts. Nat Biomed Eng. 2021 12; 5(12):1485-1499. PMID: 33875841.
      View in: PubMed
    12. Aguado BA, Porras AM. Building a virtual community to support and celebrate the success of Latinx scientists. Nat Rev Mater. 2020; 5(12):862-864. PMID: 33101711.
      View in: PubMed
    13. Grim JC, Aguado BA, Vogt BJ, Batan D, Andrichik CL, Schroeder ME, Gonzalez-Rodriguez A, Yavitt FM, Weiss RM, Anseth KS. Secreted Factors From Proinflammatory Macrophages Promote an Osteoblast-Like Phenotype in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol. 2020 11; 40(11):e296-e308. PMID: 32938214.
      View in: PubMed
    14. Caldwell AS, Aguado BA, Anseth KS. Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments. Adv Funct Mater. 2020 Sep 10; 30(37). PMID: 33841061.
      View in: PubMed
    15. Aguado BA, Schuetze KB, Grim JC, Walker CJ, Cox AC, Ceccato TL, Tan AC, Sucharov CC, Leinwand LA, Taylor MRG, McKinsey TA, Anseth KS. Transcatheter aortic valve replacements alter circulating serum factors to mediate myofibroblast deactivation. Sci Transl Med. 2019 09 11; 11(509). PMID: 31511425.
      View in: PubMed
    16. Pe?a B, Maldonado M, Bonham AJ, Aguado BA, Dominguez-Alfaro A, Laughter M, Rowland TJ, Bardill J, Farnsworth NL, Alegret Ramon N, Taylor MRG, Anseth KS, Prato M, Shandas R, McKinsey TA, Park D, Mestroni L. Gold Nanoparticle-Functionalized Reverse Thermal Gel for Tissue Engineering Applications. ACS Appl Mater Interfaces. 2019 May 22; 11(20):18671-18680. PMID: 31021594.
      View in: PubMed
    17. Grim JC, Brown TE, Aguado BA, Chapnick DA, Viert AL, Liu X, Anseth KS. A Reversible and Repeatable Thiol-Ene Bioconjugation for Dynamic Patterning of Signaling Proteins in Hydrogels. ACS Cent Sci. 2018 Jul 25; 4(7):909-916. PMID: 30062120.
      View in: PubMed
    18. Aguado BA, Hartfield RM, Bushnell GG, Decker JT, Azarin SM, Nanavati D, Schipma MJ, Rao SS, Oakes RS, Zhang Y, Jeruss JS, Shea LD. Biomaterial Scaffolds as Pre-metastatic Niche Mimics Systemically Alter the Primary Tumor and Tumor Microenvironment. Adv Healthc Mater. 2018 05; 7(10):e1700903. PMID: 29521008.
      View in: PubMed
    19. Aguado BA, Grim JC, Rosales AM, Watson-Capps JJ, Anseth KS. Engineering precision biomaterials for personalized medicine. Sci Transl Med. 2018 01 17; 10(424). PMID: 29343626.
      View in: PubMed
    20. Pe?a B, Bosi S, Aguado BA, Borin D, Farnsworth NL, Dobrinskikh E, Rowland TJ, Martinelli V, Jeong M, Taylor MRG, Long CS, Shandas R, Sbaizero O, Prato M, Anseth KS, Park D, Mestroni L. Injectable Carbon Nanotube-Functionalized Reverse Thermal Gel Promotes Cardiomyocytes Survival and Maturation. ACS Appl Mater Interfaces. 2017 Sep 20; 9(37):31645-31656. PMID: 28895403.
      View in: PubMed
    21. Aguado BA, Bushnell GG, Rao SS, Jeruss JS, Shea LD. Engineering the pre-metastatic niche. Nat Biomed Eng. 2017; 1. PMID: 28989814.
      View in: PubMed
    22. Rao SS, Bushnell GG, Azarin SM, Spicer G, Aguado BA, Stoehr JR, Jiang EJ, Backman V, Shea LD, Jeruss JS. Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo. Cancer Res. 2016 09 15; 76(18):5209-18. PMID: 27635043.
      View in: PubMed
    23. Dubash AD, Kam CY, Aguado BA, Patel DM, Delmar M, Shea LD, Green KJ. Plakophilin-2 loss promotes TGF-?1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. J Cell Biol. 2016 Feb 15; 212(4):425-38. PMID: 26858265.
      View in: PubMed
    24. Aguado BA, Caffe JR, Nanavati D, Rao SS, Bushnell GG, Azarin SM, Shea LD. Extracellular matrix mediators of metastatic cell colonization characterized using scaffold mimics of the pre-metastatic niche. Acta Biomater. 2016 Mar; 33:13-24. PMID: 26844426.
      View in: PubMed
    25. Aguado BA, Wu JJ, Azarin SM, Nanavati D, Rao SS, Bushnell GG, Medicherla CB, Shea LD. Secretome identification of immune cell factors mediating metastatic cell homing. Sci Rep. 2015 Dec 04; 5:17566. PMID: 26634905.
      View in: PubMed
    26. Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Tucker SL, Backman V, Jeruss JS, Shea LD. In vivo capture and label-free detection of early metastatic cells. Nat Commun. 2015 Sep 08; 6:8094. PMID: 26348915.
      View in: PubMed
    27. Chung EJ, Chien KB, Aguado BA, Shah RN. Osteogenic potential of BMP-2-releasing self-assembled membranes. Tissue Eng Part A. 2013 Dec; 19(23-24):2664-73. PMID: 23790163.
      View in: PubMed
    28. Chien KB, Aguado BA, Bryce PJ, Shah RN. In vivo acute and humoral response to three-dimensional porous soy protein scaffolds. Acta Biomater. 2013 Nov; 9(11):8983-90. PMID: 23851173.
      View in: PubMed
    29. Aguado BA, Mulyasasmita W, Su J, Lampe KJ, Heilshorn SC. Improving viability of stem cells during syringe needle flow through the design of hydrogel cell carriers. Tissue Eng Part A. 2012 Apr; 18(7-8):806-15. PMID: 22011213.
      View in: PubMed
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